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Items: 27


Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.

Jing E, Sundararajan P, Majumdar ID, Hazarika S, Fowler S, Szeto A, Gesta S, Mendez AJ, Vishnudas VK, Sarangarajan R, Narain NR.

Nutr Metab (Lond). 2018 Feb 2;15:11. doi: 10.1186/s12986-018-0242-6. eCollection 2018.


A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells.

Yang J, Hagen J, Guntur KV, Allette K, Schuyler S, Ranjan J, Petralia F, Gesta S, Sebra R, Mahajan M, Zhang B, Zhu J, Houten S, Kasarskis A, Vishnudas VK, Akmaev VR, Sarangarajan R, Narain NR, Schadt EE, Argmann CA, Tu Z.

BMC Genomics. 2017 Dec 22;18(1):987. doi: 10.1186/s12864-017-4359-1.


Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses.

Dowal L, Parameswaran P, Phat S, Akella S, Majumdar ID, Ranjan J, Shah C, Mogre S, Guntur K, Thapa K, Gesta S, Vishnudas VK, Narain NR, Sarangarajan R.

Mediators Inflamm. 2017;2017:9067049. doi: 10.1155/2017/9067049. Epub 2017 Mar 26.


Identification of Filamin-A and -B as potential biomarkers for prostate cancer.

Narain NR, Diers AR, Lee A, Lao S, Chan JY, Schofield S, Andreazi J, Ouro-Djobo R, Jimenez JJ, Friss T, Tanna N, Dalvi A, Wang S, Bunch D, Sun Y, Wu W, Thapa K, Gesta S, Rodrigues LO, Akmaev VR, Vishnudas VK, Sarangarajan R.

Future Sci OA. 2016 Dec 22;3(1):FSO161. doi: 10.4155/fsoa-2016-0065. eCollection 2017 Mar.


Reduced expression of collagen VI alpha 3 (COL6A3) confers resistance to inflammation-induced MCP1 expression in adipocytes.

Gesta S, Guntur K, Majumdar ID, Akella S, Vishnudas VK, Sarangarajan R, Narain NR.

Obesity (Silver Spring). 2016 Aug;24(8):1695-703. doi: 10.1002/oby.21565. Epub 2016 Jun 17.


Shox2 is a molecular determinant of depot-specific adipocyte function.

Lee KY, Yamamoto Y, Boucher J, Winnay JN, Gesta S, Cobb J, Blüher M, Kahn CR.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11409-14. doi: 10.1073/pnas.1310331110. Epub 2013 Jun 24. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2347.


Intrinsic differences in adipocyte precursor cells from different white fat depots.

Macotela Y, Emanuelli B, Mori MA, Gesta S, Schulz TJ, Tseng YH, Kahn CR.

Diabetes. 2012 Jul;61(7):1691-9. doi: 10.2337/db11-1753. Epub 2012 May 17.


The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation.

Lee KY, Gesta S, Boucher J, Wang XL, Kahn CR.

Cell Metab. 2011 Oct 5;14(4):491-503. doi: 10.1016/j.cmet.2011.08.006.


Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.

Gesta S, Bezy O, Mori MA, Macotela Y, Lee KY, Kahn CR.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2771-6. doi: 10.1073/pnas.1019704108. Epub 2011 Jan 31.


Adipose depots possess unique developmental gene signatures.

Yamamoto Y, Gesta S, Lee KY, Tran TT, Saadatirad P, Kahn CR.

Obesity (Silver Spring). 2010 May;18(5):872-878. doi: 10.1038/oby.2009.512. Epub 2010 Jan 28. Erratum in: Obesity (Silver Spring). 2010 May;18(5):1064.


Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. doi: 10.2337/db09-0362. Epub 2009 Aug 31.


Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice.

Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME.

Diabetes. 2009 Feb;58(2):460-8. doi: 10.2337/db08-0490. Epub 2008 Nov 18.


Beneficial effects of subcutaneous fat transplantation on metabolism.

Tran TT, Yamamoto Y, Gesta S, Kahn CR.

Cell Metab. 2008 May;7(5):410-20. doi: 10.1016/j.cmet.2008.04.004.


Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.

Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR.

Aging Cell. 2007 Dec;6(6):827-39.


Developmental origin of fat: tracking obesity to its source.

Gesta S, Tseng YH, Kahn CR.

Cell. 2007 Oct 19;131(2):242-56. Review. Erratum in: Cell. 2008 Oct 17;135(2):366.


TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.

Bezy O, Vernochet C, Gesta S, Farmer SR, Kahn CR.

Mol Cell Biol. 2007 Oct;27(19):6818-31. Epub 2007 Jul 23.


TNFalpha up-regulates apelin expression in human and mouse adipose tissue.

Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, Ayav A, Ziegler O, Carpene C, Saulnier-Blache JS, Valet P, Castan-Laurell I.

FASEB J. 2006 Jul;20(9):1528-30. Epub 2006 May 24.


Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

Gesta S, Blüher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, Boucher J, Lewis C, Kahn CR.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6676-81. Epub 2006 Apr 14.


Apelin, a newly identified adipokine up-regulated by insulin and obesity.

Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, Castan-Laurell I, Tack I, Knibiehler B, Carpéné C, Audigier Y, Saulnier-Blache JS, Valet P.

Endocrinology. 2005 Apr;146(4):1764-71. Epub 2005 Jan 27.


Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.

Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR.

J Biol Chem. 2004 Jul 23;279(30):31891-901. Epub 2004 May 6.


Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression.

Gesta S, Lolmède K, Daviaud D, Berlan M, Bouloumié A, Lafontan M, Valet P, Saulnier-Blache JS.

Horm Metab Res. 2003 Mar;35(3):158-63.


Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity.

Ferry G, Tellier E, Try A, Grés S, Naime I, Simon MF, Rodriguez M, Boucher J, Tack I, Gesta S, Chomarat P, Dieu M, Raes M, Galizzi JP, Valet P, Boutin JA, Saulnier-Blache JS.

J Biol Chem. 2003 May 16;278(20):18162-9. Epub 2003 Mar 17.


MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.

Roulet A, Puel O, Gesta S, Lepage JF, Drag M, Soll M, Alvinerie M, Pineau T.

Eur J Pharmacol. 2003 Jan 24;460(2-3):85-91.


Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis.

Gesta S, Simon MF, Rey A, Sibrac D, Girard A, Lafontan M, Valet P, Saulnier-Blache JS.

J Lipid Res. 2002 Jun;43(6):904-10.


[Development of nutritional obesity in transgenic mice with an adrenergic receptivity in adipose tissue comparable with that of humans].

Castan-Laurell I, Boucher J, Rey A, Sibrac D, Gesta S, Pagès C, Daviaud D, Simon MF, Lafontan M, Saulnier-Blachet JS, Valet P.

Pathol Biol (Paris). 2002 Feb;50(1):52-7. French.


In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue.

Gesta S, Hejnova J, Berlan M, Daviaud D, Crampes F, Stich V, Valet P, Saulnier-Blache JS.

Horm Metab Res. 2001 Dec;33(12):701-7.


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