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Items: 1 to 50 of 381

1.

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC.

MAbs. 2018 Apr 5:0. doi: 10.1080/19420862.2018.1458808. [Epub ahead of print]

PMID:
29621428

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2.

Drawing the line in clinical treatment of companion animals: recommendations from an ethics working party.

Grimm H, Bergadano A, Musk GC, Otto K, Taylor PM, Duncan JC.

Vet Rec. 2018 Mar 30. pii: vetrec-2017-104559. doi: 10.1136/vr.104559. [Epub ahead of print]

PMID:
29602799

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3.

Necessary, but Not Sufficient. The Benefit Concept in the Project Evaluation of Animal Research in the Context of Directive 2010/63/EU.

Eggel M, Grimm H.

Animals (Basel). 2018 Feb 28;8(3). pii: E34. doi: 10.3390/ani8030034.

PMID:
29495562
Free PMC Article

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4.

Prediction of the optimal dosing regimen using a mathematical model of tumour uptake for immunocytokine-based cancer immunotherapy.

Ribba B, Boetsch C, Nayak TK, Grimm HP, Charo JM, Evers S, Klein C, Tessier JJL, Charoin JE, Phipps A, Pisa P, Teichgräber V.

Clin Cancer Res. 2018 Feb 20. pii: clincanres.2953.2017. doi: 10.1158/1078-0432.CCR-17-2953. [Epub ahead of print]

PMID:
29463551

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5.

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

Grimm MOW, Thiel A, Lauer AA, Winkler J, Lehmann J, Regner L, Nelke C, Janitschke D, Benoist C, Streidenberger O, Stötzel H, Endres K, Herr C, Beisswenger C, Grimm HS, Bals R, Lammert F, Hartmann T.

Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. doi: 10.3390/ijms18122764.

PMID:
29257109
Free PMC Article

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6.

Interplay among Sequence, Folding Propensity, and Bio-Piezoelectric Response in Short Peptides and Peptoids.

Marvin CW, Grimm HM, Miller NC, Horne WS, Hutchison GR.

J Phys Chem B. 2017 Nov 9;121(44):10269-10275. doi: 10.1021/acs.jpcb.7b10085. Epub 2017 Oct 30.

PMID:
29035526

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7.

The Road to Hell Is Paved with Good Intentions: Why Harm-Benefit Analysis and Its Emphasis on Practical Benefit Jeopardizes the Credibility of Research.

Grimm H, Eggel M, Deplazes-Zemp A, Biller-Andorno N.

Animals (Basel). 2017 Sep 11;7(9). pii: E70. doi: 10.3390/ani7090070.

PMID:
28892015
Free PMC Article

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8.

Differential Response to Exercise in African Americans with High Levels of Inflammation.

Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins-Ball AM, Williamson ST, Ling C, Grimm H, Brown MD.

Ethn Dis. 2017 Jul 20;27(3):233-240. doi: 10.18865/ed.27.3.233. eCollection 2017 Summer.

PMID:
28811734
Free PMC Article

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9.

Quantification of IgG monoclonal antibody clearance in tissues.

Eigenmann MJ, Fronton L, Grimm HP, Otteneder MB, Krippendorff BF.

MAbs. 2017 Aug/Sep;9(6):1007-1015. doi: 10.1080/19420862.2017.1337619. Epub 2017 Jun 14.

PMID:
28613103

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10.

White paper and colourful language: Toward a realistic view of animal research.

Grimm H, Eggel M.

Altern Lab Anim. 2017 May;45(2):101-103. No abstract available.

PMID:
28598195
Free Article

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11.

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, van der Graaf PH.

CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):496-498. doi: 10.1002/psp4.12206. Epub 2017 Jul 11.

PMID:
28585415
Free PMC Article

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12.

APP Function and Lipids: A Bidirectional Link.

Grimm MO, Mett J, Grimm HS, Hartmann T.

Front Mol Neurosci. 2017 Mar 10;10:63. doi: 10.3389/fnmol.2017.00063. eCollection 2017. Review.

PMID:
28344547
Free PMC Article

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13.

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.

Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.

Biochem Cell Biol. 2016 Dec;94(6):534-542. Epub 2016 Apr 4.

PMID:
27813426

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14.

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.

Grimm MO, Regner L, Mett J, Stahlmann CP, Schorr P, Nelke C, Streidenberger O, Stoetzel H, Winkler J, Zaidan SR, Thiel A, Endres K, Grimm HS, Volmer DA, Hartmann T.

Int J Mol Sci. 2016 Oct 29;17(11). pii: E1809.

PMID:
27801864
Free PMC Article

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15.

In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing.

Lehmann S, Perera R, Grimm HP, Sam J, Colombetti S, Fauti T, Fahrni L, Schaller T, Freimoser-Grundschober A, Zielonka J, Stoma S, Rudin M, Klein C, Umana P, Gerdes C, Bacac M.

Clin Cancer Res. 2016 Sep 1;22(17):4417-27. doi: 10.1158/1078-0432.CCR-15-2622. Epub 2016 Apr 26.

PMID:
27117182
Free Article

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16.

Attitudes of Austrian veterinarians towards euthanasia in small animal practice: impacts of age and gender on views on euthanasia.

Hartnack S, Springer S, Pittavino M, Grimm H.

BMC Vet Res. 2016 Feb 4;12:26. doi: 10.1186/s12917-016-0649-0.

PMID:
26847551
Free PMC Article

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17.

Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.

Jakubiak P, Wagner B, Grimm HP, Petrig-Schaffland J, Schuler F, Alvarez-Sánchez R.

Mol Pharm. 2016 Feb 1;13(2):586-98. doi: 10.1021/acs.molpharmaceut.5b00808. Epub 2016 Jan 5.

PMID:
26674605

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18.

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing.

Grimm MO, Haupenthal VJ, Mett J, Stahlmann CP, Blümel T, Mylonas NT, Endres K, Grimm HS, Hartmann T.

Neurodegener Dis. 2016;16(1-2):44-54.

PMID:
26642316

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19.

Professionalism and ethics in animal research.

Biller-Andorno N, Grimm H, Walker RL.

Nat Biotechnol. 2015 Oct;33(10):1027-8. doi: 10.1038/nbt.3363. No abstract available.

PMID:
26448081

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20.

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.

Grimm MO, Mett J, Stahlmann CP, Grösgen S, Haupenthal VJ, Blümel T, Hundsdörfer B, Zimmer VC, Mylonas NT, Tanila H, Müller U, Grimm HS, Hartmann T.

Front Aging Neurosci. 2015 May 19;7:77. doi: 10.3389/fnagi.2015.00077. eCollection 2015.

PMID:
26074811
Free PMC Article

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21.

Vitamin E: Curse or Benefit in Alzheimer's Disease? A Systematic Investigation of the Impact of α-, γ- and δ-Tocopherol on Aß Generation and Degradation in Neuroblastoma Cells.

Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC, Lehmann J, Hundsdörfer B, Endres K, Grimm HS, Hartmann T.

J Nutr Health Aging. 2015 Jun;19(6):646-56. doi: 10.1007/s12603-015-0506-z.

PMID:
26054501

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22.

Turning apples into oranges? The harm-benefit analysis and how to take ethical considerations into account.

Grimm H.

Altern Lab Anim. 2015 May;43(2):P22-4. No abstract available.

PMID:
25995017

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23.

Chronic aerobic exercise improves blood pressure dipping status in African American nondippers.

Ling C, Diaz KM, Kretzschmar J, Feairheller DL, Sturgeon KM, Perkins A, Veerabhadrappa P, Williamson ST, Lee H, Grimm H, Babbitt DM, Brown MD.

Blood Press Monit. 2014 Dec;19(6):353-8. doi: 10.1097/MBP.0000000000000075.

PMID:
25100263
Free PMC Article

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24.

PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease.

Grimm MO, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T.

Cell Physiol Biochem. 2014;34(1):92-110. doi: 10.1159/000362987. Epub 2014 Jun 16.

PMID:
24977484
Free Article

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25.

Pharmacokinetics of paracetamol in Göttingen minipigs: in vivo studies and modeling to elucidate physiological determinants of absorption.

Suenderhauf C, Tuffin G, Lorentsen H, Grimm HP, Flament C, Parrott N.

Pharm Res. 2014 Oct;31(10):2696-707. doi: 10.1007/s11095-014-1367-6. Epub 2014 May 3.

PMID:
24792825

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26.

Effects of moderate aerobic exercise training on vascular health and blood pressure in African Americans.

Feairheller DL, Diaz KM, Kashem MA, Thakkar SR, Veerabhadrappa P, Sturgeon KM, Ling C, Williamson ST, Kretzschmar J, Lee H, Grimm H, Babbitt DM, Vin C, Fan X, Crabbe DL, Brown MD.

J Clin Hypertens (Greenwich). 2014 Jul;16(7):504-10. doi: 10.1111/jch.12328. Epub 2014 Apr 29.

PMID:
24779748
Free PMC Article

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27.

The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease.

Grimm MO, Zimmer VC, Lehmann J, Grimm HS, Hartmann T.

Biomed Res Int. 2013;2013:814390. doi: 10.1155/2013/814390. Epub 2014 Feb 19. Review.

PMID:
24575399
Free PMC Article

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28.

[Animal protection without limits? Human-animal relations in between anthropomorphism and objectification].

Grimm H, Hartnack S.

Berl Munch Tierarztl Wochenschr. 2013 Sep-Oct;126(9-10):370-7. German.

PMID:
24199378
Free Article

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29.

A standardized exercise intervention differentially affects premenopausal and postmenopausal African-American women.

Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD.

Menopause. 2014 Jun;21(6):579-84. doi: 10.1097/GME.0000000000000133.

PMID:
24193297
Free PMC Article

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30.

Impact of Vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer's disease.

Grimm MO, Lehmann J, Mett J, Zimmer VC, Grösgen S, Stahlmann CP, Hundsdörfer B, Haupenthal VJ, Rothhaar TL, Herr C, Bals R, Grimm HS, Hartmann T.

Neurodegener Dis. 2014;13(2-3):75-81. doi: 10.1159/000355462. Epub 2013 Oct 30.

PMID:
24192346

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31.

Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study.

Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lütjohann D, Hartmann T, Grimm MO.

J Neurosci. 2013 Oct 9;33(41):16072-87. doi: 10.1523/JNEUROSCI.1506-13.2013.

PMID:
24107941
Free Article

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32.

Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys.

Vexler V, Yu L, Pamulapati C, Garrido R, Grimm HP, Sriraman P, Bohini S, Schraeml M, Singh U, Brandt M, Ries S, Ma H, Klumpp K, Ji C.

MAbs. 2013 Sep-Oct;5(5):776-86. doi: 10.4161/mabs.25642. Epub 2013 Jul 8.

PMID:
23924796
Free PMC Article

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33.

Endothelial activation microparticles and inflammation status improve with exercise training in african americans.

Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Kretzschmar J, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD.

Int J Hypertens. 2013;2013:538017. doi: 10.1155/2013/538017. Epub 2013 Apr 18.

PMID:
23691280
Free PMC Article

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34.

Visit-to-visit and 24-h blood pressure variability: association with endothelial and smooth muscle function in African Americans.

Diaz KM, Veerabhadrappa P, Kashem MA, Thakkar SR, Feairheller DL, Sturgeon KM, Ling C, Williamson ST, Kretzschmar J, Lee H, Grimm H, Babbitt DM, Vin C, Fan X, Crabbe DL, Brown MD.

J Hum Hypertens. 2013 Nov;27(11):671-7. doi: 10.1038/jhh.2013.33. Epub 2013 Apr 25.

PMID:
23615389
Free PMC Article

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35.

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Sakurai T, Takai R, Bürgin H, Shioda A, Sakamoto Y, Amano J, Grimm HP, Richter WF, Higuchi Y, Chiba S, Kawamura A, Suzuki M, Müller L.

Birth Defects Res B Dev Reprod Toxicol. 2013 Apr;98(2):170-82. doi: 10.1002/bdrb.21053. Epub 2013 Mar 25.

PMID:
23529913

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36.

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

Grimm MO, Haupenthal VJ, Rothhaar TL, Zimmer VC, Grösgen S, Hundsdörfer B, Lehmann J, Grimm HS, Hartmann T.

Int J Mol Sci. 2013 Mar 13;14(3):5879-98. doi: 10.3390/ijms14035879.

PMID:
23485990
Free PMC Article

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37.

The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS).

Tluczkiewicz I, Batke M, Kroese D, Buist H, Aldenberg T, Pauné E, Grimm H, Kühne R, Schüürmann G, Mangelsdorf I, Escher SE.

Regul Toxicol Pharmacol. 2013 Nov;67(2):157-69. doi: 10.1016/j.yrtph.2013.02.004. Epub 2013 Feb 21.

PMID:
23439429

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38.

Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease.

Rothhaar TL, Grösgen S, Haupenthal VJ, Burg VK, Hundsdörfer B, Mett J, Riemenschneider M, Grimm HS, Hartmann T, Grimm MO.

ScientificWorldJournal. 2012;2012:141240. doi: 10.1100/2012/141240. Epub 2012 Apr 1.

PMID:
22547976
Free PMC Article

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39.

The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.

Tai LM, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, Grimm HP.

J Pharmacokinet Pharmacodyn. 2012 Jun;39(3):227-37. doi: 10.1007/s10928-012-9246-4. Epub 2012 Apr 6.

PMID:
22481485

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40.

Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.

Grimm MO, Zinser EG, Grösgen S, Hundsdörfer B, Rothhaar TL, Burg VK, Kaestner L, Bayer TA, Lipp P, Müller U, Grimm HS, Hartmann T.

PLoS One. 2012;7(3):e34095. doi: 10.1371/journal.pone.0034095. Epub 2012 Mar 28.

PMID:
22470521
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41.

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF.

MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1.

PMID:
22453096
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42.

Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP).

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T.

J Nutr Biochem. 2012 Oct;23(10):1214-23. doi: 10.1016/j.jnutbio.2011.06.015. Epub 2011 Dec 29.

PMID:
22209004

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43.

From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry.

Grimm MO, Grösgen S, Riemenschneider M, Tanila H, Grimm HS, Hartmann T.

J Chromatogr A. 2011 Oct 21;1218(42):7713-22. doi: 10.1016/j.chroma.2011.07.073. Epub 2011 Jul 30.

PMID:
21872257

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44.

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components.

Richter WF, Grimm HP, Theil FP.

J Pharmacokinet Pharmacodyn. 2011 Oct;38(5):581-93. doi: 10.1007/s10928-011-9209-1. Epub 2011 Jul 21.

PMID:
21779940

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45.

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.

Grimm MO, Grösgen S, Rothhaar TL, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Müller U, Fassbender K, Riemenschneider M, Grimm HS, Hartmann T.

Int J Alzheimers Dis. 2011;2011:695413. doi: 10.4061/2011/695413. Epub 2011 May 18.

PMID:
21660213
Free PMC Article

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46.

[Acceptance of killing of animals: survey among veterinarians and other professions].

Dürr S, Fahrion A, Doherr MG, Grimm H, Hartnack S.

Schweiz Arch Tierheilkd. 2011 May;153(5):215-22. doi: 10.1024/0036-7281/a000185. German.

PMID:
21541910
Free Article

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47.

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.

Grimm MO, Kuchenbecker J, Grösgen S, Burg VK, Hundsdörfer B, Rothhaar TL, Friess P, de Wilde MC, Broersen LM, Penke B, Péter M, Vígh L, Grimm HS, Hartmann T.

J Biol Chem. 2011 Apr 22;286(16):14028-39. doi: 10.1074/jbc.M110.182329. Epub 2011 Feb 15.

PMID:
21324907
Free PMC Article

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48.

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.

Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T.

J Neurochem. 2011 Mar;116(5):916-25. doi: 10.1111/j.1471-4159.2010.07070.x. Epub 2011 Jan 12.

PMID:
21214572
Free Article

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49.

Ethical implications of using the minipig in regulatory toxicology studies.

Webster J, Bollen P, Grimm H, Jennings M; Steering Group of the RETHINK Project.

J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):160-6. doi: 10.1016/j.vascn.2010.05.002. Epub 2010 May 31.

PMID:
20566379

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50.

CCL20/CCR6 expression profile in pancreatic cancer.

Rubie C, Frick VO, Ghadjar P, Wagner M, Grimm H, Vicinus B, Justinger C, Graeber S, Schilling MK.

J Transl Med. 2010 May 10;8:45. doi: 10.1186/1479-5876-8-45.

PMID:
20459729
Free PMC Article

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