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Items: 1 to 50 of 121

1.

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.

Li S, Sun Z, Pryce R, Parsy ML, Fehling SK, Schlie K, Siebert CA, Garten W, Bowden TA, Strecker T, Huiskonen JT.

PLoS Pathog. 2016 Feb 5;12(2):e1005418. doi: 10.1371/journal.ppat.1005418. eCollection 2016 Feb.

2.

Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell.

Lennartz F, Bayer K, Czerwonka N, Lu Y, Kehr K, Hirz M, Steinmetzer T, Garten W, Herden C.

Cell Microbiol. 2016 Mar;18(3):340-54. doi: 10.1111/cmi.12515. Epub 2015 Oct 12.

PMID:
26332529
3.

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics.

Garten W, Braden C, Arendt A, Peitsch C, Baron J, Lu Y, Pawletko K, Hardes K, Steinmetzer T, Böttcher-Friebertshäuser E.

Eur J Cell Biol. 2015 Jul-Sep;94(7-9):375-83. doi: 10.1016/j.ejcb.2015.05.013. Epub 2015 Jun 1.

PMID:
26095298
4.

Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.

Lu Y, Hardes K, Dahms SO, Böttcher-Friebertshäuser E, Steinmetzer T, Than ME, Klenk HD, Garten W.

Antiviral Res. 2015 Aug;120:89-100. doi: 10.1016/j.antiviral.2015.05.006. Epub 2015 May 26.

PMID:
26022200
5.

Novel Furin Inhibitors with Potent Anti-infectious Activity.

Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T.

ChemMedChem. 2015 Jul;10(7):1218-31. doi: 10.1002/cmdc.201500103. Epub 2015 May 14.

PMID:
25974265
6.

Taxonomic reorganization of the family Bornaviridae.

Kuhn JH, Dürrwald R, Bào Y, Briese T, Carbone K, Clawson AN, deRisi JL, Garten W, Jahrling PB, Kolodziejek J, Rubbenstroth D, Schwemmle M, Stenglein M, Tomonaga K, Weissenböck H, Nowotny N.

Arch Virol. 2015 Feb;160(2):621-32. doi: 10.1007/s00705-014-2276-z. Epub 2014 Dec 2.

7.

The hemagglutinin: a determinant of pathogenicity.

Böttcher-Friebertshäuser E, Garten W, Matrosovich M, Klenk HD.

Curr Top Microbiol Immunol. 2014;385:3-34. doi: 10.1007/82_2014_384. Review.

PMID:
25031010
8.

TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.

Tarnow C, Engels G, Arendt A, Schwalm F, Sediri H, Preuss A, Nelson PS, Garten W, Klenk HD, Gabriel G, Böttcher-Friebertshäuser E.

J Virol. 2014 May;88(9):4744-51. doi: 10.1128/JVI.03799-13. Epub 2014 Feb 12.

9.

Activation of influenza A viruses by host proteases from swine airway epithelium.

Peitsch C, Klenk HD, Garten W, Böttcher-Friebertshäuser E.

J Virol. 2014 Jan;88(1):282-91. doi: 10.1128/JVI.01635-13. Epub 2013 Oct 23.

10.

Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.

Böttcher-Friebertshäuser E, Klenk HD, Garten W.

Pathog Dis. 2013 Nov;69(2):87-100. doi: 10.1111/2049-632X.12053. Epub 2013 Jul 2. Review.

PMID:
23821437
11.

The role of oligomerization for the biological functions of the arenavirus nucleoprotein.

Lennartz F, Hoenen T, Lehmann M, Groseth A, Garten W.

Arch Virol. 2013 Sep;158(9):1895-905. doi: 10.1007/s00705-013-1684-9. Epub 2013 Apr 4.

PMID:
23553456
12.

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.

Meyer D, Sielaff F, Hammami M, Böttcher-Friebertshäuser E, Garten W, Steinmetzer T.

Biochem J. 2013 Jun 1;452(2):331-43. doi: 10.1042/BJ20130101.

PMID:
23527573
13.

The microtubule motor protein KIF13A is involved in intracellular trafficking of the Lassa virus matrix protein Z.

Fehling SK, Noda T, Maisner A, Lamp B, Conzelmann KK, Kawaoka Y, Klenk HD, Garten W, Strecker T.

Cell Microbiol. 2013 Feb;15(2):315-34. doi: 10.1111/cmi.12095. Epub 2013 Jan 10.

PMID:
23279019
14.

Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.

Baron J, Tarnow C, Mayoli-Nüssle D, Schilling E, Meyer D, Hammami M, Schwalm F, Steinmetzer T, Guan Y, Garten W, Klenk HD, Böttcher-Friebertshäuser E.

J Virol. 2013 Feb;87(3):1811-20. doi: 10.1128/JVI.02320-12. Epub 2012 Nov 28.

15.

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections.

Böttcher-Friebertshäuser E, Lu Y, Meyer D, Sielaff F, Steinmetzer T, Klenk HD, Garten W.

Vaccine. 2012 Dec 7;30(51):7374-80. doi: 10.1016/j.vaccine.2012.10.001. Epub 2012 Oct 13.

PMID:
23072892
16.

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.

Becker GL, Lu Y, Hardes K, Strehlow B, Levesque C, Lindberg I, Sandvig K, Bakowsky U, Day R, Garten W, Steinmetzer T.

J Biol Chem. 2012 Jun 22;287(26):21992-2003. doi: 10.1074/jbc.M111.332643. Epub 2012 Apr 26.

17.

Isolation of influenza viruses in MDCK 33016PF cells and clearance of contaminating respiratory viruses.

Roth B, Mohr H, Enders M, Garten W, Gregersen JP.

Vaccine. 2012 Jan 11;30(3):517-22. doi: 10.1016/j.vaccine.2011.11.063. Epub 2011 Nov 24.

18.

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. doi: 10.1016/j.bmcl.2011.06.033. Epub 2011 Jun 21.

PMID:
21741839
19.

Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic.

Klenk HD, Garten W, Matrosovich M.

Bioessays. 2011 Mar;33(3):180-8. doi: 10.1002/bies.201000118. Epub 2011 Jan 13.

PMID:
21319184
20.

Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.

Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W.

J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1.

21.

Maturation cleavage within the ectodomain of Lassa virus glycoprotein relies on stabilization by the cytoplasmic tail.

Schlie K, Strecker T, Garten W.

FEBS Lett. 2010 Nov 5;584(21):4379-82. doi: 10.1016/j.febslet.2010.09.032. Epub 2010 Sep 28.

22.

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.

Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W.

J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17.

23.

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.

Okumura Y, Takahashi E, Yano M, Ohuchi M, Daidoji T, Nakaya T, Böttcher E, Garten W, Klenk HD, Kido H.

J Virol. 2010 May;84(10):5089-96. doi: 10.1128/JVI.02605-09. Epub 2010 Mar 10.

24.

Viral protein determinants of Lassa virus entry and release from polarized epithelial cells.

Schlie K, Maisa A, Freiberg F, Groseth A, Strecker T, Garten W.

J Virol. 2010 Apr;84(7):3178-88. doi: 10.1128/JVI.02240-09. Epub 2010 Jan 13.

25.

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T.

J Med Chem. 2010 Feb 11;53(3):1067-75. doi: 10.1021/jm9012455.

26.

RNA induced polymerization of the Borna disease virus nucleoprotein.

Hock M, Kraus I, Schoehn G, Jamin M, Andrei-Selmer C, Garten W, Weissenhorn W.

Virology. 2010 Feb 5;397(1):64-72. doi: 10.1016/j.virol.2009.11.016. Epub 2009 Nov 30.

27.

Characterization of Lassa virus glycoprotein oligomerization and influence of cholesterol on virus replication.

Schlie K, Maisa A, Lennartz F, Ströher U, Garten W, Strecker T.

J Virol. 2010 Jan;84(2):983-92. doi: 10.1128/JVI.02039-09. Epub 2009 Nov 4.

28.

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.

Böttcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W.

Vaccine. 2009 Oct 23;27(45):6324-9. doi: 10.1016/j.vaccine.2009.03.029.

PMID:
19840668
29.

Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants.

Maisa A, Ströher U, Klenk HD, Garten W, Strecker T.

PLoS Negl Trop Dis. 2009 Jun 2;3(6):e446. doi: 10.1371/journal.pntd.0000446.

30.

Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties.

Neumann P, Lieber D, Meyer S, Dautel P, Kerth A, Kraus I, Garten W, Stubbs MT.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3710-5. doi: 10.1073/pnas.0808101106. Epub 2009 Feb 23.

31.

Restricted expression of Borna disease virus glycoprotein in brains of experimentally infected Lewis rats.

Werner-Keiss N, Garten W, Richt JA, Porombka D, Algermissen D, Herzog S, Baumgärtner W, Herden C.

Neuropathol Appl Neurobiol. 2008 Dec;34(6):590-602. doi: 10.1111/j.1365-2990.2008.00940.x. Epub 2008 Feb 14.

PMID:
18282160
32.

Role of the transmembrane domain of marburg virus surface protein GP in assembly of the viral envelope.

Mittler E, Kolesnikova L, Strecker T, Garten W, Becker S.

J Virol. 2007 Apr;81(8):3942-8. Epub 2007 Jan 31.

33.

Avian-virus-like receptor specificity of the hemagglutinin impedes influenza virus replication in cultures of human airway epithelium.

Matrosovich M, Matrosovich T, Uhlendorff J, Garten W, Klenk HD.

Virology. 2007 May 10;361(2):384-90. Epub 2007 Jan 17.

34.

The role of myristoylation in the membrane association of the Lassa virus matrix protein Z.

Strecker T, Maisa A, Daffis S, Eichler R, Lenz O, Garten W.

Virol J. 2006 Nov 5;3:93.

35.

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.

Böttcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M.

J Virol. 2006 Oct;80(19):9896-8.

36.

New low-viscosity overlay medium for viral plaque assays.

Matrosovich M, Matrosovich T, Garten W, Klenk HD.

Virol J. 2006 Aug 31;3:63.

37.
38.

Gangliosides are not essential for influenza virus infection.

Matrosovich M, Suzuki T, Hirabayashi Y, Garten W, Webster RG, Klenk HD.

Glycoconj J. 2006 Feb;23(1-2):107-13.

PMID:
16575528
39.

Maturation of Borna disease virus glycoprotein.

Eickmann M, Kiermayer S, Kraus I, Gössl M, Richt JA, Garten W.

FEBS Lett. 2005 Aug 29;579(21):4751-6.

40.

Oligomerization and assembly of the matrix protein of Borna disease virus.

Kraus I, Bogner E, Lilie H, Eickmann M, Garten W.

FEBS Lett. 2005 May 9;579(12):2686-92. Epub 2005 Apr 14.

41.

Ectodomain shedding of the glycoprotein GP of Ebola virus.

Dolnik O, Volchkova V, Garten W, Carbonnelle C, Becker S, Kahnt J, Ströher U, Klenk HD, Volchkov V.

EMBO J. 2004 May 19;23(10):2175-84. Epub 2004 Apr 22.

42.

Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP).

Eichler R, Strecker T, Kolesnikova L, ter Meulen J, Weissenhorn W, Becker S, Klenk HD, Garten W, Lenz O.

Virus Res. 2004 Mar 15;100(2):249-55.

PMID:
15019244
43.

Lassa virus glycoprotein signal peptide displays a novel topology with an extended endoplasmic reticulum luminal region.

Eichler R, Lenz O, Strecker T, Eickmann M, Klenk HD, Garten W.

J Biol Chem. 2004 Mar 26;279(13):12293-9. Epub 2004 Jan 6.

44.

Identification of Lassa virus glycoprotein signal peptide as a trans-acting maturation factor.

Eichler R, Lenz O, Strecker T, Eickmann M, Klenk HD, Garten W.

EMBO Rep. 2003 Nov;4(11):1084-8. Epub 2003 Oct 10.

45.

Crystal structure of the borna disease virus nucleoprotein.

Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R.

Structure. 2003 Oct;11(10):1219-26.

46.

Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected].

Strecker T, Eichler R, Meulen Jt, Weissenhorn W, Dieter Klenk H, Garten W, Lenz O.

J Virol. 2003 Oct;77(19):10700-5. Erratum in: J Virol. 2003 Dec;77(23):12927.

47.

Signal peptide of Lassa virus glycoprotein GP-C exhibits an unusual length.

Eichler R, Lenz O, Strecker T, Garten W.

FEBS Lett. 2003 Mar 13;538(1-3):203-6.

48.

Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.

Beyer WR, Pöpplau D, Garten W, von Laer D, Lenz O.

J Virol. 2003 Mar;77(5):2866-72.

49.

Identification of the amino terminal subunit of the glycoprotein of Borna disease virus.

Kiermayer S, Kraus I, Richt JA, Garten W, Eickmann M.

FEBS Lett. 2002 Nov 6;531(2):255-8.

50.

Crystallization and preliminary X-ray analysis of the matrix protein of Borna disease virus.

Kraus I, Scheffczik H, Eickmann M, Kiermayer S, Stubbs MT, Garten W.

Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1371-3. Epub 2002 Jul 20.

PMID:
12136159

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