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Items: 1 to 50 of 58

1.

Unmasking the skiptic task of TDP-43.

Rouaux C, Gonzalez De Aguilar JL, Dupuis L.

EMBO J. 2018 May 16. pii: e99645. doi: 10.15252/embj.201899645. [Epub ahead of print] No abstract available.

PMID:
29769403
2.

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.

von Grabowiecki Y, Abreu P, Blanchard O, Palamiuc L, Benosman S, Mériaux S, Devignot V, Gross I, Mellitzer G, Gonzalez de Aguilar JL, Gaiddon C.

Elife. 2016 Feb 26;5. pii: e10528. doi: 10.7554/eLife.10528.

3.

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis.

Loeffler JP, Picchiarelli G, Dupuis L, Gonzalez De Aguilar JL.

Brain Pathol. 2016 Mar;26(2):227-36. doi: 10.1111/bpa.12350. Review.

PMID:
26780251
4.

Analytical sequence to study G-CSF effect on the transcriptome of isolated spinal motoneurons from SOD1 G93A mice, an animal model for amyotrophic lateral sclerosis.

Henriques A, Kastner S, Wafzig O, Gonzalez De Aguilar JL, Schneider A.

Genom Data. 2015 Feb 28;4:47-9. doi: 10.1016/j.gdata.2015.02.003. eCollection 2015 Jun.

5.

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.

Henriques A, Croixmarie V, Priestman DA, Rosenbohm A, Dirrig-Grosch S, D'Ambra E, Huebecker M, Hussain G, Boursier-Neyret C, Echaniz-Laguna A, Ludolph AC, Platt FM, Walther B, Spedding M, Loeffler JP, Gonzalez De Aguilar JL.

Hum Mol Genet. 2015 Dec 20;24(25):7390-405. doi: 10.1093/hmg/ddv439. Epub 2015 Oct 19.

6.

Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis.

Henriques A, Blasco H, Fleury MC, Corcia P, Echaniz-Laguna A, Robelin L, Rudolf G, Lequeu T, Bergaentzle M, Gachet C, Pradat PF, Marchioni E, Andres CR, Tranchant C, Gonzalez De Aguilar JL, Loeffler JP.

PLoS One. 2015 Jul 6;10(7):e0131512. doi: 10.1371/journal.pone.0131512. eCollection 2015.

7.

Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients.

Bruneteau G, Bauché S, Gonzalez de Aguilar JL, Brochier G, Mandjee N, Tanguy ML, Hussain G, Behin A, Khiami F, Sariali E, Hell-Remy C, Salachas F, Pradat PF, Lacomblez L, Nicole S, Fontaine B, Fardeau M, Loeffler JP, Meininger V, Fournier E, Koenig J, Hantaï D.

Ann Clin Transl Neurol. 2015 Apr;2(4):362-72. doi: 10.1002/acn3.179. Epub 2015 Feb 16.

8.

Gene expression changes in spinal motoneurons of the SOD1(G93A) transgenic model for ALS after treatment with G-CSF.

Henriques A, Kastner S, Chatzikonstantinou E, Pitzer C, Plaas C, Kirsch F, Wafzig O, Krüger C, Spoelgen R, Gonzalez De Aguilar JL, Gretz N, Schneider A.

Front Cell Neurosci. 2015 Jan 20;8:464. doi: 10.3389/fncel.2014.00464. eCollection 2014.

9.

Blood biomarkers for amyotrophic lateral sclerosis: myth or reality?

Robelin L, Gonzalez De Aguilar JL.

Biomed Res Int. 2014;2014:525097. doi: 10.1155/2014/525097. Epub 2014 Jun 2. Review.

10.

Fatting the brain: a brief of recent research.

Hussain G, Schmitt F, Loeffler JP, Gonzalez de Aguilar JL.

Front Cell Neurosci. 2013 Sep 9;7:144. doi: 10.3389/fncel.2013.00144. Review.

11.

Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury.

Hussain G, Schmitt F, Henriques A, Lequeu T, Rene F, Bindler F, Dirrig-Grosch S, Oudart H, Palamiuc L, Metz-Boutigue MH, Dupuis L, Marchioni E, Gonzalez De Aguilar JL, Loeffler JP.

PLoS One. 2013 Jun 13;8(6):e64525. doi: 10.1371/journal.pone.0064525. Print 2013.

12.

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.

Dentel C, Palamiuc L, Henriques A, Lannes B, Spreux-Varoquaux O, Gutknecht L, René F, Echaniz-Laguna A, Gonzalez de Aguilar JL, Lesch KP, Meininger V, Loeffler JP, Dupuis L.

Brain. 2013 Feb;136(Pt 2):483-93. doi: 10.1093/brain/aws274. Epub 2012 Oct 31.

PMID:
23114367
13.

Can transcriptomics cut the gordian knot of amyotrophic lateral sclerosis?

Henriques A, Gonzalez De Aguilar JL.

Curr Genomics. 2011 Nov;12(7):506-15. doi: 10.2174/138920211797904043.

14.

Muscle gene expression is a marker of amyotrophic lateral sclerosis severity.

Pradat PF, Dubourg O, de Tapia M, di Scala F, Dupuis L, Lenglet T, Bruneteau G, Salachas F, Lacomblez L, Corvol JC, Demougin P, Primig M, Meininger V, Loeffler JP, Gonzalez de Aguilar JL.

Neurodegener Dis. 2012;9(1):38-52. doi: 10.1159/000329723. Epub 2011 Sep 21.

PMID:
21934272
15.

Muscle gene expression in ALS patients: Comment on the article by Shtilbans and collaborators.

Gonzalez de Aguilar JL, Pradat PF.

Amyotroph Lateral Scler. 2011 Nov;12(6):468-9; author reply 470. doi: 10.3109/17482968.2011.604872. Epub 2011 Sep 19. No abstract available.

PMID:
21929352
16.

Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.

Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M, Schwalenstocker B, Loeffler JP, Ludolph AC, Dupuis L.

Biochim Biophys Acta. 2011 Jan;1812(1):59-69. doi: 10.1016/j.bbadis.2010.09.009. Epub 2010 Sep 29.

17.

A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.

Braunstein KE, Eschbach J, Ròna-Vörös K, Soylu R, Mikrouli E, Larmet Y, René F, Gonzalez De Aguilar JL, Loeffler JP, Müller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstöcker B, Kassubek J, Pichler B, Stiller D, Petersen A, Ludolph AC, Dupuis L.

Hum Mol Genet. 2010 Nov 15;19(22):4385-98. doi: 10.1093/hmg/ddq361. Epub 2010 Aug 31.

18.

Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis.

Halter B, Gonzalez de Aguilar JL, Rene F, Petri S, Fricker B, Echaniz-Laguna A, Dupuis L, Larmet Y, Loeffler JP.

Free Radic Biol Med. 2010 Apr 1;48(7):915-23. doi: 10.1016/j.freeradbiomed.2010.01.014. Epub 2010 Jan 14.

PMID:
20079427
19.

Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons.

Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Eschbach J, Rene F, Oudart H, Halter B, Huze C, Schaeffer L, Bouillaud F, Loeffler JP.

PLoS One. 2009;4(4):e5390. doi: 10.1371/journal.pone.0005390. Epub 2009 Apr 30.

20.

Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.

Dupuis L, Fergani A, Braunstein KE, Eschbach J, Holl N, Rene F, Gonzalez De Aguilar JL, Zoerner B, Schwalenstocker B, Ludolph AC, Loeffler JP.

Exp Neurol. 2009 Jan;215(1):146-52. doi: 10.1016/j.expneurol.2008.09.019. Epub 2008 Oct 8.

PMID:
18952079
21.

Lesions and genes: on the edge of improved isomorphic models for Alzheimer's disease?

Gonzalez de Aguilar JL, Loeffler JP, Boutillier AL.

Neurodegener Dis. 2008;5(5):318-20. doi: 10.1159/000135616. Epub 2008 Jun 3. No abstract available.

PMID:
18520166
22.

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis.

Dupuis L, Corcia P, Fergani A, Gonzalez De Aguilar JL, Bonnefont-Rousselot D, Bittar R, Seilhean D, Hauw JJ, Lacomblez L, Loeffler JP, Meininger V.

Neurology. 2008 Mar 25;70(13):1004-9. doi: 10.1212/01.wnl.0000285080.70324.27. Epub 2008 Jan 16.

PMID:
18199832
23.

Nogo receptor antagonizes p75NTR-dependent motor neuron death.

Dupuis L, Pehar M, Cassina P, Rene F, Castellanos R, Rouaux C, Gandelman M, Dimou L, Schwab ME, Loeffler JP, Barbeito L, Gonzalez de Aguilar JL.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):740-5. doi: 10.1073/pnas.0703842105. Epub 2008 Jan 8.

24.

Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model.

Gonzalez de Aguilar JL, Niederhauser-Wiederkehr C, Halter B, De Tapia M, Di Scala F, Demougin P, Dupuis L, Primig M, Meininger V, Loeffler JP.

Physiol Genomics. 2008 Jan 17;32(2):207-18. Epub 2007 Nov 13.

PMID:
18000159
25.

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model.

Rouaux C, Panteleeva I, René F, Gonzalez de Aguilar JL, Echaniz-Laguna A, Dupuis L, Menger Y, Boutillier AL, Loeffler JP.

J Neurosci. 2007 May 23;27(21):5535-45.

26.

Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes.

Pradat PF, Bruneteau G, Gonzalez de Aguilar JL, Dupuis L, Jokic N, Salachas F, Le Forestier N, Echaniz-Laguna A, Dubourg O, Hauw JJ, Tranchant C, Loeffler JP, Meininger V.

Ann Neurol. 2007 Jul;62(1):15-20.

PMID:
17455292
27.

Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis.

Fergani A, Oudart H, Gonzalez De Aguilar JL, Fricker B, René F, Hocquette JF, Meininger V, Dupuis L, Loeffler JP.

J Lipid Res. 2007 Jul;48(7):1571-80. Epub 2007 Apr 16.

28.

Amyotrophic lateral sclerosis: all roads lead to Rome.

Gonzalez de Aguilar JL, Echaniz-Laguna A, Fergani A, René F, Meininger V, Loeffler JP, Dupuis L.

J Neurochem. 2007 Jun;101(5):1153-60. Epub 2007 Jan 23. Review.

29.

The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.

Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP.

EMBO Rep. 2006 Nov;7(11):1162-7. Epub 2006 Oct 13.

30.

Reticulons as markers of neurological diseases: focus on amyotrophic lateral sclerosis.

Fergani A, Dupuis L, Jokic N, Larmet Y, de Tapia M, Rene F, Loeffler JP, Gonzalez de Aguilar JL.

Neurodegener Dis. 2005;2(3-4):185-94. Review.

PMID:
16909024
31.

Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

Dupuis L, Gonzalez de Aguilar JL, Oudart H, de Tapia M, Barbeito L, Loeffler JP.

Neurodegener Dis. 2004;1(6):245-54. Review.

32.

Mitochondrial dysfunction in amyotrophic lateral sclerosis also affects skeletal muscle.

Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Loeffler JP.

Muscle Nerve. 2006 Aug;34(2):253-4. No abstract available.

PMID:
16642501
33.

Effect of a cyclohexenonic long-chain fatty alcohol on calcium mobilization.

Jover E, Gonzalez de Aguilar JL, Luu B, Lutz-Bucher B.

Eur J Pharmacol. 2005 Jun 15;516(3):197-203.

PMID:
15978572
34.

The metabolic hypothesis in amyotrophic lateral sclerosis: insights from mutant Cu/Zn-superoxide dismutase mice.

Gonzalez de Aguilar JL, Dupuis L, Oudart H, Loeffler JP.

Biomed Pharmacother. 2005 May;59(4):190-6. Epub 2005 Mar 17.

PMID:
15862714
35.

Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons.

Mbebi C, González de Aguilar JL, Sée V, Dupuis L, Frossard N, Mercken L, Pradier L, Larmet Y, Loeffler JP.

Neurobiol Dis. 2005 Jun-Jul;19(1-2):129-41.

PMID:
15837568
36.

Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity.

Jokic N, Gonzalez de Aguilar JL, Pradat PF, Dupuis L, Echaniz-Laguna A, Muller A, Dubourg O, Seilhean D, Hauw JJ, Loeffler JP, Meininger V.

Ann Neurol. 2005 Apr;57(4):553-6.

PMID:
15786457
37.

Tissue specificity and regulation of the N-terminal diversity of reticulon 3.

Di Scala F, Dupuis L, Gaiddon C, De Tapia M, Jokic N, Gonzalez de Aguilar JL, Raul JS, Ludes B, Loeffler JP.

Biochem J. 2005 Jan 1;385(Pt 1):125-34.

38.

Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model.

Dupuis L, Oudart H, René F, Gonzalez de Aguilar JL, Loeffler JP.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11159-64. Epub 2004 Jul 19.

39.

Early activation of antioxidant mechanisms in muscle of mutant Cu/Zn-superoxide dismutase-linked amyotrophic lateral sclerosis mice.

Jokic N, Di Scala F, Dupuis L, Rene F, Muller A, Gonzalez De Aguilar JL, Loeffler JP.

Ann N Y Acad Sci. 2003 Dec;1010:552-6.

PMID:
15033789
40.

Neuroendocrinology of neurodegenerative diseases. Insights from transgenic mouse models.

González De Aguilar JL, René F, Dupuis L, Loeffler JP.

Neuroendocrinology. 2003 Nov;78(5):244-52. Review.

PMID:
14657605
41.

Role of Ca2+ in the secretory and biosynthetic response of porcine gonadotropes to substance P and gonadotropin-releasing hormone.

Hidalgo-Díaz C, Malagón MM, García-Navarro S, Luque RM, González de Aguilar JL, Gracia-Navarro F, Castaño JP.

Regul Pept. 2003 Nov 15;116(1-3):43-52.

PMID:
14599714
42.

Denervation is not a primary cause of prion protein down-regulation occurring in the spinal cord of a transgenic model of amyotrophic lateral sclerosis.

Dupuis L, Rene F, Di Scala F, Gonzalez De Aguilar JL, De Tapia M, Loeffler JP.

Ann N Y Acad Sci. 2002 Nov;973:116-9. No abstract available.

PMID:
12485846
43.

Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis.

Dupuis L, Gonzalez de Aguilar JL, di Scala F, Rene F, de Tapia M, Pradat PF, Lacomblez L, Seihlan D, Prinjha R, Walsh FS, Meininger V, Loeffler JP.

Neurobiol Dis. 2002 Aug;10(3):358-65.

PMID:
12270696
44.

Loss of prion protein in a transgenic model of amyotrophic lateral sclerosis.

Dupuis L, Mbebi C, Gonzalez de Aguilar JL, Rene F, Muller A, de Tapia M, Loeffler JP.

Mol Cell Neurosci. 2002 Feb;19(2):216-24.

PMID:
11860274
45.

Neurotrophic activity of 2,4,4-trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one in cultured central nervous system neurons.

Gonzalez de Aguilar JL, Girlanda-Junges C, Coowar D, Duportail G, Loeffler JP, Luu B.

Brain Res. 2001 Nov 30;920(1-2):65-73.

PMID:
11716812
46.

Melanotrope cell plasticity: a key mechanism for the physiological adaptation to background color changes.

Vazquez-Martinez R, Peinado JR, Gonzalez De Aguilar JL, Desrues L, Tonon MC, Vaudry H, Gracia-Navarro F, Malagon MM.

Endocrinology. 2001 Jul;142(7):3060-7.

PMID:
11416028
47.

3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion.

Girlanda-Junges C, Lutz-Bucher B, Gonzalez de Aguilar JL, Loeffler JP, Luu B.

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2537-9.

PMID:
11086724
48.

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway.

González de Aguilar JL, Gordon JW, René F, de Tapia M, Lutz-Bucher B, Gaiddon C, Loeffler JP.

Neurobiol Dis. 2000 Aug;7(4):406-15.

PMID:
10964611
49.

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo-neurohypophysial axis.

González de Aguilar JL, Gordon JW, René F, Lutz-Bucher B, Kienlen-Campard P, Loeffler JP.

Eur J Neurosci. 1999 Dec;11(12):4179-87.

PMID:
10594643
50.

Oxidative stress and a murine superoxide dismutase-1 mutation promoting amyotrophic lateral sclerosis alter neurosecretion in the hypothalamo-neurohypophyseal axis.

Lutz-Bucher B, González de Aguilar JL, René F, Sée V, Gordon JW, Loeffler J.

Neuroendocrinology. 1999 May;69(5):377-84.

PMID:
10343179

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