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New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias.

Juen L, Brachet-Botineau M, Parmenon C, Bourgeais J, Hérault O, Gouilleux F, Viaud-Massuard MC, Prié G.

J Med Chem. 2017 Jul 27;60(14):6119-6136. doi: 10.1021/acs.jmedchem.7b00369. Epub 2017 Jul 12.


STAT5A/5B-specific expansion and transformation of hematopoietic stem cells.

Ghanem S, Friedbichler K, Boudot C, Bourgeais J, Gouilleux-Gruart V, Régnier A, Herault O, Moriggl R, Gouilleux F.

Blood Cancer J. 2017 Jan 6;7(1):e514. doi: 10.1038/bcj.2016.124. No abstract available.


O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

Freund P, Kerenyi MA, Hager M, Wagner T, Wingelhofer B, Pham HTT, Elabd M, Han X, Valent P, Gouilleux F, Sexl V, Krämer OH, Groner B, Moriggl R.

Leukemia. 2017 Oct;31(10):2132-2142. doi: 10.1038/leu.2017.4. Epub 2017 Jan 11.


Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Themanns M, Mueller KM, Kessler SM, Golob-Schwarzl N, Mohr T, Kaltenecker D, Bourgeais J, Paier-Pourani J, Friedbichler K, Schneller D, Schlederer M, Zebedin-Brandl E, Terracciano LM, Han X, Kenner L, Wagner KU, Mikulits W, Kozlov AV, Heim MH, Gouilleux F, Haybaeck J, Moriggl R.

Sci Rep. 2016 Oct 7;6:34719. doi: 10.1038/srep34719.


Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses.

Bourgeais J, Ishac N, Medrzycki M, Brachet-Botineau M, Desbourdes L, Gouilleux-Gruart V, Pecnard E, Rouleux-Bonnin F, Gyan E, Domenech J, Mazurier F, Moriggl R, Bunting KD, Herault O, Gouilleux F.

Oncotarget. 2017 Jun 27;8(26):41876-41889. doi: 10.18632/oncotarget.11480.


Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells.

Bustany S, Bourgeais J, Tchakarska G, Body S, Hérault O, Gouilleux F, Sola B.

Oncotarget. 2016 Jul 19;7(29):45214-45224. doi: 10.18632/oncotarget.9901.


IL-2 phosphorylates STAT5 to drive IFN-γ production and activation of human dendritic cells.

Herr F, Lemoine R, Gouilleux F, Meley D, Kazma I, Heraud A, Velge-Roussel F, Baron C, Lebranchu Y.

J Immunol. 2014 Jun 15;192(12):5660-70. doi: 10.4049/jimmunol.1300422. Epub 2014 May 14.


Oxidative metabolism in cancer: A STAT affair?

Bourgeais J, Gouilleux-Gruart V, Gouilleux F.

JAKSTAT. 2013 Oct 1;2(4):e25764. doi: 10.4161/jkst.25764. Epub 2013 Aug 12. Review.


PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.

Berger A, Hoelbl-Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, Uras IZ, Menzl I, Putz EM, Hoermann G, Schuster C, Fajmann S, Leitner E, Kubicek S, Moriggl R, Gouilleux F, Sexl V.

Leukemia. 2014 Mar;28(3):629-41. doi: 10.1038/leu.2013.351. Epub 2013 Nov 22.


Granulocyte-colony-stimulating factor stimulation of bone marrow mesenchymal stromal cells promotes CD34+ cell migration via a matrix metalloproteinase-2-dependent mechanism.

Ponte AL, Ribeiro-Fleury T, Chabot V, Gouilleux F, Langonné A, Hérault O, Charbord P, Domenech J.

Stem Cells Dev. 2012 Nov 20;21(17):3162-72. doi: 10.1089/scd.2012.0048. Epub 2012 Jul 24.


Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells.

Cholez E, Debuysscher V, Bourgeais J, Boudot C, Leprince J, Tron F, Brassart B, Regnier A, Bissac E, Pecnard E, Gouilleux F, Lassoued K, Gouilleux-Gruart V.

Leukemia. 2012 Nov;26(11):2390-7. doi: 10.1038/leu.2012.112. Epub 2012 Apr 23.


Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.

Friedbichler K, Hoelbl A, Li G, Bunting KD, Sexl V, Gouilleux F, Moriggl R.

Front Biosci (Landmark Ed). 2011 Jun 1;16:3043-56. Review.


The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction.

Dhennin-Duthille I, Nyga R, Yahiaoui S, Gouilleux-Gruart V, Régnier A, Lassoued K, Gouilleux F.

J Biol Chem. 2011 Feb 18;286(7):5034-42. doi: 10.1074/jbc.M110.155903. Epub 2010 Nov 24.


Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.

Li G, Miskimen KL, Wang Z, Xie XY, Tse W, Gouilleux F, Moriggl R, Bunting KD.

Leukemia. 2010 Aug;24(8):1397-405. doi: 10.1038/leu.2010.131. Epub 2010 Jun 10.


Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.

Friedbichler K, Kerenyi MA, Kovacic B, Li G, Hoelbl A, Yahiaoui S, Sexl V, Müllner EW, Fajmann S, Cerny-Reiterer S, Valent P, Beug H, Gouilleux F, Bunting KD, Moriggl R.

Blood. 2010 Sep 2;116(9):1548-58. doi: 10.1182/blood-2009-12-258913. Epub 2010 May 27.


Implication of the calcium sensing receptor and the Phosphoinositide 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells.

Boudot C, Saidak Z, Boulanouar AK, Petit L, Gouilleux F, Massy Z, Brazier M, Mentaverri R, Kamel S.

Bone. 2010 May;46(5):1416-23. doi: 10.1016/j.bone.2010.01.383. Epub 2010 Feb 10.


Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.

Baumgartner C, Cerny-Reiterer S, Sonneck K, Mayerhofer M, Gleixner KV, Fritz R, Kerenyi M, Boudot C, Gouilleux F, Kornfeld JW, Sillaber C, Moriggl R, Valent P.

Am J Pathol. 2009 Dec;175(6):2416-29. doi: 10.2353/ajpath.2009.080953. Epub 2009 Nov 5.


Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation.

El Hiani Y, Ahidouch A, Lehen'kyi V, Hague F, Gouilleux F, Mentaverri R, Kamel S, Lassoued K, Brûlé G, Ouadid-Ahidouch H.

Cell Physiol Biochem. 2009;23(4-6):335-46. doi: 10.1159/000218179. Epub 2009 May 6.


Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade.

Harir N, Boudot C, Friedbichler K, Sonneck K, Kondo R, Martin-Lannerée S, Kenner L, Kerenyi M, Yahiaoui S, Gouilleux-Gruart V, Gondry J, Bénit L, Dusanter-Fourt I, Lassoued K, Valent P, Moriggl R, Gouilleux F.

Blood. 2008 Sep 15;112(6):2463-73. doi: 10.1182/blood-2007-09-115477. Epub 2008 Jun 25. Erratum in: Blood. 2009 Aug 20;114(8):1720.


The different functions of Stat5 and chromatin alteration through Stat5 proteins.

Kornfeld JW, Grebien F, Kerenyi MA, Friedbichler K, Kovacic B, Zankl B, Hoelbl A, Nivarti H, Beug H, Sexl V, Muller M, Kenner L, Mullner EW, Gouilleux F, Moriggl R.

Front Biosci. 2008 May 1;13:6237-54. Review.


IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.

Borowiec AS, Hague F, Harir N, Guénin S, Guerineau F, Gouilleux F, Roudbaraki M, Lassoued K, Ouadid-Ahidouch H.

J Cell Physiol. 2007 Sep;212(3):690-701.


Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

Harir N, Pecquet C, Kerenyi M, Sonneck K, Kovacic B, Nyga R, Brevet M, Dhennin I, Gouilleux-Gruart V, Beug H, Valent P, Lassoued K, Moriggl R, Gouilleux F.

Blood. 2007 Feb 15;109(4):1678-86. Epub 2006 Oct 12.


The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation.

Pecquet C, Nyga R, Penard-Lacronique V, Smithgall TE, Murakami H, Régnier A, Lassoued K, Gouilleux F.

Oncogene. 2007 Mar 8;26(11):1577-85. Epub 2006 Sep 4.


Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma.

Maillard S, Gauduchon J, Marsaud V, Gouilleux F, Connault E, Opolon P, Fattal E, Sola B, Renoir JM.

J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):67-78. Epub 2006 Jun 5.


ZAP-70 tyrosine kinase is constitutively expressed and phosphorylated in B-lineage acute lymphoblastic leukemia cells.

Guillaume N, Alleaume C, Munfus D, Capiod JC, Touati G, Pautard B, Desablens B, Lefrère JJ, Gouilleux F, Lassoued K, Gouilleux-Gruart V.

Haematologica. 2005 Jul;90(7):899-905.


Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma.

Maillard S, Ameller T, Gauduchon J, Gougelet A, Gouilleux F, Legrand P, Marsaud V, Fattal E, Sola B, Renoir JM.

J Steroid Biochem Mol Biol. 2005 Feb;94(1-3):111-21. Epub 2005 Jan 27.


Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.

Nyga R, Pecquet C, Harir N, Gu H, Dhennin-Duthille I, Régnier A, Gouilleux-Gruart V, Lassoued K, Gouilleux F.

Biochem J. 2005 Aug 15;390(Pt 1):359-66.


Interleukin-7 induces apoptosis of 697 pre-B cells expressing dominant-negative forms of STAT5: evidence for caspase-dependent and -independent mechanisms.

Lanvin O, Gouilleux F, Mullié C, Mazière C, Fuentes V, Bissac E, Dantin F, Mazière JC, Régnier A, Lassoued K, Gouilleux-Gruart V.

Oncogene. 2004 Apr 15;23(17):3040-7.


The selective estrogen receptor modulator 4-hydroxy tamoxifen induces G1 arrest and apoptosis of multiple myeloma cell lines.

Gauduchon J, Gouilleux F, Maillard S, Marsaud V, Renoir MJ, Sola B.

Ann N Y Acad Sci. 2003 Dec;1010:321-5.


Differential effect of dexamethasone on cell death and STAT5 activation during in vitro eosinopoiesis.

Debierre-Grockiego F, Fuentes V, Prin L, Gouilleux F, Gouilleux-Gruart V.

Br J Haematol. 2003 Dec;123(5):933-41.


TGF-beta1 modulates Fas (APO-1/CD95)-mediated apoptosis of human pre-B cell lines.

Lanvin O, Guglielmi P, Fuentes V, Gouilleux-Gruart V, Mazière C, Bissac E, Regnier A, Benlagha K, Gouilleux F, Lassoued K.

Eur J Immunol. 2003 May;33(5):1372-81.


A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population.

Meirhaeghe A, Fajas L, Gouilleux F, Cottel D, Helbecque N, Auwerx J, Amouyel P.

Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):289-94.


Involvement of the NF-kappaB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein.

Santos SC, Monni R, Bouchaert I, Bernard O, Gisselbrecht S, Gouilleux F, Penard-Lacronique V.

FEBS Lett. 2001 May 25;497(2-3):148-52.


Constitutively active STAT5 variants induce growth and survival of hematopoietic cells through a PI 3-kinase/Akt dependent pathway.

Santos SC, Lacronique V, Bouchaert I, Monni R, Bernard O, Gisselbrecht S, Gouilleux F.

Oncogene. 2001 Apr 19;20(17):2080-90.


Regression of primary hepatocarcinoma in cancer-prone transgenic mice by local interferon-gamma delivery is associated with macrophages recruitment and nitric oxide production.

Baratin M, Ziol M, Romieu R, Kayibanda M, Gouilleux F, Briand P, Leroy P, Haddada H, Rénia L, Viguier M, Guillet JG.

Cancer Gene Ther. 2001 Mar;8(3):193-202.


The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells.

Monni R, Santos SC, Mauchauffe M, Berger R, Ghysdael J, Gouilleux F, Gisselbrecht S, Bernard O, Penard-Lacronique V.

Oncogene. 2001 Feb 15;20(7):849-58.


IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.

Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J.

Oncogene. 2000 Apr 20;19(17):2086-97.


Cooperation between STAT5 and phosphatidylinositol 3-kinase in the IL-3-dependent survival of a bone marrow derived cell line.

Rosa Santos SC, Dumon S, Mayeux P, Gisselbrecht S, Gouilleux F.

Oncogene. 2000 Feb 24;19(9):1164-72.


Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.

Lacronique V, Boureux A, Monni R, Dumon S, Mauchauffé M, Mayeux P, Gouilleux F, Berger R, Gisselbrecht S, Ghysdael J, Bernard OA.

Blood. 2000 Mar 15;95(6):2076-83.


[Interactions between the glucocorticoid receptor and transcription factors].

Gouilleux F.

J Soc Biol. 1999;193(4-5):369-73. Review. French.


IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line.

Dumon S, Santos SC, Debierre-Grockiego F, Gouilleux-Gruart V, Cocault L, Boucheron C, Mollat P, Gisselbrecht S, Gouilleux F.

Oncogene. 1999 Jul 22;18(29):4191-9.


A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

Boucheron C, Dumon S, Santos SC, Moriggl R, Hennighausen L, Gisselbrecht S, Gouilleux F.

J Biol Chem. 1998 Dec 18;273(51):33936-41.


A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.

Verdier F, Rabionet R, Gouilleux F, Beisenherz-Huss C, Varlet P, Muller O, Mayeux P, Lacombe C, Gisselbrecht S, Chretien S.

Mol Cell Biol. 1998 Oct;18(10):5852-60.


Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells.

Piekorz RP, Rinke R, Gouilleux F, Neumann B, Groner B, Hocke GM.

Biochim Biophys Acta. 1998 Apr 24;1402(3):313-23.


Activated Stat related transcription factors in acute leukemia.

Gouilleux-Gruart V, Debierre-Grockiego F, Gouilleux F, Capiod JC, Claisse JF, Delobel J, Prin L.

Leuk Lymphoma. 1997 Dec;28(1-2):83-8. Review.


Cytokine receptor-independent, constitutively active variants of STAT5.

Berchtold S, Moriggl R, Gouilleux F, Silvennoinen O, Beisenherz C, Pfitzner E, Wissler M, Stöcklin E, Groner B.

J Biol Chem. 1997 Nov 28;272(48):30237-43.


Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells.

Moriggl R, Berchtold S, Friedrich K, Standke GJ, Kammer W, Heim M, Wissler M, Stöcklin E, Gouilleux F, Groner B.

Mol Cell Biol. 1997 Jul;17(7):3663-78.


The role of GH receptor tyrosine phosphorylation in Stat5 activation.

Hansen JA, Hansen LH, Wang X, Kopchick JJ, Gouilleux F, Groner B, Nielsen JH, Møldrup A, Galsgaard ED, Billestrup N.

J Mol Endocrinol. 1997 Jun;18(3):213-21.


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