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Items: 12


Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.

Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, Huber R.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1437-E1445. doi: 10.1073/pnas.1717565115. Epub 2018 Jan 30.


Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.

Strenzke N, Chakrabarti R, Al-Moyed H, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E.

EMBO J. 2016 Dec 1;35(23):2519-2535. Epub 2016 Oct 11.


DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

Justa-Schuch D, Silva-Garcia M, Pilla E, Engelke M, Kilisch M, Lenz C, Möller U, Nakamura F, Urlaub H, Geiss-Friedlander R.

Elife. 2016 Sep 10;5. pii: e16370. doi: 10.7554/eLife.16370.


Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.

Zhang H, Maqsudi S, Rainczuk A, Duffield N, Lawrence J, Keane FM, Justa-Schuch D, Geiss-Friedlander R, Gorrell MD, Stephens AN.

FEBS J. 2015 Oct;282(19):3737-57. doi: 10.1111/febs.13371. Epub 2015 Aug 3.


Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.

Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A.

Acta Neuropathol. 2015 May;129(5):695-713. doi: 10.1007/s00401-015-1408-1. Epub 2015 Mar 17.


The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus.

Justa-Schuch D, Möller U, Geiss-Friedlander R.

Cell Mol Life Sci. 2014 Sep;71(18):3611-26. doi: 10.1007/s00018-014-1591-6. Epub 2014 Feb 23.


The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.

Pilla E, Kilisch M, Lenz C, Urlaub H, Geiss-Friedlander R.

J Biol Chem. 2013 Nov 8;288(45):32787-96. doi: 10.1074/jbc.M113.489179. Epub 2013 Sep 26.


A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.

Pilla E, Möller U, Sauer G, Mattiroli F, Melchior F, Geiss-Friedlander R.

J Biol Chem. 2012 Dec 28;287(53):44320-9. doi: 10.1074/jbc.M112.397224. Epub 2012 Nov 14.


The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.

Geiss-Friedlander R, Parmentier N, Möller U, Urlaub H, Van den Eynde BJ, Melchior F.

J Biol Chem. 2009 Oct 2;284(40):27211-9. doi: 10.1074/jbc.M109.041871. Epub 2009 Aug 10.


Concepts in sumoylation: a decade on.

Geiss-Friedlander R, Melchior F.

Nat Rev Mol Cell Biol. 2007 Dec;8(12):947-56. Review.


Proteolysis of normal and mutated steroidogenic acute regulatory proteins in the mitochondria: the fate of unwanted proteins.

Granot Z, Geiss-Friedlander R, Melamed-Book N, Eimerl S, Timberg R, Weiss AM, Hales KH, Hales DB, Stocco DM, Orly J.

Mol Endocrinol. 2003 Dec;17(12):2461-76. Epub 2003 Sep 4.


Protein dislocation from the endoplasmic reticulum--pulling out the suspect.

Jarosch E, Geiss-Friedlander R, Meusser B, Walter J, Sommer T.

Traffic. 2002 Aug;3(8):530-6. Review.

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