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Development of the Enteric Nervous System: A Genetic Guide to the Perplexed.

Gershon MD.

Gastroenterology. 2018 Feb;154(3):478-480. doi: 10.1053/j.gastro.2018.01.012. Epub 2018 Jan 11. No abstract available.


Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis.

Gross Margolis K, Vittorio J, Talavera M, Gluck K, Li Z, Iuga A, Stevanovic K, Saurman V, Israelyan N, Welch MG, Gershon MD.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G386-G398. doi: 10.1152/ajpgi.00215.2017. Epub 2017 Aug 3.


Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice.

Rao M, Rastelli D, Dong L, Chiu S, Setlik W, Gershon MD, Corfas G.

Gastroenterology. 2017 Oct;153(4):1068-1081.e7. doi: 10.1053/j.gastro.2017.07.002. Epub 2017 Jul 13.


Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

Middelhoff M, Westphalen CB, Hayakawa Y, Yan KS, Gershon MD, Wang TC, Quante M.

Am J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G285-G299. doi: 10.1152/ajpgi.00073.2017. Epub 2017 Jul 6. Review.


Neurogastroenterology: The dynamic cycle of life in the enteric nervous system.

Rao M, Gershon MD.

Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):453-454. doi: 10.1038/nrgastro.2017.85. Epub 2017 Jun 28. No abstract available.



Gershon AA, Gershon MD.

Trans Am Clin Climatol Assoc. 2016;127:282-299.


Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.

Hayakawa Y, Sakitani K, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.

Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15.


Enteric Neuronal Regulation of Intestinal Inflammation.

Margolis KG, Gershon MD.

Trends Neurosci. 2016 Sep;39(9):614-624. doi: 10.1016/j.tins.2016.06.007. Epub 2016 Jul 20. Review.


The bowel and beyond: the enteric nervous system in neurological disorders.

Rao M, Gershon MD.

Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):517-28. doi: 10.1038/nrgastro.2016.107. Epub 2016 Jul 20. Review.


Safety and Immunogenicity of the Recombinant BCG Vaccine AERAS-422 in Healthy BCG-naïve Adults: A Randomized, Active-controlled, First-in-human Phase 1 Trial.

Hoft DF, Blazevic A, Selimovic A, Turan A, Tennant J, Abate G, Fulkerson J, Zak DE, Walker R, McClain B, Sadoff J, Scott J, Shepherd B, Ishmukhamedov J, Hokey DA, Dheenadhayalan V, Shankar S, Amon L, Navarro G, Podyminogin R, Aderem A, Barker L, Brennan M, Wallis RS, Gershon AA, Gershon MD, Steinberg S.

EBioMedicine. 2016 May;7:278-86. doi: 10.1016/j.ebiom.2016.04.010. Epub 2016 Apr 19.


Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract.

Margolis KG, Gershon MD, Bogunovic M.

Trends Immunol. 2016 Jul;37(7):487-501. doi: 10.1016/ Epub 2016 Jun 9. Review.


Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD.

J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25.


White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.

Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P.

Dev Biol. 2016 Sep 15;417(2):229-51. doi: 10.1016/j.ydbio.2016.04.001. Epub 2016 Apr 5. Review.


5-HT4-mediated neuroprotection: a new therapeutic modality on the way?

Gershon MD.

Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G766-7. doi: 10.1152/ajpgi.00120.2016. Epub 2016 Mar 24. No abstract available.


A sexually dimorphic effect of cholera toxin: rapid changes in colonic motility mediated via a 5-HT3 receptor-dependent pathway in female C57Bl/6 mice.

Balasuriya GK, Hill-Yardin EL, Gershon MD, Bornstein JC.

J Physiol. 2016 Aug 1;594(15):4325-38. doi: 10.1113/JP272071. Epub 2016 May 12.


Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L.

Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10.


Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.

Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC.

Cancer Cell. 2015 Dec 14;28(6):800-814. doi: 10.1016/j.ccell.2015.10.003. Epub 2015 Nov 12.


Rebuttal from Terence K. Smith and Michael D. Gershon.

Smith TK, Gershon MD.

J Physiol. 2015 Aug 1;593(15):3233. doi: 10.1113/JP270683. No abstract available.


CrossTalk proposal: 5-HT is necessary for peristalsis.

Smith TK, Gershon MD.

J Physiol. 2015 Aug 1;593(15):3225-7. doi: 10.1113/JP270182. No abstract available.


Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system.

Rao M, Nelms BD, Dong L, Salinas-Rios V, Rutlin M, Gershon MD, Corfas G.

Glia. 2015 Jun 29. doi: 10.1002/glia.22876. [Epub ahead of print]


Use of Saliva to Identify Varicella Zoster Virus Infection of the Gut.

Gershon AA, Chen J, Gershon MD.

Clin Infect Dis. 2015 Aug 15;61(4):536-44. doi: 10.1093/cid/civ320. Epub 2015 Apr 16.


Bugs, guts, and glia: how microbiota influence enteric gliogenesis and migration.

Rao M, Gershon MD.

Neuron. 2015 Jan 21;85(2):229-30. doi: 10.1016/j.neuron.2014.12.066.


Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.

Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.


Varicella zoster virus infection.

Gershon AA, Breuer J, Cohen JI, Cohrs RJ, Gershon MD, Gilden D, Grose C, Hambleton S, Kennedy PG, Oxman MN, Seward JF, Yamanishi K.

Nat Rev Dis Primers. 2015 Jul 2;1:15016. doi: 10.1038/nrdp.2015.16. Review.


Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility.

Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M.

Cell. 2014 Aug 28;158(5):1210. doi: 10.1016/j.cell.2014.08.002. Epub 2014 Aug 28. No abstract available.


Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice.

Welch MG, Margolis KG, Li Z, Gershon MD.

Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G848-62. doi: 10.1152/ajpgi.00176.2014. Epub 2014 Aug 21.


Denervation suppresses gastric tumorigenesis.

Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, Flatberg A, Johannessen H, Friedman RA, Renz BW, Sandvik AK, Beisvag V, Tomita H, Hara A, Quante M, Li Z, Gershon MD, Kaneko K, Fox JG, Wang TC, Chen D.

Sci Transl Med. 2014 Aug 20;6(250):250ra115. doi: 10.1126/scitranslmed.3009569.


Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.

Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M.

Cell. 2014 Jul 17;158(2):300-313. doi: 10.1016/j.cell.2014.04.050. Erratum in: Cell. 2014 Aug 28;158(5):1210. Dosage error in article text.


Infected peripheral blood mononuclear cells transmit latent varicella zoster virus infection to the guinea pig enteric nervous system.

Gan L, Wang M, Chen JJ, Gershon MD, Gershon AA.

J Neurovirol. 2014 Oct;20(5):442-56. doi: 10.1007/s13365-014-0259-1. Epub 2014 Jun 26.


Long-lived intestinal tuft cells serve as colon cancer-initiating cells.

Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC.

J Clin Invest. 2014 Mar;124(3):1283-95.


Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase 1.

Heredia DJ, Gershon MD, Koh SD, Corrigan RD, Okamoto T, Smith TK.

J Physiol. 2013 Dec 1;591(23):5939-57. doi: 10.1113/jphysiol.2013.256230. Epub 2013 Oct 14.


Pathogenesis and current approaches to control of varicella-zoster virus infections.

Gershon AA, Gershon MD.

Clin Microbiol Rev. 2013 Oct;26(4):728-43. doi: 10.1128/CMR.00052-13. Review.


Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.

Margolis KG, Stevanovic K, Li Z, Yang QM, Oravecz T, Zambrowicz B, Jhaver KG, Diacou A, Gershon MD.

Gut. 2014 Jun;63(6):928-37. doi: 10.1136/gutjnl-2013-304901. Epub 2013 Jun 7.


Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense.

Gershon MD.

Trans Am Clin Climatol Assoc. 2012;123:268-80; discussion 280.


5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.

Gershon MD.

Curr Opin Endocrinol Diabetes Obes. 2013 Feb;20(1):14-21. doi: 10.1097/MED.0b013e32835bc703. Review.


Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.

Goldberg D, Borojevic R, Anderson M, Chen JJ, Gershon MD, Ratcliffe EM.

Dev Dyn. 2013 Jan;242(1):9-15. doi: 10.1002/dvdy.23898. Epub 2012 Dec 4.


NPARM in PHOX2B: why some things just should not be expanded.

Gershon MD.

J Clin Invest. 2012 Sep;122(9):3056-8. doi: 10.1172/JCI63884. Epub 2012 Aug 27.


Neuronal serotonin regulates growth of the intestinal mucosa in mice.

Gross ER, Gershon MD, Margolis KG, Gertsberg ZV, Li Z, Cowles RA.

Gastroenterology. 2012 Aug;143(2):408-17.e2. doi: 10.1053/j.gastro.2012.05.007. Epub 2012 May 15. Erratum in: Gastroenterology. 2013 Jan;144(1):249. Li, Zhishan [added].


The play is still being written on opening day: postnatal maturation of enteric neurons may provide an opening for early life mischief.

Gershon MD.

J Physiol. 2012 May 15;590(10):2185-6. doi: 10.1113/jphysiol.2012.232769. No abstract available.


Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake.

Chen X, Margolis KJ, Gershon MD, Schwartz GJ, Sze JY.

PLoS One. 2012;7(3):e32511. doi: 10.1371/journal.pone.0032511. Epub 2012 Mar 8.


Cell death and the developing enteric nervous system.

Chalazonitis A, Gershon MD, Greene LA.

Neurochem Int. 2012 Nov;61(6):839-47. doi: 10.1016/j.neuint.2012.01.028. Epub 2012 Feb 8. Review.


Varicella zoster virus (VZV) infects and establishes latency in enteric neurons.

Chen JJ, Gershon AA, Li Z, Cowles RA, Gershon MD.

J Neurovirol. 2011 Dec;17(6):578-89. doi: 10.1007/s13365-011-0070-1. Epub 2011 Dec 22.


Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling.

Chalazonitis A, Tang AA, Shang Y, Pham TD, Hsieh I, Setlik W, Gershon MD, Huang EJ.

J Neurosci. 2011 Sep 28;31(39):13746-57. doi: 10.1523/JNEUROSCI.1078-11.2011.


Behind an enteric neuron there may lie a glial cell.

Gershon MD.

J Clin Invest. 2011 Sep;121(9):3386-9. doi: 10.1172/JCI59573. Epub 2011 Aug 25.


The importance of the gastrointestinal tract in the control of bone mass accrual.

Karsenty G, Gershon MD.

Gastroenterology. 2011 Aug;141(2):439-42. doi: 10.1053/j.gastro.2011.06.011. Epub 2011 Jun 17. Review.


The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Brown PM, Drossman DA, Wood AJ, Cline GA, Frazier KS, Jackson JI, Bronner J, Freiman J, Zambrowicz B, Sands A, Gershon MD.

Gastroenterology. 2011 Aug;141(2):507-16. doi: 10.1053/j.gastro.2011.05.005. Epub 2011 May 18.


Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons.

Li Z, Chalazonitis A, Huang YY, Mann JJ, Margolis KG, Yang QM, Kim DO, Côté F, Mallet J, Gershon MD.

J Neurosci. 2011 Jun 15;31(24):8998-9009. doi: 10.1523/JNEUROSCI.6684-10.2011.


Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice.

D'Autréaux F, Margolis KG, Roberts J, Stevanovic K, Mawe G, Li Z, Karamooz N, Ahuja A, Morikawa Y, Cserjesi P, Setlick W, Gershon MD.

Gastroenterology. 2011 Aug;141(2):576-87, 587.e1-6. doi: 10.1053/j.gastro.2011.04.059. Epub 2011 May 6.


Enteric neuronal density contributes to the severity of intestinal inflammation.

Margolis KG, Stevanovic K, Karamooz N, Li ZS, Ahuja A, D'Autréaux F, Saurman V, Chalazonitis A, Gershon MD.

Gastroenterology. 2011 Aug;141(2):588-98, 598.e1-2. doi: 10.1053/j.gastro.2011.04.047. Epub 2011 Apr 28.


Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut.

Ratcliffe EM, Fan L, Mohammed TJ, Anderson M, Chalazonitis A, Gershon MD.

Dev Neurobiol. 2011 May;71(5):362-73. doi: 10.1002/dneu.20869.

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