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A model for the optimization of anti-inflammatory treatment with chemerin.

Laranjeira S, Regan-Komito D, Iqbal AJ, Greaves DR, Payne SJ, Orlowski P.

Interface Focus. 2018 Feb 6;8(1):20170007. doi: 10.1098/rsfs.2017.0007. Epub 2017 Dec 15.


Long-duration bed rest modifies sympathetic neural recruitment strategies in males and females.

Klassen SA, De Abreu S, Greaves DK, Kimmerly DS, Arbeille P, Denise P, Hughson RL, Normand H, Shoemaker JK.

J Appl Physiol (1985). 2017 Dec 6. doi: 10.1152/japplphysiol.00640.2017. [Epub ahead of print]


Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo.

Regan-Komito D, Valaris S, Kapellos TS, Recio C, Taylor L, Greaves DR, Iqbal AJ.

Front Immunol. 2017 Nov 21;8:1621. doi: 10.3389/fimmu.2017.01621. eCollection 2017.


The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease.

Recio C, Lucy D, Iveson P, Iqbal AJ, Valaris S, Wynne G, Russell AJ, Choudhury RP, O'Callaghan C, Monaco C, Greaves DR.

Antioxid Redox Signal. 2018 Jan 17. doi: 10.1089/ars.2017.7168. [Epub ahead of print]


Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.

Akbar N, Digby JE, Cahill TJ, Tavare AN, Corbin AL, Saluja S, Dawkins S, Edgar L, Rawlings N, Ziberna K, McNeill E; Oxford Acute Myocardial Infarction (OxAMI) Study, Johnson E, Aljabali AA, Dragovic RA, Rohling M, Belgard TG, Udalova IA, Greaves DR, Channon KM, Riley PR, Anthony DC, Choudhury RP.

JCI Insight. 2017 Sep 7;2(17). pii: 93344. doi: 10.1172/jci.insight.93344. [Epub ahead of print]


Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia.

Kapellos TS, Recio C, Greaves DR, Iqbal AJ.

Mediators Inflamm. 2017;2017:4315412. doi: 10.1155/2017/4315412. Epub 2017 Aug 9.


Cardiac output by pulse contour analysis does not match the increase measured by rebreathing during human spaceflight.

Hughson RL, Peterson SD, Yee NJ, Greaves DK.

J Appl Physiol (1985). 2017 Nov 1;123(5):1145-1149. doi: 10.1152/japplphysiol.00651.2017. Epub 2017 Aug 10.


The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C.

Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Wave energy absorption by a submerged air bag connected to a rigid float.

Kurniawan A, Chaplin JR, Hann MR, Greaves DM, Farley FJM.

Proc Math Phys Eng Sci. 2017 Apr;473(2200):20160861. doi: 10.1098/rspa.2016.0861. Epub 2017 Apr 5.


Non-contact hemodynamic imaging reveals the jugular venous pulse waveform.

Amelard R, Hughson RL, Greaves DK, Pfisterer KJ, Leung J, Clausi DA, Wong A.

Sci Rep. 2017 Jan 9;7:40150. doi: 10.1038/srep40150.


Development and Preliminary Evaluation of an Integrated Cognitive-Behavior Treatment for Chronic Pain and Substance Use Disorder in Patients with the Hepatitis C Virus.

Morasco BJ, Greaves DW, Lovejoy TI, Turk DC, Dobscha SK, Hauser P.

Pain Med. 2016 Dec;17(12):2280-2290. doi: 10.1093/pm/pnw076. Epub 2016 Jun 27.


Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report.

McNeill E, Iqbal AJ, Jones D, Patel J, Coutinho P, Taylor L, Greaves DR, Channon KM.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):258-263. doi: 10.1161/ATVBAHA.116.308367. Epub 2016 Dec 1.


Inflammation-a Critical Appreciation of the Role of Myeloid Cells.

Iqbal AJ, Fisher EA, Greaves DR.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.MCHD-0027-2016. Review.


Elevated End-Tidal Pco2 During Long-Duration Spaceflight.

Hughson RL, Yee NJ, Greaves DK.

Aerosp Med Hum Perform. 2016;87(10):894-897.


Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.

Iqbal AJ, Barrett TJ, Taylor L, McNeill E, Manmadhan A, Recio C, Carmineri A, Brodermann MH, White GE, Cooper D, DiDonato JA, Zamanian-Daryoush M, Hazen SL, Channon KM, Greaves DR, Fisher EA.

Elife. 2016 Aug 30;5. pii: e15190. doi: 10.7554/eLife.15190.


Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

Taylor L, Brodermann MH, McCaffary D, Iqbal AJ, Greaves DR.

PLoS One. 2016 Aug 10;11(8):e0160685. doi: 10.1371/journal.pone.0160685. eCollection 2016.


A novel real time imaging platform to quantify macrophage phagocytosis.

Kapellos TS, Taylor L, Lee H, Cowley SA, James WS, Iqbal AJ, Greaves DR.

Biochem Pharmacol. 2016 Sep 15;116:107-19. doi: 10.1016/j.bcp.2016.07.011. Epub 2016 Jul 27.


Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.

Wendt E, White GE, Ferry H, Huhn M, Greaves DR, Keshav S.

J Immunol. 2016 May 1;196(9):3910-9. doi: 10.4049/jimmunol.1500619. Epub 2016 Mar 25.


Doctors and nurses have different priorities in using the Modified Early Warning Score protocol.

Greaves J, Greaves D, Gallagher H, Steven A, Pearson P.

Br J Anaesth. 2016 Feb;116(2):298. doi: 10.1093/bja/aev464. No abstract available.


Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts.

Hughson RL, Robertson AD, Arbeille P, Shoemaker JK, Rush JW, Fraser KS, Greaves DK.

Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H628-38. doi: 10.1152/ajpheart.00802.2015. Epub 2016 Jan 8.


Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo.

McNeill E, Iqbal AJ, White GE, Patel J, Greaves DR, Channon KM.

Sci Rep. 2015 Dec 1;5:17404. doi: 10.1038/srep17404.


Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis.

James RE, Hillis J, Adorján I, Gration B, Mundim MV, Iqbal AJ, Majumdar MM, Yates RL, Richards MM, Goings GE, DeLuca GC, Greaves DR, Miller SD, Szele FG.

Glia. 2016 Jan;64(1):105-21. doi: 10.1002/glia.22906. Epub 2015 Sep 4.


The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C.

Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11.


Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.

Taylor L, Christou I, Kapellos TS, Buchan A, Brodermann MH, Gianella-Borradori M, Russell A, Iqbal AJ, Greaves DR.

Sci Rep. 2015 Jun 2;5:10682. doi: 10.1038/srep10682.


Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice.

Zamora DA, Downs KP, Ullevig SL, Tavakoli S, Kim HS, Qiao M, Greaves DR, Asmis R.

Atherosclerosis. 2015 Jul;241(1):69-78. doi: 10.1016/j.atherosclerosis.2015.04.805. Epub 2015 Apr 26.


Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsets.

Wendt ER, Ferry H, Greaves DR, Keshav S.

PLoS One. 2015 Apr 2;10(3):e0119532. doi: 10.1371/journal.pone.0119532. eCollection 2015.


RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.

Patel J, McNeill E, Douglas G, Hale AB, de Bono J, Lee R, Iqbal AJ, Regan-Komito D, Stylianou E, Greaves DR, Channon KM.

Nat Commun. 2015 Mar 18;6:6614. doi: 10.1038/ncomms7614.


Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus.

Ellington MJ, Reuter S, Harris SR, Holden MT, Cartwright EJ, Greaves D, Gerver SM, Hope R, Brown NM, Török ME, Parkhill J, Köser CU, Peacock SJ.

Int J Antimicrob Agents. 2015 May;45(5):477-84. doi: 10.1016/j.ijantimicag.2015.01.009. Epub 2015 Feb 19.


Prior head-down tilt does not impair the cerebrovascular response to head-up tilt.

Yang C, Gao Y, Greaves DK, Villar R, Beltrame T, Fraser KS, Hughson RL.

J Appl Physiol (1985). 2015 Jun 1;118(11):1356-63. doi: 10.1152/japplphysiol.00871.2014. Epub 2015 Mar 6.


Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.

Gianella-Borradori M, Christou I, Bataille CJ, Cross RL, Wynne GM, Greaves DR, Russell AJ.

Bioorg Med Chem. 2015 Jan 1;23(1):241-63. doi: 10.1016/j.bmc.2014.11.002. Epub 2014 Nov 8.


Wave energy devices with compressible volumes.

Kurniawan A, Greaves D, Chaplin J.

Proc Math Phys Eng Sci. 2014 Dec 8;470(2172):20140559.


Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.

Free Radic Biol Med. 2015 Feb;79:206-16. doi: 10.1016/j.freeradbiomed.2014.10.575. Epub 2014 Nov 6.


Fractalkine promotes human monocyte survival via a reduction in oxidative stress.

White GE, McNeill E, Channon KM, Greaves DR.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2554-62. doi: 10.1161/ATVBAHA.114.304717. Epub 2014 Oct 30.


Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse.

Wong AS, Mortin-Toth S, Sung M, Canty AJ, Gulban O, Greaves DR, Danska JS.

J Immunol. 2014 Nov 15;193(10):4833-44. doi: 10.4049/jimmunol.1401984. Epub 2014 Oct 10.


Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis.

McNeill E, Iqbal AJ, Patel J, White GE, Regan-Komito D, Greaves DR, Channon KM.

J Mol Med (Berl). 2014 Nov;92(11):1169-78. doi: 10.1007/s00109-014-1194-6. Epub 2014 Aug 1.


Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.

Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR.

Blood. 2014 Oct 9;124(15):e33-44. doi: 10.1182/blood-2014-04-568691. Epub 2014 Jul 16.


Zero tolerance for healthcare-associated MRSA bacteraemia: is it realistic?

Török ME, Harris SR, Cartwright EJ, Raven KE, Brown NM, Allison ME, Greaves D, Quail MA, Limmathurotsakul D, Holden MT, Parkhill J, Peacock SJ.

J Antimicrob Chemother. 2014 Aug;69(8):2238-45. doi: 10.1093/jac/dku128. Epub 2014 Apr 30.


The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.

Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.


Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy.

Thoma C, Bachy V, Seaton P, Green NK, Greaves DR, Klavinskis L, Seymour LW, Morrison J.

Virology. 2013 Dec;447(1-2):74-83. doi: 10.1016/j.virol.2013.08.032. Epub 2013 Sep 20.


Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.

Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C, George I, Greaves DR, Xu Q, Channon KM.

Circulation. 2013 Sep 10;128(11 Suppl 1):S50-S58. doi: 10.1161/CIRCULATIONAHA.112.000249.


The Journal of Medical Ethics and Medical Humanities: offsprings of the London Medical Group.

Campbell AV, Gillon R, Savulescu J, Harris J, Holm S, Evans HM, Greaves D, Macnaughton J, Kirklin D, Eckstein S.

J Med Ethics. 2013 Nov;39(11):667-8. doi: 10.1136/medethics-2013-101813. No abstract available.


Strongyloides stercoralis infection.

Greaves D, Coggle S, Pollard C, Aliyu SH, Moore EM.

BMJ. 2013 Jul 30;347:f4610. doi: 10.1136/bmj.f4610. Review. No abstract available.


Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.

Bryant JM, Grogono DM, Greaves D, Foweraker J, Roddick I, Inns T, Reacher M, Haworth CS, Curran MD, Harris SR, Peacock SJ, Parkhill J, Floto RA.

Lancet. 2013 May 4;381(9877):1551-60. doi: 10.1016/S0140-6736(13)60632-7. Epub 2013 Mar 29.


A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.

Iqbal AJ, Regan-Komito D, Christou I, White GE, McNeill E, Kenyon A, Taylor L, Kapellos TS, Fisher EA, Channon KM, Greaves DR.

PLoS One. 2013;8(3):e58744. doi: 10.1371/journal.pone.0058744. Epub 2013 Mar 14.


An unexpected finding after a fall from a horse.

Raby S, Greaves D, Padayatty J, Huntly B.

BMJ. 2013 Feb 12;346:f724. doi: 10.1136/bmj.f724. No abstract available.


CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges.

White GE, Iqbal AJ, Greaves DR.

Pharmacol Rev. 2013 Jan 8;65(1):47-89. doi: 10.1124/pr.111.005074. Print 2013 Jan. Review.


Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.

Martinez FO, Helming L, Milde R, Varin A, Melgert BN, Draijer C, Thomas B, Fabbri M, Crawshaw A, Ho LP, Ten Hacken NH, Cobos Jiménez V, Kootstra NA, Hamann J, Greaves DR, Locati M, Mantovani A, Gordon S.

Blood. 2013 Feb 28;121(9):e57-69. doi: 10.1182/blood-2012-06-436212. Epub 2013 Jan 4.


HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.

Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20.


Generation of a novel mouse model for the inducible depletion of macrophages in vivo.

Gheryani N, Coffelt SB, Gartland A, Rumney RM, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN, Miller G.

Genesis. 2013 Jan;51(1):41-9. doi: 10.1002/dvg.22343. Epub 2012 Sep 20.


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