Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 230

1.

TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells.

Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, Wang J, Kirsanov K, Yakubovskaya MG, Gudkov AV, Gurova K.

Elife. 2018 Feb 5;7. pii: e30842. doi: 10.7554/eLife.30842.

2.

Novel mouse models of hepatic artery infusion.

Kim M, Fisher DT, Powers CA, Gabriel EM, Korman AM, Sexton S, Gudkov AV, Skitzki JJ.

J Surg Res. 2017 Nov;219:25-32. doi: 10.1016/j.jss.2017.05.083. Epub 2017 Jun 21.

PMID:
29078890
3.

Mobilan: a recombinant adenovirus carrying Toll-like receptor 5 self-activating cassette for cancer immunotherapy.

Mett V, Komarova EA, Greene K, Bespalov I, Brackett C, Gillard B, Gleiberman AS, Toshkov IA, Aygün-Sunar S, Johnson C, Karasik E, Bapardekar-Nair M, Kurnasov OV, Osterman AL, Stanhope-Baker PS, Morrison C, Moser MT, Foster BA, Gudkov AV.

Oncogene. 2018 Jan 25;37(4):439-449. doi: 10.1038/onc.2017.346. Epub 2017 Oct 2.

4.

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin II, Leonova KI, Consiglio CR, Gollnick SO, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Aug 2;9(8):1867-1884. doi: 10.18632/aging.101268.

5.

Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.

Frescas D, Hall BM, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV.

Cell Cycle. 2017 Aug 18;16(16):1526-1533. doi: 10.1080/15384101.2017.1339850. Epub 2017 Jun 26.

PMID:
28650766
6.

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice.

Antoch MP, Wrobel M, Kuropatwinski KK, Gitlin I, Leonova KI, Toshkov I, Gleiberman AS, Hutson AD, Chernova OB, Gudkov AV.

Aging (Albany NY). 2017 Mar 19;9(3):615-626. doi: 10.18632/aging.101206.

7.

Mitigation of Radiation-Induced Epithelial Damage by the TLR5 Agonist Entolimod in a Mouse Model of Fractionated Head and Neck Irradiation.

Toshkov IA, Gleiberman AS, Mett VL, Hutson AD, Singh AK, Gudkov AV, Burdelya LG.

Radiat Res. 2017 May;187(5):570-580. doi: 10.1667/RR14514.1. Epub 2017 Mar 21.

PMID:
28323577
8.

Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.

Frescas D, Roux CM, Aygun-Sunar S, Gleiberman AS, Krasnov P, Kurnasov OV, Strom E, Virtuoso LP, Wrobel M, Osterman AL, Antoch MP, Mett V, Chernova OB, Gudkov AV.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1668-E1677. doi: 10.1073/pnas.1614661114. Epub 2017 Feb 13.

9.

A review of the biomedical innovations for healthy longevity.

Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A.

Aging (Albany NY). 2017 Jan 29;9(1):7-25. doi: 10.18632/aging.101163. No abstract available.

10.

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas.

Kim M, Neznanov N, Wilfong CD, Fleyshman DI, Purmal AA, Haderski G, Stanhope-Baker P, Burkhart CA, Gurova KV, Gudkov AV, Skitzki JJ.

Cancer Res. 2016 Nov 15;76(22):6620-6630. doi: 10.1158/0008-5472.CAN-15-2764. Epub 2016 Sep 28.

11.

p53 and the Carcinogenicity of Chronic Inflammation.

Gudkov AV, Komarova EA.

Cold Spring Harb Perspect Med. 2016 Nov 1;6(11). pii: a026161. doi: 10.1101/cshperspect.a026161. Review.

PMID:
27549311
12.

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.

Hall BM, Balan V, Gleiberman AS, Strom E, Krasnov P, Virtuoso LP, Rydkina E, Vujcic S, Balan K, Gitlin I, Leonova K, Polinsky A, Chernova OB, Gudkov AV.

Aging (Albany NY). 2016 Jul;8(7):1294-315. doi: 10.18632/aging.100991.

13.

Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.

Barone TA, Burkhart CA, Safina A, Haderski G, Gurova KV, Purmal AA, Gudkov AV, Plunkett RJ.

Neuro Oncol. 2017 Feb 1;19(2):186-196. doi: 10.1093/neuonc/now141.

14.

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.

Somers K, Chudakova DA, Middlemiss SM, Wen VW, Clifton M, Kwek A, Liu B, Mayoh C, Bongers A, Karsa M, Pan S, Cruikshank S, Scandlyn M, Hoang W, Imamura T, Kees UR, Gudkov AV, Chernova OB, Haber M, Norris MD, Henderson MJ.

Oncotarget. 2016 Jul 19;7(29):46067-46087. doi: 10.18632/oncotarget.10022.

15.

Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses.

Tukhvatulin AI, Dzharullaeva AS, Tukhvatulina NM, Shcheblyakov DV, Shmarov MM, Dolzhikova IV, Stanhope-Baker P, Naroditsky BS, Gudkov AV, Logunov DY, Gintsburg AL.

PLoS One. 2016 May 17;11(5):e0155650. doi: 10.1371/journal.pone.0155650. eCollection 2016.

16.

Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure.

Komarov AP, Komarova EA, Green K, Novototskaya LR, Baker PS, Eroshkin A, Osterman AL, Chenchick AA, Frangou C, Gudkov AV.

Cell Death Dis. 2016 Mar 17;7:e2145. doi: 10.1038/cddis.2016.45.

17.

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.

Brackett CM, Kojouharov B, Veith J, Greene KF, Burdelya LG, Gollnick SO, Abrams SI, Gudkov AV.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E874-83. doi: 10.1073/pnas.1521359113. Epub 2016 Feb 1.

18.

The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism.

Yang H, Brackett CM, Morales-Tirado VM, Li Z, Zhang Q, Wilson MW, Benjamin C, Harris W, Waller EK, Gudkov AV, Burdelya LG, Grossniklaus HE.

Oncotarget. 2016 Jan 19;7(3):2936-50. doi: 10.18632/oncotarget.6500.

19.

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

Tanne A, Muniz LR, Puzio-Kuter A, Leonova KI, Gudkov AV, Ting DT, Monasson R, Cocco S, Levine AJ, Bhardwaj N, Greenbaum BD.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15154-9. doi: 10.1073/pnas.1517584112. Epub 2015 Nov 2.

20.

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

Carter DR, Murray J, Cheung BB, Gamble L, Koach J, Tsang J, Sutton S, Kalla H, Syed S, Gifford AJ, Issaeva N, Biktasova A, Atmadibrata B, Sun Y, Sokolowski N, Ling D, Kim PY, Webber H, Clark A, Ruhle M, Liu B, Oberthuer A, Fischer M, Byrne J, Saletta F, Thwe le M, Purmal A, Haderski G, Burkhart C, Speleman F, De Preter K, Beckers A, Ziegler DS, Liu T, Gurova KV, Gudkov AV, Norris MD, Haber M, Marshall GM.

Sci Transl Med. 2015 Nov 4;7(312):312ra176. doi: 10.1126/scitranslmed.aab1803.

PMID:
26537256
21.

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.

Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E.

PLoS One. 2015 Sep 14;10(9):e0135388. doi: 10.1371/journal.pone.0135388. eCollection 2015.

22.

[Light- and electron-microscopic study of pelobiont Pelomyxa secunda (Gruber, 1884) comb. nov. (Archamoebae, Pelobiontida)].

Berdieva MA, Chistiakova LV, Miteva OA, Frolov AO, Gudkov AV.

Tsitologiia. 2015;57(1):62-9. Russian.

PMID:
25872377
23.

[Reisolation and redescription of pelobiont Pelomyxa paradoxa Penard, 1902 (Archamoebae, Pelobiontida)].

Chistiakova LV, Berdieva MA, Frolov AO, Gudkov AV.

Tsitologiia. 2014;56(10):770-8. Russian.

PMID:
25711087
24.

[Stress proteins in the cells of Porphyra purpurea (Rhodophyta) thallus].

Podlipaeva IuI, Ful'da S, Gudkov AV.

Tsitologiia. 2014;56(7):536-9. Russian.

PMID:
25696998
25.

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, Fletcher JI, Haber M, Norris MD.

Biochem Pharmacol. 2014 Sep 1;91(1):97-108. doi: 10.1016/j.bcp.2014.05.023. Epub 2014 Jun 25.

PMID:
24973542
26.

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice.

Kojouharov BM, Brackett CM, Veith JM, Johnson CP, Gitlin II, Toshkov IA, Gleiberman AS, Gudkov AV, Burdelya LG.

Oncotarget. 2014 Feb 15;5(3):802-14.

27.

Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation.

Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AV.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E474-83. doi: 10.1073/pnas.1311945111. Epub 2014 Jan 13.

28.

A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.

Leigh ND, Bian G, Ding X, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X.

PLoS One. 2014 Jan 14;9(1):e85587. doi: 10.1371/journal.pone.0085587. eCollection 2014.

29.

Dysregulation of the mTOR pathway in p53-deficient mice.

Leontieva OV, Novototskaya LR, Paszkiewicz GM, Komarova EA, Gudkov AV, Blagosklonny MV.

Cancer Biol Ther. 2013 Dec;14(12):1182-8. doi: 10.4161/cbt.26947. Epub 2013 Nov 1.

30.

A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.

Wawrzyniak JA, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, Nikiforov MA.

Cell Rep. 2013 Oct 31;5(2):493-507. doi: 10.1016/j.celrep.2013.09.015. Epub 2013 Oct 17.

31.

Cell-based methods for the identification of MYC-inhibitory small molecules.

Burkhart CA, Haber M, Norris MD, Gudkov AV, Nikiforov MA.

Methods Mol Biol. 2013;1012:255-64. doi: 10.1007/978-1-62703-429-6_18.

32.

ATM is activated in blood monocytes after tumor radiation.

Gudkov AV, Komarova EA.

Oncotarget. 2013 Aug;4(8):1125. No abstract available.

33.

Combined stimulation of Toll-like receptor 5 and NOD1 strongly potentiates activity of NF-κB, resulting in enhanced innate immune reactions and resistance to Salmonella enterica serovar Typhimurium infection.

Tukhvatulin AI, Gitlin II, Shcheblyakov DV, Artemicheva NM, Burdelya LG, Shmarov MM, Naroditsky BS, Gudkov AV, Gintsburg AL, Logunov DY.

Infect Immun. 2013 Oct;81(10):3855-64. doi: 10.1128/IAI.00525-13. Epub 2013 Jul 29.

34.

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist.

Burdelya LG, Brackett CM, Kojouharov B, Gitlin II, Leonova KI, Gleiberman AS, Aygun-Sunar S, Veith J, Johnson C, Haderski GJ, Stanhope-Baker P, Allamaneni S, Skitzki J, Zeng M, Martsen E, Medvedev A, Scheblyakov D, Artemicheva NM, Logunov DY, Gintsburg AL, Naroditsky BS, Makarov SS, Gudkov AV.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):E1857-66. doi: 10.1073/pnas.1222805110. Epub 2013 Apr 29.

35.

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion.

Mannava S, Moparthy KC, Wheeler LJ, Leonova KI, Wawrzyniak JA, Bianchi-Smiraglia A, Berman AE, Flanagan S, Shewach DS, Zeitouni NC, Gudkov AV, Mathews CK, Nikiforov MA.

Aging (Albany NY). 2012 Dec;4(12):917-22.

36.

p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.

Leonova KI, Brodsky L, Lipchick B, Pal M, Novototskaya L, Chenchik AA, Sen GC, Komarova EA, Gudkov AV.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98. doi: 10.1073/pnas.1216922110. Epub 2012 Dec 10.

37.

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.

Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19392-6. doi: 10.1073/pnas.1217211109. Epub 2012 Nov 5.

38.

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.

Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV.

Aging (Albany NY). 2012 Oct;4(10):709-14.

39.

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP.

Aging (Albany NY). 2012 Oct;4(10):715-22.

40.

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.

Ding X, Bian G, Leigh ND, Qiu J, McCarthy PL, Liu H, Aygun-Sunar S, Burdelya LG, Gudkov AV, Cao X.

J Immunol. 2012 Nov 15;189(10):4719-27. doi: 10.4049/jimmunol.1201206. Epub 2012 Oct 8.

41.

Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.

Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65. doi: 10.1073/pnas.1206274109. Epub 2012 Aug 15.

42.

[A contact electroimpulse impact on the ureteral and bladder wall of mature dogs: a 1-year results of a morphological prospective study].

Gudkov AV, Boshchenko VS, Arsen'ev AV, Nedosekov VV, Afonin VIa.

Urologiia. 2012 Mar-Apr;(2):70-5. Russian.

PMID:
22876639
43.

Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13314-8. doi: 10.1073/pnas.1205690109. Epub 2012 Jul 30.

44.

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure.

Krivokrysenko VI, Shakhov AN, Singh VK, Bone F, Kononov Y, Shyshynova I, Cheney A, Maitra RK, Purmal A, Whitnall MH, Gudkov AV, Feinstein E.

J Pharmacol Exp Ther. 2012 Nov;343(2):497-508. doi: 10.1124/jpet.112.196071. Epub 2012 Jul 26.

45.

Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.

Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV.

Cancer Prev Res (Phila). 2012 Aug;5(8):1025-35. doi: 10.1158/1940-6207.CAPR-11-0529. Epub 2012 Jun 11.

46.

The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P.

Aging (Albany NY). 2012 May;4(5):305-17. No abstract available.

47.

Structural basis of TLR5-flagellin recognition and signaling.

Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA.

Science. 2012 Feb 17;335(6070):859-64. doi: 10.1126/science.1215584.

48.

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.

Hu Y, Spengler ML, Kuropatwinski KK, Comas-Soberats M, Jackson M, Chernov MV, Gleiberman AS, Fedtsova N, Rustum YM, Gudkov AV, Antoch MP.

Oncotarget. 2011 Dec;2(12):1279-90.

49.

CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure.

Singh VK, Ducey EJ, Fatanmi OO, Singh PK, Brown DS, Purmal A, Shakhova VV, Gudkov AV, Feinstein E, Shakhov A.

Radiat Res. 2012 May;177(5):628-42. Epub 2011 Dec 16.

PMID:
22175300
50.

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.

Leontieva OV, Demidenko ZN, Gudkov AV, Blagosklonny MV.

PLoS One. 2011;6(10):e26126. doi: 10.1371/journal.pone.0026126. Epub 2011 Oct 11.

Supplemental Content

Loading ...
Support Center