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RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP.

Cancer Res. 2018 Feb 12. pii: canres.2215.2017. doi: 10.1158/0008-5472.CAN-17-2215. [Epub ahead of print]


Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study.

Gravel S, Chiasson JL, Dallaire S, Turgeon J, Michaud V.

BMJ Open. 2018 Feb 8;8(2):e020922. doi: 10.1136/bmjopen-2017-020922.


Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.

Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Eur J Pharm Sci. 2018 Mar 30;115:88-99. doi: 10.1016/j.ejps.2018.01.021. Epub 2018 Jan 12.


On the decidability of population size histories from finite allele frequency spectra.

Baharian S, Gravel S.

Theor Popul Biol. 2018 Jan 3;120:42-51. doi: 10.1016/j.tpb.2017.12.008. [Epub ahead of print]


Has the question of e-waste opened a Pandora's box? An overview of unpredictable issues and challenges.

Bakhiyi B, Gravel S, Ceballos D, Flynn MA, Zayed J.

Environ Int. 2018 Jan;110:173-192. doi: 10.1016/j.envint.2017.10.021. Epub 2017 Nov 6. Review.


AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.

Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RG.

Cell Rep. 2017 Oct 3;21(1):1-9. doi: 10.1016/j.celrep.2017.09.026.


Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.

Ye Q, Chourey S, Wang R, Chintam NR, Gravel S, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4770-4776. doi: 10.1016/j.bmcl.2017.08.034. Epub 2017 Aug 19.


Glutaric Aciduria Type 3: Three Unrelated Canadian Cases, with Different Routes of Ascertainment.

Waters PJ, Kitzler TM, Feigenbaum A, Geraghty MT, Al-Dirbashi O, Bherer P, Auray-Blais C, Gravel S, McIntosh N, Siriwardena K, Trakadis Y, Brunel-Guitton C, Al-Hertani W.

JIMD Rep. 2017 Aug 2. doi: 10.1007/8904_2017_49. [Epub ahead of print]


PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.

Uetani N, Hardy S, Gravel SP, Kiessling S, Pietrobon A, Wong NN, Chénard V, Cermakian N, St-Pierre J, Tremblay ML.

JCI Insight. 2017 Jul 6;2(13). pii: 91722. doi: 10.1172/jci.insight.91722. [Epub ahead of print]


Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation.

Jouganous J, Long W, Ragsdale AP, Gravel S.

Genetics. 2017 Jul;206(3):1549-1567. doi: 10.1534/genetics.117.200493. Epub 2017 May 11.


In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Biochem Pharmacol. 2017 Aug 15;138:107-118. doi: 10.1016/j.bcp.2017.04.031. Epub 2017 May 3.


Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Martin AR, Gignoux CR, Walters RK, Wojcik GL, Neale BM, Gravel S, Daly MJ, Bustamante CD, Kenny EE.

Am J Hum Genet. 2017 Apr 6;100(4):635-649. doi: 10.1016/j.ajhg.2017.03.004. Epub 2017 Mar 30.


Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human.

Grangeon A, Gravel S, Gaudette F, Turgeon J, Michaud V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:144-158. doi: 10.1016/j.jchromb.2016.12.006. Epub 2016 Dec 6.


Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

J Med Chem. 2016 Nov 23;59(22):10127-10146. Epub 2016 Nov 7.


Methylmalonyl-coA epimerase deficiency: A new case, with an acute metabolic presentation and an intronic splicing mutation in the MCEE gene.

Waters PJ, Thuriot F, Clarke JT, Gravel S, Watkins D, Rosenblatt DS, Lévesque S.

Mol Genet Metab Rep. 2016 Sep 24;9:19-24. eCollection 2016 Dec.


Metabolomics Analyses of Cancer Cells in Controlled Microenvironments.

Gravel SP, Avizonis D, St-Pierre J.

Methods Mol Biol. 2016;1458:273-90. doi: 10.1007/978-1-4939-3801-8_20.


Stronger and More Vulnerable: A Balanced View of the Impacts of the NICU Experience on Parents.

Janvier A, Lantos J, Aschner J, Barrington K, Batton B, Batton D, Berg SF, Carter B, Campbell D, Cohn F, Lyerly AD, Ellsbury D, Fanaroff A, Fanaroff J, Fanaroff K, Gravel S, Haward M, Kutzsche S, Marlow N, Montello M, Maitre N, Morris JT, Paulsen OG, Prentice T, Spitzer AR.

Pediatrics. 2016 Sep;138(3). pii: e20160655. doi: 10.1542/peds.2016-0655. Epub 2016 Aug 3.


ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.

Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.


The Great Migration and African-American Genomic Diversity.

Baharian S, Barakatt M, Gignoux CR, Shringarpure S, Errington J, Blot WJ, Bustamante CD, Kenny EE, Williams SM, Aldrich MC, Gravel S.

PLoS Genet. 2016 May 27;12(5):e1006059. doi: 10.1371/journal.pgen.1006059. eCollection 2016 May.


When Is Selection Effective?

Gravel S.

Genetics. 2016 May;203(1):451-62. doi: 10.1534/genetics.115.184630. Epub 2016 Mar 23.


nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I.

Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16.


The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J.

Cell Rep. 2016 Feb 2;14(4):920-931. doi: 10.1016/j.celrep.2015.12.086. Epub 2016 Jan 21.


Genomic Insights into the Ancestry and Demographic History of South America.

Homburger JR, Moreno-Estrada A, Gignoux CR, Nelson D, Sanchez E, Ortiz-Tello P, Pons-Estel BA, Acevedo-Vasquez E, Miranda P, Langefeld CD, Gravel S, Alarcón-Riquelme ME, Bustamante CD.

PLoS Genet. 2015 Dec 4;11(12):e1005602. doi: 10.1371/journal.pgen.1005602. eCollection 2015 Dec.


Computationally Efficient Composite Likelihood Statistics for Demographic Inference.

Coffman AJ, Hsieh PH, Gravel S, Gutenkunst RN.

Mol Biol Evol. 2016 Feb;33(2):591-3. doi: 10.1093/molbev/msv255. Epub 2015 Nov 5.


DNA damage checkpoint adaptation genes are required for division of cells harbouring eroded telomeres.

Mersaoui SY, Gravel S, Karpov V, Wellinger RJ.

Microb Cell. 2015 Sep 21;2(10):394-405. doi: 10.15698/mic2015.10.229.


Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.

Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS.

Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. Epub 2015 May 29.


Estimating the mutation load in human genomes.

Henn BM, Botigué LR, Bustamante CD, Clark AG, Gravel S.

Nat Rev Genet. 2015 Jun;16(6):333-43. doi: 10.1038/nrg3931. Epub 2015 May 12. Review.


The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population.

Dagenais M, MacDonald D, Baron M, Hudson M, Tatibouet S, Steele R, Gravel S, Mohit S, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Aug;120(2):104-11. doi: 10.1016/j.oooo.2015.03.002. Epub 2015 Mar 25.


The existence and abundance of ghost ancestors in biparental populations.

Gravel S, Steel M.

Theor Popul Biol. 2015 May;101:47-53. doi: 10.1016/j.tpb.2015.02.002. Epub 2015 Feb 19.


Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

Montpas N, Cabana J, St-Onge G, Gravel S, Morin G, Kuroyanagi T, Lavigne P, Fujii N, Oishi S, Heveker N.

Biochemistry. 2015 Feb 24;54(7):1505-15. doi: 10.1021/bi501526s. Epub 2015 Feb 11.


mTOR coordinates protein synthesis, mitochondrial activity and proliferation.

Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I.

Cell Cycle. 2015;14(4):473-80. doi: 10.4161/15384101.2014.991572. Review.


Serine deprivation enhances antineoplastic activity of biguanides.

Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M.

Cancer Res. 2014 Dec 15;74(24):7521-33. doi: 10.1158/0008-5472.CAN-14-2643-T. Epub 2014 Nov 6.


Relationship between disease characteristics and orofacial manifestations in systemic sclerosis: Canadian Systemic Sclerosis Oral Health Study III.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masetto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira G, Robinson D, Fritzler M, Gornitsky M.

Arthritis Care Res (Hoboken). 2015 May;67(5):681-90. doi: 10.1002/acr.22490.


The Canadian systemic sclerosis oral health study II: the relationship between oral and global health-related quality of life in systemic sclerosis.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masetto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.

Rheumatology (Oxford). 2015 Apr;54(4):692-6. doi: 10.1093/rheumatology/keu396. Epub 2014 Oct 6.


Metformin directly acts on mitochondria to alter cellular bioenergetics.

Andrzejewski S, Gravel SP, Pollak M, St-Pierre J.

Cancer Metab. 2014 Aug 28;2:12. doi: 10.1186/2049-3002-2-12. eCollection 2014.


Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.

Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3596-603. doi: 10.1073/pnas.1402875111. Epub 2014 Aug 18.


Two Potent OXE-R Antagonists: Assignment of Stereochemistry.

Patel P, Reddy CN, Gore V, Chourey S, Ye Q, Ouedraogo YP, Gravel S, Powell WS, Rokach J.

ACS Med Chem Lett. 2014 May 29;5(7):815-9. doi: 10.1021/ml500161v. eCollection 2014 Jul 10.


Stable isotope tracer analysis in isolated mitochondria from mammalian systems.

Gravel SP, Andrzejewski S, Avizonis D, St-Pierre J.

Metabolites. 2014 Apr 10;4(2):166-83. doi: 10.3390/metabo4020166.


Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.

Gore V, Chourey S, Ye Q, Patel P, Ouedraogo Y, Gravel S, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3385-8. doi: 10.1016/j.bmcl.2014.05.090. Epub 2014 Jun 4.


Predicting discovery rates of genomic features.

Gravel S; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project.

Genetics. 2014 Jun;197(2):601-10. doi: 10.1534/genetics.114.162149. Epub 2014 Mar 17. Erratum in: Genetics. 2016 Jun;203(2):997.


Pulling out the 1%: whole-genome capture for the targeted enrichment of ancient DNA sequencing libraries.

Carpenter ML, Buenrostro JD, Valdiosera C, Schroeder H, Allentoft ME, Sikora M, Rasmussen M, Gravel S, Guillén S, Nekhrizov G, Leshtakov K, Dimitrova D, Theodossiev N, Pettener D, Luiselli D, Sandoval K, Moreno-Estrada A, Li Y, Wang J, Gilbert MT, Willerslev E, Greenleaf WJ, Bustamante CD.

Am J Hum Genet. 2013 Nov 7;93(5):852-64. doi: 10.1016/j.ajhg.2013.10.002. Epub 2013 Oct 25.


The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.

Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L.

Nat Commun. 2014;5:3163. doi: 10.1038/ncomms4163.


The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis compared with the general population.

Baron M, Hudson M, Tatibouet S, Steele R, Lo E, Gravel S, Gyger G, El Sayegh T, Pope J, Fontaine A, Masseto A, Matthews D, Sutton E, Thie N, Jones N, Copete M, Kolbinson D, Markland J, Nogueira-Filho G, Robinson D, Gornitsky M.

Rheumatology (Oxford). 2014 Aug;53(8):1386-94. doi: 10.1093/rheumatology/ket441. Epub 2014 Jan 24.


Reconstructing Native American migrations from whole-genome and whole-exome data.

Gravel S, Zakharia F, Moreno-Estrada A, Byrnes JK, Muzzio M, Rodriguez-Flores JL, Kenny EE, Gignoux CR, Maples BK, Guiblet W, Dutil J, Via M, Sandoval K, Bedoya G; 1000 Genomes Project, Oleksyk TK, Ruiz-Linares A, Burchard EG, Martinez-Cruzado JC, Bustamante CD.

PLoS Genet. 2013;9(12):e1004023. doi: 10.1371/journal.pgen.1004023. Epub 2013 Dec 26.


Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.

Gore V, Gravel S, Cossette C, Patel P, Chourey S, Ye Q, Rokach J, Powell WS.

J Med Chem. 2014 Jan 23;57(2):364-77. doi: 10.1021/jm401292m. Epub 2014 Jan 6.


PGC-1α supports glutamine metabolism in breast cancer.

McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J.

Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22.


Reconstructing the population genetic history of the Caribbean.

Moreno-Estrada A, Gravel S, Zakharia F, McCauley JL, Byrnes JK, Gignoux CR, Ortiz-Tello PA, Martínez RJ, Hedges DJ, Morris RW, Eng C, Sandoval K, Acevedo-Acevedo S, Norman PJ, Layrisse Z, Parham P, Martínez-Cruzado JC, Burchard EG, Cuccaro ML, Martin ER, Bustamante CD.

PLoS Genet. 2013 Nov;9(11):e1003925. doi: 10.1371/journal.pgen.1003925. Epub 2013 Nov 14.


mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N.

Cell Metab. 2013 Nov 5;18(5):698-711. doi: 10.1016/j.cmet.2013.10.001.

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