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Items: 1 to 50 of 95

1.

Microcirculation in the murine liver: a computational fluid dynamic model based on 3D reconstruction from in vivo microscopy.

Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G.

J Biomech. 2017 Oct 3;63:125-134. doi: 10.1016/j.jbiomech.2017.08.011. Epub 2017 Sep 2.

PMID:
28917579
2.

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens.

Jiménez de Oya N, De Giovanni M, Fioravanti J, Übelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M.

EMBO Mol Med. 2017 Nov;9(11):1482-1490. doi: 10.15252/emmm.201707732.

3.

Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology.

Fioravanti J, Di Lucia P, Magini D, Moalli F, Boni C, Benechet AP, Fumagalli V, Inverso D, Vecchi A, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M.

J Hepatol. 2017 Sep;67(3):543-548. doi: 10.1016/j.jhep.2017.04.020. Epub 2017 May 5.

PMID:
28483675
4.

Inflammatory monocytes hinder antiviral B cell responses.

Sammicheli S, Kuka M, Di Lucia P, de Oya NJ, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M.

Sci Immunol. 2016 Oct 21;1(4). pii: eaah6789.

5.

IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.

Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G.

EMBO Mol Med. 2016 Feb 1;8(2):155-70. doi: 10.15252/emmm.201505395.

6.

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.

Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.

J Thromb Haemost. 2015 Nov;13(11):2108-18. doi: 10.1111/jth.13150. Epub 2015 Oct 23.

7.

Mouse Models of Hepatitis B Virus Pathogenesis.

Iannacone M, Guidotti LG.

Cold Spring Harb Perspect Med. 2015 Aug 20;5(11). pii: a021477. doi: 10.1101/cshperspect.a021477. Review.

8.

Host-virus interactions in hepatitis B virus infection.

Guidotti LG, Isogawa M, Chisari FV.

Curr Opin Immunol. 2015 Oct;36:61-6. doi: 10.1016/j.coi.2015.06.016. Epub 2015 Jul 15. Review.

9.

Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M.

Cell. 2015 Apr 23;161(3):486-500. doi: 10.1016/j.cell.2015.03.005. Epub 2015 Apr 16.

10.

Editorial overview: Viral pathogenesis.

Guidotti LG, Iannacone M.

Curr Opin Virol. 2015 Apr;11:v-vii. doi: 10.1016/j.coviro.2015.03.003. Epub 2015 Mar 18. No abstract available.

PMID:
25795138
11.

In vivo flow mapping in complex vessel networks by single image correlation.

Sironi L, Bouzin M, Inverso D, D'Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G.

Sci Rep. 2014 Dec 5;4:7341. doi: 10.1038/srep07341.

12.

The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver.

Panattoni M, Maiorino L, Lukacs A, Zentilin L, Mazza D, Sanvito F, Sitia G, Guidotti LG, Pardi R.

Hepatology. 2014 Jun;59(6):2331-43. doi: 10.1002/hep.27028. Epub 2014 Apr 30.

PMID:
24452456
13.

Bisphosphonates target B cells to enhance humoral immune responses.

Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M.

Cell Rep. 2013 Oct 31;5(2):323-30. doi: 10.1016/j.celrep.2013.09.004. Epub 2013 Oct 10.

14.

Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.

Sitia G, Iannacone M, Guidotti LG.

J Hepatol. 2013 Nov;59(5):1135-8. doi: 10.1016/j.jhep.2013.05.040. Epub 2013 Jun 4.

15.

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb.

Patel AS, Smith A, Nucera S, Biziato D, Saha P, Attia RQ, Humphries J, Mattock K, Grover SP, Lyons OT, Guidotti LG, Siow R, Ivetic A, Egginton S, Waltham M, Naldini L, De Palma M, Modarai B.

EMBO Mol Med. 2013 Jun;5(6):858-69. doi: 10.1002/emmm.201302752. Epub 2013 May 7.

16.

Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.

Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, Sitia G, Harrelson Z, Evans SM, Guidotti LG, Harvey RP, Brendolan A.

Immunity. 2013 Apr 18;38(4):782-91. doi: 10.1016/j.immuni.2012.12.005.

17.

Effector CD8 T cell trafficking within the liver.

Guidotti LG, Iannacone M.

Mol Immunol. 2013 Aug;55(1):94-9. doi: 10.1016/j.molimm.2012.10.032. Epub 2012 Nov 10. Review.

18.

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.

Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2165-72. doi: 10.1073/pnas.1209182109. Epub 2012 Jul 2.

19.

Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help.

Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P.

J Immunol. 2012 Apr 1;188(7):3217-22. doi: 10.4049/jimmunol.1103501. Epub 2012 Feb 29.

20.

Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.

Sitia G, Iannacone M, Aiolfi R, Isogawa M, van Rooijen N, Scozzesi C, Bianchi ME, von Andrian UH, Chisari FV, Guidotti LG.

PLoS Pathog. 2011 Jun;7(6):e1002061. doi: 10.1371/journal.ppat.1002061. Epub 2011 Jun 2.

21.

Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.

Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH.

Nature. 2010 Jun 24;465(7301):1079-83. doi: 10.1038/nature09118.

22.

Role of CCL2/MCP-1 in islet transplantation.

Melzi R, Mercalli A, Sordi V, Cantarelli E, Nano R, Maffi P, Sitia G, Guidotti LG, Secchi A, Bonifacio E, Piemonti L.

Cell Transplant. 2010;19(8):1031-46. doi: 10.3727/096368910X514639. Epub 2010 Jun 11.

PMID:
20546673
23.

Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes.

Piemonti L, Guidotti LG, Battaglia M.

Adv Exp Med Biol. 2010;654:725-47. doi: 10.1007/978-90-481-3271-3_32. Review.

PMID:
20217522
24.

Bone marrow as an alternative site for islet transplantation.

Cantarelli E, Melzi R, Mercalli A, Sordi V, Ferrari G, Lederer CW, Mrak E, Rubinacci A, Ponzoni M, Sitia G, Guidotti LG, Bonifacio E, Piemonti L.

Blood. 2009 Nov 12;114(20):4566-74. doi: 10.1182/blood-2009-03-209973. Epub 2009 Sep 22.

25.

On the role of platelets in the pathogenesis of viral hepatitis.

Iannacone M, Sitia G, Guidotti LG.

J Hepatol. 2009 Sep;51(3):599-600. doi: 10.1016/j.jhep.2009.05.005. Epub 2009 May 21. No abstract available.

26.

Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis.

De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S, Falini A, Guidotti LG, Galli R, Naldini L.

Cancer Cell. 2008 Oct 7;14(4):299-311. doi: 10.1016/j.ccr.2008.09.004.

27.

Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.

Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):629-34. doi: 10.1073/pnas.0711200105. Epub 2008 Jan 9.

28.

Immunobiology and pathogenesis of viral hepatitis.

Guidotti LG, Chisari FV.

Annu Rev Pathol. 2006;1:23-61. Review.

PMID:
18039107
29.

Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus.

Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG.

Clin Vaccine Immunol. 2007 Nov;14(11):1532-5. Epub 2007 Sep 19.

30.

HBV pathogenesis in animal models: recent advances on the role of platelets.

Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG.

J Hepatol. 2007 Apr;46(4):719-26. Epub 2007 Jan 29. Review.

31.

In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.

Brown BD, Sitia G, Annoni A, Hauben E, Sergi LS, Zingale A, Roncarolo MG, Guidotti LG, Naldini L.

Blood. 2007 Apr 1;109(7):2797-805.

32.

Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.

Trifari S, Sitia G, Aiuti A, Scaramuzza S, Marangoni F, Guidotti LG, Martino S, Saracco P, Notarangelo LD, Roncarolo MG, Dupré L.

J Immunol. 2006 Nov 15;177(10):7451-61.

33.

Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice.

Sitia G, Iannacone M, Müller S, Bianchi ME, Guidotti LG.

J Leukoc Biol. 2007 Jan;81(1):100-7. Epub 2006 Aug 25.

PMID:
16935945
34.

Reduced severity of liver ischemia/reperfusion injury following hepatic resection in humans is associated with enhanced intrahepatic expression of Th2 cytokines.

Pulitanò C, Sitia G, Aldrighetti L, Finazzi R, Arru M, Catena M, Guidotti LG, Ferla G.

Hepatol Res. 2006 Sep;36(1):20-6. Epub 2006 Jul 10.

PMID:
16831568
35.

Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy.

Sitia G, De Bona A, Bagaglio S, Galli L, Paties CT, Uberti-Foppa C, Guidotti LG, Lazzarin A, Morsica G.

Antivir Ther. 2006;11(3):385-9.

PMID:
16759056
36.

Platelets mediate cytotoxic T lymphocyte-induced liver damage.

Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG.

Nat Med. 2005 Nov;11(11):1167-9. Epub 2005 Oct 30.

37.

Immune tolerance split between hepatitis B virus precore and core proteins.

Chen M, Sällberg M, Hughes J, Jones J, Guidotti LG, Chisari FV, Billaud JN, Milich DR.

J Virol. 2005 Mar;79(5):3016-27.

38.

A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen.

Chen MT, Billaud JN, Sällberg M, Guidotti LG, Chisari FV, Jones J, Hughes J, Milich DR.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14913-8. Epub 2004 Oct 5.

39.

MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs.

Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG.

J Clin Invest. 2004 Apr;113(8):1158-67.

40.

Pathogenesis of viral hepatitis.

Guidotti LG.

J Biol Regul Homeost Agents. 2003 Apr-Jun;17(2):115-9. Review.

PMID:
14518707
41.

Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes.

Wieland SF, Vega RG, Müller R, Evans CF, Hilbush B, Guidotti LG, Sutcliffe JG, Schultz PG, Chisari FV.

J Virol. 2003 Jan;77(2):1227-36.

42.

The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection.

Guidotti LG.

Vaccine. 2002 Dec 19;20 Suppl 4:A80-2. Review.

PMID:
12477433
43.

Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice.

Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV.

J Immunol. 2002 Nov 1;169(9):5188-95.

44.

Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.

Sitia G, Isogawa M, Kakimi K, Wieland SF, Chisari FV, Guidotti LG.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13717-22. Epub 2002 Oct 4.

45.

Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice.

Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV.

J Virol. 2002 Nov;76(21):10702-7.

46.

Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice.

Su AI, Guidotti LG, Pezacki JP, Chisari FV, Schultz PG.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11181-6. Epub 2002 Aug 12.

47.

Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.

Guidotti LG, Morris A, Mendez H, Koch R, Silverman RH, Williams BR, Chisari FV.

J Virol. 2002 Mar;76(6):2617-21.

49.
50.

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