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Items: 1 to 50 of 69

1.

miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders.

Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M.

EMBO Mol Med. 2018 Jan 26. pii: e8046. doi: 10.15252/emmm.201708046. [Epub ahead of print]

2.

Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling.

Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL.

Elife. 2018 Jan 16;7. pii: e31684. doi: 10.7554/eLife.31684.

3.

Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.

Mendiara I, Domeño C, Nerín C, Geurts AM, Osada J, Martínez-Beamonte R.

J Pharm Biomed Anal. 2018 Feb 20;150:396-405. doi: 10.1016/j.jpba.2017.12.033. Epub 2017 Dec 21.

PMID:
29288965
4.

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats.

Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH.

J Vis Exp. 2017 Dec 5;(130). doi: 10.3791/56133.

PMID:
29286398
5.

Nitric oxide production by glomerular podocytes.

Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A.

Nitric Oxide. 2018 Jan 30;72:24-31. doi: 10.1016/j.niox.2017.11.005. Epub 2017 Nov 8.

PMID:
29128399
6.

In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit.

Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S.

Hum Mol Genet. 2017 Dec 1;26(23):4541-4555. doi: 10.1093/hmg/ddx333.

PMID:
28973657
7.

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A.

JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. [Epub ahead of print]

8.

Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain.

Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M.

Physiol Genomics. 2017 Sep 1;49(9):496-504. doi: 10.1152/physiolgenomics.00063.2017. Epub 2017 Jul 28.

PMID:
28754823
9.

Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.

Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A.

Breast Cancer Res Treat. 2017 Aug;165(1):53-64. doi: 10.1007/s10549-017-4311-8. Epub 2017 May 31.

PMID:
28567545
10.

Intravital imaging of the kidney in a rat model of salt-sensitive hypertension.

Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F163-F173. doi: 10.1152/ajprenal.00466.2016. Epub 2017 Apr 12.

PMID:
28404591
11.

Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.

Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER.

Exp Lung Res. 2017 Feb;43(1):38-48. doi: 10.1080/01902148.2017.1286697. Epub 2017 Mar 7.

PMID:
28266889
12.

Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection.

Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM.

Stem Cell Reports. 2017 Mar 14;8(3):491-499. doi: 10.1016/j.stemcr.2017.01.021. Epub 2017 Feb 24.

13.

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.

McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM.

PLoS One. 2017 Feb 3;12(2):e0170458. doi: 10.1371/journal.pone.0170458. eCollection 2017.

14.

A RATional choice for translational research?

Aitman T, Dhillon P, Geurts AM.

Dis Model Mech. 2016 Oct 1;9(10):1069-1072.

15.

Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.

McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM.

Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.

16.

Gene Editing: Practical Application in the Lab.

Geurts AM, Ekker SC.

Hum Gene Ther. 2016 Jun;27(6):417-8. doi: 10.1089/hum.2016.29029.amg. No abstract available. Erratum in: Hum Gene Ther. 2016 Jul;27(7):559.

17.

p66Shc regulates renal vascular tone in hypertension-induced nephropathy.

Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A.

J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

18.

The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.

Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ.

J Biol Chem. 2016 Jul 15;291(29):14939-53. doi: 10.1074/jbc.M116.730481. Epub 2016 May 19.

19.

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E.

Sci Rep. 2016 Feb 26;6:22154. doi: 10.1038/srep22154.

20.

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease.

Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M.

J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701.

21.

Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.

Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR.

J Appl Physiol (1985). 2016 May 1;120(9):1070-81. doi: 10.1152/japplphysiol.01015.2015. Epub 2016 Feb 11.

22.

Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.

Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JL, Lawlor MW, Dimmock DP.

Free Radic Biol Med. 2016 Mar;92:141-51. doi: 10.1016/j.freeradbiomed.2016.01.001. Epub 2016 Jan 8.

23.

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction.

Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH.

Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87. doi: 10.1152/ajpheart.00586.2015. Epub 2015 Dec 4.

24.

Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.

Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M.

Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3.

25.

Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells.

Hegan PS, Ostertag E, Geurts AM, Mooseker MS.

Cytoskeleton (Hoboken). 2015 Oct;72(10):503-16. doi: 10.1002/cm.21259. Epub 2015 Oct 23.

26.

Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.

Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA.

Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.

27.

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta.

Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O.

J Vis Exp. 2015 Jun 10;(100):e52734. doi: 10.3791/52734.

28.

Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.

Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M.

Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24.

29.

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H.

Genetics. 2015 Jun;200(2):423-30. doi: 10.1534/genetics.115.176594. Epub 2015 Mar 27.

30.

Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.

Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL.

Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.

31.

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ.

Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.

32.

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.

Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R379-90. doi: 10.1152/ajpregu.00256.2014. Epub 2014 Dec 24.

33.

Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.

Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr.

Hypertension. 2015 Feb;65(2):447-55. doi: 10.1161/HYPERTENSIONAHA.114.04179. Epub 2014 Dec 1.

34.

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ.

PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

35.

CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.

Cancer Res. 2014 Nov 15;74(22):6419-29. doi: 10.1158/0008-5472.CAN-13-3212. Epub 2014 Aug 29.

36.

Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.

Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.

37.

HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.

Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM.

Hypertension. 2014 Sep;64(3):541-50. doi: 10.1161/HYPERTENSIONAHA.114.03549. Epub 2014 Jun 16.

38.

CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.

Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL; PhysGen Knockout Program.

Hypertension. 2014 Mar;63(3):559-64. doi: 10.1161/HYPERTENSIONAHA.113.02191. Epub 2013 Dec 16.

39.

Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.

Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH.

Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.

40.

Identifying multiple causative genes at a single GWAS locus.

Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C.

Genome Res. 2013 Dec;23(12):1996-2002. doi: 10.1101/gr.160283.113. Epub 2013 Sep 4.

41.

Gene targeting in NOD mouse embryos using zinc-finger nucleases.

Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM.

Diabetes. 2014 Jan;63(1):68-74. doi: 10.2337/db13-0192. Epub 2013 Aug 23.

42.

Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.

Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA.

Neuropharmacology. 2014 Jan;76 Pt B:250-8. doi: 10.1016/j.neuropharm.2013.05.047. Epub 2013 Jun 18.

43.

Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains.

Yang S, Takizawa A, Foeckler J, Zappa A, Gjoka M, Schilling R, Hansen C, Xu H, Kalloway S, Grzybowski M, Davis GD, Jacob HJ, Geurts AM.

Stem Cells Dev. 2013 May 1. doi: 10.1089/scd.2012.0416. Epub 2013 May 1. Retraction in: Stem Cells Dev. 2013 Oct 15;22(20):2813.

PMID:
23635087
44.

Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage.

Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R407-14. doi: 10.1152/ajpregu.00304.2012. Epub 2013 Jan 30.

45.

Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury.

Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ.

Physiol Genomics. 2013 Feb 4;45(3):110-8. doi: 10.1152/physiolgenomics.00119.2012. Epub 2012 Dec 18.

46.

Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.

Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z.

FASEB J. 2013 Mar;27(3):930-41. doi: 10.1096/fj.12-205526. Epub 2012 Nov 29.

47.

Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.

Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr.

Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.

48.

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U.

Stem Cells Int. 2011;2011:717069. doi: 10.4061/2011/717069. Epub 2011 Oct 2.

49.

The emerging role for rat models in gene discovery.

Dwinell MR, Lazar J, Geurts AM.

Mamm Genome. 2011 Aug;22(7-8):466-75. doi: 10.1007/s00335-011-9346-2. Epub 2011 Jul 6. Review.

50.

Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase.

Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y.

Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.

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