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Items: 28

1.

Heterocyclic thioureylenes protect from calcium-dependent neuronal cell death.

Humar M, Graetz C, Roesslein M, Goebel U, Geiger KK, Heimrich B, Pannen BH.

Mol Pharmacol. 2009 Mar;75(3):667-76. doi: 10.1124/mol.108.052183. Epub 2008 Dec 22.

2.

Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway.

Schwer CI, Guerrero AM, Humar M, Roesslein M, Goebel U, Stoll P, Geiger KK, Pannen BH, Hoetzel A, Schmidt R.

J Pharmacol Exp Ther. 2008 Dec;327(3):863-71. doi: 10.1124/jpet.108.136549. Epub 2008 Sep 10.

3.

Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs.

Goebel U, Siepe M, Mecklenburg A, Stein P, Roesslein M, Schwer CI, Schmidt R, Doenst T, Geiger KK, Pahl HL, Schlensak C, Loop T.

Anesthesiology. 2008 Jun;108(6):1025-36. doi: 10.1097/ALN.0b013e3181733115.

PMID:
18497603
4.

Protective role of heme oxygenase-1 in pancreatic microcirculatory dysfunction after ischemia/reperfusion in rats.

von Dobschuetz E, Schmidt R, Scholtes M, Thomusch O, Schwer CI, Geiger KK, Hopt UT, Pannen BH.

Pancreas. 2008 May;36(4):377-84. doi: 10.1097/MPA.0b013e31815ceb0e.

PMID:
18437084
5.

Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells.

Roesslein M, Frick M, Auwaerter V, Humar M, Goebel U, Schwer C, Geiger KK, Pahl HL, Pannen BH, Loop T.

Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.

PMID:
18349187
6.

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70.

Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL, Pannen BH, Loop T.

J Pharmacol Exp Ther. 2008 Apr;325(1):217-25. doi: 10.1124/jpet.107.133108. Epub 2008 Jan 24.

7.

Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha.

Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer CI, Loop T, Geiger KK, Pahl HL, Pannen BH.

J Pharmacol Exp Ther. 2008 Mar;324(3):1037-44. Epub 2007 Nov 30.

8.

Nitric oxide-deficiency regulates hepatic heme oxygenase-1.

Hoetzel A, Welle A, Schmidt R, Loop T, Humar M, Ryter SW, Geiger KK, Choi AM, Pannen BH.

Nitric Oxide. 2008 Feb;18(1):61-9. Epub 2007 Dec 3.

PMID:
17999922
9.

Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure.

Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer CI, Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH.

Mol Pharmacol. 2007 Dec;72(6):1647-56. Epub 2007 Sep 18.

10.

The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun.

Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BH.

Int J Biochem Cell Biol. 2007;39(12):2278-88. Epub 2007 Jul 1.

PMID:
17689131
11.

Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury.

Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK, Pannen BH.

Ann Surg. 2007 Jun;245(6):931-42.

12.

Dihydralazine treatment limits liver injury after hemorrhagic shock in rats.

Schmidt R, Baechle T, Hoetzel A, Loop T, Humar M, Roesslein M, Geiger KK, Pannen BH.

Crit Care Med. 2006 Mar;34(3):815-22.

PMID:
16521277
13.

Mechanism of hepatic heme oxygenase-1 induction by isoflurane.

Hoetzel A, Leitz D, Schmidt R, Tritschler E, Bauer I, Loop T, Humar M, Geiger KK, Pannen BH.

Anesthesiology. 2006 Jan;104(1):101-9.

PMID:
16394696
14.

Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.

Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH.

Anesthesiology. 2005 Jun;102(6):1147-57.

PMID:
15915027
15.

Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs.

Kirchner EA, Mols G, Hermle G, Muehlschlegel JD, Geiger KK, Guttmann J, Pahl HL.

Br J Anaesth. 2005 Apr;94(4):530-5. Epub 2005 Jan 21.

16.

Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo.

Schmidt R, Hoetzel A, Baechle T, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BH.

J Hepatol. 2004 Nov;41(5):706-13.

PMID:
15519641
17.

Dobutamine inhibits phorbol-myristate-acetate-induced activation of nuclear factor-kappaB in human T lymphocytes in vitro.

Loop T, Bross T, Humar M, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BH.

Anesth Analg. 2004 Nov;99(5):1508-15; table of contents.

PMID:
15502056
18.

Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway.

Loop T, Scheiermann P, Doviakue D, Musshoff F, Humar M, Roesslein M, Hoetzel A, Schmidt R, Madea B, Geiger KK, Pahl HL, Pannen BH.

Anesthesiology. 2004 Sep;101(3):710-21.

PMID:
15329596
19.

Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1.

Humar M, Andriopoulos N, Pischke SE, Loop T, Schmidt R, Hoetzel A, Roesslein M, Pahl HL, Geiger KK, Pannen BH.

J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. Epub 2004 Jul 19.

20.

Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells.

Humar M, Pischke SE, Loop T, Hoetzel A, Schmidt R, Klaas C, Pahl HL, Geiger KK, Pannen BH.

Mol Pharmacol. 2004 Feb;65(2):350-61.

21.

Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity.

Loop T, Humar M, Pischke S, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BH.

Anesthesiology. 2003 Aug;99(2):360-7.

PMID:
12883408
22.

Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat.

Hoetzel A, Geiger S, Loop T, Welle A, Schmidt R, Humar M, Pahl HL, Geiger KK, Pannen BH.

Anesthesiology. 2002 Nov;97(5):1318-21. No abstract available.

PMID:
12411824
23.

Thiopental inhibits the activation of nuclear factor kappaB.

Loop T, Liu Z, Humar M, Hoetzel A, Benzing A, Pahl HL, Geiger KK, J Pannen BH.

Anesthesiology. 2002 May;96(5):1202-13.

PMID:
11981162
24.

Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1.

Pannen BH, Schroll S, Loop T, Bauer M, Hoetzel A, Geiger KK.

Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1075-84.

25.

Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat.

Hoetzel A, Vagts DA, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BH.

Hepatology. 2001 Apr;33(4):925-37.

PMID:
11283857
26.

Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.

Pannen BH, Köhler N, Hole B, Bauer M, Clemens MG, Geiger KK.

J Clin Invest. 1998 Sep 15;102(6):1220-8.

27.

Role of endothelins and nitric oxide in hepatic reperfusion injury in the rat.

Pannen BH, Al-Adili F, Bauer M, Clemens MG, Geiger KK.

Hepatology. 1998 Mar;27(3):755-64.

PMID:
9500704
28.

Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins.

Pannen BH, Bauer M, Nöldge-Schomburg GF, Zhang JX, Robotham JL, Clemens MG, Geiger KK.

Am J Physiol. 1997 Jun;272(6 Pt 2):H2736-45.

PMID:
9227553

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