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Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.

Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C.

Sci Rep. 2018 Feb 6;8(1):2524. doi: 10.1038/s41598-018-20980-3.


Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors.

Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM.

Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017.


Criteria to Screen for Traumatic Cervical Spine Instability: A Consensus of Chiropractic Radiologists.

Dion S, Stupar M, Côté P, Grenier JM, Taylor JA.

J Manipulative Physiol Ther. 2018 Jan 9. pii: S0161-4754(17)30139-2. doi: 10.1016/j.jmpt.2017.10.002. [Epub ahead of print]


BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.

Kaufmann E, Sanz J, Dunn JL, Khan N, Mendonça LE, Pacis A, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Mailhot-Léonard F, Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi M.

Cell. 2018 Jan 11;172(1-2):176-190.e19. doi: 10.1016/j.cell.2017.12.031.


Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.

Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC.

FASEB J. 2018 Jan 8:fj201701008R. doi: 10.1096/fj.201701008R. [Epub ahead of print]


Relaxed Selection During a Recent Human Expansion.

Peischl S, Dupanloup I, Foucal A, Jomphe M, Bruat V, Grenier JC, Gouy A, Gilbert KJ, Gbeha E, Bosshard L, Hip-Ki E, Agbessi M, Hodgkinson A, Vézina H, Awadalla P, Excoffier L.

Genetics. 2018 Feb;208(2):763-777. doi: 10.1534/genetics.117.300551. Epub 2017 Nov 29.


RNA-seq transcriptome analysis of formalin fixed, paraffin-embedded canine meningioma.

Grenier JK, Foureman PA, Sloma EA, Miller AD.

PLoS One. 2017 Oct 26;12(10):e0187150. doi: 10.1371/journal.pone.0187150. eCollection 2017.


XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris).

Meyers-Wallen VN, Boyko AR, Danko CG, Grenier JK, Mezey JG, Hayward JJ, Shannon LM, Gao C, Shafquat A, Rice EJ, Pujar S, Eggers S, Ohnesorg T, Sinclair AH.

PLoS One. 2017 Oct 20;12(10):e0186331. doi: 10.1371/journal.pone.0186331. eCollection 2017.


Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.

Sarzi E, Seveno M, Angebault C, Milea D, Rönnbäck C, Quilès M, Adrian M, Grenier J, Caignard A, Lacroux A, Lavergne C, Reynier P, Larsen M, Hamel CP, Delettre C, Lenaers G, Müller A.

Hum Mol Genet. 2017 Dec 1;26(23):4764. doi: 10.1093/hmg/ddx376. No abstract available.


Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.

Moon H, Donahue LR, Choi E, Scumpia PO, Lowry WE, Grenier JK, Zhu J, White AC.

Cell Stem Cell. 2017 Nov 2;21(5):665-678.e6. doi: 10.1016/j.stem.2017.09.001. Epub 2017 Oct 12.


Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis.

Houdebine L, Gallelli CA, Rastelli M, Sampathkumar NK, Grenier J.

Chem Phys Lipids. 2017 Oct;207(Pt B):127-134. doi: 10.1016/j.chemphyslip.2017.06.002. Epub 2017 Jun 9. Review.


Blood Pressure Management in Patients with Diabetes: Insights From the Diabetes Mellitus Status in Canada Survey.

Grenier J, Goodman SG, Leiter LA, Langer A, Teoh H, Bhatt DL, Cheng AYY, Tan MK, Ransom T, Connelly KA, Yan AT.

Can J Diabetes. 2017 May 25. pii: S1499-2671(16)30557-3. doi: 10.1016/j.jcjd.2017.01.005. [Epub ahead of print]


The burden of generalized anxiety disorder in Canada.

Pelletier L, O'Donnell S, McRae L, Grenier J.

Health Promot Chronic Dis Prev Can. 2017 Feb;37(2):54-62. English, French.


[Erratum to: "Breast cancer screening: On our way to the future" [Bull. Cancer 103 (2016) 753-763]].

Delaloge S, Bachelot T, Bidard FC, Espie M, Brain E, Bonnefoi H, Gligorov J, Dalenc F, Hardy-Bessard AC, Azria D, Jacquin JP, Lemonnier J, Jacot W, Goncalves A, Coutant C, Ganem G, Petit T, Penault-Llorca F, Debled M, Campone M, Levy C, Coudert B, Lortholary A, Venat-Bouvet L, Grenier J, Bourgeois H, Asselain B, Arvis J, Castro M, Tardivon A, Cox DG, Arveux P, Balleyguier C, André F, Rouzier R; Intergroupe national de recherche sur le cancer du sein Unicancer (UCBG).

Bull Cancer. 2016 Nov;103(11):951-952. doi: 10.1016/j.bulcan.2016.10.009. Epub 2016 Oct 28. French. No abstract available.


SIRT7 Is an RNA-Activated Protein Lysine Deacylase.

Tong Z, Wang M, Wang Y, Kim DD, Grenier JK, Cao J, Sadhukhan S, Hao Q, Lin H.

ACS Chem Biol. 2017 Jan 20;12(1):300-310. doi: 10.1021/acschembio.6b00954. Epub 2016 Dec 20.


Social status alters immune regulation and response to infection in macaques.

Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J.

Science. 2016 Nov 25;354(6315):1041-1045.


Survey of Global Genetic Diversity Within the Drosophila Immune System.

Early AM, Arguello JR, Cardoso-Moreira M, Gottipati S, Grenier JK, Clark AG.

Genetics. 2017 Jan;205(1):353-366. doi: 10.1534/genetics.116.195016. Epub 2016 Nov 4.


Paraquat Induces Peripheral Myelin Disruption and Locomotor Defects: Crosstalk with LXR and Wnt Pathways.

Hichor M, Sampathkumar NK, Montanaro J, Borderie D, Petit PX, Gorgievski V, Tzavara ET, Eid AA, Charbonnier F, Grenier J, Massaad C.

Antioxid Redox Signal. 2017 Jul 20;27(3):168-183. doi: 10.1089/ars.2016.6711. Epub 2016 Dec 19.


Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.

Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB.

Cell. 2016 Oct 20;167(3):657-669.e21. doi: 10.1016/j.cell.2016.09.025.


Comparison of the Pharmacokinetics of Ketorolac Tromethamine After Continuous Subcutaneous Infusion and Repeat Intramuscular Bolus Injections in Healthy Adult Subjects.

Burdick M, Mamelok R, Hurliman M, Dupuis M, Xie Y, Grenier J, Sheldon C, Gartner M, Noymer P.

Clin Pharmacol Drug Dev. 2017 Jul;6(4):343-349. doi: 10.1002/cpdd.319. Epub 2017 Jan 11.


Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.

Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB.

PLoS Genet. 2016 Sep 30;12(9):e1006338. doi: 10.1371/journal.pgen.1006338. eCollection 2016 Sep.


A haplotype-based normalization technique for the analysis and detection of allele specific expression.

Hodgkinson A, Grenier JC, Gbeha E, Awadalla P.

BMC Bioinformatics. 2016 Sep 13;17(1):364. doi: 10.1186/s12859-016-1238-8.


[Breast cancer screening: On our way to the future].

Delaloge S, Bachelot T, Bidard FC, Espie M, Brain E, Bonnefoi H, Gligorov J, Dalenc F, Hardy-Bessard AC, Azria D, Jacquin JP, Lemonnier J, Jacot W, Goncalves A, Coutant C, Ganem G, Petit T, Penault-Lorca F, Debled M, Campone M, Levy C, Coudert B, Lortholary A, Venat-Bouvet L, Grenier J, Bourgeois H, Asselain B, Arvis J, Castro M, Tardivon A, Cox DG, Arveux P, Balleyguier C, André F, Rouzier R; Intergroupe national de recherche sur le cancer du sein Unicancer (UCBG).

Bull Cancer. 2016 Sep;103(9):753-63. doi: 10.1016/j.bulcan.2016.06.005. Epub 2016 Jul 26. Review. French.


WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP.

Ophthalmology. 2016 Sep;123(9):1989-98. doi: 10.1016/j.ophtha.2016.05.036. Epub 2016 Jul 7.


Extensive local adaptation within the chemosensory system following Drosophila melanogaster's global expansion.

Arguello JR, Cardoso-Moreira M, Grenier JK, Gottipati S, Clark AG, Benton R.

Nat Commun. 2016 Jun 13;7:ncomms11855. doi: 10.1038/ncomms11855.


Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.

Sarzi E, Seveno M, Angebault C, Milea D, Rönnbäck C, Quilès M, Adrian M, Grenier J, Caignard A, Lacroux A, Lavergne C, Reynier P, Larsen M, Hamel CP, Lenaers G, Müller A.

Hum Mol Genet. 2016 Jun 15;25(12):2539-2551. Epub 2016 Jun 3.


Evidence for the fixation of gene duplications by positive selection in Drosophila.

Cardoso-Moreira M, Arguello JR, Gottipati S, Harshman LG, Grenier JK, Clark AG.

Genome Res. 2016 Jun;26(6):787-98. doi: 10.1101/gr.199323.115. Epub 2016 Apr 12.


A phase II trial of abiraterone acetate plus prednisone in patients with triple-negative androgen receptor positive locally advanced or metastatic breast cancer (UCBG 12-1).

Bonnefoi H, Grellety T, Tredan O, Saghatchian M, Dalenc F, Mailliez A, L'Haridon T, Cottu P, Abadie-Lacourtoisie S, You B, Mousseau M, Dauba J, Del Piano F, Desmoulins I, Coussy F, Madranges N, Grenier J, Bidard FC, Proudhon C, MacGrogan G, Orsini C, Pulido M, Gonçalves A.

Ann Oncol. 2016 May;27(5):812-8. doi: 10.1093/annonc/mdw067. Epub 2016 Feb 18.


Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury.

Ritzel RM, Crapser J, Patel AR, Verma R, Grenier JM, Chauhan A, Jellison ER, McCullough LD.

J Immunol. 2016 Apr 15;196(8):3318-30. doi: 10.4049/jimmunol.1502021. Epub 2016 Mar 9.


Reviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens.

Qiu Z, Grenier JM, Khanna KM.

Oncoimmunology. 2015 Jun 5;5(1):e1056974. eCollection 2016.


Liver X Receptors differentially modulate central myelin gene mRNA levels in a region-, age- and isoform-specific manner.

Shackleford GG, Grenier J, Abi Habib W, Massaad C, Meffre D.

J Steroid Biochem Mol Biol. 2017 May;169:61-68. doi: 10.1016/j.jsbmb.2016.02.032. Epub 2016 Mar 3.


Structure and reactivity with oxygen of Pr2NiO(4+δ): an in situ synchrotron X-ray powder diffraction study.

Broux T, Prestipino C, Bahout M, Paofai S, Elkaïm E, Vibhu V, Grenier JC, Rougier A, Bassat JM, Hernandez O.

Dalton Trans. 2016 Feb 21;45(7):3024-33. doi: 10.1039/c5dt03482e. Epub 2016 Jan 13.


Conservative treatment of a rock climber with a SLAP lesion: a case report.

Blanchette MA, Pham AT, Grenier JM.

J Can Chiropr Assoc. 2015 Sep;59(3):238-44.


Bacterial infection remodels the DNA methylation landscape of human dendritic cells.

Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB.

Genome Res. 2015 Dec;25(12):1801-11. doi: 10.1101/gr.192005.115. Epub 2015 Sep 21.


Femtosecond laser inscription of asymmetric directional couplers for in-fiber optical taps and fiber cladding photonics.

Grenier JR, Fernandes LA, Herman PR.

Opt Express. 2015 Jun 29;23(13):16760-71. doi: 10.1364/OE.23.016760.


Aortic Dilatation Associated With a De Novo Mutation in the SOX18 Gene: Expanding the Clinical Spectrum of Hypotrichosis-Lymphedema-Telangiectasia Syndrome.

Wünnemann F, Kokta V, Leclerc S, Thibeault M, McCuaig C, Hatami A, Stheneur C, Grenier JC, Awadalla P, Mitchell GA, Andelfinger G, Preuss C.

Can J Cardiol. 2016 Jan;32(1):135.e1-7. doi: 10.1016/j.cjca.2015.04.004. Epub 2015 Apr 13.


miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, Williams DA.

Mol Ther. 2015 Sep;23(9):1465-74. doi: 10.1038/mt.2015.113. Epub 2015 Jun 17.


A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.

Johansen LM, DeWald LE, Shoemaker CJ, Hoffstrom BG, Lear-Rooney CM, Stossel A, Nelson E, Delos SE, Simmons JA, Grenier JM, Pierce LT, Pajouhesh H, Lehár J, Hensley LE, Glass PJ, White JM, Olinger GG.

Sci Transl Med. 2015 Jun 3;7(290):290ra89. doi: 10.1126/scitranslmed.aaa5597.


Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.

Meffre D, Shackleford G, Hichor M, Gorgievski V, Tzavara ET, Trousson A, Ghoumari AM, Deboux C, Nait Oumesmar B, Liere P, Schumacher M, Baulieu EE, Charbonnier F, Grenier J, Massaad C.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7587-92. doi: 10.1073/pnas.1424951112. Epub 2015 May 28.


Functional differences between microglia and monocytes after ischemic stroke.

Ritzel RM, Patel AR, Grenier JM, Crapser J, Verma R, Jellison ER, McCullough LD.

J Neuroinflammation. 2015 May 29;12:106. doi: 10.1186/s12974-015-0329-1.


Behavioral idiosyncrasy reveals genetic control of phenotypic variability.

Ayroles JF, Buchanan SM, O'Leary C, Skutt-Kakaria K, Grenier JK, Clark AG, Hartl DL, de Bivort BL.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6706-11. doi: 10.1073/pnas.1503830112. Epub 2015 May 7.


Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.

Modzelewski AJ, Hilz S, Crate EA, Schweidenback CT, Fogarty EA, Grenier JK, Freire R, Cohen PE, Grimson A.

J Cell Sci. 2015 Jun 15;128(12):2314-27. doi: 10.1242/jcs.167148. Epub 2015 May 1.


Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects.

Nguyen L, Holland J, Mamelok R, Laberge MK, Grenier J, Swearingen D, Armas D, Lacy S.

J Clin Pharmacol. 2015 Nov;55(11):1293-302. doi: 10.1002/jcph.526. Epub 2015 Jun 26.


Social networks predict gut microbiome composition in wild baboons.

Tung J, Barreiro LB, Burns MB, Grenier JC, Lynch J, Grieneisen LE, Altmann J, Alberts SC, Blekhman R, Archie EA.

Elife. 2015 Mar 16;4. doi: 10.7554/eLife.05224.


Recombination affects accumulation of damaging and disease-associated mutations in human populations.

Hussin JG, Hodgkinson A, Idaghdour Y, Grenier JC, Goulet JP, Gbeha E, Hip-Ki E, Awadalla P.

Nat Genet. 2015 Apr;47(4):400-4. doi: 10.1038/ng.3216. Epub 2015 Feb 16.


Fiber optic stress-independent helical torsion sensor.

Fernandes LA, Grenier JR, Aitchison JS, Herman PR.

Opt Lett. 2015 Feb 15;40(4):657-60. doi: 10.1364/OL.40.000657.


Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.

Grenier JK, Arguello JR, Moreira MC, Gottipati S, Mohammed J, Hackett SR, Boughton R, Greenberg AJ, Clark AG.

G3 (Bethesda). 2015 Feb 11;5(4):593-603. doi: 10.1534/g3.114.015883.


Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma.

Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM.

Cancer Immunol Res. 2015 May;3(5):536-46. doi: 10.1158/2326-6066.CIR-14-0044. Epub 2015 Jan 29.


[Advocating for the Inclusion of Psychologists in Family Health Teams in Ontario, Canada].

Grenier J, Chomienne MH, Gaboury I.

Sante Ment Que. 2015 Winter;40(4):79-99. French.


[Collaboration between Medicine and Psychology: Evolving Mentalities in Belgium and Evolution of the Health Care System in Canada].

Chomienne MH, Vanneste P, Grenier J, Hendrick S.

Sante Ment Que. 2015 Winter;40(4):59-77. French.


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