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A triad of NRP2, DLX and p53 proteins in lung cancer metastasis.

Drabkin HA, Starkova J, Gemmill RM.

Oncotarget. 2017 Oct 26;8(57):96464-96465. doi: 10.18632/oncotarget.22097. eCollection 2017 Nov 14. No abstract available.


Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer.

Roche J, Gemmill RM, Drabkin HA.

Cancers (Basel). 2017 Jun 24;9(7). pii: E72. doi: 10.3390/cancers9070072. Review.


The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer.

Gemmill RM, Nasarre P, Nair-Menon J, Cappuzzo F, Landi L, D'Incecco A, Uramoto H, Yoshida T, Haura EB, Armeson K, Drabkin HA.

Sci Signal. 2017 Jan 17;10(462). pii: eaag0528. doi: 10.1126/scisignal.aag0528.


ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.

Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam KC, Muñoz-Antonia T, Qu X, Eschrich S, Uramoto H, Tanaka F, Nasarre P, Gemmill RM, Roche J, Drabkin HA, Haura EB.

PLoS One. 2016 Jan 20;11(1):e0147344. doi: 10.1371/journal.pone.0147344. eCollection 2016.


The emerging role of class-3 semaphorins and their neuropilin receptors in oncology.

Nasarre P, Gemmill RM, Drabkin HA.

Onco Targets Ther. 2014 Sep 24;7:1663-87. doi: 10.2147/OTT.S37744. eCollection 2014. Review.


Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation.

Kato T, Franconi CP, Sheridan MB, Hacker AM, Inagakai H, Glover TW, Arlt MF, Drabkin HA, Gemmill RM, Kurahashi H, Emanuel BS.

Cancer Genet. 2014 Apr;207(4):133-40. doi: 10.1016/j.cancergen.2014.03.004. Epub 2014 Mar 18.


Neuropilin-2 Is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition.

Nasarre P, Gemmill RM, Potiron VA, Roche J, Lu X, Barón AE, Korch C, Garrett-Mayer E, Lagana A, Howe PH, Drabkin HA.

Cancer Res. 2013 Dec 1;73(23):7111-21. doi: 10.1158/0008-5472.CAN-13-1755. Epub 2013 Oct 11. Erratum in: Cancer Res. 2014 Jan 15;74(2):637.


Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors.

Chakravarty S, Lai WC, Zou Y, Drabkin HA, Gemmill RM, Simon GR, Chin SH, Chen RT.

Biosens Bioelectron. 2013 May 15;43:50-5. doi: 10.1016/j.bios.2012.11.012. Epub 2012 Nov 27.


Cholesterol and the development of clear-cell renal carcinoma.

Drabkin HA, Gemmill RM.

Curr Opin Pharmacol. 2012 Dec;12(6):742-50. doi: 10.1016/j.coph.2012.08.002. Epub 2012 Aug 30. Review.


Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination.

Millward M, Price T, Townsend A, Sweeney C, Spencer A, Sukumaran S, Longenecker A, Lee L, Lay A, Sharma G, Gemmill RM, Drabkin HA, Lloyd GK, Neuteboom ST, McConkey DJ, Palladino MA, Spear MA.

Invest New Drugs. 2012 Dec;30(6):2303-17. doi: 10.1007/s10637-011-9766-6. Epub 2011 Nov 12.


Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.

Tamburini BA, Phang TL, Fosmire SP, Scott MC, Trapp SC, Duckett MM, Robinson SR, Slansky JE, Sharkey LC, Cutter GR, Wojcieszyn JW, Bellgrau D, Gemmill RM, Hunter LE, Modiano JF.

BMC Cancer. 2010 Nov 9;10:619. doi: 10.1186/1471-2407-10-619.


ZEB1-responsive genes in non-small cell lung cancer.

Gemmill RM, Roche J, Potiron VA, Nasarre P, Mitas M, Coldren CD, Helfrich BA, Garrett-Mayer E, Bunn PA, Drabkin HA.

Cancer Lett. 2011 Jan 1;300(1):66-78. doi: 10.1016/j.canlet.2010.09.007. Epub 2010 Oct 25.


A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: the t(8;22)(q24.13;q11.21).

Sheridan MB, Kato T, Haldeman-Englert C, Jalali GR, Milunsky JM, Zou Y, Klaes R, Gimelli G, Gimelli S, Gemmill RM, Drabkin HA, Hacker AM, Brown J, Tomkins D, Shaikh TH, Kurahashi H, Zackai EH, Emanuel BS.

Am J Hum Genet. 2010 Aug 13;87(2):209-18. doi: 10.1016/j.ajhg.2010.07.002. Epub 2010 Jul 30.


Obesity, cholesterol, and clear-cell renal cell carcinoma (RCC).

Drabkin HA, Gemmill RM.

Adv Cancer Res. 2010;107:39-56. doi: 10.1016/S0065-230X(10)07002-8. Review.


The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.

Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA, Gemmill RM.

Mol Cancer Res. 2010 Jan;8(1):93-106. doi: 10.1158/1541-7786.MCR-08-0491. Epub 2010 Jan 12.


Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.

Kakihana M, Ohira T, Chan D, Webster RB, Kato H, Drabkin HA, Gemmill RM.

J Thorac Oncol. 2009 Dec;4(12):1455-65. doi: 10.1097/JTO.0b013e3181bc9419.


The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ.

J Cell Biol. 2009 Sep 7;186(5):685-92. doi: 10.1083/jcb.200906110. Epub 2009 Aug 31.


The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma.

Gimelli S, Beri S, Drabkin HA, Gambini C, Gregorio A, Fiorio P, Zuffardi O, Gemmill RM, Giorda R, Gimelli G.

Mol Cancer. 2009 Jul 30;8:52. doi: 10.1186/1476-4598-8-52.


ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.

Clarhaut J, Gemmill RM, Potiron VA, Ait-Si-Ali S, Imbert J, Drabkin HA, Roche J.

Neoplasia. 2009 Feb;11(2):157-66.


Pulsed-field gel electrophoresis for long-range restriction mapping.

Gemmill RM, Bolin R, Albertsen H, Tomkins JP, Wing RA.

Curr Protoc Hum Genet. 2002 Feb;Chapter 5:Unit5.1. doi: 10.1002/0471142905.hg0501s31.


Purification and characterization of YACs containing large inserts.

Gemmill RM, Bolin R, Strauss WM, Pavan W.

Curr Protoc Hum Genet. 2001 May;Chapter 5:Unit 5.7. doi: 10.1002/0471142905.hg0507s00.


Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells.

Potiron VA, Sharma G, Nasarre P, Clarhaut JA, Augustin HG, Gemmill RM, Roche J, Drabkin HA.

Cancer Res. 2007 Sep 15;67(18):8708-15.


A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.

Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin HA, Gemmill RM, Plon SE.

Genes Chromosomes Cancer. 2007 Sep;46(9):805-12.


Upstream signaling inhibition enhances rapamycin effect on growth of kidney cancer cells.

Costa LJ, Gemmill RM, Drabkin HA.

Urology. 2007 Mar;69(3):596-602.


RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.

Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM.

Oncogene. 2007 Apr 5;26(16):2263-71. Epub 2006 Oct 2.


Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer.

Dohadwala M, Yang SC, Luo J, Sharma S, Batra RK, Huang M, Lin Y, Goodglick L, Krysan K, Fishbein MC, Hong L, Lai C, Cameron RB, Gemmill RM, Drabkin HA, Dubinett SM.

Cancer Res. 2006 May 15;66(10):5338-45.


Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, Chan Z, Baron A, Franklin W, Drabkin HA, Girard L, Gazdar AF, Minna JD, Bunn PA Jr.

Cancer Res. 2006 Jan 15;66(2):944-50.


Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells.

Kusy S, Nasarre P, Chan D, Potiron V, Meyronet D, Gemmill RM, Constantin B, Drabkin HA, Roche J.

Neoplasia. 2005 May;7(5):457-65.


Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma.

Gemmill RM, Zhou M, Costa L, Korch C, Bukowski RM, Drabkin HA.

Br J Cancer. 2005 Jun 20;92(12):2266-77.


Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.

Gemmill RM, Lee JP, Chamovitz DA, Segal D, Hooper JE, Drabkin HA.

Oncogene. 2005 May 12;24(21):3503-11.


Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics.

Roche J, Zeng C, Barón A, Gadgil S, Gemmill RM, Tigaud I, Thomas X, Drabkin HA.

Leukemia. 2004 Jun;18(6):1059-63.


WNT7a induces E-cadherin in lung cancer cells.

Ohira T, Gemmill RM, Ferguson K, Kusy S, Roche J, Brambilla E, Zeng C, Baron A, Bemis L, Erickson P, Wilder E, Rustgi A, Kitajewski J, Gabrielson E, Bremnes R, Franklin W, Drabkin HA.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10429-34. Epub 2003 Aug 22.


The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.

Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA.

Oncogene. 2002 May 16;21(22):3507-16.


High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer.

Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, Bemis L, Gemmill RM, Drabkin HA, Franklin WA.

J Clin Oncol. 2002 May 15;20(10):2417-28.


Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting.

Varella-Garcia M, Hogan CJ, Odom LF, Murata-Collins JL, Ai H, Chen L, Richkind K, Paskulin G, Andreeff M, Brizard A, McGavran L, Gemmill RM, Berger R, Drabkin HA.

Leukemia. 2001 Sep;15(9):1408-14.


One-step duplex reverse transcription-polymerase chain reaction for quantitative assessment of RNA degradation.

Sugita M, Haney JL, Gemmill RM, Franklin WA.

Anal Biochem. 2001 Aug 1;295(1):113-6. No abstract available.


Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomas.

Ueda M, Gemmill RM, West J, Winn R, Sugita M, Tanaka N, Ueki M, Drabkin HA.

Br J Cancer. 2001 Jul 6;85(1):64-8.


Altered HOX and WNT7A expression in human lung cancer.

Calvo R, West J, Franklin W, Erickson P, Bemis L, Li E, Helfrich B, Bunn P, Roche J, Brambilla E, Rosell R, Gemmill RM, Drabkin HA.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12776-81.


Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer.

Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WA.

Clin Cancer Res. 2000 May;6(5):1616-25.


Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung.

Sugita M, Tanaka N, Davidson S, Sekiya S, Varella-Garcia M, West J, Drabkin HA, Gemmill RM.

Cancer Genet Cytogenet. 2000 Feb;117(1):9-18.


DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC.

Drabkin HA, West JD, Hotfilder M, Heng YM, Erickson P, Calvo R, Dalmau J, Gemmill RM, Sablitzky F.

Oncogene. 1999 Apr 22;18(16):2589-97.


Chromosomal duplication accompanies allelic loss in non-small cell lung carcinoma.

Varella-Garcia M, Gemmill RM, Rabenhorst SH, Lotto A, Drabkin HA, Archer PA, Franklin WA.

Cancer Res. 1998 Oct 15;58(20):4701-7.


The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9572-7.


Homozygous deletions of human chromosome 3p in lung tumors.

Todd S, Franklin WA, Varella-Garcia M, Kennedy T, Hilliker CE Jr, Hahner L, Anderson M, Wiest JS, Drabkin HA, Gemmill RM.

Cancer Res. 1997 Apr 1;57(7):1344-52.


Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.

Boldog F, Gemmill RM, West J, Robinson M, Robinson L, Li E, Roche J, Todd S, Waggoner B, Lundstrom R, Jacobson J, Mullokandov MR, Klinger H, Drabkin HA.

Hum Mol Genet. 1997 Feb;6(2):193-203.


Correlative assessment of morphologic, immunophenotypic, and genetic changes in bronchial epithelium of tobacco smokers.

Franklin WA, Todd S, Gemmill RM, Drabkin HA, Cook R, Sorenson J, Folkvord J, Haney J, Low R, Parks T, Proudfoot S, Kennedy T, Miller YE.

Chest. 1996 Mar;109(3 Suppl):26S. No abstract available.


Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybrids.

Song WJ, Van Keuren ML, Drabkin HA, Cypser JR, Gemmill RM, Kurnit DM.

Cytogenet Cell Genet. 1996;75(1):36-7. No abstract available.


Report of the sixth international workshop on human chromosome 3 mapping 1995.

Naylor SL, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice P, Alimov A, Ashworth T, Bonifas J, Bugert P, Buys CH, Chipperfield MA, Deng G, Drabkin H, Gemmill RM, Grompe M, Joensuu T, Jonasdottir A, Gizatullin R, Krols L, Leach RJ, Lott ST, Killary A, Martinsson T, Messiaen L, et al.

Cytogenet Cell Genet. 1996;72(4):255-70. No abstract available.


A second-generation YAC contig map of human chromosome 3.

Gemmill RM, Chumakov I, Scott P, Waggoner B, Rigault P, Cypser J, Chen Q, Weissenbach J, Gardiner K, Wang H, et al.

Nature. 1995 Sep 28;377(6547 Suppl):299-319.


Defining the position of the breakpoint of the constitutional t(3;6) occurring in a family with renal cell carcinoma.

van den Berg A, van der Veen AY, Hulsbeek MM, Kovacs G, Gemmill RM, Drabkin HA, Buys CH.

Genes Chromosomes Cancer. 1995 Mar;12(3):224-8.


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