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Development of a prediction tool for patients presenting with acute cough in primary care: a prognostic study spanning six European countries.

Bruyndonckx R, Hens N, Verheij TJ, Aerts M, Ieven M, Butler CC, Little P, Goossens H, Coenen S; GRACE project group.

Br J Gen Pract. 2018 Apr 9. pii: bjgp18X695789. doi: 10.3399/bjgp18X695789. [Epub ahead of print]


Global increase and geographic convergence in antibiotic consumption between 2000 and 2015.

Klein EY, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, Goossens H, Laxminarayan R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3463-E3470. doi: 10.1073/pnas.1717295115. Epub 2018 Mar 26.


High Rates of Prescribing Antimicrobials for Prophylaxis in Children and Neonates: Results From the Antibiotic Resistance and Prescribing in European Children Point Prevalence Survey.

Hufnagel M, Versporten A, Bielicki J, Drapier N, Sharland M, Goossens H; ARPEC Project Group .

J Pediatric Infect Dis Soc. 2018 Mar 22. doi: 10.1093/jpids/piy019. [Epub ahead of print]


Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries.

Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, Henriques-Normark B, Crook D, Huygen K, Butler CC, Verheij TJM, Little P, Zlateva K, van Loon A, Claas ECJ, Goossens H; GRACE consortium.

Clin Microbiol Infect. 2018 Feb 12. pii: S1198-743X(18)30152-6. doi: 10.1016/j.cmi.2018.02.004. [Epub ahead of print]


Economic evaluation of pneumococcal vaccines for adults aged over 50 years in Belgium.

Willem L, Blommaert A, Hanquet G, Thiry N, Bilcke J, Theeten H, Verhaegen J, Goossens H, Beutels P.

Hum Vaccin Immunother. 2018 Feb 8:1-12. doi: 10.1080/21645515.2018.1428507. [Epub ahead of print]


Effect of outpatient antibiotics for urinary tract infections on antimicrobial resistance among commensal Enterobacteriaceae: a multinational prospective cohort study.

Stewardson AJ, Vervoort J, Adriaenssens N, Coenen S, Godycki-Cwirko M, Kowalczyk A, Huttner BD, Lammens C, Malhotra-Kumar S, Goossens H, Harbarth S; SATURN WP1 Study Group; SATURN WP3 Study Group.

Clin Microbiol Infect. 2018 Jan 10. pii: S1198-743X(18)30031-4. doi: 10.1016/j.cmi.2017.12.026. [Epub ahead of print]


Formation of Fluorinated Amido Esters through Unexpected C3-C4 Bond Fission in 4-Trifluoromethyl-3-oxo-β-lactams.

Dao Thi H, Goossens H, Hertsen D, Otte V, Van Nguyen T, Van Speybroeck V, D'hooghe M.

Chem Asian J. 2018 Feb 16;13(4):421-431. doi: 10.1002/asia.201701636. Epub 2018 Jan 29.


Adverse Effects of Amoxicillin for Acute Lower Respiratory Tract Infection in Primary Care: Secondary and Subgroup Analysis of a Randomised Clinical Trial.

Tandan M, Vellinga A, Bruyndonckx R, Little P, Verheij T, Butler CC, Goossens H, Coenen S.

Antibiotics (Basel). 2017 Dec 13;6(4). pii: E36. doi: 10.3390/antibiotics6040036.


Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity.

Meysman P, De Neuter N, Bartholomeus E, Elias G, Van den Bergh J, Emonds MP, Haasnoot GW, Heynderickx S, Wens J, Michels NR, Lambert J, Lion E, Claas FHJ, Goossens H, Smits E, Van Damme P, Van Tendeloo V, Beutels P, Suls A, Mortier G, Laukens K, Ogunjimi B.

Immunogenetics. 2017 Dec 1. doi: 10.1007/s00251-017-1047-x. [Epub ahead of print]


Nasopharyngeal s. pneumoniae carriage and density in Belgian infants after 9 years of pneumococcal conjugate vaccine programme.

Wouters I, Van Heirstraeten L, Desmet S, Blaizot S, Verhaegen J, Goossens H, Van Damme P, Malhotra-Kumar S, Theeten H; NPcarriage Study Group.

Vaccine. 2018 Jan 2;36(1):15-22. doi: 10.1016/j.vaccine.2017.11.052. Epub 2017 Nov 24.


Evaluation of colistin stability in agar and comparison of four methods for MIC testing of colistin.

Turlej-Rogacka A, Xavier BB, Janssens L, Lammens C, Zarkotou O, Pournaras S, Goossens H, Malhotra-Kumar S.

Eur J Clin Microbiol Infect Dis. 2018 Feb;37(2):345-353. doi: 10.1007/s10096-017-3140-3. Epub 2017 Nov 25.


Mechanical ventilation induces IL-4 secretion in lungs and reduces the phagocytic capacity of lung macrophages.

Bielen K, Jongers B', Boddaert J, Lammens C, Jorens PG, Malhotra-Kumar S, Goossens H, Kumar-Singh S.

J Infect Dis. 2017 Nov 13. doi: 10.1093/infdis/jix573. [Epub ahead of print]


Amoxicillin for acute lower respiratory tract infection in primary care: subgroup analysis by bacterial and viral aetiology.

Bruyndonckx R, Stuart B, Little P, Hens N, Ieven M, Butler CC, Verheij T, Goossens H, Coenen S; GRACE project group.

Clin Microbiol Infect. 2017 Nov 3. pii: S1198-743X(17)30626-2. doi: 10.1016/j.cmi.2017.10.032. [Epub ahead of print]


Reactivity of 3-Oxo-β-lactams with Respect to Primary Amines-An Experimental and Computational Approach.

Piens N, Goossens H, Hertsen D, Deketelaere S, Crul L, Demeurisse L, De Moor J, Van den Broeck E, Mollet K, Van Hecke K, Van Speybroeck V, D'hooghe M.

Chemistry. 2017 Dec 19;23(71):18002-18009. doi: 10.1002/chem.201703852. Epub 2017 Dec 4.


Rationale and design of ASPIRE-ICU: a prospective cohort study on the incidence and predictors of Staphylococcus aureus and Pseudomonas aeruginosa pneumonia in the ICU.

Paling FP, Troeman DPR, Wolkewitz M, Kalyani R, Prins DR, Weber S, Lammens C, Timbermont L, Goossens H, Malhotra-Kumar S, Sifakis F, Bonten MJM, Kluytmans JAJW.

BMC Infect Dis. 2017 Sep 25;17(1):643. doi: 10.1186/s12879-017-2739-4.


Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia.

Anguille S, Van de Velde AL, Smits EL, Van Tendeloo VF, Juliusson G, Cools N, Nijs G, Stein B, Lion E, Van Driessche A, Vandenbosch I, Verlinden A, Gadisseur AP, Schroyens WA, Muylle L, Vermeulen K, Maes MB, Deiteren K, Malfait R, Gostick E, Lammens M, Couttenye MM, Jorens P, Goossens H, Price DA, Ladell K, Oka Y, Fujiki F, Oji Y, Sugiyama H, Berneman ZN.

Blood. 2017 Oct 12;130(15):1713-1721. doi: 10.1182/blood-2017-04-780155. Epub 2017 Aug 22.


Human resources estimates and funding for antibiotic stewardship teams are urgently needed.

Pulcini C, Morel CM, Tacconelli E, Beovic B, de With K, Goossens H, Harbarth S, Holmes A, Howard P, Morris AM, Nathwani D, Sharland M, Schouten J, Thursky K, Laxminarayan R, Mendelson M.

Clin Microbiol Infect. 2017 Nov;23(11):785-787. doi: 10.1016/j.cmi.2017.07.013. Epub 2017 Aug 2. No abstract available.


Biofilm-Induced Type 2 Innate Immunity in a Cystic Fibrosis Model of Pseudomonas aeruginosa.

Bielen K, 's Jongers B, Boddaert J, Raju TK, Lammens C, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.

Front Cell Infect Microbiol. 2017 Jun 21;7:274. doi: 10.3389/fcimb.2017.00274. eCollection 2017.


Emergence of antimicrobial resistance to Pseudomonas aeruginosa in the intensive care unit: association with the duration of antibiotic exposure and mode of administration.

Yusuf E, Van Herendael B, Verbrugghe W, Ieven M, Goovaerts E, Bergs K, Wouters K, Jorens PG, Goossens H.

Ann Intensive Care. 2017 Dec;7(1):72. doi: 10.1186/s13613-017-0296-z. Epub 2017 Jun 29.


Design of a thermally controlled sequence of triazolinedione-based click and transclick reactions.

Houck HA, De Bruycker K, Billiet S, Dhanis B, Goossens H, Catak S, Van Speybroeck V, Winne JM, Du Prez FE.

Chem Sci. 2017 Apr 1;8(4):3098-3108. doi: 10.1039/c7sc00119c. Epub 2017 Feb 16.


Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey.

Cai Y, Venkatachalam I, Tee NW, Tan TY, Kurup A, Wong SY, Low CY, Wang Y, Lee W, Liew YX, Ang B, Lye DC, Chow A, Ling ML, Oh HM, Cuvin CA, Ooi ST, Pada SK, Lim CH, Tan JWC, Chew KL, Nguyen VH, Fisher DA, Goossens H, Kwa AL, Tambyah PA, Hsu LY, Marimuthu K.

Clin Infect Dis. 2017 May 15;64(suppl_2):S61-S67. doi: 10.1093/cid/cix103.


Animal models of hospital-acquired pneumonia: current practices and future perspectives.

Bielen K, 's Jongers B, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S.

Ann Transl Med. 2017 Mar;5(6):132. doi: 10.21037/atm.2017.03.72. Review.


Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.

Ogunjimi B, Van den Bergh J, Meysman P, Heynderickx S, Bergs K, Jansen H, Leuridan E, Vorsters A, Goossens H, Laukens K, Cools N, Van Tendeloo V, Hens N, Van Damme P, Smits E, Beutels P.

Sci Rep. 2017 Apr 24;7(1):1077. doi: 10.1038/s41598-017-01024-8.


In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp.

Hotterbeekx A, Kumar-Singh S, Goossens H, Malhotra-Kumar S.

Front Cell Infect Microbiol. 2017 Apr 3;7:106. doi: 10.3389/fcimb.2017.00106. eCollection 2017. Review.


The first clonal spread of vanA-positive Enterococcus raffinosus in a nursing home.

Yusuf E, Loens K, Jans B, Cox P, Ieven M, Goossens H.

J Hosp Infect. 2017 May;96(1):72-74. doi: 10.1016/j.jhin.2017.03.008. Epub 2017 Mar 11. No abstract available.


Disease Course of Lower Respiratory Tract Infection With a Bacterial Cause.

Teepe J, Broekhuizen BD, Loens K, Lammens C, Ieven M, Goossens H, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Verheij T; GRACE Consortium.

Ann Fam Med. 2016 Nov;14(6):534-539. doi: 10.1370/afm.1974.


EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study.

Gutiérrez-Gutiérrez B, Sojo-Dorado J, Bravo-Ferrer J, Cuperus N, de Kraker M, Kostyanev T, Raka L, Daikos G, Feifel J, Folgori L, Pascual A, Goossens H, O'Brien S, Bonten MJ, Rodríguez-Baño J; EURECA project team.

BMJ Open. 2017 Apr 3;7(4):e015365. doi: 10.1136/bmjopen-2016-015365. Erratum in: BMJ Open. 2017 Aug 11;7(8):e015365corr1.


Optics of the human cornea influence the accuracy of stereo eye-tracking methods: a simulation study.

Barsingerhorn AD, Boonstra FN, Goossens HH.

Biomed Opt Express. 2017 Jan 9;8(2):712-725. doi: 10.1364/BOE.8.000712. eCollection 2017 Feb 1.


Concise Review: Innate and Adaptive Immune Recognition of Allogeneic and Xenogeneic Cell Transplants in the Central Nervous System.

Hoornaert CJ, Le Blon D, Quarta A, Daans J, Goossens H, Berneman Z, Ponsaerts P.

Stem Cells Transl Med. 2017 May;6(5):1434-1441. doi: 10.1002/sctm.16-0434. Epub 2017 Feb 28.


Shout about the European Union's success.

Goossens H.

Nature. 2017 Feb 14;542(7641):273. doi: 10.1038/542273a. No abstract available.


Desirable cytolytic immune effector cell recruitment by interleukin-15 dendritic cells.

Van Acker HH, Beretta O, Anguille S, De Caluwé L, Papagna A, Van den Bergh JM, Willemen Y, Goossens H, Berneman ZN, Van Tendeloo VF, Smits EL, Foti M, Lion E.

Oncotarget. 2017 Feb 21;8(8):13652-13665. doi: 10.18632/oncotarget.14622.


Persistence of antimicrobial resistance in respiratory streptococci.

Bruyndonckx R, Hens N, Aerts M, Goossens H, Latour K, Catry B, Coenen S.

J Glob Antimicrob Resist. 2017 Mar;8:6-12. doi: 10.1016/j.jgar.2016.09.009. Epub 2016 Nov 9.


Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.

Le Blon D, Guglielmetti C, Hoornaert C, Quarta A, Daans J, Dooley D, Lemmens E, Praet J, De Vocht N, Reekmans K, Santermans E, Hens N, Goossens H, Verhoye M, Van der Linden A, Berneman Z, Hendrix S, Ponsaerts P.

J Neuroinflammation. 2016 Nov 9;13(1):288.


The endotracheal tube microbiome associated with Pseudomonas aeruginosa or Staphylococcus epidermidis.

Hotterbeekx A, Xavier BB, Bielen K, Lammens C, Moons P, Schepens T, Ieven M, Jorens PG, Goossens H, Kumar-Singh S, Malhotra-Kumar S.

Sci Rep. 2016 Nov 4;6:36507. doi: 10.1038/srep36507.


Using a simple point-prevalence survey to define appropriate antibiotic prescribing in hospitalised children across the UK.

Gharbi M, Doerholt K, Vergnano S, Bielicki JA, Paulus S, Menson E, Riordan A, Lyall H, Patel SV, Bernatoniene J, Versporten A, Heginbothom M, Goossens H, Sharland M; ARPEC project Group members.

BMJ Open. 2016 Nov 3;6(11):e012675. doi: 10.1136/bmjopen-2016-012675.


Predicting the presence of bacterial pathogens in the airways of primary care patients with acute cough.

Teepe J, Broekhuizen BD, Loens K, Lammens C, Ieven M, Goossens H, Little P, Butler CC, Coenen S, Godycki-Cwirko M, Verheij TJ; GRACE Consortium.

CMAJ. 2016 Oct 24. pii: cmaj.151364. [Epub ahead of print]


Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.

Guglielmetti C, Le Blon D, Santermans E, Salas-Perdomo A, Daans J, De Vocht N, Shah D, Hoornaert C, Praet J, Peerlings J, Kara F, Bigot C, Mai Z, Goossens H, Hens N, Hendrix S, Verhoye M, Planas AM, Berneman Z, van der Linden A, Ponsaerts P.

Glia. 2016 Dec;64(12):2181-2200. doi: 10.1002/glia.23053. Epub 2016 Sep 29.


Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens.

Lee WP, Willekens B, Cras P, Goossens H, Martínez-Cáceres E, Berneman ZN, Cools N.

J Immunol Res. 2016;2016:5392623. Epub 2016 Sep 14.


The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells.

Willemen Y, Van den Bergh JM, Bonte SM, Anguille S, Heirman C, Stein BM, Goossens H, Kerre T, Thielemans K, Peeters M, Van Tendeloo VF, Smits EL, Berneman ZN.

Oncotarget. 2016 Nov 8;7(45):73960-73970. doi: 10.18632/oncotarget.12170.


Efficient Delivery of Investigational Antibacterial Agents via Sustainable Clinical Trial Networks.

McDonnell A, Rex JH, Goossens H, Bonten M, Fowler VG Jr, Dane A.

Clin Infect Dis. 2016 Aug 15;63 Suppl 2:S57-9. doi: 10.1093/cid/ciw244. Review.


Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

Xavier BB, Lammens C, Ruhal R, Kumar-Singh S, Butaye P, Goossens H, Malhotra-Kumar S.

Euro Surveill. 2016 Jul 7;21(27). doi: 10.2807/1560-7917.ES.2016.21.27.30280. Erratum in: Euro Surveill. 2016 Jul 14;21(28):.


Cost effectiveness of amoxicillin for lower respiratory tract infections in primary care: an economic evaluation accounting for the cost of antimicrobial resistance.

Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Moore M, Coast J.

Br J Gen Pract. 2016 Sep;66(650):e633-9. doi: 10.3399/bjgp16X686533. Epub 2016 Jul 11.


Impact of amoxicillin therapy on resistance selection in patients with community-acquired lower respiratory tract infections: a randomized, placebo-controlled study.

Malhotra-Kumar S, Van Heirstraeten L, Coenen S, Lammens C, Adriaenssens N, Kowalczyk A, Godycki-Cwirko M, Bielicka Z, Hupkova H, Lannering C, Mölstad S, Fernandez-Vandellos P, Torres A, Parizel M, Ieven M, Butler CC, Verheij T, Little P, Goossens H; GRACE study group.

J Antimicrob Chemother. 2016 Nov;71(11):3258-3267. Epub 2016 Jun 26.


Immune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side-effect?

Le Blon D, Hoornaert C, Detrez JR, Bevers S, Daans J, Goossens H, De Vos WH, Berneman Z, Ponsaerts P.

J Tissue Eng Regen Med. 2017 Oct;11(10):2846-2852. doi: 10.1002/term.2188. Epub 2016 Jun 20.


Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium.

Vorsters A, Cornelissen T, Leuridan E, Bogers J, Vanden Broeck D, Benoy I, Goossens H, Hens N, Van Damme P.

BMC Public Health. 2016 Jun 7;16:477. doi: 10.1186/s12889-016-3099-5.


Complete sequence of an IncFII plasmid harbouring the colistin resistance gene mcr-1 isolated from Belgian pig farms.

Xavier BB, Lammens C, Butaye P, Goossens H, Malhotra-Kumar S.

J Antimicrob Chemother. 2016 Aug;71(8):2342-4. doi: 10.1093/jac/dkw191. Epub 2016 Jun 3. No abstract available.


GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical Trial.

Van Damme P, Bouillette-Marussig M, Hens A, De Coster I, Depuydt C, Goubier A, Van Tendeloo V, Cools N, Goossens H, Hercend T, Timmerman B, Bissery MC.

Clin Cancer Res. 2016 Jul 1;22(13):3238-48. doi: 10.1158/1078-0432.CCR-16-0085. Epub 2016 Jun 1.


Development of a national EUCAST challenge panel for antimicrobial susceptibility testing.

Desmet S, Verhaegen J, Glupzcynski Y, Van Eldere J, Melin P, Goossens H, Piérard D, Declercq P, Lagrou K, Boel A, Cartuyvels R, Denis O, Vandewal W, Saegeman V.

Clin Microbiol Infect. 2016 Aug;22(8):704-10. doi: 10.1016/j.cmi.2016.05.011. Epub 2016 May 24.

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