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Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm.

Nguyen TD, Zhang S, Gupta A, Zhao Y, Gauthier SA, Wang Y.

AJNR Am J Neuroradiol. 2018 Mar 8. doi: 10.3174/ajnr.A5594. [Epub ahead of print]


Magnetic susceptibility increases as diamagnetic molecules breakdown: Myelin digestion during multiple sclerosis lesion formation contributes to increase on QSM.

Deh K, Ponath GD, Molvi Z, Parel GT, Gillen KM, Zhang S, Nguyen TD, Spincemaille P, Ma Y, Gupta A, Gauthier SA, Pitt D, Wang Y.

J Magn Reson Imaging. 2018 Mar 8. doi: 10.1002/jmri.25997. [Epub ahead of print]


Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment.

Gauthier S, Ng KP, Pascoal TA, Zhang H, Rosa-Neto P.

J Alzheimers Dis. 2018 Mar 1. doi: 10.3233/JAD-179924. [Epub ahead of print]


Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.

Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J; Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) Research Group.

JAMA Neurol. 2018 Feb 26. doi: 10.1001/jamaneurol.2017.5135. [Epub ahead of print]


Corrigendum to "Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation"[NeuroImage 129 (2016) 1-14].

Schoemaker D, Buss C, Head K, Sandman CA, Davis EP, Chakravarty MM, Gauthier S, Pruessner JC.

Neuroimage. 2018 Feb 21;173:1-2. doi: 10.1016/j.neuroimage.2018.02.009. [Epub ahead of print] No abstract available.


CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem.

Benedet AL, Yu L, Labbe A, Mathotaarachchi S, Pascoal TA, Shin M, Kang MS, Gauthier S, Rouleau GA, Poirier J, Bennett DA, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative.

Neurol Genet. 2018 Jan 30;4(1):e216. doi: 10.1212/NXG.0000000000000216. eCollection 2018 Feb.


Push-pull D-π-Ru-π-A chromophores: synthesis and electrochemical, photophysical and second-order nonlinear optical properties.

Durand RJ, Gauthier S, Achelle S, Groizard T, Kahlal S, Saillard JY, Barsella A, Le Poul N, Le Guen FR.

Dalton Trans. 2018 Mar 12;47(11):3965-3975. doi: 10.1039/c8dt00093j.


Dementia clinical trial implications of mild behavioral impairment.

Mortby ME, Black SE, Gauthier S, Miller D, Porsteinsson A, Smith EE, Ismail Z.

Int Psychogeriatr. 2018 Feb;30(2):171-175. doi: 10.1017/S1041610218000042.


Anosognosia predicts default mode network hypometabolism and clinical progression to dementia.

Therriault J, Ng KP, Pascoal TA, Mathotaarachchi S, Kang MS, Struyfs H, Shin M, Benedet AL, Walpola IC, Nair V, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2018 Mar 13;90(11):e932-e939. doi: 10.1212/WNL.0000000000005120. Epub 2018 Feb 14.


The cost of Alzheimer's disease in China and re-estimation of costs worldwide.

Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, Zhao L, Jin H, Xu H, Wang F, Zhou A, Zuo X, Wu L, Han Y, Han Y, Huang L, Wang Q, Li D, Chu C, Shi L, Gong M, Du Y, Zhang J, Zhang J, Zhou C, Lv J, Lv Y, Xie H, Ji Y, Li F, Yu E, Luo B, Wang Y, Yang S, Qu Q, Guo Q, Liang F, Zhang J, Tan L, Shen L, Zhang K, Zhang J, Peng D, Tang M, Lv P, Fang B, Chu L, Jia L, Gauthier S.

Alzheimers Dement. 2018 Jan 11. pii: S1552-5260(17)33877-3. doi: 10.1016/j.jalz.2017.12.006. [Epub ahead of print]


Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.

Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.

Eur J Nucl Med Mol Imaging. 2018 Feb 2. doi: 10.1007/s00259-018-3933-3. [Epub ahead of print]


Diagnostic accuracy of semiautomatic lesion detection plus quantitative susceptibility mapping in the identification of new and enhancing multiple sclerosis lesions.

Zhang S, Nguyen TD, Zhao Y, Gauthier SA, Wang Y, Gupta A.

Neuroimage Clin. 2018 Jan 28;18:143-148. doi: 10.1016/j.nicl.2018.01.013. eCollection 2018.


Quantitative Susceptibility Mapping of the Thalamus: Relationships with Thalamic Volume, Total Gray Matter Volume, and T2 Lesion Burden.

Chiang GC, Hu J, Morris E, Wang Y, Gauthier SA.

AJNR Am J Neuroradiol. 2018 Jan 25. doi: 10.3174/ajnr.A5537. [Epub ahead of print]


MEMO+: Efficacy, Durability and Effect of Cognitive Training and Psychosocial Intervention in Individuals with Mild Cognitive Impairment.

Belleville S, Hudon C, Bier N, Brodeur C, Gilbert B, Grenier S, Ouellet MC, Viscogliosi C, Gauthier S.

J Am Geriatr Soc. 2018 Jan 4. doi: 10.1111/jgs.15192. [Epub ahead of print]


Impacts of salvage logging on biodiversity: a meta-analysis.

Thorn S, Bässler C, Brandl R, Burton PJ, Cahall R, Campbell JL, Castro J, Choi CY, Cobb T, Donato DC, Durska E, Fontaine JB, Gauthier S, Hebert C, Hothorn T, Hutto RL, Lee EJ, Leverkus AB, Lindenmayer DB, Obrist MK, Rost J, Seibold S, Seidl R, Thom D, Waldron K, Wermelinger B, Winter MB, Zmihorski M, Müller J.

J Appl Ecol. 2018 Jan;55(1):279-289. doi: 10.1111/1365-2664.12945. Epub 2017 Jul 5.


Comparative effect of statins on the risk of incident Alzheimer disease.

Sinyavskaya L, Gauthier S, Renoux C, Dell'Aniello S, Suissa S, Brassard P.

Neurology. 2018 Jan 16;90(3):e179-e187. doi: 10.1212/WNL.0000000000004818. Epub 2017 Dec 15.


Combining Quantitative Susceptibility Mapping with Automatic Zero Reference (QSM0) and Myelin Water Fraction Imaging to Quantify Iron-Related Myelin Damage in Chronic Active MS Lesions.

Yao Y, Nguyen TD, Pandya S, Zhang Y, Hurtado Rúa S, Kovanlikaya I, Kuceyeski A, Liu Z, Wang Y, Gauthier SA.

AJNR Am J Neuroradiol. 2018 Feb;39(2):303-310. doi: 10.3174/ajnr.A5482. Epub 2017 Dec 14.


EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials.

Aisen P, Touchon J, Amariglio R, Andrieu S, Bateman R, Breitner J, Donohue M, Dunn B, Doody R, Fox N, Gauthier S, Grundman M, Hendrix S, Ho C, Isaac M, Raman R, Rosenberg P, Schindler R, Schneider L, Sperling R, Tariot P, Welsh-Bohmer K, Weiner M, Vellas B.

J Prev Alzheimers Dis. 2017;4(2):116-124. doi: 10.14283/jpad.2017.13.


Dependence Levels as Interim Clinical Milestones Along the Continuum of Alzheimer's Disease: 18-Month Results from the GERAS Observational Study.

Kahle-Wrobleski K, Andrews JS, Belger M, Ye W, Gauthier S, Rentz DM, Galasko D.

J Prev Alzheimers Dis. 2017;4(2):72-80. doi: 10.14283/jpad.2017.2.


Clinical Effects of Tramiprosate in APOE4/4 Homozygous Patients with Mild Alzheimer's Disease Suggest Disease Modification Potential.

Abushakra S, Porsteinsson A, Scheltens P, Sadowsky C, Vellas B, Cummings J, Gauthier S, Hey JA, Power A, Wang P, Shen L, Tolar M.

J Prev Alzheimers Dis. 2017;4(3):149-156. doi: 10.14283/jpad.2017.26.


Characterizing biomarker features of cognitively normal individuals with ventriculomegaly.

Li X, Ba M, Ng KP, Mathotaarachchi S, Pascoal TA, Rosa-Neto P, Gauthier S.

Alzheimers Dement (Amst). 2017 Sep 5;10:12-21. doi: 10.1016/j.dadm.2017.08.001. eCollection 2018.


Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial.

Wilcock GK, Gauthier S, Frisoni GB, Jia J, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Schelter BO, Wischik DJ, Davis CS, Staff RT, Vuksanovic V, Ahearn T, Bracoud L, Shamsi K, Marek K, Seibyl J, Riedel G, Storey JMD, Harrington CR, Wischik CM.

J Alzheimers Dis. 2018;61(1):435-457. doi: 10.3233/JAD-170560.


Progress in transnational scientific and ethics review: Commentary on the proposal for a single North American review board for research on dementia.

Gauthier S, Robillard J, de Champlain J.

Alzheimers Dement. 2018 Jan;14(1):115-116. doi: 10.1016/j.jalz.2017.10.001. Epub 2017 Oct 28. No abstract available.


Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.

Parent MJ, Zimmer ER, Shin M, Kang MS, Fonov VS, Mathieu A, Aliaga A, Kostikov A, Do Carmo S, Dea D, Poirier J, Soucy JP, Gauthier S, Cuello AC, Rosa-Neto P.

J Neurosci. 2017 Dec 13;37(50):12263-12271. doi: 10.1523/JNEUROSCI.1346-17.2017. Epub 2017 Nov 2.


Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease.

Gauthier S, Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedetti AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P.

Neurology. 2017 Oct 31;89(18):1931. doi: 10.1212/WNL.0000000000004593. No abstract available.


The prevalence and biomarkers' characteristic of rapidly progressive Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database.

Ba M, Li X, Ng KP, Pascoal TA, Mathotaarachchi S, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2017 Feb 9;3(1):107-113. doi: 10.1016/j.trci.2016.12.005. eCollection 2017 Jan.


Reversible Redox Switching of Chromophoric Phenylmethylenepyrans by Carbon-Carbon Bond Making/Breaking.

Wojcik L, Michaud F, Gauthier S, Cabon N, Le Poul P, Gloaguen F, Le Poul N.

J Org Chem. 2017 Dec 1;82(23):12395-12405. doi: 10.1021/acs.joc.7b02199. Epub 2017 Oct 31.


Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials.

Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S.

Int Psychogeriatr. 2017 Sep 21:1-9. doi: 10.1017/S1041610217001892. [Epub ahead of print]


Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV.

Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA.

Mol Psychiatry. 2017 Nov;22(11):1531-1538. doi: 10.1038/mp.2017.183. Epub 2017 Sep 12.


Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities.

Gauthier SA, Pérez-González R, Sharma A, Huang FK, Alldred MJ, Pawlik M, Kaur G, Ginsberg SD, Neubert TA, Levy E.

Acta Neuropathol Commun. 2017 Aug 29;5(1):65. doi: 10.1186/s40478-017-0466-0.


Familiarity deficits in cognitively normal aging individuals with APOE ε4: A follow-up investigation of medial temporal lobe structural correlates.

Schoemaker D, Poirier J, Collins DL, Gauthier S, Pruessner JC.

Alzheimers Dement (Amst). 2017 Jun 15;9:21-24. doi: 10.1016/j.dadm.2017.05.008. eCollection 2017.


Identifying incipient dementia individuals using machine learning and amyloid imaging.

Mathotaarachchi S, Pascoal TA, Shin M, Benedet AL, Kang MS, Beaudry T, Fonov VS, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2017 Nov;59:80-90. doi: 10.1016/j.neurobiolaging.2017.06.027. Epub 2017 Jul 11.


Quantifying the Susceptibility Variation of Normal-Appearing White Matter in Multiple Sclerosis by Quantitative Susceptibility Mapping.

Chen W, Zhang Y, Mu K, Pan C, Gauthier SA, Zhu W, Wang Y.

AJR Am J Roentgenol. 2017 Oct;209(4):889-894. doi: 10.2214/AJR.16.16851. Epub 2017 Jul 13.


Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation.

Kaunzner UW, Kang Y, Monohan E, Kothari PJ, Nealon N, Perumal J, Vartanian T, Kuceyeski A, Vallabhajosula S, Mozley PD, Riley CS, Newman SM, Gauthier SA.

Mult Scler Relat Disord. 2017 Jul;15:27-33. doi: 10.1016/j.msard.2017.04.008. Epub 2017 Apr 29.


A developmental and clinical perspective of rhythmic interpersonal coordination: From mimicry toward the interconnection of minds.

Xavier J, Magnat J, Sherman A, Gauthier S, Cohen D, Chaby L.

J Physiol Paris. 2016 Nov;110(4 Pt B):420-426. doi: 10.1016/j.jphysparis.2017.06.001. Epub 2017 Jul 4. Review.


MRI in the assessment and monitoring of multiple sclerosis: an update on best practice.

Kaunzner UW, Gauthier SA.

Ther Adv Neurol Disord. 2017 Jun;10(6):247-261. doi: 10.1177/1756285617708911. Epub 2017 May 12. Review.


MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning.

Dayan M, Hurtado Rúa SM, Monohan E, Fujimoto K, Pandya S, LoCastro EM, Vartanian T, Nguyen TD, Raj A, Gauthier SA.

Front Neurosci. 2017 May 26;11:284. doi: 10.3389/fnins.2017.00284. eCollection 2017.


Application of calibrated fMRI in Alzheimer's disease.

Lajoie I, Nugent S, Debacker C, Dyson K, Tancredi FB, Badhwar A, Belleville S, Deschaintre Y, Bellec P, Doyon J, Bocti C, Gauthier S, Arnold D, Kergoat MJ, Chertkow H, Monchi O, Hoge RD.

Neuroimage Clin. 2017 May 16;15:348-358. doi: 10.1016/j.nicl.2017.05.009. eCollection 2017.


Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment.

Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J.

Sleep Med. 2017 Jun;34:134-140. doi: 10.1016/j.sleep.2017.01.025. Epub 2017 Mar 30.


Suicide and assisted dying in dementia: what we know and what we need to know. A narrative literature review.

Diehl-Schmid J, Jox R, Gauthier S, Belleville S, Racine E, Schüle C, Turecki G, Richard-Devantoy S.

Int Psychogeriatr. 2017 Aug;29(8):1247-1259. doi: 10.1017/S1041610217000679. Epub 2017 May 2.


Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer's disease.

Müller WE, Eckert A, Eckert GP, Fink H, Friedland K, Gauthier S, Hoerr R, Ihl R, Kasper S, Möller HJ.

World J Biol Psychiatry. 2017 May 2:1-17. doi: 10.1080/15622975.2017.1308552. [Epub ahead of print]


Defining Disease Activity and Response to Therapy in MS.

Kaunzner UW, Al-Kawaz M, Gauthier SA.

Curr Treat Options Neurol. 2017 May;19(5):20. doi: 10.1007/s11940-017-0454-5. Review.


Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife.

Rajah MN, Wallace LMK, Ankudowich E, Yu EH, Swierkot A, Patel R, Chakravarty MM, Naumova D, Pruessner J, Joober R, Gauthier S, Pasvanis S.

Neuroimage Clin. 2017 Mar 31;14:760-774. doi: 10.1016/j.nicl.2017.03.016. eCollection 2017.


Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease.

Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative.

Neurology. 2017 May 9;88(19):1814-1821. doi: 10.1212/WNL.0000000000003916. Epub 2017 Apr 12.


Chitosan: A promising polymer for cartilage repair and viscosupplementation.

Comblain F, Rocasalbas G, Gauthier S, Henrotin Y.

Biomed Mater Eng. 2017;28(s1):S209-S215. doi: 10.3233/BME-171643. Review.


Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.

Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P.

Alzheimers Res Ther. 2017 Mar 31;9(1):25. doi: 10.1186/s13195-017-0253-y.


Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care.

Wang Y, Spincemaille P, Liu Z, Dimov A, Deh K, Li J, Zhang Y, Yao Y, Gillen KM, Wilman AH, Gupta A, Tsiouris AJ, Kovanlikaya I, Chiang GC, Weinsaft JW, Tanenbaum L, Chen W, Zhu W, Chang S, Lou M, Kopell BH, Kaplitt MG, Devos D, Hirai T, Huang X, Korogi Y, Shtilbans A, Jahng GH, Pelletier D, Gauthier SA, Pitt D, Bush AI, Brittenham GM, Prince MR.

J Magn Reson Imaging. 2017 Oct;46(4):951-971. doi: 10.1002/jmri.25693. Epub 2017 Mar 10. Review.


Recollection and familiarity in aging individuals: Gaining insight into relationships with medial temporal lobe structural integrity.

Schoemaker D, Mascret C, Collins DL, Yu E, Gauthier S, Pruessner JC.

Hippocampus. 2017 Jun;27(6):692-701. doi: 10.1002/hipo.22725. Epub 2017 Apr 10.


Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer's disease.

Jia J, Gauthier S, Pallotta S, Ji Y, Wei W, Xiao S, Peng D, Guo Q, Wu L, Chen S, Kuang W, Zhang J, Wei C, Tang Y.

Alzheimers Dement. 2017 May;13(5):592-597. doi: 10.1016/j.jalz.2017.01.007. Epub 2017 Feb 24.


Incorporation of a platinum center in the pi-conjugated core of push-pull chromophores for nonlinear optics (NLO).

Durand RJ, Gauthier S, Achelle S, Kahlal S, Saillard JY, Barsella A, Wojcik L, Le Poul N, Robin-Le Guen F.

Dalton Trans. 2017 Feb 28;46(9):3059-3069. doi: 10.1039/c7dt00252a.

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