Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 147

1.

A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16╬▒-carbonitrile.

Bailey I, Gibson GG, Plant K, Graham M, Plant N.

PLoS One. 2011 Feb 2;6(2):e16703. doi: 10.1371/journal.pone.0016703.

2.

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.

Plant KE, Anderson E, Simecek N, Brown R, Forster S, Spinks J, Toms N, Gibson GG, Lyon J, Plant N.

Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34. doi: 10.1016/j.taap.2008.10.019. Epub 2008 Dec 6.

PMID:
19101580
3.

In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein.

Howe K, Gibson GG, Coleman T, Plant N.

Drug Metab Dispos. 2009 Feb;37(2):391-9. doi: 10.1124/dmd.108.022921. Epub 2008 Nov 20.

4.
5.

Transcriptional regulation of the human pregnane-X receptor.

Gibson GG, Phillips A, Aouabdi S, Plant K, Plant N.

Drug Metab Rev. 2006;38(1-2):31-49. Review.

PMID:
16684647
6.

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression.

Phillips A, Hood SR, Gibson GG, Plant NJ.

Drug Metab Dispos. 2005 Feb;33(2):233-42. Epub 2004 Nov 2.

7.

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.

Bombail V, Taylor K, Gibson GG, Plant N.

Drug Metab Dispos. 2004 May;32(5):525-35.

8.

Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression.

Ulrich RG, Rockett JC, Gibson GG, Pettit SD.

Environ Health Perspect. 2004 Mar;112(4):423-7.

9.

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.

Crunkhorn SE, Plant KE, Gibson GG, Kramer K, Lyon J, Lord PG, Plant NJ.

Biochem Pharmacol. 2004 Jan 1;67(1):107-18.

PMID:
14667933
10.

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis.

Coulson M, Gibson GG, Plant N, Hammond T, Graham M.

Toxicol Appl Pharmacol. 2003 Oct 15;192(2):154-63.

PMID:
14550749
11.

Evaluation of the toxicological relevance of CYP3A4 induction.

Plant NJ, Gibson GG.

Curr Opin Drug Discov Devel. 2003 Jan;6(1):50-6. Review.

PMID:
12613276
12.

Learning disabilities, professionalism, and the practice of medical education.

Hafferty FW, Gibson GG.

Acad Med. 2003 Feb;78(2):189-201.

PMID:
12584098
13.

Receptor-dependent regulation of the CYP3A4 gene.

Gibson GG, el-Sankary W, Plant NJ.

Toxicology. 2002 Dec 27;181-182:199-202.

PMID:
12505310
15.
16.

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

Gibson GG, Plant NJ, Swales KE, Ayrton A, El-Sankary W.

Xenobiotica. 2002 Mar;32(3):165-206. Review.

PMID:
11958559
17.

The transcription of the peroxisome proliferator-activated receptor alpha gene is regulated by protein kinase C.

Yaacob NS, Norazmi MN, Gibson GG, Kass GE.

Toxicol Lett. 2001 Dec 15;125(1-3):133-41.

PMID:
11701232
18.

Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers.

El-Sankary W, Gibson GG, Ayrton A, Plant N.

Drug Metab Dispos. 2001 Nov;29(11):1499-504.

19.

Learning disabilities and the meaning of medical education.

Hafferty FW, Gibson GG.

Acad Med. 2001 Oct;76(10):1027-31. No abstract available.

PMID:
11597841
21.

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors.

El-Sankary W, Plant NJ, Gibson GG, Moore DJ.

Drug Metab Dispos. 2000 May;28(5):493-6.

22.

Control and statistical analysis of in vitro reporter gene assays.

Plant NJ, Ogg M, Crowder M, Gibson GG.

Anal Biochem. 2000 Feb 15;278(2):170-4.

PMID:
10660459
23.

Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential.

Rockett JC, Esdaile DJ, Gibson GG.

Xenobiotica. 1999 Jul;29(7):655-91. Review.

PMID:
10456687
24.

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Ogg MS, Williams JM, Tarbit M, Goldfarb PS, Gray TJ, Gibson GG.

Xenobiotica. 1999 Mar;29(3):269-79.

PMID:
10219967
25.

Developmental modulation of cysteine conjugate beta-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain.

Plant N, Kitchen I, Goldfarb PS, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):335-9.

PMID:
9512931
26.

Molecular profiling of non-genotoxic hepatocarcinogenesis using differential display reverse transcription-polymerase chain reaction (ddRT-PCR).

Rockett JC, Esdaile DJ, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):329-33.

PMID:
9512930
27.

An epitope-tagging system for studying regulation of the peroxisome proliferator activated receptor alpha (PPAR alpha).

Owens JM, Tugwood JD, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):325-8.

PMID:
9512929
28.

Use of competitive RT-PCR in the molecular analysis of peroxisome proliferation.

Yaacob NS, Norazmi MN, Kass GE, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):321-4.

PMID:
9512928
29.
30.

Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.

Ogg MS, Gray TJ, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1997 Oct-Dec;22(4):311-3.

PMID:
9512926
31.

Ascorbic acid deficiency decreases the expression of CYP4A1 in liver microsomes of guinea pigs.

Roomi MW, Ogg M, Tsao CS, Gibson GG.

Res Commun Mol Pathol Pharmacol. 1997 Jan;95(1):3-10.

PMID:
9055344
32.

Peroxisome proliferators and cytochrome P4504A induction.

Gibson GG.

Ann N Y Acad Sci. 1996 Dec 27;804:328-40. No abstract available.

PMID:
8993554
33.
34.

Human safety assessment of xenobiotics.

Gibson GG.

Xenobiotica. 1995 Nov;25(11):1167-8. No abstract available.

PMID:
8592866
35.

Diverse mechanisms of calcium mobilization by peroxisome proliferators in rat hepatocytes.

Shackleton GL, Gibson GG, Sharma RK, Howes D, Orrenius S, Kass GE.

Toxicol Appl Pharmacol. 1995 Feb;130(2):294-303.

PMID:
7871541
36.

Coordinate induction of hepatic fatty acyl-CoA oxidase and P4504A1 in rat after activation of the peroxisome proliferator-activated receptor (PPAR) by sulphur-substituted fatty acid analogues.

Demoz A, Vaagenes H, Aarsaether N, Hvattum E, Skorve J, G├Âttlicher M, Lillehaug JR, Gibson GG, Gustafsson JA, Hood S, et al.

Xenobiotica. 1994 Sep;24(9):943-56.

PMID:
7810175
37.

Molecular toxicology of peroxisome proliferators.

McNae F, Sharma R, Gibson GG.

Eur J Drug Metab Pharmacokinet. 1994 Jul-Sep;19(3):219-23.

PMID:
7867664
38.

Induction of hepatic microsomal CYP4A activity and of peroxisomal beta-oxidation by two non-steroidal anti-inflammatory drugs.

Rekka E, Ayalogu EO, Lewis DF, Gibson GG, Ioannides C.

Arch Toxicol. 1994;68(2):73-8.

PMID:
8179485
39.

Chlorotrifluoroethylene trimer and tetramer are inducers of the CYP4A subfamily.

Diaz MJ, Chinje E, Kentish P, Jarnot B, George M, Gibson GG.

Biochem Pharmacol. 1993 Sep 14;46(6):1076-80.

PMID:
8216351
40.

Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase.

Perry SJ, Schofield MA, MacFarlane M, Lock EA, King LJ, Gibson GG, Goldfarb PS.

Mol Pharmacol. 1993 May;43(5):660-5.

PMID:
8502223
41.

Peroxisome proliferators: paradigms and prospects.

Gibson GG.

Toxicol Lett. 1993 May;68(1-2):193-201. Review.

PMID:
8390728
42.

Radiative climate forcing by the mount pinatubo eruption.

Minnis P, Harrison EF, Stowe LL, Gibson GG, Denn FM, Doelling DR, Smith WL Jr.

Science. 1993 Mar 5;259(5100):1411-5.

PMID:
17801273
43.

Dose-dependent induction or depression of cysteine conjugate beta-lyase in rat kidney by N-acetyl-S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-L-cysteine.

MacFarlane M, Schofield M, Parker N, Roelandt L, David M, Lock EA, King LJ, Goldfarb PS, Gibson GG.

Toxicology. 1993 Jan 29;77(1-2):133-44.

PMID:
8442009
44.

Peroxisome proliferators, a unique set of drug-metabolizing enzyme inducers: commentary on a symposium.

Moody DE, Gibson GG, Grant DF, Magdalou J, Rao MS.

Drug Metab Dispos. 1992 Nov-Dec;20(6):779-91. Review. No abstract available.

PMID:
1362927
45.
46.

Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene.

Richardson TH, Schenkman JB, Turcan R, Goldfarb PS, Gibson GG.

Xenobiotica. 1992 Jun;22(6):621-31.

PMID:
1441586
47.

Alternatives to Aroclor 1254-induced S9 in in vitro genotoxicity assays.

Elliott BM, Combes RD, Elcombe CR, Gatehouse DG, Gibson GG, Mackay JM, Wolf RC.

Mutagenesis. 1992 May;7(3):175-7.

PMID:
1602970
48.

Species and congener specific induction of hepatic cytochrome P4504A by polychlorinated biphenyls.

Huang S, Gibson GG.

Biochem Pharmacol. 1992 Feb 4;43(3):637-9. No abstract available.

PMID:
1540218
49.
50.

Supplemental Content

Loading ...
Support Center