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Items: 31


Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.

McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R.

Cancer Discov. 2017 Oct;7(10):1136-1153. doi: 10.1158/2159-8290.CD-17-0399. Epub 2017 Jul 20.


Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.

Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG.

Cell Rep. 2014 Nov 6;9(3):1163-70. doi: 10.1016/j.celrep.2014.10.018. Epub 2014 Oct 30.


Genome-wide localization of small molecules.

Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA.

Nat Biotechnol. 2014 Jan;32(1):92-6. doi: 10.1038/nbt.2776. Epub 2013 Dec 15.


Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2876-81. doi: 10.1073/pnas.1221904110. Epub 2013 Feb 4.


CpG island structure and trithorax/polycomb chromatin domains in human cells.

Orlando DA, Guenther MG, Frampton GM, Young RA.

Genomics. 2012 Nov;100(5):320-6. doi: 10.1016/j.ygeno.2012.07.006. Epub 2012 Jul 20.


Grounded: transcriptional pausing in naive mESCs.

Guenther MG, Young RA.

Cell Stem Cell. 2012 May 4;10(5):484-5. doi: 10.1016/j.stem.2012.04.016.


Transcriptional control of embryonic and induced pluripotent stem cells.

Guenther MG.

Epigenomics. 2011 Jun;3(3):323-43. doi: 10.2217/epi.11.15. Review.


Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA.

Cell. 2011 Oct 28;147(3):565-76. doi: 10.1016/j.cell.2011.08.050.


Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state.

Golob JL, Kumar RM, Guenther MG, Pabon LM, Pratt GA, Loring JF, Laurent LC, Young RA, Murry CE.

PLoS One. 2011;6(8):e22416. doi: 10.1371/journal.pone.0022416. Epub 2011 Aug 19.


Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA.

Cell Stem Cell. 2010 Aug 6;7(2):249-57. doi: 10.1016/j.stem.2010.06.015.


Transcription. Repressive transcription.

Guenther MG, Young RA.

Science. 2010 Jul 9;329(5988):150-1. doi: 10.1126/science.1193995. No abstract available.


Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.

Cell. 2010 May 28;141(5):872-83. doi: 10.1016/j.cell.2010.04.010. Epub 2010 May 13.


Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.

Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA.

Genes Dev. 2008 Dec 15;22(24):3403-8. doi: 10.1101/gad.1741408.


Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.

Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA.

Cell. 2008 Aug 8;134(3):521-33. doi: 10.1016/j.cell.2008.07.020.


A chromatin landmark and transcription initiation at most promoters in human cells.

Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA.

Cell. 2007 Jul 13;130(1):77-88.


Control of developmental regulators by Polycomb in human embryonic stem cells.

Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA.

Cell. 2006 Apr 21;125(2):301-13.


Core transcriptional regulatory circuitry in human embryonic stem cells.

Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA.

Cell. 2005 Sep 23;122(6):947-56.


Global and Hox-specific roles for the MLL1 methyltransferase.

Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8603-8. Epub 2005 Jun 7.


Biochemical isolation and analysis of a nuclear receptor corepressor complex.

Guenther MG, Lazar MA.

Methods Enzymol. 2003;364:246-57. No abstract available.


A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.

Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA.

EMBO J. 2003 Jul 1;22(13):3403-10.


Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.

Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ.

J Cell Biol. 2003 Mar 31;160(7):1017-27.


Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.

Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA.

Genes Dev. 2002 Dec 15;16(24):3130-5.


Cytosolic phospholipase A2 shows burst kinetics consistent with the slow, reversible formation of a dead-end complex.

Guenther MG, Witmer MR, Burke JR.

Arch Biochem Biophys. 2002 Feb 1;398(1):101-8.


Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.

Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E.

Mol Cell. 2002 Jan;9(1):45-57.


The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.

Guenther MG, Barak O, Lazar MA.

Mol Cell Biol. 2001 Sep;21(18):6091-101.


Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.

Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS.

J Biol Chem. 2001 Sep 28;276(39):36734-41. Epub 2001 Jul 25.


A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.

Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R.

Genes Dev. 2000 May 1;14(9):1048-57.


Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.

Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA.

Genes Dev. 2000 Jan 1;14(1):45-54.


Coactivators for the orphan nuclear receptor RORalpha.

Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA.

Mol Endocrinol. 1999 Sep;13(9):1550-7.


Proteasomal regulation of nuclear receptor corepressor-mediated repression.

Zhang J, Guenther MG, Carthew RW, Lazar MA.

Genes Dev. 1998 Jun 15;12(12):1775-80.


Presence of glycerol masks the effects of phosphorylation on the catalytic efficiency of cytosolic phospholipase A2.

Burke JR, Guenther MG, Witmer MR, Tredup JA, Hail ME, Micanovic R, Villafranca JJ.

Arch Biochem Biophys. 1997 May 1;341(1):177-85.


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