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Items: 1 to 50 of 120

1.

Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.

Song HY, Rellinger EJ, Park SH, Paul P, Qiao J, Vasilopoulos A, Ozden O, Gius D, Chung DH.

Anticancer Res. 2018 Feb;38(2):647-654.

PMID:
29374686
2.

Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury.

Zhu Y, Gius D.

Clin Cancer Res. 2018 Apr 1;24(7):1516-1517. doi: 10.1158/1078-0432.CCR-17-3276. Epub 2018 Jan 22.

PMID:
29358501
3.

Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.

Traver G, Mont S, Gius D, Lawson WE, Ding GX, Sekhar KR, Freeman ML.

Free Radic Biol Med. 2017 Nov;112:578-586. doi: 10.1016/j.freeradbiomed.2017.08.026. Epub 2017 Sep 1.

PMID:
28870520
4.

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Zou X, Ratti BA, O'Brien JG, Lautenschlager SO, Gius DR, Bonini MG, Zhu Y.

J Bioenerg Biomembr. 2017 Aug;49(4):325-333. doi: 10.1007/s10863-017-9718-8. Epub 2017 Jun 14. Review.

PMID:
28616679
5.

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2.

Traba J, Geiger SS, Kwarteng-Siaw M, Han K, Ra OH, Siegel RM, Gius D, Sack MN.

J Biol Chem. 2017 Jul 21;292(29):12153-12164. doi: 10.1074/jbc.M117.791715. Epub 2017 Jun 5.

PMID:
28584055
6.

SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth.

Zou X, Zhu Y, Park SH, Liu G, O'Brien J, Jiang H, Gius D.

Cancer Res. 2017 Aug 1;77(15):3990-3999. doi: 10.1158/0008-5472.CAN-16-2393. Epub 2017 May 23.

PMID:
28536275
7.

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.

Shi H, Deng HX, Gius D, Schumacker PT, Surmeier DJ, Ma YC.

Hum Mol Genet. 2017 May 15;26(10):1915-1926. doi: 10.1093/hmg/ddx100.

PMID:
28369333
8.

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.

Yang X, Park SH, Chang HC, Shapiro JS, Vassilopoulos A, Sawicki KT, Chen C, Shang M, Burridge PW, Epting CL, Wilsbacher LD, Jenkitkasemwong S, Knutson M, Gius D, Ardehali H.

J Clin Invest. 2017 Apr 3;127(4):1505-1516. doi: 10.1172/JCI88574. Epub 2017 Mar 13.

9.

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.

Jablonski RP, Kim SJ, Cheresh P, Williams DB, Morales-Nebreda L, Cheng Y, Yeldandi A, Bhorade S, Pardo A, Selman M, Ridge K, Gius D, Budinger GRS, Kamp DW.

FASEB J. 2017 Jun;31(6):2520-2532. doi: 10.1096/fj.201601077R. Epub 2017 Mar 3.

PMID:
28258190
10.

Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas.

Vidimar V, Gius D, Chakravarti D, Bulun SE, Wei JJ, Kim JJ.

Sci Adv. 2016 Nov 4;2(11):e1601132. eCollection 2016 Nov.

11.

SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.

Song HY, Biancucci M, Kang HJ, O'Callaghan C, Park SH, Principe DR, Jiang H, Yan Y, Satchell KF, Raparia K, Gius D, Vassilopoulos A.

Oncotarget. 2016 Dec 6;7(49):80336-80349. doi: 10.18632/oncotarget.12015.

12.

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.

Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D.

Antioxid Redox Signal. 2017 May 20;26(15):849-863. doi: 10.1089/ars.2016.6662. Epub 2016 Sep 8.

PMID:
27460777
13.

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.

Park SH, Ozden O, Liu G, Song HY, Zhu Y, Yan Y, Zou X, Kang HJ, Jiang H, Principe DR, Cha YI, Roh M, Vassilopoulos A, Gius D.

Cancer Res. 2016 Jul 1;76(13):3802-12. doi: 10.1158/0008-5472.CAN-15-2498. Epub 2016 Apr 27.

14.

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype.

Zou X, Santa-Maria CA, O'Brien J, Gius D, Zhu Y.

Antioxid Redox Signal. 2016 Aug 20;25(6):326-36. doi: 10.1089/ars.2016.6641. Epub 2016 Apr 15. Review.

15.

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.

Zhang H, Head PE, Daddacha W, Park SH, Li X, Pan Y, Madden MZ, Duong DM, Xie M, Yu B, Warren MD, Liu EA, Dhere VR, Li C, Pradilla I, Torres MA, Wang Y, Dynan WS, Doetsch PW, Deng X, Seyfried NT, Gius D, Yu DS.

Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4.

16.

G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes.

Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Gius DR, Saleem MA, Levi M.

J Am Soc Nephrol. 2016 May;27(5):1362-78. doi: 10.1681/ASN.2014121271. Epub 2015 Sep 30.

17.

The Makes Caterpillars Floppy (MCF)-Like Domain of Vibrio vulnificus Induces Mitochondrion-Mediated Apoptosis.

Agarwal S, Zhu Y, Gius DR, Satchell KJ.

Infect Immun. 2015 Nov;83(11):4392-403. doi: 10.1128/IAI.00570-15. Epub 2015 Sep 8.

18.

CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.

Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, Zou JX, Zhang T, Juma S, Jin C, Li RF, Perks J, Sun LQ, Vaughan AT, Hai CX, Gius DR, Li JJ.

Mol Cancer Ther. 2015 Sep;14(9):2090-102. doi: 10.1158/1535-7163.MCT-15-0017. Epub 2015 Jul 3.

19.

Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma.

Zhu Y, Paul P, Lee S, Craig BT, Rellinger EJ, Qiao J, Gius DR, Chung DH.

Surgery. 2015 Sep;158(3):827-36. doi: 10.1016/j.surg.2015.03.062. Epub 2015 Jun 16.

20.

Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain.

Antic I, Biancucci M, Zhu Y, Gius DR, Satchell KJ.

Nat Commun. 2015 Jun 8;6:7396. doi: 10.1038/ncomms8396.

21.

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice.

Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH.

Diabetes. 2015 Sep;64(9):3081-92. doi: 10.2337/db14-1810. Epub 2015 May 6.

22.

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.

Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP.

Nat Commun. 2015 Apr 14;6:6656. doi: 10.1038/ncomms7656.

23.

SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.

Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Gius D.

Cancer Metab. 2014 Oct 20;2:15. doi: 10.1186/2049-3002-2-15. eCollection 2014. Review.

24.

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Ozden O, Park SH, Wagner BA, Song HY, Zhu Y, Vassilopoulos A, Jung B, Buettner GR, Gius D.

Free Radic Biol Med. 2014 Nov;76:163-172. doi: 10.1016/j.freeradbiomed.2014.08.001. Epub 2014 Aug 22.

25.

WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.

Vassilopoulos A, Tominaga Y, Kim HS, Lahusen T, Li B, Yu H, Gius D, Deng CX.

Oncogene. 2015 Jun 4;34(23):3023-35. doi: 10.1038/onc.2014.239. Epub 2014 Aug 4.

26.

Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: image guidance and beyond.

Chi A, Nguyen NP, Welsh JS, Tse W, Monga M, Oduntan O, Almubarak M, Rogers J, Remick SC, Gius D.

Front Oncol. 2014 Jun 20;4:156. doi: 10.3389/fonc.2014.00156. eCollection 2014. Review.

27.

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.

Xu Y, Gao XD, Lee JH, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Gius D, Siziopikou KP, Peng J, Xiao X, Cheng C.

Genes Dev. 2014 Jun 1;28(11):1191-203. doi: 10.1101/gad.241968.114. Epub 2014 May 19.

28.

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer.

Desouki MM, Doubinskaia I, Gius D, Abdulkadir SA.

Hum Pathol. 2014 May;45(5):1071-7. doi: 10.1016/j.humpath.2014.01.004. Epub 2014 Jan 23.

29.

SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.

Vassilopoulos A, Pennington JD, Andresson T, Rees DM, Bosley AD, Fearnley IM, Ham A, Flynn CR, Hill S, Rose KL, Kim HS, Deng CX, Walker JE, Gius D.

Antioxid Redox Signal. 2014 Aug 1;21(4):551-64. doi: 10.1089/ars.2013.5420. Epub 2014 Mar 6.

30.

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.

Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J.

Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19.

31.

Metabolic regulation of Sirtuins upon fasting and the implication for cancer.

Zhu Y, Yan Y, Gius DR, Vassilopoulos A.

Curr Opin Oncol. 2013 Nov;25(6):630-6. doi: 10.1097/01.cco.0000432527.49984.a3. Review.

32.

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR.

Antioxid Redox Signal. 2014 Mar 20;20(9):1423-35. doi: 10.1089/ars.2012.5091. Epub 2013 Sep 28.

33.

SIRT2 directs the replication stress response through CDK9 deacetylation.

Zhang H, Park SH, Pantazides BG, Karpiuk O, Warren MD, Hardy CW, Duong DM, Park SJ, Kim HS, Vassilopoulos A, Seyfried NT, Johnsen SA, Gius D, Yu DS.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13546-51. doi: 10.1073/pnas.1301463110. Epub 2013 Jul 29.

34.

Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis.

Tao R, Vassilopoulos A, Parisiadou L, Yan Y, Gius D.

Antioxid Redox Signal. 2014 Apr 1;20(10):1646-54. doi: 10.1089/ars.2013.5482. Epub 2013 Sep 14. Review.

35.

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.

Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR.

Radiat Res. 2013 Aug;180(2):156-65. doi: 10.1667/RR3293.1. Epub 2013 Jul 2.

36.

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.

Liang Q, Benavides GA, Vassilopoulos A, Gius D, Darley-Usmar V, Zhang J.

Biochem J. 2013 Sep 1;454(2):249-57. doi: 10.1042/BJ20130414.

37.

Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.

Shankavaram U, Fliedner SM, Elkahloun AG, Barb JJ, Munson PJ, Huynh TT, Matro JC, Turkova H, Linehan WM, Timmers HJ, Tischler AS, Powers JF, de Krijger R, Baysal BE, Takacova M, Pastorekova S, Gius D, Lehnert H, Camphausen K, Pacak K.

Neoplasia. 2013 Apr;15(4):435-47.

38.

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.

Nottingham LK, Yan CH, Yang X, Si H, Coupar J, Bian Y, Cheng TF, Allen C, Arun P, Gius D, Dang L, Van Waes C, Chen Z.

Oncogene. 2014 Feb 27;33(9):1135-47. doi: 10.1038/onc.2013.49. Epub 2013 Mar 4.

39.

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.

Park SH, Zhu Y, Ozden O, Kim HS, Jiang H, Deng CX, Gius D, Vassilopoulos A.

Transl Cancer Res. 2012 Jun 1;1(1):15-21. Epub 2012 May 22.

40.

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity.

Zhu Y, Park SH, Ozden O, Kim HS, Jiang H, Vassilopoulos A, Spitz DR, Gius D.

Free Radic Biol Med. 2012 Aug 15;53(4):828-33. doi: 10.1016/j.freeradbiomed.2012.06.020. Epub 2012 Jun 23. Review.

41.

SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis.

Haigis MC, Deng CX, Finley LW, Kim HS, Gius D.

Cancer Res. 2012 May 15;72(10):2468-72. doi: 10.1158/0008-5472.CAN-11-3633.

42.

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR.

Free Radic Biol Med. 2012 Jan 15;52(2):436-43. doi: 10.1016/j.freeradbiomed.2011.10.493. Epub 2011 Nov 4.

43.

Sirt3, mitochondrial ROS, ageing, and carcinogenesis.

Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS.

Int J Mol Sci. 2011;12(9):6226-39. doi: 10.3390/ijms12096226. Epub 2011 Sep 23. Review.

44.

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX.

Cancer Cell. 2011 Oct 18;20(4):487-99. doi: 10.1016/j.ccr.2011.09.004.

45.

Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.

Wang J, Anderson PD, Luo W, Gius D, Roh M, Abdulkadir SA.

Oncogene. 2012 Apr 5;31(14):1794-803. doi: 10.1038/onc.2011.371. Epub 2011 Aug 22.

46.

The human sirtuin family: evolutionary divergences and functions.

Vassilopoulos A, Fritz KS, Petersen DR, Gius D.

Hum Genomics. 2011 Jul;5(5):485-96.

47.

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.

Ozden O, Park SH, Kim HS, Jiang H, Coleman MC, Spitz DR, Gius D.

Aging (Albany NY). 2011 Feb;3(2):102-7. Review.

48.

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D.

Mol Cell. 2010 Dec 22;40(6):893-904. doi: 10.1016/j.molcel.2010.12.013.

49.

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR.

Biochem J. 2011 Feb 1;433(3):505-14. doi: 10.1042/BJ20100791.

50.

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Deng CX.

J Biol Chem. 2010 Nov 19;285(47):36776-84. doi: 10.1074/jbc.M110.168039. Epub 2010 Sep 16.

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