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Items: 1 to 50 of 192

1.

Purine- and pyrimidine-triple-helix-forming oligonucleotides recognize qualitatively different target sites at the ribosomal DNA locus.

Maldonado R, Filarsky M, Grummt I, Längst G.

RNA. 2018 Mar;24(3):371-380. doi: 10.1261/rna.063800.117. Epub 2017 Dec 8.

2.

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.

Song C, Hotz-Wagenblatt A, Voit R, Grummt I.

Genes Dev. 2017 Aug 8. doi: 10.1101/gad.300624.117. [Epub ahead of print]

3.

Ribosomes Dance to a Daily Rhythm.

Iyer A, Grummt I.

Trends Biochem Sci. 2017 Aug;42(8):585-587. doi: 10.1016/j.tibs.2017.06.001. Epub 2017 Jun 17.

PMID:
28633974
4.

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.

Blank MF, Chen S, Poetz F, Schnölzer M, Voit R, Grummt I.

Nucleic Acids Res. 2017 Mar 17;45(5):2675-2686. doi: 10.1093/nar/gkx053.

5.

The seven faces of SIRT7.

Blank MF, Grummt I.

Transcription. 2017 Mar 15;8(2):67-74. doi: 10.1080/21541264.2016.1276658. Epub 2017 Jan 9. Review.

6.

Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning.

Zhao Z, Dammert MA, Hoppe S, Bierhoff H, Grummt I.

Nucleic Acids Res. 2016 Sep 30;44(17):8144-52. doi: 10.1093/nar/gkw496. Epub 2016 Jun 1.

7.

lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress.

Zhao Z, Dammert MA, Grummt I, Bierhoff H.

Cell Rep. 2016 Mar 1;14(8):1876-82. doi: 10.1016/j.celrep.2016.01.073. Epub 2016 Feb 18.

8.

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.

Chen S, Blank MF, Iyer A, Huang B, Wang L, Grummt I, Voit R.

Nat Commun. 2016 Feb 12;7:10734. doi: 10.1038/ncomms10734.

9.

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.

Postepska-Igielska A, Giwojna A, Gasri-Plotnitsky L, Schmitt N, Dold A, Ginsberg D, Grummt I.

Mol Cell. 2015 Nov 19;60(4):626-36. doi: 10.1016/j.molcel.2015.10.001.

10.

Alu element-containing RNAs maintain nucleolar structure and function.

Caudron-Herger M, Pankert T, Seiler J, Németh A, Voit R, Grummt I, Rippe K.

EMBO J. 2015 Nov 12;34(22):2758-74. doi: 10.15252/embj.201591458. Epub 2015 Oct 13.

11.

Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.

Voit R, Seiler J, Grummt I.

PLoS Genet. 2015 May 29;11(5):e1005246. doi: 10.1371/journal.pgen.1005246. eCollection 2015 May.

12.

A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes.

Anosova I, Melnik S, Tripsianes K, Kateb F, Grummt I, Sattler M.

Nucleic Acids Res. 2015 May 26;43(10):5208-20. doi: 10.1093/nar/gkv365. Epub 2015 Apr 27.

13.

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C.

Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031. Epub 2014 Jul 31.

14.

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.

Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I.

Mol Cell. 2014 May 22;54(4):675-82. doi: 10.1016/j.molcel.2014.03.032. Epub 2014 Apr 24.

15.

NoRC silences rRNA genes, telomeres, and centromeres.

Postepska-Igielska A, Grummt I.

Cell Cycle. 2014;13(4):493-4. doi: 10.4161/cc.27783. Epub 2014 Jan 13. No abstract available.

PMID:
24419143
16.

Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.

Chen S, Seiler J, Santiago-Reichelt M, Felbel K, Grummt I, Voit R.

Mol Cell. 2013 Nov 7;52(3):303-13. doi: 10.1016/j.molcel.2013.10.010.

17.

Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements.

Bierhoff H, Postepska-Igielska A, Grummt I.

Epigenetics. 2014 Jan;9(1):53-61. doi: 10.4161/epi.26485. Epub 2013 Oct 11. Review.

18.

Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.

Diermeier SD, Németh A, Rehli M, Grummt I, Längst G.

PLoS Genet. 2013;9(9):e1003786. doi: 10.1371/journal.pgen.1003786. Epub 2013 Sep 12.

19.

The nucleolus—guardian of cellular homeostasis and genome integrity.

Grummt I.

Chromosoma. 2013 Dec;122(6):487-97. Review.

PMID:
24022641
20.

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres.

Postepska-Igielska A, Krunic D, Schmitt N, Greulich-Bode KM, Boukamp P, Grummt I.

EMBO Rep. 2013 Aug;14(8):704-10. doi: 10.1038/embor.2013.87. Epub 2013 Jun 25. Erratum in: EMBO Rep. 2013 Sep;14(9):845.

21.

A neuroprotective phase precedes striatal degeneration upon nucleolar stress.

Kreiner G, Bierhoff H, Armentano M, Rodriguez-Parkitna J, Sowodniok K, Naranjo JR, Bonfanti L, Liss B, Schütz G, Grummt I, Parlato R.

Cell Death Differ. 2013 Nov;20(11):1455-64. doi: 10.1038/cdd.2013.66. Epub 2013 Jun 14.

22.

NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells.

Luo M, Ling T, Xie W, Sun H, Zhou Y, Zhu Q, Shen M, Zong L, Lyu G, Zhao Y, Ye T, Gu J, Tao W, Lu Z, Grummt I.

Stem Cells. 2013 Jul;31(7):1278-86. doi: 10.1002/stem.1374.

23.

Epigenetic control of RNA polymerase I transcription in mammalian cells.

Grummt I, Längst G.

Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):393-404. doi: 10.1016/j.bbagrm.2012.10.004. Epub 2012 Oct 12. Review.

PMID:
23063748
24.

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions.

Xie W, Ling T, Zhou Y, Feng W, Zhu Q, Stunnenberg HG, Grummt I, Tao W.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8161-6. doi: 10.1073/pnas.1201262109. Epub 2012 May 8.

25.

Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes.

Bierhoff H, Schmitz K, Maass F, Ye J, Grummt I.

Cold Spring Harb Symp Quant Biol. 2010;75:357-64. doi: 10.1101/sqb.2010.75.060. Epub 2011 Apr 18.

PMID:
21502405
26.

Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.

Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R.

PLoS One. 2011 Feb 17;6(2):e14711. doi: 10.1371/journal.pone.0014711.

27.

A model for the topology of active ribosomal RNA genes.

Denissov S, Lessard F, Mayer C, Stefanovsky V, van Driel M, Grummt I, Moss T, Stunnenberg HG.

EMBO Rep. 2011 Mar;12(3):231-7. doi: 10.1038/embor.2011.8. Epub 2011 Feb 18.

28.

Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.

Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schütz G, Parlato R.

J Neurosci. 2011 Jan 12;31(2):453-60. doi: 10.1523/JNEUROSCI.0590-10.2011.

29.
30.

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes.

Schmitz KM, Mayer C, Postepska A, Grummt I.

Genes Dev. 2010 Oct 15;24(20):2264-9. doi: 10.1101/gad.590910.

31.

DNA sequence encoded repression of rRNA gene transcription in chromatin.

Felle M, Exler JH, Merkl R, Dachauer K, Brehm A, Grummt I, Längst G.

Nucleic Acids Res. 2010 Sep;38(16):5304-14. doi: 10.1093/nar/gkq263. Epub 2010 Apr 25.

32.

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I.

Nat Struct Mol Biol. 2010 Apr;17(4):445-50. doi: 10.1038/nsmb.1778. Epub 2010 Mar 7.

PMID:
20208542
33.

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats.

Guetg C, Lienemann P, Sirri V, Grummt I, Hernandez-Verdun D, Hottiger MO, Fussenegger M, Santoro R.

EMBO J. 2010 Jul 7;29(13):2135-46. doi: 10.1038/emboj.2010.17. Epub 2010 Feb 18. Erratum in: EMBO J. 2010 Jul 7;29(13):2253.

34.

The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.

Drygin D, Rice WG, Grummt I.

Annu Rev Pharmacol Toxicol. 2010;50:131-56. doi: 10.1146/annurev.pharmtox.010909.105844. Review.

PMID:
20055700
35.

Linking rDNA transcription to the cellular energy supply.

Grummt I, Voit R.

Cell Cycle. 2010 Jan 15;9(2):225-6. Epub 2010 Jan 12. No abstract available.

PMID:
20023389
36.

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans.

Santoro R, Schmitz KM, Sandoval J, Grummt I.

EMBO Rep. 2010 Jan;11(1):52-8. doi: 10.1038/embor.2009.254. Epub 2009 Dec 4.

37.

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply.

Hoppe S, Bierhoff H, Cado I, Weber A, Tiebe M, Grummt I, Voit R.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17781-6. doi: 10.1073/pnas.0909873106. Epub 2009 Oct 6.

38.

Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.

Zhou Y, Schmitz KM, Mayer C, Yuan X, Akhtar A, Grummt I.

Nat Cell Biol. 2009 Aug;11(8):1010-6. doi: 10.1038/ncb1914. Epub 2009 Jul 5.

PMID:
19578370
39.

Dynamic subcellular partitioning of the nucleolar transcription factor TIF-IA under ribotoxic stress.

Szymański J, Mayer C, Hoffmann-Rohrer U, Kalla C, Grummt I, Weiss M.

Biochim Biophys Acta. 2009 Jul;1793(7):1191-8. doi: 10.1016/j.bbamcr.2009.05.004. Epub 2009 May 18.

40.

TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation.

Schmitz KM, Schmitt N, Hoffmann-Rohrer U, Schäfer A, Grummt I, Mayer C.

Mol Cell. 2009 Feb 13;33(3):344-53. doi: 10.1016/j.molcel.2009.01.015.

41.

Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice.

Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schütz G.

J Neurosci. 2008 Nov 26;28(48):12759-64. doi: 10.1523/JNEUROSCI.2439-08.2008.

42.

Proteasomal ATPases are associated with rDNA: the ubiquitin proteasome system plays a direct role in RNA polymerase I transcription.

Fátyol K, Grummt I.

Biochim Biophys Acta. 2008 Dec;1779(12):850-9. doi: 10.1016/j.bbagrm.2008.08.010. Epub 2008 Sep 6.

PMID:
18804559
43.

The epigenetics of rRNA genes: from molecular to chromosome biology.

McStay B, Grummt I.

Annu Rev Cell Dev Biol. 2008;24:131-57. doi: 10.1146/annurev.cellbio.24.110707.175259. Review.

PMID:
18616426
44.

The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus.

Mayer C, Neubert M, Grummt I.

EMBO Rep. 2008 Aug;9(8):774-80. doi: 10.1038/embor.2008.109. Epub 2008 Jul 4.

45.

Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.

Bierhoff H, Dundr M, Michels AA, Grummt I.

Mol Cell Biol. 2008 Aug;28(16):4988-98. doi: 10.1128/MCB.00492-08. Epub 2008 Jun 16.

46.

Modulation of RNA polymerase assembly dynamics in transcriptional regulation.

Gorski SA, Snyder SK, John S, Grummt I, Misteli T.

Mol Cell. 2008 May 23;30(4):486-97. doi: 10.1016/j.molcel.2008.04.021.

47.

A metabolic throttle regulates the epigenetic state of rDNA.

Grummt I, Ladurner AG.

Cell. 2008 May 16;133(4):577-80. doi: 10.1016/j.cell.2008.04.026. Review.

48.

Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription.

Ye J, Zhao J, Hoffmann-Rohrer U, Grummt I.

Genes Dev. 2008 Feb 1;22(3):322-30. doi: 10.1101/gad.455908. Epub 2008 Jan 29.

49.
50.

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