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New techniques, applications and perspectives in neuropeptide research.

DeLaney K, Buchberger AR, Atkinson L, Gründer S, Mousley A, Li L.

J Exp Biol. 2018 Feb 8;221(Pt 3). pii: jeb151167. doi: 10.1242/jeb.151167. Review.


Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3.

Tian Y, Bresenitz P, Reska A, El Moussaoui L, Beier CP, Gründer S.

Sci Rep. 2017 Oct 20;7(1):13674. doi: 10.1038/s41598-017-13666-9.


Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).

Schmidt A, Rossetti G, Joussen S, Gründer S.

Mol Pharmacol. 2017 Dec;92(6):665-675. doi: 10.1124/mol.117.110064. Epub 2017 Oct 12.


Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.

Reimers C, Lee CH, Kalbacher H, Tian Y, Hung CH, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen CC, Gründer S.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3507-E3515. doi: 10.1073/pnas.1616232114. Epub 2017 Apr 10.


Back to the Basics: Cnidarians Start to Fire.

Bosch TCG, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R.

Trends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005. Epub 2016 Dec 30. Review.


ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.

Komnig D, Imgrund S, Reich A, Gründer S, Falkenburger BH.

PLoS One. 2016 Nov 7;11(11):e0165235. doi: 10.1371/journal.pone.0165235. eCollection 2016.


A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).

Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.

J Biol Chem. 2016 Nov 18;291(47):24551-24565. Epub 2016 Sep 27.


Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.

Joeres N, Augustinowski K, Neuhof A, Assmann M, Gründer S.

Sci Rep. 2016 Jun 9;6:27647. doi: 10.1038/srep27647.


Non-Interpenetrated Metal-Organic Frameworks Based on Copper(II) Paddlewheel and Oligoparaxylene-Isophthalate Linkers: Synthesis, Structure, and Gas Adsorption.

Yan Y, Juríček M, Coudert FX, Vermeulen NA, Grunder S, Dailly A, Lewis W, Blake AJ, Stoddart JF, Schröder M.

J Am Chem Soc. 2016 Mar 16;138(10):3371-81. doi: 10.1021/jacs.5b12312. Epub 2016 Mar 1.


Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.

Schwartz V, Friedrich K, Polleichtner G, Gründer S.

Sci Rep. 2015 Dec 15;5:18242. doi: 10.1038/srep18242.


Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.

Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. doi: 10.1016/j.bmcl.2015.09.012. Epub 2015 Sep 8.


Peptide-gated ion channels and the simple nervous system of Hydra.

Gründer S, Assmann M.

J Exp Biol. 2015 Feb 15;218(Pt 4):551-61. doi: 10.1242/jeb.111666. Review.


Biophysical properties of acid-sensing ion channels (ASICs).

Gründer S, Pusch M.

Neuropharmacology. 2015 Jul;94:9-18. doi: 10.1016/j.neuropharm.2014.12.016. Epub 2015 Jan 10. Review.


The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment.

Schmidt A, Lenzig P, Oslender-Bujotzek A, Kusch J, Lucas SD, Gründer S, Wiemuth D.

PLoS One. 2014 Oct 31;9(10):e111549. doi: 10.1371/journal.pone.0111549. eCollection 2014.


The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission.

Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S.

BMC Biol. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2.


Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.

Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8281-6. doi: 10.1073/pnas.1324060111. Epub 2014 May 20.


The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC.

Wiemuth D, Assmann M, Gründer S.

Channels (Austin). 2014;8(1):29-34. doi: 10.4161/chan.27493. Epub 2013 Dec 23. Review.


Bile acids increase the activity of the epithelial Na+ channel.

Wiemuth D, Lefèvre CM, Heidtmann H, Gründer S.

Pflugers Arch. 2014 Sep;466(9):1725-33. doi: 10.1007/s00424-013-1403-0. Epub 2013 Nov 30.


A water-soluble pH-triggered molecular switch.

Grunder S, McGrier PL, Whalley AC, Boyle MM, Stern C, Stoddart JF.

J Am Chem Soc. 2013 Nov 27;135(47):17691-4. doi: 10.1021/ja409006y. Epub 2013 Nov 18.


Controllability of the Coulomb charging energy in close-packed nanoparticle arrays.

Duan C, Wang Y, Sun J, Guan C, Grunder S, Mayor M, Peng L, Liao J.

Nanoscale. 2013 Nov 7;5(21):10258-66. doi: 10.1039/c3nr02334f. Epub 2013 Sep 6.


Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).

Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D.

Pflugers Arch. 2014 Feb;466(2):253-63. doi: 10.1007/s00424-013-1310-4. Epub 2013 Jul 11.


Three-dimensional architectures incorporating stereoregular donor-acceptor stacks.

Cao D, Juríček M, Brown ZJ, Sue AC, Liu Z, Lei J, Blackburn AK, Grunder S, Sarjeant AA, Coskun A, Wang C, Farha OK, Hupp JT, Stoddart JF.

Chemistry. 2013 Jun 24;19(26):8457-65. doi: 10.1002/chem.201300762. Epub 2013 May 6.


Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin.

Wiemuth D, van de Sandt L, Herr R, Gründer S.

FEBS Lett. 2012 Dec 14;586(24):4276-81. doi: 10.1016/j.febslet.2012.10.046. Epub 2012 Nov 15.


Molecular gauge blocks for building on the nanoscale.

Grunder S, Valente C, Whalley AC, Sampath S, Portmann J, Botros YY, Stoddart JF.

Chemistry. 2012 Dec 3;18(49):15632-49. doi: 10.1002/chem.201201985. Epub 2012 Oct 22.


Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.

Wiemuth D, Sahin H, Lefèvre CM, Wasmuth HE, Gründer S.

Channels (Austin). 2013 Jan 1;7(1):38-42. doi: 10.4161/chan.22406. Epub 2012 Oct 12.


High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra.

Dürrnagel S, Falkenburger BH, Gründer S.

J Gen Physiol. 2012 Oct;140(4):391-402.


Toxin binding reveals two open state structures for one acid-sensing ion channel.

Gründer S, Augustinowski K.

Channels (Austin). 2012 Nov-Dec;6(6):409-13. doi: 10.4161/chan.22154. Epub 2012 Sep 18.


Efficient long-range stereochemical communication and cooperative effects in self-assembled Fe4L6 cages.

Ousaka N, Grunder S, Castilla AM, Whalley AC, Stoddart JF, Nitschke JR.

J Am Chem Soc. 2012 Sep 19;134(37):15528-37. Epub 2012 Sep 5.


The effects of conformation on the noncovalent bonding interactions in a bistable donor-acceptor [3]catenane.

Wang C, Cao D, Fahrenbach AC, Grunder S, Dey SK, Sarjeant AA, Stoddart JF.

Chem Commun (Camb). 2012 Sep 25;48(74):9245-7. doi: 10.1039/c2cc34190e. Epub 2012 Aug 8.


BASIC--a bile acid-sensitive ion channel highly expressed in bile ducts.

Wiemuth D, Sahin H, Falkenburger BH, Lefèvre CM, Wasmuth HE, Gründer S.

FASEB J. 2012 Oct;26(10):4122-30. doi: 10.1096/fj.12-207043. Epub 2012 Jun 26.


Large-pore apertures in a series of metal-organic frameworks.

Deng H, Grunder S, Cordova KE, Valente C, Furukawa H, Hmadeh M, Gándara F, Whalley AC, Liu Z, Asahina S, Kazumori H, O'Keeffe M, Terasaki O, Stoddart JF, Yaghi OM.

Science. 2012 May 25;336(6084):1018-23. doi: 10.1126/science.1220131.


Giving substance to the Losanitsch series.

Grunder S, Stoddart JF.

Chem Commun (Camb). 2012 Mar 28;48(26):3158-60. doi: 10.1039/c2cc17734j. Epub 2012 Feb 16.


The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates.

Wiemuth D, Gründer S.

Mol Pharmacol. 2011 Nov;80(5):911-9. doi: 10.1124/mol.111.073726. Epub 2011 Aug 9.


The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.

Springauf A, Bresenitz P, Gründer S.

J Biol Chem. 2011 Jul 8;286(27):24374-84. doi: 10.1074/jbc.M111.230797. Epub 2011 May 16.


Novel cruciform structures as model compounds for coordination induced single molecule switches.

Grunder S, Huber R, Wu S, Schönenberger C, Calame M, Mayor M.

Chimia (Aarau). 2010;64(3):140-4.


Electroluminescence from a single nanotube-molecule-nanotube junction.

Marquardt CW, Grunder S, Błaszczyk A, Dehm S, Hennrich F, Löhneysen HV, Mayor M, Krupke R.

Nat Nanotechnol. 2010 Dec;5(12):863-7. doi: 10.1038/nnano.2010.230. Epub 2010 Nov 28.


A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC).

Wiemuth D, Gründer S.

J Biol Chem. 2010 Oct 1;285(40):30404-10. doi: 10.1074/jbc.M110.153064. Epub 2010 Jul 23.


Three homologous subunits form a high affinity peptide-gated ion channel in Hydra.

Dürrnagel S, Kuhn A, Tsiairis CD, Williamson M, Kalbacher H, Grimmelikhuijzen CJ, Holstein TW, Gründer S.

J Biol Chem. 2010 Apr 16;285(16):11958-65. doi: 10.1074/jbc.M109.059998. Epub 2010 Feb 16.


Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.

Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK; Nasonia Genome Working Group, Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK, Beukeboom LW, Desplan C, Elsik CG, Grimmelikhuijzen CJ, Kitts P, Lynch JA, Murphy T, Oliveira DC, Smith CD, van de Zande L, Worley KC, Zdobnov EM, Aerts M, Albert S, Anaya VH, Anzola JM, Barchuk AR, Behura SK, Bera AN, Berenbaum MR, Bertossa RC, Bitondi MM, Bordenstein SR, Bork P, Bornberg-Bauer E, Brunain M, Cazzamali G, Chaboub L, Chacko J, Chavez D, Childers CP, Choi JH, Clark ME, Claudianos C, Clinton RA, Cree AG, Cristino AS, Dang PM, Darby AC, de Graaf DC, Devreese B, Dinh HH, Edwards R, Elango N, Elhaik E, Ermolaeva O, Evans JD, Foret S, Fowler GR, Gerlach D, Gibson JD, Gilbert DG, Graur D, Gründer S, Hagen DE, Han Y, Hauser F, Hultmark D, Hunter HC 4th, Hurst GD, Jhangian SN, Jiang H, Johnson RM, Jones AK, Junier T, Kadowaki T, Kamping A, Kapustin Y, Kechavarzi B, Kim J, Kim J, Kiryutin B, Koevoets T, Kovar CL, Kriventseva EV, Kucharski R, Lee H, Lee SL, Lees K, Lewis LR, Loehlin DW, Logsdon JM Jr, Lopez JA, Lozado RJ, Maglott D, Maleszka R, Mayampurath A, Mazur DJ, McClure MA, Moore AD, Morgan MB, Muller J, Munoz-Torres MC, Muzny DM, Nazareth LV, Neupert S, Nguyen NB, Nunes FM, Oakeshott JG, Okwuonu GO, Pannebakker BA, Pejaver VR, Peng Z, Pratt SC, Predel R, Pu LL, Ranson H, Raychoudhury R, Rechtsteiner A, Reese JT, Reid JG, Riddle M, Robertson HM, Romero-Severson J, Rosenberg M, Sackton TB, Sattelle DB, Schlüns H, Schmitt T, Schneider M, Schüler A, Schurko AM, Shuker DM, Simões ZL, Sinha S, Smith Z, Solovyev V, Souvorov A, Springauf A, Stafflinger E, Stage DE, Stanke M, Tanaka Y, Telschow A, Trent C, Vattathil S, Verhulst EC, Viljakainen L, Wanner KW, Waterhouse RM, Whitfield JB, Wilkes TE, Williamson M, Willis JH, Wolschin F, Wyder S, Yamada T, Yi SV, Zecher CN, Zhang L, Gibbs RA.

Science. 2010 Jan 15;327(5963):343-8. doi: 10.1126/science.1178028. Erratum in: Science. 2010 Mar 26;327(5973):1577.


An acid-sensing ion channel from shark (Squalus acanthias) mediates transient and sustained responses to protons.

Springauf A, Gründer S.

J Physiol. 2010 Mar 1;588(Pt 5):809-20. doi: 10.1113/jphysiol.2009.182931. Epub 2010 Jan 11.


Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.

Gründer S, Chen X.

Int J Physiol Pathophysiol Pharmacol. 2010 Mar 18;2(2):73-94.


Analysis of continuous patient data from the Czech National Register of patients with type 1 and type 2 diabetes using insulin pump therapy.

Jankovec Z, Hahn M, Grunder S, Lacigova S, Cechurova D, Krcma M, Zourek M, Haladova I, Rusavy Z.

Diabetes Res Clin Pract. 2010 Feb;87(2):219-23. doi: 10.1016/j.diabres.2009.09.028. Epub 2009 Oct 23.


A single conserved proline residue determines the membrane topology of stomatin.

Kadurin I, Huber S, Gründer S.

Biochem J. 2009 Mar 15;418(3):587-94. doi: 10.1042/BJ20081662.


Molecular junctions based on aromatic coupling.

Wu S, González MT, Huber R, Grunder S, Mayor M, Schönenberger C, Calame M.

Nat Nanotechnol. 2008 Sep;3(9):569-74. doi: 10.1038/nnano.2008.237. Epub 2008 Aug 17.


International survey of insulin pump users: Impact of continuous subcutaneous insulin infusion therapy on glucose control and quality of life.

Hammond P, Liebl A, Grunder S.

Prim Care Diabetes. 2007 Sep;1(3):143-6. doi: 10.1016/j.pcd.2007.07.005. Epub 2007 Aug 10.


Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1b.

Kadurin I, Golubovic A, Leisle L, Schindelin H, Gründer S.

Biochem J. 2008 Jun 15;412(3):469-75. doi: 10.1042/BJ20071614.


Electrical conductance of conjugated oligomers at the single molecule level.

Huber R, González MT, Wu S, Langer M, Grunder S, Horhoiu V, Mayor M, Bryce MR, Wang C, Jitchati R, Schönenberger C, Calame M.

J Am Chem Soc. 2008 Jan 23;130(3):1080-4. doi: 10.1021/ja0767940. Epub 2007 Dec 29.


Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.

Paukert M, Chen X, Polleichtner G, Schindelin H, Gründer S.

J Biol Chem. 2008 Jan 4;283(1):572-81. Epub 2007 Nov 1.


New cruciform structures: toward coordination induced single molecule switches.

Grunder S, Huber R, Horhoiu V, González MT, Schönenberger C, Calame M, Mayor M.

J Org Chem. 2007 Oct 26;72(22):8337-44. Epub 2007 Oct 4.


A peptide-gated ion channel from the freshwater polyp Hydra.

Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein TW, Grimmelikhuijzen CJ, Gründer S.

J Biol Chem. 2007 Nov 30;282(48):35098-103. Epub 2007 Oct 2.

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