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Nuclear positioning in migrating fibroblasts.

Zhu R, Liu C, Gundersen GG.

Semin Cell Dev Biol. 2017 Dec 11. pii: S1084-9521(17)30497-4. doi: 10.1016/j.semcdb.2017.11.006. [Epub ahead of print] Review.


Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning.

Zhu R, Antoku S, Gundersen GG.

Curr Biol. 2017 Oct 23;27(20):3097-3110.e5. doi: 10.1016/j.cub.2017.08.073. Epub 2017 Oct 5.


Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity.

Qu X, Yuan FN, Corona C, Pasini S, Pero ME, Gundersen GG, Shelanski ML, Bartolini F.

J Cell Biol. 2017 Oct 2;216(10):3161-3178. doi: 10.1083/jcb.201701045. Epub 2017 Sep 6.


TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement.

Saunders CA, Harris NJ, Willey PT, Woolums BM, Wang Y, McQuown AJ, Schoenhofen A, Worman HJ, Dauer WT, Gundersen GG, Luxton GW.

J Cell Biol. 2017 Mar 6;216(3):657-674. doi: 10.1083/jcb.201507113. Epub 2017 Feb 27.


Independent variability of microtubule perturbations associated with dystrophinopathy.

Belanto JJ, Olthoff JT, Mader TL, Chamberlain CM, Nelson DM, McCourt PM, Talsness DM, Gundersen GG, Lowe DA, Ervasti JM.

Hum Mol Genet. 2016 Nov 15;25(22):4951-4961. doi: 10.1093/hmg/ddw318.


Identification of ginkgolide targets in brain by photoaffinity labeling.

Kawamura A, Washington I, Mihai DM, Bartolini F, Gundersen GG, Mark MT, Nakanishi K.

Chem Biol Drug Des. 2017 Apr;89(4):475-481. doi: 10.1111/cbdd.12883. Epub 2016 Nov 10.


Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.

Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Pfisterer K, Tootle T, Charras G, Gundersen GG, Parsons M.

Dev Cell. 2016 Aug 22;38(4):371-83. doi: 10.1016/j.devcel.2016.07.021.


Swollen Nuclei Signal from the Grave.

Chang W, Gundersen GG.

Cell. 2016 May 19;165(5):1051-1052. doi: 10.1016/j.cell.2016.05.015.


Wound-Healing Assays to Study Mechanisms of Nuclear Movement in Fibroblasts and Myoblasts.

Chang W, Antoku S, Gundersen GG.

Methods Mol Biol. 2016;1411:255-67. doi: 10.1007/978-1-4939-3530-7_17.


FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly.

Nader GP, Ezratty EJ, Gundersen GG.

Nat Cell Biol. 2016 May;18(5):491-503. doi: 10.1038/ncb3333. Epub 2016 Apr 4.


A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.

Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ.

J Cell Sci. 2016 May 15;129(10):1975-80. doi: 10.1242/jcs.187302. Epub 2016 Mar 31.


An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.

Bartolini F, Andres-Delgado L, Qu X, Nik S, Ramalingam N, Kremer L, Alonso MA, Gundersen GG.

Mol Biol Cell. 2016 Jun 1;27(11):1797-808. doi: 10.1091/mbc.E15-07-0489. Epub 2016 Mar 30. Erratum in: Mol Biol Cell. 2017 Jan 15;28(2):356.


Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension.

Arsenovic PT, Ramachandran I, Bathula K, Zhu R, Narang JD, Noll NA, Lemmon CA, Gundersen GG, Conway DE.

Biophys J. 2016 Jan 5;110(1):34-43. doi: 10.1016/j.bpj.2015.11.014.


Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

Li Y, Lovett D, Zhang Q, Neelam S, Kuchibhotla RA, Zhu R, Gundersen GG, Lele TP, Dickinson RB.

Biophys J. 2015 Aug 18;109(4):670-86. doi: 10.1016/j.bpj.2015.07.006.


Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement.

Antoku S, Zhu R, Kutscheidt S, Fackler OT, Gundersen GG.

Cell Cycle. 2015;14(14):2200-5. doi: 10.1080/15384101.2015.1053665. Epub 2015 Jun 17.


Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.

Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM.

Mol Biol Cell. 2015 Apr 1;26(7):1273-85. doi: 10.1091/mbc.E14-09-1373. Epub 2015 Jan 28.


Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts.

Chang W, Antoku S, Östlund C, Worman HJ, Gundersen GG.

Nucleus. 2015;6(1):77-88. doi: 10.1080/19491034.2015.1004947.


Accessorizing and anchoring the LINC complex for multifunctionality.

Chang W, Worman HJ, Gundersen GG.

J Cell Biol. 2015 Jan 5;208(1):11-22. doi: 10.1083/jcb.201409047. Review.


Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.

Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman KR, Worman HJ, Gundersen GG, Lattanzi G, Wehnert M, Shackleton S.

PLoS Genet. 2014 Sep 11;10(9):e1004605. doi: 10.1371/journal.pgen.1004605. eCollection 2014 Sep.


FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.

Kutscheidt S, Zhu R, Antoku S, Luxton GW, Stagljar I, Fackler OT, Gundersen GG.

Nat Cell Biol. 2014 Jul;16(7):708-15. doi: 10.1038/ncb2981. Epub 2014 Jun 1.


Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.

Morris EJ, Nader GP, Ramalingam N, Bartolini F, Gundersen GG.

PLoS One. 2014 Mar 21;9(3):e91568. doi: 10.1371/journal.pone.0091568. eCollection 2014.


CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.

Shahbazi MN, Megias D, Epifano C, Akhmanova A, Gundersen GG, Fuchs E, Perez-Moreno M.

J Cell Biol. 2013 Dec 23;203(6):1043-61. doi: 10.1083/jcb.201306019.


HIV-1 induces the formation of stable microtubules to enhance early infection.

Sabo Y, Walsh D, Barry DS, Tinaztepe S, de Los Santos K, Goff SP, Gundersen GG, Naghavi MH.

Cell Host Microbe. 2013 Nov 13;14(5):535-46. doi: 10.1016/j.chom.2013.10.012.


Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts.

Chang W, Folker ES, Worman HJ, Gundersen GG.

Mol Biol Cell. 2013 Dec;24(24):3869-80. doi: 10.1091/mbc.E13-06-0307. Epub 2013 Oct 23.


Plus-end tracking proteins, CLASPs, and a viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus spread.

Naghavi MH, Gundersen GG, Walsh D.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18268-73. doi: 10.1073/pnas.1310760110. Epub 2013 Oct 21.


Nuclear positioning.

Gundersen GG, Worman HJ.

Cell. 2013 Mar 14;152(6):1376-89. doi: 10.1016/j.cell.2013.02.031. Review.


INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells.

Andrés-Delgado L, Antón OM, Bartolini F, Ruiz-Sáenz A, Correas I, Gundersen GG, Alonso MA.

J Cell Biol. 2012 Sep 17;198(6):1025-37. doi: 10.1083/jcb.201202137.


Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1.

Bartolini F, Ramalingam N, Gundersen GG.

Mol Biol Cell. 2012 Oct;23(20):4032-40. doi: 10.1091/mbc.E12-05-0338. Epub 2012 Aug 23.


Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.

Wang Y, Ostlund C, Choi JC, Swayne TC, Gundersen GG, Worman HJ.

Nucleus. 2012 Sep-Oct;3(5):452-62. doi: 10.4161/nucl.21675. Epub 2012 Aug 16.


Aquaporin 2 promotes cell migration and epithelial morphogenesis.

Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA.

J Am Soc Nephrol. 2012 Sep;23(9):1506-17. doi: 10.1681/ASN.2012010079. Epub 2012 Aug 2.


Orientation and function of the nuclear-centrosomal axis during cell migration.

Luxton GW, Gundersen GG.

Curr Opin Cell Biol. 2011 Oct;23(5):579-88. doi: 10.1016/ Epub 2011 Aug 30. Review.


TAN lines: a novel nuclear envelope structure involved in nuclear positioning.

Luxton GW, Gomes ER, Folker ES, Worman HJ, Gundersen GG.

Nucleus. 2011 May-Jun;2(3):173-81. doi: 10.1073/pnas.1000824108.


Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.

Folker ES, Ostlund C, Luxton GW, Worman HJ, Gundersen GG.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):131-6. doi: 10.1073/pnas.1000824108. Epub 2010 Dec 20.


Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.

Luxton GW, Gomes ER, Folker ES, Vintinner E, Gundersen GG.

Science. 2010 Aug 20;329(5994):956-9. doi: 10.1126/science.1189072.


Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL.

J Cell Biol. 2010 Jun 28;189(7):1087-96. doi: 10.1083/jcb.201001016. Epub 2010 Jun 21.


Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells.

Ezratty EJ, Bertaux C, Marcantonio EE, Gundersen GG.

J Cell Biol. 2009 Nov 30;187(5):733-47. doi: 10.1083/jcb.200904054.


Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.

Ostlund C, Folker ES, Choi JC, Gomes ER, Gundersen GG, Worman HJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4099-108. doi: 10.1242/jcs.057075. Epub 2009 Oct 20.


Formins and microtubules.

Bartolini F, Gundersen GG.

Biochim Biophys Acta. 2010 Feb;1803(2):164-73. doi: 10.1016/j.bbamcr.2009.07.006. Epub 2009 Jul 23. Review.


Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration.

Schmoranzer J, Fawcett JP, Segura M, Tan S, Vallee RB, Pawson T, Gundersen GG.

Curr Biol. 2009 Jul 14;19(13):1065-74. doi: 10.1016/j.cub.2009.05.065. Epub 2009 Jun 18.


Microtubule plus-end binding protein EB1 is necessary for muscle cell differentiation, elongation and fusion.

Zhang T, Zaal KJ, Sheridan J, Mehta A, Gundersen GG, Ralston E.

J Cell Sci. 2009 May 1;122(Pt 9):1401-9. doi: 10.1242/jcs.039255. Epub 2009 Apr 14.


Beyond polymer polarity: how the cytoskeleton builds a polarized cell.

Li R, Gundersen GG.

Nat Rev Mol Cell Biol. 2008 Nov;9(11):860-73. doi: 10.1038/nrm2522. Review.


The formin mDia2 stabilizes microtubules independently of its actin nucleation activity.

Bartolini F, Moseley JB, Schmoranzer J, Cassimeris L, Goode BL, Gundersen GG.

J Cell Biol. 2008 May 5;181(3):523-36. doi: 10.1083/jcb.200709029.


HDAC6-pack: cortactin acetylation joins the brew.

Luxton GW, Gundersen GG.

Dev Cell. 2007 Aug;13(2):161-2.


Regulated binding of adenomatous polyposis coli protein to actin.

Moseley JB, Bartolini F, Okada K, Wen Y, Gundersen GG, Goode BL.

J Biol Chem. 2007 Apr 27;282(17):12661-8. Epub 2007 Feb 8.


Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.

Naghavi MH, Valente S, Hatziioannou T, de Los Santos K, Wen Y, Mott C, Gundersen GG, Goff SP.

EMBO J. 2007 Jan 10;26(1):41-52. Epub 2006 Dec 14.


Generation of noncentrosomal microtubule arrays.

Bartolini F, Gundersen GG.

J Cell Sci. 2006 Oct 15;119(Pt 20):4155-63. Review.


Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function.

Yeo MG, Partridge MA, Ezratty EJ, Shen Q, Gundersen GG, Marcantonio EE.

Mol Cell Biol. 2006 Jun;26(12):4399-409.


Real-time centrosome reorientation during fibroblast migration.

Gomes ER, Gundersen GG.

Methods Enzymol. 2006;406:579-92.


The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization.

Xiao D, Deguchi A, Gundersen GG, Oehlen B, Arnold L, Weinstein IB.

Mol Cancer Ther. 2006 Jan;5(1):60-7.

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