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Items: 1 to 50 of 189

1.

Evolutionary advantage of directional symmetry breaking in self-replicating polymers.

Subramanian H, Gatenby RA.

J Theor Biol. 2018 Jun 7;446:128-136. doi: 10.1016/j.jtbi.2018.03.012. Epub 2018 Mar 12.

PMID:
29544886
2.

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies.

Gallaher JA, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson ARA.

Cancer Res. 2018 Apr 15;78(8):2127-2139. doi: 10.1158/0008-5472.CAN-17-2649. Epub 2018 Jan 30.

PMID:
29382708
3.

Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer.

Zhang J, Cunningham JJ, Brown JS, Gatenby RA.

Nat Commun. 2017 Nov 28;8(1):1816. doi: 10.1038/s41467-017-01968-5.

4.

Cellular information dynamics through transmembrane flow of ions.

Gatenby RA, Frieden BR.

Sci Rep. 2017 Nov 8;7(1):15075. doi: 10.1038/s41598-017-15182-2.

5.

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand.

Epstein T, Gatenby RA, Brown JS.

PLoS One. 2017 Sep 18;12(9):e0185085. doi: 10.1371/journal.pone.0185085. eCollection 2017.

6.

Radiologic Pearls for Internists: A Case-Based Review.

McGettigan MJ, Gatenby RA.

Am J Med. 2018 Jan;131(1):9-16. doi: 10.1016/j.amjmed.2017.08.022. Epub 2017 Sep 7. Review.

PMID:
28889930
7.

Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model.

You L, Brown JS, Thuijsman F, Cunningham JJ, Gatenby RA, Zhang J, Staňková K.

J Theor Biol. 2017 Dec 21;435:78-97. doi: 10.1016/j.jtbi.2017.08.022. Epub 2017 Sep 21.

PMID:
28870617
8.

Is the Genetic Paradigm of Cancer Complete?

Gatenby RA.

Radiology. 2017 Jul;284(1):1-3. doi: 10.1148/radiol.2017171004. No abstract available.

PMID:
28628406
9.

Tris-base buffer: a promising new inhibitor for cancer progression and metastasis.

Ibrahim-Hashim A, Abrahams D, Enriquez-Navas PM, Luddy K, Gatenby RA, Gillies RJ.

Cancer Med. 2017 Jul;6(7):1720-1729. doi: 10.1002/cam4.1032. Epub 2017 May 29.

10.

Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy.

Gravenmier CA, Siddique M, Gatenby RA.

Bull Math Biol. 2017 May 15. doi: 10.1007/s11538-017-0261-x. [Epub ahead of print]

PMID:
28508297
11.

Innovations in Diagnostic Imaging and the Transformation of the Clinical Practice of Radiology in Collaborative, Multidisciplinary Cancer Care.

Arrington JA, Klippenstein DL, Gatenby RA.

Cancer Control. 2017 Apr;24(2):115-117. No abstract available.

PMID:
28441378
12.

Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer.

Gatenby RA, Brown J.

Biochim Biophys Acta. 2017 Apr;1867(2):162-166. doi: 10.1016/j.bbcan.2017.03.005. Epub 2017 Mar 21. Review.

13.

Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution.

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA.

Cancer Res. 2017 May 1;77(9):2242-2254. doi: 10.1158/0008-5472.CAN-16-2844. Epub 2017 Mar 1.

PMID:
28249898
14.

Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer.

Brown JS, Cunningham JJ, Gatenby RA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):512-518. doi: 10.1109/TBME.2016.2623564. Epub 2016 Nov 1.

15.

Stem Cell Plasticity and Niche Dynamics in Cancer Progression.

Picco N, Gatenby RA, Anderson ARA.

IEEE Trans Biomed Eng. 2017 Mar;64(3):528-537. doi: 10.1109/TBME.2016.2607183. Epub 2016 Sep 8.

16.

Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.

Kim JY, Gatenby RA.

Methods Mol Biol. 2017;1513:61-81. Review.

PMID:
27807831
17.

Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction.

Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA.

J Magn Reson Imaging. 2017 Jul;46(1):115-123. doi: 10.1002/jmri.25497. Epub 2016 Sep 28.

PMID:
27678245
18.

Predicting Malignant Nodules from Screening CT Scans.

Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ.

J Thorac Oncol. 2016 Dec;11(12):2120-2128. doi: 10.1016/j.jtho.2016.07.002. Epub 2016 Jul 13. Erratum in: J Thorac Oncol. 2018 Feb;13(2):280-281.

19.

Transmissible cancers, are they more common than thought?

Ujvari B, Gatenby RA, Thomas F.

Evol Appl. 2016 May 17;9(5):633-4. doi: 10.1111/eva.12372. eCollection 2016 Jun. No abstract available.

20.

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces.

Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA.

Cancer Res. 2016 Jun 1;76(11):3136-44. doi: 10.1158/0008-5472.CAN-15-2962. Epub 2016 Mar 23.

21.

Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer.

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Sci Transl Med. 2016 Feb 24;8(327):327ra24. doi: 10.1126/scitranslmed.aad7842.

22.

The evolutionary ecology of transmissible cancers.

Ujvari B, Gatenby RA, Thomas F.

Infect Genet Evol. 2016 Apr;39:293-303. doi: 10.1016/j.meegid.2016.02.005. Epub 2016 Feb 6. Review.

PMID:
26861618
23.

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.

Damaghi M, Tafreshi NK, Lloyd MC, Sprung R, Estrella V, Wojtkowiak JW, Morse DL, Koomen JM, Bui MM, Gatenby RA, Gillies RJ.

Nat Commun. 2015 Dec 10;6:8752. doi: 10.1038/ncomms9752.

24.

Application of Evolutionary Principles to Cancer Therapy.

Enriquez-Navas PM, Wojtkowiak JW, Gatenby RA.

Cancer Res. 2015 Nov 15;75(22):4675-80. doi: 10.1158/0008-5472.CAN-15-1337. Epub 2015 Nov 2. Review.

25.

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.

Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG.

PLoS Comput Biol. 2015 Sep 11;11(9):e1004493. doi: 10.1371/journal.pcbi.1004493. eCollection 2015 Sep.

26.

Ancient hot and cold genes and chemotherapy resistance emergence.

Wu A, Zhang Q, Lambert G, Khin Z, Gatenby RA, Kim HJ, Pourmand N, Bussey K, Davies PC, Sturm JC, Austin RH.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10467-72. doi: 10.1073/pnas.1512396112. Epub 2015 Aug 3.

27.

Evolutionary perspective of cancer: myth, metaphors, and reality.

Arnal A, Ujvari B, Crespi B, Gatenby RA, Tissot T, Vittecoq M, Ewald PW, Casali A, Ducasse H, Jacqueline C, Missé D, Renaud F, Roche B, Thomas F.

Evol Appl. 2015 Jul;8(6):541-4. doi: 10.1111/eva.12265. Epub 2015 May 27.

28.

Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine.

Ducasse H, Arnal A, Vittecoq M, Daoust SP, Ujvari B, Jacqueline C, Tissot T, Ewald P, Gatenby RA, King KC, Bonhomme F, Brodeur J, Renaud F, Solary E, Roche B, Thomas F.

Evol Appl. 2015 Jul;8(6):527-40. doi: 10.1111/eva.12232. Epub 2015 Mar 26. Review.

29.

The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression.

Brown JS, Cunningham JJ, Gatenby RA.

Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). pii: 20140221. doi: 10.1098/rstb.2014.0221.

30.

Pathology to enhance precision medicine in oncology: lessons from landscape ecology.

Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM.

Adv Anat Pathol. 2015 Jul;22(4):267-72. doi: 10.1097/PAP.0000000000000078. Review.

31.

Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis.

Chaudhury B, Zhou M, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Patel BK, Weinfurtner RJ, Drukteinis JS.

J Magn Reson Imaging. 2015 Nov;42(5):1421-30. doi: 10.1002/jmri.24921. Epub 2015 Apr 17.

32.

Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.

Robertson-Tessi M, Gillies RJ, Gatenby RA, Anderson AR.

Cancer Res. 2015 Apr 15;75(8):1567-79. doi: 10.1158/0008-5472.CAN-14-1428.

33.

Metabolism and its sequelae in cancer evolution and therapy.

Gillies RJ, Gatenby RA.

Cancer J. 2015 Mar-Apr;21(2):88-96. doi: 10.1097/PPO.0000000000000102. Review.

34.

Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance.

Verduzco D, Lloyd M, Xu L, Ibrahim-Hashim A, Balagurunathan Y, Gatenby RA, Gillies RJ.

PLoS One. 2015 Mar 26;10(3):e0120958. doi: 10.1371/journal.pone.0120958. eCollection 2015.

35.

Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites.

Cunningham JJ, Brown JS, Vincent TL, Gatenby RA.

Evol Med Public Health. 2015 Mar 20;2015(1):76-87. doi: 10.1093/emph/eov006.

36.

Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma.

Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ.

PLoS One. 2015 Mar 4;10(3):e0118261. doi: 10.1371/journal.pone.0118261. eCollection 2015.

37.

Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302.

Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ.

Cancer Metab. 2015 Jan 29;3(1):2. doi: 10.1186/s40170-014-0026-z. eCollection 2015.

38.

Cancer suppression by compression.

Frieden BR, Gatenby RA.

Bull Math Biol. 2015 Jan;77(1):71-82. doi: 10.1007/s11538-014-0051-7. Epub 2014 Dec 18.

PMID:
25520262
39.

Erratum to: microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy.

Fais S, Venturi G, Gatenby RA.

Cancer Metastasis Rev. 2015 Mar;34(1):165. doi: 10.1007/s10555-014-9534-0. No abstract available.

40.

Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations.

Gatenby RA, Cunningham JJ, Brown JS.

Nat Commun. 2014 Nov 19;5:5499. doi: 10.1038/ncomms6499.

41.

Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance.

Kam Y, Das T, Minton S, Gatenby RA.

Womens Health (Lond). 2014 Jul;10(4):423-30. doi: 10.2217/whe.14.23. Review.

42.

Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".

Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Int J Cancer. 2015 Feb 15;136(4):E188-96. doi: 10.1002/ijc.29158. Epub 2014 Sep 2.

43.

Test-retest reproducibility analysis of lung CT image features.

Balagurunathan Y, Kumar V, Gu Y, Kim J, Wang H, Liu Y, Goldgof DB, Hall LO, Korn R, Zhao B, Schwartz LH, Basu S, Eschrich S, Gatenby RA, Gillies RJ.

J Digit Imaging. 2014 Dec;27(6):805-23. doi: 10.1007/s10278-014-9716-x.

44.

Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane.

Epstein T, Xu L, Gillies RJ, Gatenby RA.

Cancer Metab. 2014 Jun 5;2:7. doi: 10.1186/2049-3002-2-7. eCollection 2014.

45.

Reproducibility and Prognosis of Quantitative Features Extracted from CT Images.

Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ.

Transl Oncol. 2014 Feb 1;7(1):72-87. eCollection 2014 Feb.

46.

Vascular measurements correlate with estrogen receptor status.

Lloyd MC, Alfarouk KO, Verduzco D, Bui MM, Gillies RJ, Ibrahim ME, Brown JS, Gatenby RA.

BMC Cancer. 2014 Apr 23;14:279. doi: 10.1186/1471-2407-14-279.

47.

Commentary on a paper by Verbeni et al.

Gatenby RA.

Phys Life Rev. 2013 Dec;10(4):480-1; discussion 495-7. doi: 10.1016/j.plrev.2013.10.011. Epub 2013 Oct 21. No abstract available.

PMID:
24231516
48.

Principle of maximum Fisher information from Hardy's axioms applied to statistical systems.

Frieden BR, Gatenby RA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Oct;88(4):042144. Epub 2013 Oct 28.

49.

Life history trade-offs in cancer evolution.

Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC.

Nat Rev Cancer. 2013 Dec;13(12):883-92. doi: 10.1038/nrc3606. Epub 2013 Nov 11. Review.

50.

Quantitative imaging in cancer evolution and ecology.

Gatenby RA, Grove O, Gillies RJ.

Radiology. 2013 Oct;269(1):8-15. doi: 10.1148/radiol.13122697. Review.

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