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Items: 1 to 50 of 75

1.

Forces driving the three-dimensional folding of eukaryotic genomes.

Rada-Iglesias A, Grosveld FG, Papantonis A.

Mol Syst Biol. 2018 Jun 1;14(6):e8214. doi: 10.15252/msb.20188214. Review.

2.

The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes.

Knoch TA, Wachsmuth M, Kepper N, Lesnussa M, Abuseiris A, Ali Imam AM, Kolovos P, Zuin J, Kockx CEM, Brouwer RWW, van de Werken HJG, van IJcken WFJ, Wendt KS, Grosveld FG.

Epigenetics Chromatin. 2016 Dec 24;9:58. doi: 10.1186/s13072-016-0089-x. eCollection 2016.

3.

Exploiting native forces to capture chromosome conformation in mammalian cell nuclei.

Brant L, Georgomanolis T, Nikolic M, Brackley CA, Kolovos P, van Ijcken W, Grosveld FG, Marenduzzo D, Papantonis A.

Mol Syst Biol. 2016 Dec 9;12(12):891. doi: 10.15252/msb.20167311.

4.

Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response.

Kolovos P, Georgomanolis T, Koeferle A, Larkin JD, Brant L, Nikolicć M, Gusmao EG, Zirkel A, Knoch TA, van Ijcken WF, Cook PR, Costa IG, Grosveld FG, Papantonis A.

Genome Res. 2016 Nov;26(11):1478-1489. Epub 2016 Sep 15.

5.

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, Francis A, Umans L, van IJcken WF, Berx G, van Grunsven LA, Grosveld FG, Goossens S, Haigh JJ, Huylebroeck D.

Stem Cells. 2017 Mar;35(3):611-625. doi: 10.1002/stem.2521. Epub 2016 Nov 8.

6.

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

7.

NLS-tagging: an alternative strategy to tag nuclear proteins.

Giraud G, Stadhouders R, Conidi A, Dekkers DH, Huylebroeck D, Demmers JA, Soler E, Grosveld FG.

Nucleic Acids Res. 2014 Dec 1;42(21). doi: 10.1093/nar/gku869. Epub 2014 Sep 26.

8.

Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

Ochieng JK, Schilders K, Kool H, Boerema-De Munck A, Buscop-Van Kempen M, Gontan C, Smits R, Grosveld FG, Wijnen RM, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):311-22. doi: 10.1165/rcmb.2013-0419OC.

PMID:
24669837
9.

Transcription in the context of the 3D nucleus.

Wendt KS, Grosveld FG.

Curr Opin Genet Dev. 2014 Apr;25:62-7. doi: 10.1016/j.gde.2013.11.020. Epub 2014 Feb 15. Review.

PMID:
24534714
10.

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.

Zuin J, Dixon JR, van der Reijden MI, Ye Z, Kolovos P, Brouwer RW, van de Corput MP, van de Werken HJ, Knoch TA, van IJcken WF, Grosveld FG, Ren B, Wendt KS.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):996-1001. doi: 10.1073/pnas.1317788111. Epub 2013 Dec 13.

11.

Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord.

Francius C, Harris A, Rucchin V, Hendricks TJ, Stam FJ, Barber M, Kurek D, Grosveld FG, Pierani A, Goulding M, Clotman F.

PLoS One. 2013 Aug 15;8(8):e70325. doi: 10.1371/journal.pone.0070325. eCollection 2013.

12.

r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data.

Thongjuea S, Stadhouders R, Grosveld FG, Soler E, Lenhard B.

Nucleic Acids Res. 2013 Jul;41(13):e132. doi: 10.1093/nar/gkt373. Epub 2013 May 13.

13.

In vivo live imaging of RNA polymerase II transcription factories in primary cells.

Ghamari A, van de Corput MP, Thongjuea S, van Cappellen WA, van Ijcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FG.

Genes Dev. 2013 Apr 1;27(7):767-77. doi: 10.1101/gad.216200.113. Erratum in: Genes Dev. 2013 Jun 15;27(12):1434. Genes Dev. 2013 May 15;27(10):1216.

14.

Next generation sequencing of SNPs for non-invasive prenatal diagnosis: challenges and feasibility as illustrated by an application to β-thalassaemia.

Papasavva T, van Ijcken WF, Kockx CE, van den Hout MC, Kountouris P, Kythreotis L, Kalogirou E, Grosveld FG, Kleanthous M.

Eur J Hum Genet. 2013 Dec;21(12):1403-10. doi: 10.1038/ejhg.2013.47. Epub 2013 Apr 10.

15.

Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.

Outchkourov NS, Muiño JM, Kaufmann K, van Ijcken WF, Groot Koerkamp MJ, van Leenen D, de Graaf P, Holstege FC, Grosveld FG, Timmers HT.

Cell Rep. 2013 Apr 25;3(4):1071-9. doi: 10.1016/j.celrep.2013.02.030. Epub 2013 Mar 28.

16.

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.

van den Berghe V, Stappers E, Vandesande B, Dimidschstein J, Kroes R, Francis A, Conidi A, Lesage F, Dries R, Cazzola S, Berx G, Kessaris N, Vanderhaeghen P, van Ijcken W, Grosveld FG, Goossens S, Haigh JJ, Fishell G, Goffinet A, Aerts S, Huylebroeck D, Seuntjens E.

Neuron. 2013 Jan 9;77(1):70-82. doi: 10.1016/j.neuron.2012.11.009.

17.

KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.

Borg J, Phylactides M, Bartsakoulia M, Tafrali C, Lederer C, Felice AE, Papachatzopoulou A, Kourakli A, Stavrou EF, Christou S, Hou J, Karkabouna S, Lappa-Manakou C, Ozgur Z, van Ijcken W, von Lindern M, Grosveld FG, Georgitsi M, Kleanthous M, Philipsen S, Patrinos GP.

Pharmacogenomics. 2012 Oct;13(13):1487-500. doi: 10.2217/pgs.12.125.

PMID:
23057549
18.

The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.

Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

19.

RTTN mutations link primary cilia function to organization of the human cerebral cortex.

Kheradmand Kia S, Verbeek E, Engelen E, Schot R, Poot RA, de Coo IF, Lequin MH, Poulton CJ, Pourfarzad F, Grosveld FG, Brehm A, de Wit MC, Oegema R, Dobyns WB, Verheijen FW, Mancini GM.

Am J Hum Genet. 2012 Sep 7;91(3):533-40. doi: 10.1016/j.ajhg.2012.07.008. Epub 2012 Aug 30.

20.

Super-resolution imaging reveals three-dimensional folding dynamics of the β-globin locus upon gene activation.

van de Corput MP, de Boer E, Knoch TA, van Cappellen WA, Quintanilla A, Ferrand L, Grosveld FG.

J Cell Sci. 2012 Oct 1;125(Pt 19):4630-9. doi: 10.1242/jcs.108522. Epub 2012 Jul 5.

21.

A new function of ROD1 in nonsense-mediated mRNA decay.

Brazão TF, Demmers J, van IJcken W, Strouboulis J, Fornerod M, Romão L, Grosveld FG.

FEBS Lett. 2012 Apr 24;586(8):1101-10. doi: 10.1016/j.febslet.2012.03.015. Epub 2012 Mar 21.

22.

Enhancers and silencers: an integrated and simple model for their function.

Kolovos P, Knoch TA, Grosveld FG, Cook PR, Papantonis A.

Epigenetics Chromatin. 2012 Jan 9;5(1):1. doi: 10.1186/1756-8935-5-1.

23.

NARWHAL, a primary analysis pipeline for NGS data.

Brouwer RW, van den Hout MC, Grosveld FG, van Ijcken WF.

Bioinformatics. 2012 Jan 15;28(2):284-5. doi: 10.1093/bioinformatics/btr613. Epub 2011 Nov 8.

PMID:
22072383
24.

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.

Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van Ijcken W, Dekkers DH, Demmers J, Rijkers EJ, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RA.

Nat Genet. 2011 Jun;43(6):607-11. doi: 10.1038/ng.825. Epub 2011 May 1.

PMID:
21532573
25.

The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons.

Tsarovina K, Reiff T, Stubbusch J, Kurek D, Grosveld FG, Parlato R, Schütz G, Rohrer H.

J Neurosci. 2010 Aug 11;30(32):10833-43. doi: 10.1523/JNEUROSCI.0175-10.2010.

26.

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.

Borg J, Papadopoulos P, Georgitsi M, Gutiérrez L, Grech G, Fanis P, Phylactides M, Verkerk AJ, van der Spek PJ, Scerri CA, Cassar W, Galdies R, van Ijcken W, Ozgür Z, Gillemans N, Hou J, Bugeja M, Grosveld FG, von Lindern M, Felice AE, Patrinos GP, Philipsen S.

Nat Genet. 2010 Sep;42(9):801-5. doi: 10.1038/ng.630. Epub 2010 Aug 1.

27.

Differential proteomics based on 18O labeling to determine the cyclin dependent kinase 9 interactome.

Bezstarosti K, Ghamari A, Grosveld FG, Demmers JA.

J Proteome Res. 2010 Sep 3;9(9):4464-75. doi: 10.1021/pr100217d.

PMID:
20593818
28.

Parallel high-performance grid computing: capabilities and opportunities of a novel demanding service and business class allowing highest resource efficiency.

Kepper N, Ettig R, Dickmann F, Stehr R, Grosveld FG, Wedemann G, Knoch TA.

Stud Health Technol Inform. 2010;159:264-71.

PMID:
20543448
29.

Visualization, analysis, and design of COMBO-FISH probes in the grid-based GLOBE 3D genome platform.

Kepper N, Schmitt E, Lesnussa M, Weiland Y, Eussen HB, Grosveld FG, Hausmann M, Knoch TA.

Stud Health Technol Inform. 2010;159:171-80.

PMID:
20543436
30.

GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data.

Estrada K, Abuseiris A, Grosveld FG, Uitterlinden AG, Knoch TA, Rivadeneira F.

Bioinformatics. 2009 Oct 15;25(20):2750-2. doi: 10.1093/bioinformatics/btp497. Epub 2009 Aug 21.

31.

e-Human Grid Ecology - understanding and approaching the inverse tragedy of the commons in the e-Grid society.

Knoch TA, Baumgärtner V, de Zeeuw LV, Grosveld FG, Egger K.

Stud Health Technol Inform. 2009;147:269-76.

PMID:
19593066
32.

The GLOBE 3D Genome Platform - towards a novel system-biological paper tool to integrate the huge complexity of genome organization and function.

Knoch TA, Lesnussa M, Kepper N, Eussen HB, Grosveld FG.

Stud Health Technol Inform. 2009;147:105-16.

PMID:
19593049
33.

Fine-structured multi-scaling long-range correlations in completely sequenced genomes--features, origin, and classification.

Knoch TA, Göker M, Lohner R, Abuseiris A, Grosveld FG.

Eur Biophys J. 2009 Jul;38(6):757-79. doi: 10.1007/s00249-009-0489-y. Epub 2009 Jun 17.

34.

Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors.

Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, Tibboel D, Görlich D, Poot RA, Rottier RJ.

J Cell Biol. 2009 Apr 6;185(1):27-34. doi: 10.1083/jcb.200810106.

35.

The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

Jhunjhunwala S, van Zelm MC, Peak MM, Cutchin S, Riblet R, van Dongen JJ, Grosveld FG, Knoch TA, Murre C.

Cell. 2008 Apr 18;133(2):265-79. doi: 10.1016/j.cell.2008.03.024.

36.

Pharmacogenomics and therapeutics of hemoglobinopathies.

Patrinos GP, Grosveld FG.

Hemoglobin. 2008;32(1-2):229-36. doi: 10.1080/03630260701680367. Review.

PMID:
18275000
37.

Differentiation and gene regulation.

Grosveld FG, Duboule D.

Curr Opin Genet Dev. 2007 Oct;17(5):369-72. Epub 2007 Oct 23. No abstract available.

PMID:
17959371
38.

Increased gamma-globin gene expression in beta-thalassemia intermedia patients correlates with a mutation in 3'HS1.

Papachatzopoulou A, Kaimakis P, Pourfarzad F, Menounos PG, Evangelakou P, Kollia P, Grosveld FG, Patrinos GP.

Am J Hematol. 2007 Nov;82(11):1005-9.

39.

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.

Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE.

Nat Cell Biol. 2007 Feb;9(2):201-9. Epub 2006 Dec 24.

PMID:
17187062
40.

Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.

Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG.

Development. 2007 Jan;134(2):261-72. Epub 2006 Dec 6.

41.

Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder.

van der Wees J, van Looij MA, de Ruiter MM, Elias H, van der Burg H, Liem SS, Kurek D, Engel JD, Karis A, van Zanten BG, de Zeeuw CI, Grosveld FG, van Doorninck JH.

Neurobiol Dis. 2004 Jun;16(1):169-78.

PMID:
15207274
42.

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

Patrinos GP, de Krom M, de Boer E, Langeveld A, Imam AM, Strouboulis J, de Laat W, Grosveld FG.

Genes Dev. 2004 Jun 15;18(12):1495-509.

43.

Fluorescence in situ hybridization analysis of transcript dynamics in cells.

van de Corput MP, Grosveld FG.

Methods. 2001 Sep;25(1):111-8.

PMID:
11559002
44.

Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.

Imam AM, Patrinos GP, de Krom M, Bottardi S, Janssens RJ, Katsantoni E, Wai AW, Sherratt DJ, Grosveld FG.

Nucleic Acids Res. 2000 Jun 15;28(12):E65.

45.

Cloning and sequencing of the CRABP-I locus from chicken and pufferfish: analysis of the promoter regions in transgenic mice.

Kleinjan DA, Dekker S, Guy JA, Grosveld FG.

Transgenic Res. 1998 Mar;7(2):85-94.

PMID:
9608736
46.

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.

van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Köycü S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM.

Science. 1998 Jan 9;279(5348):242-7.

47.

The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism.

Longo L, Bygrave A, Grosveld FG, Pandolfi PP.

Transgenic Res. 1997 Sep;6(5):321-8.

PMID:
9322369
48.

GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.

Elefanty AG, Antoniou M, Custodio N, Carmo-Fonseca M, Grosveld FG.

EMBO J. 1996 Jan 15;15(2):319-33.

49.

Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.

Zhou XY, Morreau H, Rottier R, Davis D, Bonten E, Gillemans N, Wenger D, Grosveld FG, Doherty P, Suzuki K, Grosveld GC, d'Azzo A.

Genes Dev. 1995 Nov 1;9(21):2623-34.

50.

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.

Pandolfi PP, Roth ME, Karis A, Leonard MW, Dzierzak E, Grosveld FG, Engel JD, Lindenbaum MH.

Nat Genet. 1995 Sep;11(1):40-4.

PMID:
7550312

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