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Items: 22


Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix.

Wu J, Young M, Lewis AH, Martfeld AN, Kalmeta B, Grandl J.

Cell Rep. 2017 Nov 28;21(9):2357-2366. doi: 10.1016/j.celrep.2017.10.120.


Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects.

Hutson MR, Keyte AL, Hernández-Morales M, Gibbs E, Kupchinsky ZA, Argyridis I, Erwin KN, Pegram K, Kneifel M, Rosenberg PB, Matak P, Xie L, Grandl J, Davis EE, Katsanis N, Liu C, Benner EJ.

Sci Signal. 2017 Oct 10;10(500). pii: eaal4055. doi: 10.1126/scisignal.aal4055.


Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.

Lewis AH, Cui AF, McDonald MF, Grandl J.

Cell Rep. 2017 Jun 20;19(12):2572-2585. doi: 10.1016/j.celrep.2017.05.079.


Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):266-270.e3. doi: 10.1016/j.neuron.2017.03.039.


Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):265. doi: 10.1016/j.neuron.2017.03.041. No abstract available.


TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.

Sosa-Pagán JO, Iversen ES, Grandl J.

Sci Rep. 2017 Apr 3;7(1):549. doi: 10.1038/s41598-017-00636-4.


Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

Wu J, Lewis AH, Grandl J.

Trends Biochem Sci. 2017 Jan;42(1):57-71. doi: 10.1016/j.tibs.2016.09.004. Epub 2016 Oct 12. Review.


Localized force application reveals mechanically sensitive domains of Piezo1.

Wu J, Goyal R, Grandl J.

Nat Commun. 2016 Oct 3;7:12939. doi: 10.1038/ncomms12939.


Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension.

Lewis AH, Grandl J.

Elife. 2015 Dec 8;4. pii: e12088. doi: 10.7554/eLife.12088.


Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae.

Mauthner SE, Hwang RY, Lewis AH, Xiao Q, Tsubouchi A, Wang Y, Honjo K, Skene JH, Grandl J, Tracey WD Jr.

Curr Biol. 2014 Dec 15;24(24):2920-5. doi: 10.1016/j.cub.2014.10.038. Epub 2014 Nov 26.


Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5114-22. doi: 10.1073/pnas.1414298111. Epub 2014 Nov 10.


The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole.

Moldenhauer H, Latorre R, Grandl J.

PLoS One. 2014 Sep 2;9(9):e106776. doi: 10.1371/journal.pone.0106776. eCollection 2014.


Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.

Jabba S, Goyal R, Sosa-Pagán JO, Moldenhauer H, Wu J, Kalmeta B, Bandell M, Latorre R, Patapoutian A, Grandl J.

Neuron. 2014 Jun 4;82(5):1017-31. doi: 10.1016/j.neuron.2014.04.016. Epub 2014 May 8.


Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations.

Kim SE, Patapoutian A, Grandl J.

PLoS One. 2013;8(3):e59593. doi: 10.1371/journal.pone.0059593. Epub 2013 Mar 26.


High-Throughput Approaches to Studying Mechanisms of TRP Channel Activation.

Hu H, Bandell M, Grandl J, Petrus M.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 12.


Piezo proteins are pore-forming subunits of mechanically activated channels.

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A.

Nature. 2012 Feb 19;483(7388):176-81. doi: 10.1038/nature10812.


Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.

Grandl J, Kim SE, Uzzell V, Bursulaya B, Petrus M, Bandell M, Patapoutian A.

Nat Neurosci. 2010 Jun;13(6):708-14. doi: 10.1038/nn.2552. Epub 2010 Apr 22.


Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.

Hu H, Grandl J, Bandell M, Petrus M, Patapoutian A.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1626-31. doi: 10.1073/pnas.0812209106. Epub 2009 Jan 21.


Pore region of TRPV3 ion channel is specifically required for heat activation.

Grandl J, Hu H, Bandell M, Bursulaya B, Schmidt M, Petrus M, Patapoutian A.

Nat Neurosci. 2008 Sep;11(9):1007-13. doi: 10.1038/nn.2169.


Fluorescent epibatidine agonists for neuronal and muscle-type nicotinic acetylcholine receptors.

Grandl J, Sakr E, Kotzyba-Hibert F, Krieger F, Bertrand S, Bertrand D, Vogel H, Goeldner M, Hovius R.

Angew Chem Int Ed Engl. 2007;46(19):3505-8. No abstract available.


Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel.

Danelon C, Grandl J, Hovius R, Vogel H.

Biochim Biophys Acta. 2007 Jan;1768(1):76-89. Epub 2006 Aug 2.


Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors.

Grandl J, Danelon C, Hovius R, Vogel H.

Eur Biophys J. 2006 Oct;35(8):685-93. Epub 2006 Jul 13.


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