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Items: 1 to 50 of 282

1.

Mechanisms of cancer resistance in long-lived mammals.

Seluanov A, Gladyshev VN, Vijg J, Gorbunova V.

Nat Rev Cancer. 2018 Apr 5. doi: 10.1038/s41568-018-0004-9. [Epub ahead of print] Review.

PMID:
29622806
2.

Accurate translation is important for longevity.

Ke Z, Seluanov A, Gorbunova V.

Aging (Albany NY). 2018 Mar 12;10(3):297-298. doi: 10.18632/aging.101398. No abstract available.

3.

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.

Ghosh S, Wong SK, Jiang Z, Liu B, Wang Y, Hao Q, Gorbunova V, Liu X, Zhou Z.

Elife. 2018 Feb 23;7. pii: e32127. doi: 10.7554/eLife.32127.

4.

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1801-1806. doi: 10.1073/pnas.1721160115. Epub 2018 Feb 5.

PMID:
29432174
5.

Evolution of telomere maintenance and tumour suppressor mechanisms across mammals.

Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160443. doi: 10.1098/rstb.2016.0443.

PMID:
29335367
6.

Cross-species Comparison of Proteome Turnover Kinetics.

Swovick K, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S.

Mol Cell Proteomics. 2018 Apr;17(4):580-591. doi: 10.1074/mcp.RA117.000574. Epub 2018 Jan 10.

7.

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming.

Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V.

Stem Cell Reports. 2017 Nov 14;9(5):1721-1734. doi: 10.1016/j.stemcr.2017.10.001. Epub 2017 Oct 26.

8.

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD.

Oncogene. 2018 Jan 25;37(4):427-438. doi: 10.1038/onc.2017.340. Epub 2017 Oct 2.

9.

A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.

Ajani JA, Abramov M, Bondarenko I, Shparyk Y, Gorbunova V, Hontsa A, Otchenash N, Alsina M, Lazarev S, Feliu J, Elme A, Esko V, Abdalla K, Verma U, Benedetti F, Aoyama T, Mizuguchi H, Makris L, Rosati G; DIGEST Study Group.

Ann Oncol. 2017 Sep 1;28(9):2142-2148. doi: 10.1093/annonc/mdx275.

PMID:
28911091
10.

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species.

Tian X, Seluanov A, Gorbunova V.

Trends Endocrinol Metab. 2017 Oct;28(10):722-734. doi: 10.1016/j.tem.2017.07.004. Epub 2017 Sep 7. Review.

PMID:
28888702
11.

Translation fidelity coevolves with longevity.

Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V.

Aging Cell. 2017 Oct;16(5):988-993. doi: 10.1111/acel.12628. Epub 2017 Jul 13.

12.

A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)-only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer.

Kristeleit R, Davidenko I, Shirinkin V, El-Khouly F, Bondarenko I, Goodheart MJ, Gorbunova V, Penning CA, Shi JG, Liu X, Newton RC, Zhao Y, Maleski J, Leopold L, Schilder RJ.

Gynecol Oncol. 2017 Sep;146(3):484-490. doi: 10.1016/j.ygyno.2017.07.005. Epub 2017 Jul 8.

PMID:
28698009
13.

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

Yang CS, Jividen K, Spencer A, Dworak N, Ni L, Oostdyk LT, Chatterjee M, Kuśmider B, Reon B, Parlak M, Gorbunova V, Abbas T, Jeffery E, Sherman NE, Paschal BM.

Mol Cell. 2017 May 18;66(4):503-516.e5. doi: 10.1016/j.molcel.2017.04.028.

14.

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells.

Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T.

J Clin Invest. 2017 Jun 1;127(6):2392-2406. doi: 10.1172/JCI90825. Epub 2017 May 8.

15.

Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging.

Tian X, Seluanov A, Gorbunova V.

Cell Metab. 2017 May 2;25(5):991-992. doi: 10.1016/j.cmet.2017.04.022.

16.

Smoking History Predicts Sensitivity to PARP Inhibitor Veliparib in Patients with Advanced Non-Small Cell Lung Cancer.

Reck M, Blais N, Juhasz E, Gorbunova V, Jones CM, Urban L, Orlov S, Barlesi F, Kio E, Keilholz U, Qin Q, Qian J, Nickner C, Dziubinski J, Xiong H, Mittapalli RK, Dunbar M, Ansell P, He L, McKee M, Giranda V, Ramalingam SS.

J Thorac Oncol. 2017 Jul;12(7):1098-1108. doi: 10.1016/j.jtho.2017.04.010. Epub 2017 Apr 29.

17.

Diagnosis and treatment challenges of parathyroid carcinoma in a 27-year-old woman with multiple lung metastases.

Rozhinskaya L, Pigarova E, Sabanova E, Mamedova E, Voronkova I, Krupinova J, Dzeranova L, Tiulpakov A, Gorbunova V, Orel N, Zalian A, Melnichenko G, Dedov I.

Endocrinol Diabetes Metab Case Rep. 2017 Mar 13;2017. pii: 16-0113. doi: 10.1530/EDM-16-0113. eCollection 2017.

18.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.

Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242.

19.

Non-canonical aging model systems and why we need them.

Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V.

EMBO J. 2017 Apr 13;36(8):959-963. doi: 10.15252/embj.201796837. Epub 2017 Mar 20. Review. No abstract available.

20.

A review of the biomedical innovations for healthy longevity.

Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A.

Aging (Albany NY). 2017 Jan 29;9(1):7-25. doi: 10.18632/aging.101163. No abstract available.

21.

Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.

Sci Rep. 2017 Jan 31;7(1):5. doi: 10.1038/s41598-017-00037-7.

22.

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN.

Elife. 2016 Nov 22;5. pii: e19130. doi: 10.7554/eLife.19130.

23.

Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non-Small Cell Lung Cancer.

Ramalingam SS, Blais N, Mazieres J, Reck M, Jones CM, Juhasz E, Urban L, Orlov S, Barlesi F, Kio E, Keiholz U, Qin Q, Qian J, Nickner C, Dziubinski J, Xiong H, Ansell P, McKee M, Giranda V, Gorbunova V.

Clin Cancer Res. 2017 Apr 15;23(8):1937-1944. doi: 10.1158/1078-0432.CCR-15-3069. Epub 2016 Oct 10.

24.

[CDC73 mutations in young patients with primary hyperparathyroidism: A description of two clinical cases].

Mamedova EO, Mokrysheva NG, Pigarova EA, Przhiyalkovskaya EG, Voronkova IA, Vasilyev EV, Petrov VM, Gorbunova VA, Rozhinskaya LY, Belaya ZE, Tyulpakov AN.

Ter Arkh. 2016;88(10):57-62. doi: 10.17116/terarkh201688657-62. Russian.

PMID:
27801421
25.

Veliparib in combination with whole-brain radiation therapy for patients with brain metastases from non-small cell lung cancer: results of a randomized, global, placebo-controlled study.

Chabot P, Hsia TC, Ryu JS, Gorbunova V, Belda-Iniesta C, Ball D, Kio E, Mehta M, Papp K, Qin Q, Qian J, Holen KD, Giranda V, Suh JH.

J Neurooncol. 2017 Jan;131(1):105-115. doi: 10.1007/s11060-016-2275-x. Epub 2016 Sep 21.

26.

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.

27.

Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM.

Dokukin M, Ablaeva Y, Kalaparthi V, Seluanov A, Gorbunova V, Sokolov I.

Biophys J. 2016 Jul 12;111(1):236-46. doi: 10.1016/j.bpj.2016.06.005.

28.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

29.

Dangerous Entrapment for NRF2.

Gorbunova V, Rezazadeh S, Seluanov A.

Cell. 2016 Jun 2;165(6):1312-1313. doi: 10.1016/j.cell.2016.05.061.

30.

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coşkun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V.

Aging (Albany NY). 2016 May;8(5):841-7. doi: 10.18632/aging.100958.

31.

A Randomized, Double-Blind, Placebo-Controlled, Phase III Study to Assess Efficacy and Safety of Weekly Farletuzumab in Combination With Carboplatin and Taxane in Patients With Ovarian Cancer in First Platinum-Sensitive Relapse.

Vergote I, Armstrong D, Scambia G, Teneriello M, Sehouli J, Schweizer C, Weil SC, Bamias A, Fujiwara K, Ochiai K, Poole C, Gorbunova V, Wang W, O'Shannessy D, Herzog TJ.

J Clin Oncol. 2016 Jul 1;34(19):2271-8. doi: 10.1200/JCO.2015.63.2596. Epub 2016 Mar 21.

PMID:
27001568
32.

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma.

Koschmann C, Calinescu AA, Nunez FJ, Mackay A, Fazal-Salom J, Thomas D, Mendez F, Kamran N, Dzaman M, Mulpuri L, Krasinkiewicz J, Doherty R, Lemons R, Brosnan-Cashman JA, Li Y, Roh S, Zhao L, Appelman H, Ferguson D, Gorbunova V, Meeker A, Jones C, Lowenstein PR, Castro MG.

Sci Transl Med. 2016 Mar 2;8(328):328ra28. doi: 10.1126/scitranslmed.aac8228.

33.

DNA double strand break repair, aging and the chromatin connection.

Gorbunova V, Seluanov A.

Mutat Res. 2016 Jun;788:2-6. doi: 10.1016/j.mrfmmm.2016.02.004. Epub 2016 Feb 15. Review.

34.

DNA repair in species with extreme lifespan differences.

MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J.

Aging (Albany NY). 2015 Dec;7(12):1171-84.

35.

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Brohus M, Gorbunova V, Faulkes CG, Overgaard MT, Conover CA.

PLoS One. 2015 Dec 22;10(12):e0145587. doi: 10.1371/journal.pone.0145587. eCollection 2015.

36.

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN.

Cell Rep. 2015 Nov 17;13(7):1319-1326. doi: 10.1016/j.celrep.2015.10.014. Epub 2015 Nov 5.

37.

Pharmacoeconomic Analysis Of Afatinib As 1st-Line Treatment Of Metastatic Non-Small Cell Lung Cancer With Del19 Mutation Of Egfr Gene.

Belousov D, Gorbunova V, Orlov S, Afanasieva E.

Value Health. 2015 Nov;18(7):A458-9. doi: 10.1016/j.jval.2015.09.1180. Epub 2015 Oct 20. No abstract available.

38.

Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li K, Peng S, Zhu X, Liao X, Li S, Krogh A, Zhou X, Brodsky L, Wang J.

Nat Commun. 2015 Aug 12;6:8051. doi: 10.1038/ncomms9051. No abstract available.

PMID:
26264976
39.

Reversibility of trapped air on chest computed tomography in cystic fibrosis patients.

Loeve M, Rosenow T, Gorbunova V, Hop WC, Tiddens HA, de Bruijne M.

Eur J Radiol. 2015 Jun;84(6):1184-90. doi: 10.1016/j.ejrad.2015.02.011. Epub 2015 Feb 21.

PMID:
25840703
40.

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD.

Aging Cell. 2015 Apr;14(2):288-91. doi: 10.1111/acel.12314. Epub 2015 Jan 28.

41.

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner.

Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z.

Cell Cycle. 2015;14(2):269-76. doi: 10.4161/15384101.2014.980641.

42.

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.

Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, Gorbunova V, Hirsh V, Bennouna J, Orlov S, Mok T, Boyer M, Su WC, Lee KH, Kato T, Massey D, Shahidi M, Zazulina V, Sequist LV.

Lancet Oncol. 2015 Feb;16(2):141-51. doi: 10.1016/S1470-2045(14)71173-8. Epub 2015 Jan 12.

PMID:
25589191
43.

Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.

Ramalingam SS, Shtivelband M, Soo RA, Barrios CH, Makhson A, Segalla JG, Pittman KB, Kolman P, Pereira JR, Srkalovic G, Belani CP, Axelrod R, Owonikoko TK, Qin Q, Qian J, McKeegan EM, Devanarayan V, McKee MD, Ricker JL, Carlson DM, Gorbunova VA.

J Clin Oncol. 2015 Feb 10;33(5):433-41. doi: 10.1200/JCO.2014.55.7173. Epub 2015 Jan 5.

44.

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1053-8. doi: 10.1073/pnas.1418203112. Epub 2014 Dec 30.

45.

Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial.

Cainap C, Qin S, Huang WT, Chung IJ, Pan H, Cheng Y, Kudo M, Kang YK, Chen PJ, Toh HC, Gorbunova V, Eskens FA, Qian J, McKee MD, Ricker JL, Carlson DM, El-Nowiem S.

J Clin Oncol. 2015 Jan 10;33(2):172-9. doi: 10.1200/JCO.2013.54.3298. Epub 2014 Dec 8.

46.

Human Genomics. Sleeping dogs of the genome.

Gorbunova V, Boeke JD, Helfand SL, Sedivy JM.

Science. 2014 Dec 5;346(6214):1187-8. doi: 10.1126/science.aaa3177. No abstract available.

47.

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

Van Meter M, Kashyap M, Rezazadeh S, Geneva AJ, Morello TD, Seluanov A, Gorbunova V.

Nat Commun. 2014 Sep 23;5:5011. doi: 10.1038/ncomms6011.

48.

Primary results of ROSE/TRIO-12, a randomized placebo-controlled phase III trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer.

Mackey JR, Ramos-Vazquez M, Lipatov O, McCarthy N, Krasnozhon D, Semiglazov V, Manikhas A, Gelmon KA, Konecny GE, Webster M, Hegg R, Verma S, Gorbunova V, Abi Gerges D, Thireau F, Fung H, Simms L, Buyse M, Ibrahim A, Martin M.

J Clin Oncol. 2015 Jan 10;33(2):141-8. doi: 10.1200/JCO.2014.57.1513. Epub 2014 Sep 2.

49.

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.

Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP.

Bioinformatics. 2014 Dec 15;30(24):3558-60. doi: 10.1093/bioinformatics/btu579. Epub 2014 Aug 28.

50.

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response.

de Azambuja E, Holmes AP, Piccart-Gebhart M, Holmes E, Di Cosimo S, Swaby RF, Untch M, Jackisch C, Lang I, Smith I, Boyle F, Xu B, Barrios CH, Perez EA, Azim HA Jr, Kim SB, Kuemmel S, Huang CS, Vuylsteke P, Hsieh RK, Gorbunova V, Eniu A, Dreosti L, Tavartkiladze N, Gelber RD, Eidtmann H, Baselga J.

Lancet Oncol. 2014 Sep;15(10):1137-46. doi: 10.1016/S1470-2045(14)70320-1. Epub 2014 Aug 14.

PMID:
25130998

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