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Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr., Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.


Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.

Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P.

Science. 2018 Feb 16;359(6377):794-797. doi: 10.1126/science.aao4988.


Molecular level investigation of the role of peptide interactions in the glyphosate analytics.

Ahmed AA, Gros P, Kühn O, Leinweber P.

Chemosphere. 2018 Apr;196:129-134. doi: 10.1016/j.chemosphere.2017.12.162. Epub 2017 Dec 27.



Gros P, Videnovic A.

Curr Sleep Med Rep. 2017 Sep;3(3):222-234. doi: 10.1007/s40675-017-0079-y. Epub 2017 Jul 6.


Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry.

Rodenburg RNP, Snijder J, van de Waterbeemd M, Schouten A, Granneman J, Heck AJR, Gros P.

Nat Commun. 2017 Nov 3;8(1):1280. doi: 10.1038/s41467-017-01461-z.


Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.

El-Hassan AR, Leung V, Kharfallah F, Guyot MC, Allache R, Gros P, Kibar Z.

Mamm Genome. 2017 Oct 24. doi: 10.1007/s00335-017-9721-8. [Epub ahead of print]


CCDC88B is required for pathogenesis of inflammatory bowel disease.

Fodil N, Moradin N, Leung V, Olivier JF, Radovanovic I, Jeyakumar T, Flores Molina M, McFarquhar A, Cayrol R, Bozec D, Shoukry NH, Kubo M, Dimitrieva J, Louis E, Theatre E, Dahan S, Momozawa Y, Georges M, Yeretssian G, Gros P.

Nat Commun. 2017 Oct 13;8(1):932. doi: 10.1038/s41467-017-01381-y.


Controlling charge-transfer properties through a microwave-assisted mono- or bis-annulation of dialkynyl-N-(het)arylpyrroles.

Pierrat P, Hesse S, Cebrián C, Gros PC.

Org Biomol Chem. 2017 Oct 18;15(40):8568-8575. doi: 10.1039/c7ob02149f.


IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.

Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM.

PLoS Pathog. 2017 Oct 2;13(10):e1006647. doi: 10.1371/journal.ppat.1006647. eCollection 2017 Oct.


New ruthenium compounds bearing semicarbazone 2-formylopyridine moiety: Playing with auxiliary ligands for tuning the mechanism of biological activity.

Łomzik M, Mazuryk O, Rutkowska-Zbik D, Stochel G, Gros PC, Brindell M.

J Inorg Biochem. 2017 Oct;175:80-91. doi: 10.1016/j.jinorgbio.2017.07.006. Epub 2017 Jul 14.


Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.

Xue X, Wu J, Ricklin D, Forneris F, Di Crescenzio P, Schmidt CQ, Granneman J, Sharp TH, Lambris JD, Gros P.

Nat Struct Mol Biol. 2017 Aug;24(8):643-651. doi: 10.1038/nsmb.3427. Epub 2017 Jul 3.


A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.

De Nardis C, Hendriks LJA, Poirier E, Arvinte T, Gros P, Bakker ABH, de Kruif J.

J Biol Chem. 2017 Sep 1;292(35):14706-14717. doi: 10.1074/jbc.M117.793497. Epub 2017 Jun 27.


Sexual dimorphism in the alpine butterflies Boloria pales and Boloria napaea: differences in movement and foraging behavior (Lepidoptera: Nymphalidae).

Ehl S, Hostert K, Korsch J, Gros P, Schmitt T.

Insect Sci. 2017 Jun 15. doi: 10.1111/1744-7917.12494. [Epub ahead of print]


The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.

Laroque A, Min-Oo G, Tam M, Ponka P, Stevenson MM, Gros P.

PLoS One. 2017 May 18;12(5):e0177818. doi: 10.1371/journal.pone.0177818. eCollection 2017.


Glyphosate binding in soil as revealed by sorption experiments and quantum-chemical modeling.

Gros P, Ahmed A, Kühn O, Leinweber P.

Sci Total Environ. 2017 May 15;586:527-535. doi: 10.1016/j.scitotenv.2017.02.007. Epub 2017 Feb 21.


Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea.

Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M.

Neurology. 2017 Mar 21;88(12):1120-1128. doi: 10.1212/WNL.0000000000003738. Epub 2017 Feb 22.


A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.

Förster M, Boora RK, Petrov JC, Fodil N, Albanese I, Kim J, Gros P, Nijnik A.

Immunology. 2017 May;151(1):110-121. doi: 10.1111/imm.12710. Epub 2017 Feb 20.


Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).

De Nardis C, Lössl P, van den Biggelaar M, Madoori PK, Leloup N, Mertens K, Heck AJ, Gros P.

J Biol Chem. 2017 Jan 20;292(3):912-924. doi: 10.1074/jbc.M116.758862. Epub 2016 Dec 12.


Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies.

Langlais D, Fodil N, Gros P.

Annu Rev Immunol. 2017 Apr 26;35:1-30. doi: 10.1146/annurev-immunol-051116-052442. Epub 2016 Dec 1. Review.


Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.


USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.


Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense.

Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD.

Immunol Rev. 2016 Nov;274(1):33-58. doi: 10.1111/imr.12500. Review.


Interfacial charge separation and photovoltaic efficiency in Fe(ii)-carbene sensitized solar cells.

Pastore M, Duchanois T, Liu L, Monari A, Assfeld X, Haacke S, Gros PC.

Phys Chem Chem Phys. 2016 Oct 12;18(40):28069-28081.


Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation.

Sharp TH, Faas FGA, Koster AJ, Gros P.

J Struct Biol. 2017 Feb;197(2):155-162. doi: 10.1016/j.jsb.2016.09.008. Epub 2016 Sep 20.


Specialized or opportunistic-how does the high mountain endemic butterfly Erebia nivalis survive in its extreme habitats?

Ehl S, Dalstein V, Tull F, Gros P, Schmitt T.

Insect Sci. 2018 Feb;25(1):161-171. doi: 10.1111/1744-7917.12400. Epub 2016 Nov 11.


Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

Wang G, de Jong RN, van den Bremer ET, Beurskens FJ, Labrijn AF, Ugurlar D, Gros P, Schuurman J, Parren PW, Heck AJ.

Mol Cell. 2016 Jul 7;63(1):135-45. doi: 10.1016/j.molcel.2016.05.016. Epub 2016 Jun 16.


Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.

Moradin N, Torre S, Gauthier S, Tam M, Hawari J, Vandercruyssen K, De Spiegeleer B, Fortin A, Stevenson MM, Gros P.

Malar J. 2016 May 6;15(1):260. doi: 10.1186/s12936-016-1317-3.


A new record excited state (3)MLCT lifetime for metalorganic iron(ii) complexes.

Liu L, Duchanois T, Etienne T, Monari A, Beley M, Assfeld X, Haacke S, Gros PC.

Phys Chem Chem Phys. 2016 May 14;18(18):12550-6. doi: 10.1039/c6cp01418f. Epub 2016 Apr 18.


Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography.

Sharp TH, Koster AJ, Gros P.

Cell Rep. 2016 Apr 5;15(1):1-8. doi: 10.1016/j.celrep.2016.03.002. Epub 2016 Mar 24.


Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JC, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P.

EMBO J. 2016 May 17;35(10):1133-49. doi: 10.15252/embj.201593673. Epub 2016 Mar 24.


The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

Langlais D, Barreiro LB, Gros P.

J Exp Med. 2016 Apr 4;213(4):585-603. doi: 10.1084/jem.20151764. Epub 2016 Mar 21.


Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.

Van Der Kraak L, Langlais D, Jothy S, Beauchemin N, Gros P.

Mamm Genome. 2016 Jun;27(5-6):213-24. doi: 10.1007/s00335-016-9625-z. Epub 2016 Mar 15.


Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection.

Fodil N, Langlais D, Gros P.

Trends Immunol. 2016 Feb;37(2):126-140. doi: 10.1016/ Epub 2016 Jan 12. Review.


Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.

Belle JI, Petrov JC, Langlais D, Robert F, Cencic R, Shen S, Pelletier J, Gros P, Nijnik A.

Cell Death Differ. 2016 May;23(5):759-75. doi: 10.1038/cdd.2015.140. Epub 2016 Jan 15.


Interaction of Iron II Complexes with B-DNA. Insights from Molecular Modeling, Spectroscopy, and Cellular Biology.

Gattuso H, Duchanois T, Besancenot V, Barbieux C, Assfeld X, Becuwe P, Gros PC, Grandemange S, Monari A.

Front Chem. 2015 Dec 18;3:67. doi: 10.3389/fchem.2015.00067. eCollection 2015.


Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.

van Bruggen R, Gualtieri C, Iliescu A, Louicharoen Cheepsunthorn C, Mungkalasut P, Trape JF, Modiano D, Sirima BS, Singhasivanon P, Lathrop M, Sakuntabhai A, Bureau JF, Gros P.

PLoS One. 2015 Dec 14;10(12):e0144555. doi: 10.1371/journal.pone.0144555. eCollection 2015.


Three in One--Multiple Faunal Elements within an Endangered European Butterfly Species.

Junker M, Zimmermann M, Ramos AA, Gros P, Konvička M, Nève G, Rákosy L, Tammaru T, Castilho R, Schmitt T.

PLoS One. 2015 Nov 13;10(11):e0142282. doi: 10.1371/journal.pone.0142282. eCollection 2015.


Colitis-associated colon cancer: Is it in your genes?

Van Der Kraak L, Gros P, Beauchemin N.

World J Gastroenterol. 2015 Nov 7;21(41):11688-99. doi: 10.3748/wjg.v21.i41.11688. Review.


Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes.

Berends ET, Gorham RD Jr, Ruyken M, Soppe JA, Orhan H, Aerts PC, de Haas CJ, Gros P, Rooijakkers SH.

BMC Biol. 2015 Nov 9;13:93. doi: 10.1186/s12915-015-0203-8.


Diagnosis of Obstructive Sleep Apnea in Parkinson's Disease Patients: Is Unattended Portable Monitoring a Suitable Tool?

Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M.

Parkinsons Dis. 2015;2015:258418. doi: 10.1155/2015/258418. Epub 2015 Oct 13.


Accounting for partiality in serial crystallography using ray-tracing principles.

Kroon-Batenburg LM, Schreurs AM, Ravelli RB, Gros P.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1799-811. doi: 10.1107/S1399004715011803. Epub 2015 Aug 25.


Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime.

Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M.

Sleep Breath. 2016 Mar;20(1):205-12. doi: 10.1007/s11325-015-1208-9. Epub 2015 Jun 13.


The planar cell polarity protein Vangl2 is required for retinal axon guidance.

Leung V, Iliescu A, Jolicoeur C, Gravel M, Apuzzo S, Torban E, Cayouette M, Gros P.

Dev Neurobiol. 2016 Feb;76(2):150-65. doi: 10.1002/dneu.22305. Epub 2015 Jun 2.


Mercury(II) trace detection by a gold nanoparticle-modified glassy carbon electrode using square-wave anodic stripping voltammetry including a chloride desorption step.

Laffont L, Hezard T, Gros P, Heimbürger LE, Sonke JE, Behra P, Evrard D.

Talanta. 2015 Aug 15;141:26-32. doi: 10.1016/j.talanta.2015.03.036. Epub 2015 Mar 27.


Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans.

Seo JH, Zilber Y, Babayeva S, Liu J, Kyriakopoulos P, De Marco P, Merello E, Capra V, Gros P, Torban E.

Hum Mol Genet. 2015 Jul 1;24(13):3893. doi: 10.1093/hmg/ddv131. Epub 2015 May 7. No abstract available.


p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.

Belle JI, Langlais D, Petrov JC, Pardo M, Jones RG, Gros P, Nijnik A.

Blood. 2015 Apr 9;125(15):2344-8. doi: 10.1182/blood-2014-05-574111. Epub 2015 Feb 20.


Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.

Fodil N, Langlais D, Moussa P, Boivin GA, Di Pietrantonio T, Radovanovic I, Dumaine A, Blanchette M, Schurr E, Gros P, Vidal SM.

PLoS Pathog. 2014 Dec 4;10(12):e1004511. doi: 10.1371/journal.ppat.1004511. eCollection 2014 Dec.


THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.

Torre S, Faucher SP, Fodil N, Bongfen SE, Berghout J, Schwartzentruber JA, Majewski J, Lathrop M, Cooper AM, Vidal SM, Gros P.

Infect Immun. 2015 Feb;83(2):759-68. doi: 10.1128/IAI.02586-14. Epub 2014 Dec 1.


CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.

Kennedy JM, Fodil N, Torre S, Bongfen SE, Olivier JF, Leung V, Langlais D, Meunier C, Berghout J, Langat P, Schwartzentruber J, Majewski J, Lathrop M, Vidal SM, Gros P.

J Exp Med. 2014 Dec 15;211(13):2519-35. doi: 10.1084/jem.20140455. Epub 2014 Nov 17.


Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.

Zhang X, Bogunovic D, Payelle-Brogard B, Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O, Mansouri D, Tezcan I, Rice GI, Chen C, Mansouri N, Mahdaviani SA, Itan Y, Boisson B, Okada S, Zeng L, Wang X, Jiang H, Liu W, Han T, Liu D, Ma T, Wang B, Liu M, Liu JY, Wang QK, Yalnizoglu D, Radoshevich L, Uzé G, Gros P, Rozenberg F, Zhang SY, Jouanguy E, Bustamante J, García-Sastre A, Abel L, Lebon P, Notarangelo LD, Crow YJ, Boisson-Dupuis S, Casanova JL, Pellegrini S.

Nature. 2015 Jan 1;517(7532):89-93. doi: 10.1038/nature13801. Epub 2014 Oct 12.

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