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Targeting skeletal endothelium to ameliorate bone loss.

Xu R, Yallowitz A, Qin A, Wu Z, Shin DY, Kim JM, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim JH, Glimcher LH, Greenblatt MB.

Nat Med. 2018 Jun;24(6):823-833. doi: 10.1038/s41591-018-0020-z. Epub 2018 May 21.


Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.


T-bet Runs INTERFERence.

Lazarevic V, Szabo S, Glimcher LH.

Immunity. 2017 Jun 20;46(6):968-970. doi: 10.1016/j.immuni.2017.05.010.


Post-translational control of T cell development by the ESCRT protein CHMP5.

Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH.

Nat Immunol. 2017 Jul;18(7):780-790. doi: 10.1038/ni.3764. Epub 2017 May 29.


SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts.

Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W.

Nat Commun. 2017 Feb 20;8:14570. doi: 10.1038/ncomms14570.


Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer.

Cubillos-Ruiz JR, Bettigole SE, Glimcher LH.

Cell. 2017 Feb 9;168(4):692-706. doi: 10.1016/j.cell.2016.12.004. Review.


The ripple effect: why promoting female leadership in global health matters.

Downs JA, Mathad JS, Reif LK, McNairy ML, Celum C, Boutin-Foster C, Deschamps MM, Gupta A, Hokororo A, Katz IT, Konopasek L, Nelson R, Riviere C, Glimcher LH, Fitzgerald DW.

Public Health Action. 2016 Dec 21;6(4):210-211. doi: 10.5588/pha.16.0072.


Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu CF, Brandt GS, Hoang QQ, Naumova N, Lazarevic V, Hwang ES, Dekker J, Glimcher LH, Ringe D, Petsko GA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6572-E6581. Epub 2016 Oct 10.


Targeting abnormal ER stress responses in tumors: A new approach to cancer immunotherapy.

Cubillos-Ruiz JR, Glimcher LH.

Oncoimmunology. 2015 Oct 29;5(3):e1098802. eCollection 2016 Mar.


Novel roles for XBP1 in hematopoietic development.

Bettigole SE, Glimcher LH.

Cell Cycle. 2016 Jul 2;15(13):1653-4. doi: 10.1080/15384101.2016.1172470. Epub 2016 Apr 8. No abstract available.


Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment.

Cubillos-Ruiz JR, Bettigole SE, Glimcher LH.

Clin Cancer Res. 2016 May 1;22(9):2121-6. doi: 10.1158/1078-0432.CCR-15-1570. Epub 2016 Mar 15. Review.


MEKK2 mediates an alternative β-catenin pathway that promotes bone formation.

Greenblatt MB, Shin DY, Oh H, Lee KY, Zhai B, Gygi SP, Lotinun S, Baron R, Liu D, Su B, Glimcher LH, Shim JH.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1226-35. doi: 10.1073/pnas.1600813113. Epub 2016 Feb 16.


Regulation of Memory Formation by the Transcription Factor XBP1.

Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C.

Cell Rep. 2016 Feb 16;14(6):1382-1394. doi: 10.1016/j.celrep.2016.01.028. Epub 2016 Feb 4.


William Erwin Paul (1936-2015).

Davis MM, Glimcher LH.

Cell. 2015 Oct 22;163(3):529-30. doi: 10.1016/j.cell.2015.10.024. No abstract available.


XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease.

Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF.

PLoS Genet. 2015 Sep 15;11(9):e1005505. doi: 10.1371/journal.pgen.1005505. eCollection 2015 Sep.


An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease.

Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao B, Korzenik JR, Glickman JN, Vemula PK, Glimcher LH, Traverso G, Langer R, Karp JM.

Sci Transl Med. 2015 Aug 12;7(300):300ra128. doi: 10.1126/scitranslmed.aaa5657.


The transcription factor XBP1 is selectively required for eosinophil differentiation.

Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA, Weller PF, Glimcher LH.

Nat Immunol. 2015 Aug;16(8):829-37. doi: 10.1038/ni.3225. Epub 2015 Jul 6.


IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.

Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH.

Nat Commun. 2015 Jun 25;6:7562. doi: 10.1038/ncomms8562.


ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH.

Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11.


Pillars article: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000. 100: 655-669.

Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH.

J Immunol. 2015 Apr 1;194(7):2961-75. No abstract available.


Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.

Cameron TL, Gresshoff IL, Bell KM, Piróg KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF.

Osteoarthritis Cartilage. 2015 Apr;23(4):661-70. doi: 10.1016/j.joca.2015.01.001. Epub 2015 Jan 17.


Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties.

Singh A, Lester C, Drapp R, Hu DZ, Glimcher LH, Jones D.

Development. 2015 Feb 1;142(3):438-43. doi: 10.1242/dev.113571. Epub 2015 Jan 6.


Endoplasmic reticulum stress in immunity.

Bettigole SE, Glimcher LH.

Annu Rev Immunol. 2015;33:107-38. doi: 10.1146/annurev-immunol-032414-112116. Epub 2014 Dec 10. Review.


p38α MAPK is required for tooth morphogenesis and enamel secretion.

Greenblatt MB, Kim JM, Oh H, Park KH, Choo MK, Sano Y, Tye CE, Skobe Z, Davis RJ, Park JM, Bei M, Glimcher LH, Shim JH.

J Biol Chem. 2015 Jan 2;290(1):284-95. doi: 10.1074/jbc.M114.599274. Epub 2014 Nov 18.


Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

Ermann J, Staton T, Glickman JN, de Waal Malefyt R, Glimcher LH.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2559-66. doi: 10.1073/pnas.1408540111. Epub 2014 Jun 9.


XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH.

Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23.


NFATc1 and NFATc2 repress spontaneous osteoarthritis.

Greenblatt MB, Ritter SY, Wright J, Tsang K, Hu D, Glimcher LH, Aliprantis AO.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19914-9. doi: 10.1073/pnas.1320036110. Epub 2013 Nov 18.


T-bet: a bridge between innate and adaptive immunity.

Lazarevic V, Glimcher LH, Lord GM.

Nat Rev Immunol. 2013 Nov;13(11):777-89. doi: 10.1038/nri3536. Epub 2013 Oct 11. Review.


Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.

Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC.

J Clin Invest. 2013 Sep;123(9):4010-22. doi: 10.1172/JCI69443. Epub 2013 Aug 15.


The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.

Zou W, Greenblatt MB, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi SP, Baron R, Glimcher LH, Jones DC.

J Exp Med. 2013 Aug 26;210(9):1793-806. doi: 10.1084/jem.20111790. Epub 2013 Aug 5.


Mitogen-activated protein kinase pathways in osteoblasts.

Greenblatt MB, Shim JH, Glimcher LH.

Annu Rev Cell Dev Biol. 2013;29:63-79. doi: 10.1146/annurev-cellbio-101512-122347. Epub 2013 May 31. Review.


The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2013 May 15;13(5):558-569. doi: 10.1016/j.chom.2013.03.011. Retraction in: Cell Host Microbe. 2018 Apr 11;23 (4):571.


Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.

Park TY, Kim SH, Shin YC, Lee NH, Lee RK, Shim JH, Glimcher LH, Mook-Jung I, Cheong E, Kim WK, Honda F, Morio T, Lim JS, Lee SK.

J Control Release. 2013 Mar 28;166(3):307-15. doi: 10.1016/j.jconrel.2012.12.022. Epub 2013 Jan 5.


Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH.

Cell Metab. 2012 Oct 3;16(4):487-99. doi: 10.1016/j.cmet.2012.09.004.


After GWAS: mice to the rescue?

Ermann J, Glimcher LH.

Curr Opin Immunol. 2012 Oct;24(5):564-70. doi: 10.1016/j.coi.2012.09.005. Epub 2012 Sep 29. Review.


Control of bone resorption in mice by Schnurri-3.

Wein MN, Jones DC, Shim JH, Aliprantis AO, Sulyanto R, Lazarevic V, Poliachik SL, Gross TS, Glimcher LH.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8173-8. doi: 10.1073/pnas.1205848109. Epub 2012 May 9.


Translating research into therapies.

Glimcher LH, Lindvall O, Aguirre V, Topalian SL, Musunuru K, Fauci AS.

Cell. 2012 Mar 16;148(6):1077-8. No abstract available.


Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.

Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.

Hum Mol Genet. 2012 May 15;21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14.


Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z.

Neuron. 2012 Feb 9;73(3):445-52. doi: 10.1016/j.neuron.2011.11.026.


IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.

Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH.

J Exp Med. 2012 Feb 13;209(2):307-18. doi: 10.1084/jem.20111298. Epub 2012 Jan 30.


Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.

Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO.

Am J Pathol. 2012 Mar;180(3):1080-94. doi: 10.1016/j.ajpath.2011.11.024. Epub 2012 Jan 11.


Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W.

Mol Cell. 2011 Dec 9;44(5):721-33. doi: 10.1016/j.molcel.2011.09.024.


Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.

Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Péterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA.

Circ Cardiovasc Genet. 2012 Feb 1;5(1):66-72. doi: 10.1161/CIRCGENETICS.111.960864. Epub 2011 Dec 1.


Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.

Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH.

J Clin Invest. 2012 Jan;122(1):91-106. doi: 10.1172/JCI59466. Epub 2011 Dec 1. Erratum in: J Clin Invest. 2012 May 1;122(5):1948.


Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI.

J Biol Chem. 2012 Jan 20;287(4):2558-67. doi: 10.1074/jbc.M111.316760. Epub 2011 Nov 28.


The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

Hetz C, Martinon F, Rodriguez D, Glimcher LH.

Physiol Rev. 2011 Oct;91(4):1219-43. doi: 10.1152/physrev.00001.2011. Review.


MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.

Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH.

J Clin Invest. 2011 Nov;121(11):4383-92. doi: 10.1172/JCI59041. Epub 2011 Oct 3.


Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection.

Jones D, Glimcher LH, Aliprantis AO.

J Clin Invest. 2011 Jul;121(7):2534-42. doi: 10.1172/JCI46262. Epub 2011 Jul 1.


Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice.

Hess DA, Humphrey SE, Ishibashi J, Damsz B, Lee AH, Glimcher LH, Konieczny SF.

Gastroenterology. 2011 Oct;141(4):1463-72. doi: 10.1053/j.gastro.2011.06.045. Epub 2011 Jun 24.


T-bet in disease.

Lazarevic V, Glimcher LH.

Nat Immunol. 2011 Jun 20;12(7):597-606. doi: 10.1038/ni.2059. Review.


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