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Items: 1 to 50 of 81

1.

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function.

Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG.

Biol Open. 2018 Jan 5;7(1). pii: bio029512. doi: 10.1242/bio.029512.

2.

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.

Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman EB, Zarnescu DC, Wong PK, Gregorio CC.

Circulation. 2018 Feb 6;137(6):605-618. doi: 10.1161/CIRCULATIONAHA.117.028976. Epub 2017 Nov 3.

PMID:
29101288
3.

HSPB7 is indispensable for heart development by modulating actin filament assembly.

Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961. doi: 10.1073/pnas.1713763114. Epub 2017 Oct 23.

PMID:
29078393
4.

Overview of the Muscle Cytoskeleton.

Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC.

Compr Physiol. 2017 Jun 18;7(3):891-944. doi: 10.1002/cphy.c160033.

PMID:
28640448
5.

The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function.

Ly T, Moroz N, Pappas CT, Novak SM, Tolkatchev D, Wooldridge D, Mayfield RM, Helms G, Gregorio CC, Kostyukova AS.

Mol Biol Cell. 2016 Aug 15;27(16):2565-75. doi: 10.1091/mbc.E16-03-0200. Epub 2016 Jun 15.

6.

Mutation-specific effects on thin filament length in thin filament myopathy.

Winter JM, Joureau B, Lee EJ, Kiss B, Yuen M, Gupta VA, Pappas CT, Gregorio CC, Stienen GJ, Edvardson S, Wallgren-Pettersson C, Lehtokari VL, Pelin K, Malfatti E, Romero NB, Engelen BG, Voermans NC, Donkervoort S, Bönnemann CG, Clarke NF, Beggs AH, Granzier H, Ottenheijm CA.

Ann Neurol. 2016 Jun;79(6):959-69. doi: 10.1002/ana.24654. Epub 2016 Apr 30.

7.

Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes.

Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP.

Arch Biochem Biophys. 2016 Jul 1;601:32-41. doi: 10.1016/j.abb.2016.03.012. Epub 2016 Mar 10.

8.

Nebulin, a multi-functional giant.

Chu M, Gregorio CC, Pappas CT.

J Exp Biol. 2016 Jan;219(Pt 2):146-52. doi: 10.1242/jeb.126383. Review.

9.

Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.

Novak SM, Joardar A, Gregorio CC, Zarnescu DC.

PLoS One. 2015 Nov 16;10(11):e0142836. doi: 10.1371/journal.pone.0142836. eCollection 2015.

10.

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.

Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13573-8. doi: 10.1073/pnas.1508273112. Epub 2015 Oct 20.

11.

c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury.

Fu P, Usatyuk PV, Lele A, Harijith A, Gregorio CC, Garcia JG, Salgia R, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1025-38. doi: 10.1152/ajplung.00306.2014. Epub 2015 Mar 20.

12.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF.

J Clin Invest. 2015 Jan;125(1):456-7. doi: 10.1172/JCI80057. Epub 2015 Jan 2. No abstract available.

13.

The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.

Ono Y, Shindo M, Doi N, Kitamura F, Gregorio CC, Sorimachi H.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5527-36. doi: 10.1073/pnas.1411959111. Epub 2014 Dec 15.

14.

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis.

Nworu CU, Kraft R, Schnurr DC, Gregorio CC, Krieg PA.

J Cell Sci. 2015 Jan 15;128(2):239-50. doi: 10.1242/jcs.152702. Epub 2014 Nov 27.

15.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF.

J Clin Invest. 2014 Nov;124(11):4693-708. doi: 10.1172/JCI75199. Epub 2014 Sep 24. Erratum in: J Clin Invest. 2015 Jan;125(1):456-7.

16.

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.

Granzier HL, Hutchinson KR, Tonino P, Methawasin M, Li FW, Slater RE, Bull MM, Saripalli C, Pappas CT, Gregorio CC, Smith JE 3rd.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14589-94. doi: 10.1073/pnas.1411493111. Epub 2014 Sep 22.

17.

Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.

Bliss KT, Tsukada T, Novak SM, Dorovkov MV, Shah SP, Nworu C, Kostyukova AS, Gregorio CC.

FASEB J. 2014 Sep;28(9):3987-95. doi: 10.1096/fj.13-246009. Epub 2014 Jun 2.

18.

Preparation of developing Xenopus muscle for sarcomeric protein localization by high-resolution imaging.

Nworu CU, Krieg PA, Gregorio CC.

Methods. 2014 Apr 1;66(3):370-9. doi: 10.1016/j.ymeth.2013.06.015. Epub 2013 Jun 25.

19.

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Ono Y, Iemura S, Novak SM, Doi N, Kitamura F, Natsume T, Gregorio CC, Sorimachi H.

J Mol Biol. 2013 Aug 23;425(16):2955-72. doi: 10.1016/j.jmb.2013.05.009. Epub 2013 May 21.

20.

Fragile hearts: new insights into translational control in cardiac muscle.

Zarnescu DC, Gregorio CC.

Trends Cardiovasc Med. 2013 Nov;23(8):275-81. doi: 10.1016/j.tcm.2013.03.003. Epub 2013 Apr 10. Review.

21.

Investigating lasp-2 in cell adhesion: new binding partners and roles in motility.

Bliss KT, Chu M, Jones-Weinert CM, Gregorio CC.

Mol Biol Cell. 2013 Apr;24(7):995-1006. doi: 10.1091/mbc.E12-10-0723. Epub 2013 Feb 6.

22.

Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes.

Moroz NA, Novak SM, Azevedo R, Colpan M, Uversky VN, Gregorio CC, Kostyukova AS.

J Biol Chem. 2013 Feb 15;288(7):4899-907. doi: 10.1074/jbc.M112.434522. Epub 2012 Dec 27.

23.

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F.

J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9.

24.

Mutations in the sensitive giant titin result in a broken heart.

Leinwand LA, Tardiff JC, Gregorio CC.

Circ Res. 2012 Jul 6;111(2):158-61. doi: 10.1161/RES.0b013e3182635ca2. No abstract available.

25.

Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart.

Warkman AS, Whitman SA, Miller MK, Garriock RJ, Schwach CM, Gregorio CC, Krieg PA.

Cytoskeleton (Hoboken). 2012 May;69(5):324-35. doi: 10.1002/cm.21029. Epub 2012 Apr 30. Erratum in: Cytoskeleton (Hoboken). 2012 Dec;69(12):1086.

26.

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.

Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A, Linke WA.

Genes Dev. 2012 Jan 15;26(2):114-9. doi: 10.1101/gad.177758.111. Epub 2012 Jan 12.

27.

Cellular self-organization by autocatalytic alignment feedback.

Junkin M, Leung SL, Whitman S, Gregorio CC, Wong PK.

J Cell Sci. 2011 Dec 15;124(Pt 24):4213-20. doi: 10.1242/jcs.088898. Epub 2011 Dec 22.

28.

The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments.

Conover GM, Gregorio CC.

J Cell Sci. 2011 Oct 15;124(Pt 20):3464-76. doi: 10.1242/jcs.087080. Epub 2011 Oct 7.

29.

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.

Whitman SA, Cover C, Yu L, Nelson DL, Zarnescu DC, Gregorio CC.

Circ Res. 2011 Jul 22;109(3):262-71. doi: 10.1161/CIRCRESAHA.111.244244. Epub 2011 Jun 9.

30.

Identification of residues within tropomodulin-1 responsible for its localization at the pointed ends of the actin filaments in cardiac myocytes.

Tsukada T, Kotlyanskaya L, Huynh R, Desai B, Novak SM, Kajava AV, Gregorio CC, Kostyukova AS.

J Biol Chem. 2011 Jan 21;286(3):2194-204. doi: 10.1074/jbc.M110.186924. Epub 2010 Nov 15.

31.

The Nebulin family: an actin support group.

Pappas CT, Bliss KT, Zieseniss A, Gregorio CC.

Trends Cell Biol. 2011 Jan;21(1):29-37. doi: 10.1016/j.tcb.2010.09.005. Epub 2010 Oct 15. Review.

32.

Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.

Tsukada T, Pappas CT, Moroz N, Antin PB, Kostyukova AS, Gregorio CC.

J Cell Sci. 2010 Sep 15;123(Pt 18):3136-45. doi: 10.1242/jcs.071837. Epub 2010 Aug 24.

33.

Nebulin regulates actin filament lengths by a stabilization mechanism.

Pappas CT, Krieg PA, Gregorio CC.

J Cell Biol. 2010 May 31;189(5):859-70. doi: 10.1083/jcb.201001043. Epub 2010 May 24.

34.

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle.

Tonino P, Pappas CT, Hudson BD, Labeit S, Gregorio CC, Granzier H.

J Cell Sci. 2010 Feb 1;123(Pt 3):384-91. doi: 10.1242/jcs.042234. Epub 2010 Jan 5.

35.

A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture.

Conover GM, Henderson SN, Gregorio CC.

Mol Biol Cell. 2009 Feb;20(3):834-45. doi: 10.1091/mbc.E08-07-0753. Epub 2008 Nov 12.

36.

Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle.

Moran CM, Garriock RJ, Miller MK, Heimark RL, Gregorio CC, Krieg PA.

Cell Motil Cytoskeleton. 2008 Aug;65(8):652-61. doi: 10.1002/cm.20291.

37.

Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc.

Pappas CT, Bhattacharya N, Cooper JA, Gregorio CC.

Mol Biol Cell. 2008 May;19(5):1837-47. doi: 10.1091/mbc.E07-07-0690. Epub 2008 Feb 13.

38.

Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein.

Zieseniss A, Terasaki AG, Gregorio CC.

Cell Motil Cytoskeleton. 2008 Jan;65(1):59-72.

PMID:
17968983
39.
40.

Nebulin regulates the assembly and lengths of the thin filaments in striated muscle.

McElhinny AS, Schwach C, Valichnac M, Mount-Patrick S, Gregorio CC.

J Cell Biol. 2005 Sep 12;170(6):947-57.

42.

Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.

Adameyko II, Mudry RE, Houston-Cummings NR, Veselov AP, Gregorio CC, Tevosian SG.

Dev Dyn. 2005 Jun;233(2):540-52.

43.

Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.

McElhinny AS, Perry CN, Witt CC, Labeit S, Gregorio CC.

J Cell Sci. 2004 Jul 1;117(Pt 15):3175-88. Epub 2004 Jun 15.

44.

The sensitive giant: the role of titin-based stretch sensing complexes in the heart.

Miller MK, Granzier H, Ehler E, Gregorio CC.

Trends Cell Biol. 2004 Mar;14(3):119-26. Review.

PMID:
15003620
45.

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.

Witt CC, Ono Y, Puschmann E, McNabb M, Wu Y, Gotthardt M, Witt SH, Haak M, Labeit D, Gregorio CC, Sorimachi H, Granzier H, Labeit S.

J Mol Biol. 2004 Feb 6;336(1):145-54.

PMID:
14741210
46.

Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality.

Fritz-Six KL, Cox PR, Fischer RS, Xu B, Gregorio CC, Zoghbi HY, Fowler VM.

J Cell Biol. 2003 Dec 8;163(5):1033-44. Epub 2003 Dec 1.

47.

The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S.

J Mol Biol. 2003 Nov 7;333(5):951-64.

PMID:
14583192
48.

The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes.

Mudry RE, Perry CN, Richards M, Fowler VM, Gregorio CC.

J Cell Biol. 2003 Sep 15;162(6):1057-68.

49.

Nebulin: the nebulous, multifunctional giant of striated muscle.

McElhinny AS, Kazmierski ST, Labeit S, Gregorio CC.

Trends Cardiovasc Med. 2003 Jul;13(5):195-201. Review.

PMID:
12837582
50.

The complete mouse nebulin gene sequence and the identification of cardiac nebulin.

Kazmierski ST, Antin PB, Witt CC, Huebner N, McElhinny AS, Labeit S, Gregorio CC.

J Mol Biol. 2003 May 9;328(4):835-46.

PMID:
12729758

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