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Items: 1 to 50 of 199

1.

Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1.

Aluri S, Zhao R, Lubout C, Goorden SMI, Fiser A, Goldman ID.

Blood Adv. 2018 Jan 5;2(1):61-68. doi: 10.1182/bloodadvances.2017012690. eCollection 2018 Jan 9.

2.

Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.

Zhao R, Najmi M, Aluri S, Spray DC, Goldman ID.

Mol Pharmacol. 2018 Mar;93(3):208-215. doi: 10.1124/mol.117.110445. Epub 2018 Jan 11.

PMID:
29326243
3.

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1).

Aluri S, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C289-C296. doi: 10.1152/ajpcell.00215.2017. Epub 2017 Nov 22.

PMID:
29167151
4.

Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier.

Alam C, Hoque MT, Finnell RH, Goldman ID, Bendayan R.

Mol Pharm. 2017 Nov 6;14(11):3848-3858. doi: 10.1021/acs.molpharmaceut.7b00572. Epub 2017 Sep 26.

PMID:
28885847
5.

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.

Aluri S, Zhao R, Fiser A, Goldman ID.

Biochim Biophys Acta. 2017 Nov;1859(11):2193-2202. doi: 10.1016/j.bbamem.2017.08.006. Epub 2017 Aug 9.

PMID:
28802835
6.

Hereditary Folate Malabsorption.

Kronn D, Goldman ID.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2008 Jun 17 [updated 2017 Apr 27].

7.

Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.

Zhao R, Najmi M, Aluri S, Goldman ID.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C517-C526. doi: 10.1152/ajpcell.00350.2016. Epub 2017 Jan 25.

8.

The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.

Zhao R, Aluri S, Goldman ID.

Mol Aspects Med. 2017 Feb;53:57-72. doi: 10.1016/j.mam.2016.09.002. Epub 2016 Sep 21. Review.

9.

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.

Najmi M, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C150-7. doi: 10.1152/ajpcell.00084.2016. Epub 2016 Jun 1.

10.

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.

Zhao R, Najmi M, Fiser A, Goldman ID.

J Biol Chem. 2016 Apr 8;291(15):8162-72. doi: 10.1074/jbc.M115.693929. Epub 2016 Feb 16.

11.

Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.

Zhao R, Visentin M, Goldman ID.

Cancer Chemother Pharmacol. 2015 Jun;75(6):1163-73. doi: 10.1007/s00280-015-2733-8. Epub 2015 Apr 7.

12.

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).

Visentin M, Unal ES, Najmi M, Fiser A, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C631-41. doi: 10.1152/ajpcell.00238.2014. Epub 2015 Jan 21.

13.

A conversation with Susan Band Horwitz.

Horwitz SB, Goldman ID.

Annu Rev Pharmacol Toxicol. 2015;55:1-9. doi: 10.1146/annurev-pharmtox-010814-124519.

PMID:
25562642
14.

The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.

Visentin M, Unal ES, Goldman ID.

Cancer Chemother Pharmacol. 2014 May;73(5):1055-62. doi: 10.1007/s00280-014-2441-9. Epub 2014 Mar 29.

15.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

16.

The intestinal absorption of folates.

Visentin M, Diop-Bove N, Zhao R, Goldman ID.

Annu Rev Physiol. 2014;76:251-74. doi: 10.1146/annurev-physiol-020911-153251. Review.

17.

The proton-coupled folate transporter: physiological and pharmacological roles.

Zhao R, Goldman ID.

Curr Opin Pharmacol. 2013 Dec;13(6):875-80. Review.

19.

The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitor.

Visentin M, Unal ES, Zhao R, Goldman ID.

Cancer Chemother Pharmacol. 2013 Sep;72(3):597-606. doi: 10.1007/s00280-013-2231-9. Epub 2013 Jul 24.

20.

A novel deletion mutation in the proton-coupled folate transporter (PCFT; SLC46A1) in a Nicaraguan child with hereditary folate malabsorption.

Diop-Bove N, Jain M, Scaglia F, Goldman ID.

Gene. 2013 Sep 25;527(2):673-4. doi: 10.1016/j.gene.2013.06.039. Epub 2013 Jun 28.

21.

Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.

Zhao R, Visentin M, Suadicani SO, Goldman ID.

Mol Pharmacol. 2013 Jul;84(1):95-103. doi: 10.1124/mol.113.085605. Epub 2013 Apr 22.

22.

Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.

Shin DS, Zhao R, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2013 Jun 15;304(12):C1159-67. doi: 10.1152/ajpcell.00353.2012. Epub 2013 Apr 3.

23.

Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.

Zhao R, Goldman ID.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):373-85. doi: 10.1016/j.mam.2012.07.006. Review.

24.

Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).

Zhao R, Shin DS, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 Sep 15;303(6):C673-81. doi: 10.1152/ajpcell.00123.2012. Epub 2012 Jul 11.

25.
26.

The antifolates.

Visentin M, Zhao R, Goldman ID.

Hematol Oncol Clin North Am. 2012 Jun;26(3):629-48, ix. doi: 10.1016/j.hoc.2012.02.002. Review.

27.

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.

Shin DS, Zhao R, Yap EH, Fiser A, Goldman ID.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1405-12. doi: 10.1152/ajpcell.00435.2011. Epub 2012 Feb 15.

28.

Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).

Visentin M, Chang MH, Romero MF, Zhao R, Goldman ID.

Mol Pharmacol. 2012 Feb;81(2):134-42. doi: 10.1124/mol.111.074823. Epub 2011 Oct 21.

29.

Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.

Zhao R, Shin DS, Diop-Bove N, Ovits CG, Goldman ID.

J Biol Chem. 2011 Jul 8;286(27):24150-8. doi: 10.1074/jbc.M111.236539. Epub 2011 May 20.

30.

Mechanisms of membrane transport of folates into cells and across epithelia.

Zhao R, Diop-Bove N, Visentin M, Goldman ID.

Annu Rev Nutr. 2011 Aug 21;31:177-201. doi: 10.1146/annurev-nutr-072610-145133. Review.

31.

Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico.

Mahadeo KM, Diop-Bove N, Ramirez SI, Cadilla CL, Rivera E, Martin M, Lerner NB, DiAntonio L, Duva S, Santiago-Borrero PJ, Goldman ID.

J Pediatr. 2011 Oct;159(4):623-7.e1. doi: 10.1016/j.jpeds.2011.03.005. Epub 2011 Apr 13.

32.

Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.

Shin DS, Mahadeo K, Min SH, Diop-Bove N, Clayton P, Zhao R, Goldman ID.

Mol Genet Metab. 2011 May;103(1):33-7. doi: 10.1016/j.ymgme.2011.01.008. Epub 2011 Jan 25.

33.

Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.

Zhao R, Shin DS, Goldman ID.

Biochim Biophys Acta. 2011 Apr;1808(4):1140-5. doi: 10.1016/j.bbamem.2011.01.008. Epub 2011 Jan 20.

34.
35.

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.

Shin DS, Min SH, Russell L, Zhao R, Fiser A, Goldman ID.

Blood. 2010 Dec 9;116(24):5162-9. doi: 10.1182/blood-2010-06-291237. Epub 2010 Aug 30.

36.

Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption.

Atabay B, Turker M, Ozer EA, Mahadeo K, Diop-Bove N, Goldman ID.

Pediatr Hematol Oncol. 2010 Nov;27(8):614-9. doi: 10.3109/08880018.2010.481705.

37.

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.

Mahadeo K, Diop-Bove N, Shin D, Unal ES, Teo J, Zhao R, Chang MH, Fulterer A, Romero MF, Goldman ID.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1153-61. doi: 10.1152/ajpcell.00113.2010. Epub 2010 Aug 4.

38.

Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.

Zhao R, Unal ES, Shin DS, Goldman ID.

Biochemistry. 2010 Apr 6;49(13):2925-31. doi: 10.1021/bi9021439.

39.

Molecular and biochemical characterization of folate transport proteins in retinal Müller cells.

Bozard BR, Ganapathy PS, Duplantier J, Mysona B, Ha Y, Roon P, Smith R, Goldman ID, Prasad P, Martin PM, Ganapathy V, Smith SB.

Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3226-35. doi: 10.1167/iovs.09-4833. Epub 2010 Jan 6.

40.

Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.

Diop-Bove NK, Wu J, Zhao R, Locker J, Goldman ID.

Mol Cancer Ther. 2009 Aug;8(8):2424-31. doi: 10.1158/1535-7163.MCT-08-0938. Epub 2009 Aug 11.

41.

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Goldman ID.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C66-74. doi: 10.1152/ajpcell.00096.2009. Epub 2009 Apr 29.

42.

The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.

Unal ES, Zhao R, Chang MH, Fiser A, Romero MF, Goldman ID.

J Biol Chem. 2009 Jun 26;284(26):17846-57. doi: 10.1074/jbc.M109.008060. Epub 2009 Apr 23.

43.

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.

Zhao R, Matherly LH, Goldman ID.

Expert Rev Mol Med. 2009 Jan 28;11:e4. doi: 10.1017/S1462399409000969. Review.

44.

A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

Zhao R, Min SH, Wang Y, Campanella E, Low PS, Goldman ID.

J Biol Chem. 2009 Feb 13;284(7):4267-74. doi: 10.1074/jbc.M807665200. Epub 2008 Dec 11.

45.

The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption.

Min SH, Oh SY, Karp GI, Poncz M, Zhao R, Goldman ID.

J Pediatr. 2008 Sep;153(3):435-7. doi: 10.1016/j.jpeds.2008.04.009.

46.

The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.

Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID.

Mol Pharmacol. 2008 Sep;74(3):854-62. doi: 10.1124/mol.108.045443. Epub 2008 Jun 4.

47.

N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).

Unal ES, Zhao R, Qiu A, Goldman ID.

Biochim Biophys Acta. 2008 Jun;1778(6):1407-14. doi: 10.1016/j.bbamem.2008.03.009. Epub 2008 Mar 20.

48.

Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model.

Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich SC, Smith A, Goldman ID, Qiu A, Cole PD, Glod J, Kamen B.

J Neurochem. 2008 Mar;104(6):1494-503. Epub 2007 Dec 10.

49.

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID.

Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. Epub 2007 Sep 26.

50.

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