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Items: 1 to 50 of 146


Bassoon Controls Presynaptic Autophagy through Atg5.

Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC.

Neuron. 2018 Feb 7;97(3):727. doi: 10.1016/j.neuron.2018.01.010. No abstract available.


N-terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors.

Goodman L, Baddeley D, Ambroziak W, Waites CL, Garner CC, Soeller C, Montgomery JM.

Hippocampus. 2017 Jun;27(6):668-682. doi: 10.1002/hipo.22723. Epub 2017 Mar 20.


Bassoon Controls Presynaptic Autophagy through Atg5.

Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC.

Neuron. 2017 Feb 22;93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026. Erratum in: Neuron. 2018 Feb 7;97(3):727.


Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome.

Colas D, Chuluun B, Garner CC, Heller HC.

Neurobiol Learn Mem. 2017 Apr;140:11-16. doi: 10.1016/j.nlm.2017.02.006. Epub 2017 Feb 12.


Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon.

Terry-Lorenzo RT, Torres VI, Wagh D, Galaz J, Swanson SK, Florens L, Washburn MP, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC.

PLoS One. 2016 Dec 1;11(12):e0167535. doi: 10.1371/journal.pone.0167535. eCollection 2016.


Reply: In vitro effects of a human monoclonal antibody against the N-methyl-d-aspartate receptor.

Kreye J, Wenke NK, Garner CC, Wardemann H, Prüss H.

Brain. 2017 Feb;140(2):e10. doi: 10.1093/brain/aww290. Epub 2016 Nov 17. No abstract available.


Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.

Arons MH, Lee K, Thynne CJ, Kim SA, Schob C, Kindler S, Montgomery JM, Garner CC.

J Neurosci. 2016 Aug 31;36(35):9124-34. doi: 10.1523/JNEUROSCI.0116-16.2016.


Rescuing the Lost in Translation.

Gehr S, Garner CC.

Cell. 2016 May 5;165(4):765-70. doi: 10.1016/j.cell.2016.04.043.


Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.

Gundelfinger ED, Reissner C, Garner CC.

Front Synaptic Neurosci. 2016 Jan 12;7:19. doi: 10.3389/fnsyn.2015.00019. eCollection 2015. Review.


Presynaptic active zones in invertebrates and vertebrates.

Ackermann F, Waites CL, Garner CC.

EMBO Rep. 2015 Aug;16(8):923-38. doi: 10.15252/embr.201540434. Epub 2015 Jul 9. Review.


Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1.

Wagh D, Terry-Lorenzo R, Waites CL, Leal-Ortiz SA, Maas C, Reimer RJ, Garner CC.

PLoS One. 2015 Apr 21;10(4):e0120093. doi: 10.1371/journal.pone.0120093. eCollection 2015.


Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.

Heller HC, Salehi A, Chuluun B, Das D, Lin B, Moghadam S, Garner CC, Colas D.

Neurobiol Learn Mem. 2014 Dec;116:162-71. doi: 10.1016/j.nlm.2014.10.002. Epub 2014 Oct 29.


Plasma membrane and actin cytoskeleton as synergistic barriers to nanowire cell penetration.

Aalipour A, Xu AM, Leal-Ortiz S, Garner CC, Melosh NA.

Langmuir. 2014 Oct 21;30(41):12362-7. doi: 10.1021/la502273f. Epub 2014 Oct 6.


In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses.

Regus-Leidig H, Fuchs M, Löhner M, Leist SR, Leal-Ortiz S, Chiodo VA, Hauswirth WW, Garner CC, Brandstätter JH.

Front Cell Neurosci. 2014 Sep 3;8:259. doi: 10.3389/fncel.2014.00259. eCollection 2014.


Quantification of nanowire penetration into living cells.

Xu AM, Aalipour A, Leal-Ortiz S, Mekhdjian AH, Xie X, Dunn AR, Garner CC, Melosh NA.

Nat Commun. 2014 Apr 7;5:3613. doi: 10.1038/ncomms4613.


Greater trochanteric hip pain.

Kimpel DM, Garner CC, Magone KM, May JH, Lawless MW.

Orthop Nurs. 2014 Mar-Apr;33(2):95-9; quiz 100-1. doi: 10.1097/NOR.0000000000000034. Review.


Usp16 contributes to somatic stem-cell defects in Down's syndrome.

Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF.

Nature. 2013 Sep 19;501(7467):380-4. doi: 10.1038/nature12530. Epub 2013 Sep 11.


Nanostraw-electroporation system for highly efficient intracellular delivery and transfection.

Xie X, Xu AM, Leal-Ortiz S, Cao Y, Garner CC, Melosh NA.

ACS Nano. 2013 May 28;7(5):4351-8. doi: 10.1021/nn400874a. Epub 2013 Apr 23.


Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome.

Colas D, Chuluun B, Warrier D, Blank M, Wetmore DZ, Buckmaster P, Garner CC, Heller HC.

Br J Pharmacol. 2013 Jul;169(5):963-73. doi: 10.1111/bph.12169.


Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.

Waites CL, Leal-Ortiz SA, Okerlund N, Dalke H, Fejtova A, Altrock WD, Gundelfinger ED, Garner CC.

EMBO J. 2013 Apr 3;32(7):954-69. doi: 10.1038/emboj.2013.27. Epub 2013 Feb 12.


Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling.

Arons MH, Thynne CJ, Grabrucker AM, Li D, Schoen M, Cheyne JE, Boeckers TM, Montgomery JM, Garner CC.

J Neurosci. 2012 Oct 24;32(43):14966-78. doi: 10.1523/JNEUROSCI.2215-12.2012.


Formation of Golgi-derived active zone precursor vesicles.

Maas C, Torres VI, Altrock WD, Leal-Ortiz S, Wagh D, Terry-Lorenzo RT, Fejtova A, Gundelfinger ED, Ziv NE, Garner CC.

J Neurosci. 2012 Aug 8;32(32):11095-108. doi: 10.1523/JNEUROSCI.0195-12.2012.


RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.

Grill B, Chen L, Tulgren ED, Baker ST, Bienvenut W, Anderson M, Quadroni M, Jin Y, Garner CC.

J Neurosci. 2012 Feb 22;32(8):2628-36. doi: 10.1523/JNEUROSCI.2901-11.2012.


Synaptic pathology of Down syndrome.

Garner CC, Wetmore DZ.

Adv Exp Med Biol. 2012;970:451-68. doi: 10.1007/978-3-7091-0932-8_20. Review.


Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review.

Grabrucker AM, Rowan M, Garner CC.

Drug Deliv Lett. 2011 Sep;1(1):13-23.


Use dependence of presynaptic tenacity.

Fisher-Lavie A, Zeidan A, Stern M, Garner CC, Ziv NE.

J Neurosci. 2011 Nov 16;31(46):16770-80. doi: 10.1523/JNEUROSCI.3384-11.2011.


Piccolo regulates the dynamic assembly of presynaptic F-actin.

Waites CL, Leal-Ortiz SA, Andlauer TF, Sigrist SJ, Garner CC.

J Neurosci. 2011 Oct 5;31(40):14250-63. doi: 10.1523/JNEUROSCI.1835-11.2011.


Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.

Grabrucker AM, Schmeisser MJ, Udvardi PT, Arons M, Schoen M, Woodling NS, Andreasson KI, Hof PR, Buxbaum JD, Garner CC, Boeckers TM.

Mol Neurodegener. 2011 Sep 22;6:65. doi: 10.1186/1750-1326-6-65.


v-SNARE composition distinguishes synaptic vesicle pools.

Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH.

Neuron. 2011 Aug 11;71(3):474-87. doi: 10.1016/j.neuron.2011.06.010.


SAP97 directs NMDA receptor spine targeting and synaptic plasticity.

Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM.

J Physiol. 2011 Sep 15;589(Pt 18):4491-510. doi: 10.1113/jphysiol.2011.215566. Epub 2011 Jul 18.


Presynaptic function in health and disease.

Waites CL, Garner CC.

Trends Neurosci. 2011 Jun;34(6):326-37. doi: 10.1016/j.tins.2011.03.004. Epub 2011 May 17. Review.


The Down syndrome critical region regulates retinogeniculate refinement.

Blank M, Fuerst PG, Stevens B, Nouri N, Kirkby L, Warrier D, Barres BA, Feller MB, Huberman AD, Burgess RW, Garner CC.

J Neurosci. 2011 Apr 13;31(15):5764-76. doi: 10.1523/JNEUROSCI.6015-10.2011.


Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.

Grabrucker AM, Garner CC, Boeckers TM, Bondioli L, Ruozi B, Forni F, Vandelli MA, Tosi G.

PLoS One. 2011 Mar 23;6(3):e17851. doi: 10.1371/journal.pone.0017851.


Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation.

Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM.

EMBO J. 2011 Feb 2;30(3):569-81. doi: 10.1038/emboj.2010.336. Epub 2011 Jan 7.


Emerging pharmacotherapies for neurodevelopmental disorders.

Wetmore DZ, Garner CC.

J Dev Behav Pediatr. 2010 Sep;31(7):564-81. doi: 10.1097/DBP.0b013e3181ee3833. Review.


A bicistronic lentiviral vector based on the 1D/2A sequence of foot-and-mouth disease virus expresses proteins stoichiometrically.

Torres V, Barra L, Garcés F, Ordenes K, Leal-Ortiz S, Garner CC, Fernandez F, Zamorano P.

J Biotechnol. 2010 Apr 1;146(3):138-42. doi: 10.1016/j.jbiotec.2010.01.017. Epub 2010 Feb 2.


Circadian locomotor rhythms are normal in Ts65Dn "Down syndrome" mice and unaffected by pentylenetetrazole.

Ruby NF, Fernandez F, Zhang P, Klima J, Heller HC, Garner CC.

J Biol Rhythms. 2010 Feb;25(1):63-6. doi: 10.1177/0748730409356202.


Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses.

Nash JE, Appleby VJ, Corrêa SA, Wu H, Fitzjohn SM, Garner CC, Collingridge GL, Molnár E.

J Neurochem. 2010 Feb;112(3):677-90. doi: 10.1111/j.1471-4159.2009.06480.x. Epub 2009 Nov 6.


Rapid assembly of functional presynaptic boutons triggered by adhesive contacts.

Lucido AL, Suarez Sanchez F, Thostrup P, Kwiatkowski AV, Leal-Ortiz S, Gopalakrishnan G, Liazoghli D, Belkaid W, Lennox RB, Grutter P, Garner CC, Colman DR.

J Neurosci. 2009 Oct 7;29(40):12449-66. doi: 10.1523/JNEUROSCI.1381-09.2009.


SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.

Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN.

Nat Neurosci. 2009 Aug;12(8):1011-9. doi: 10.1038/nn.2362. Epub 2009 Jul 20.


Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome.

Fernandez F, Trinidad JC, Blank M, Feng DD, Burlingame AL, Garner CC.

J Neurochem. 2009 Jul;110(1):157-69. doi: 10.1111/j.1471-4159.2009.06110.x. Epub 2009 Apr 22.


Cell autonomous defects in cortical development revealed by two-color chimera analysis.

Kwiatkowski AV, Garner CC, Nelson WJ, Gertler FB.

Mol Cell Neurosci. 2009 May;41(1):44-50. doi: 10.1016/j.mcn.2009.01.008. Epub 2009 Feb 5.


Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon.

Fejtova A, Davydova D, Bischof F, Lazarevic V, Altrock WD, Romorini S, Schöne C, Zuschratter W, Kreutz MR, Garner CC, Ziv NE, Gundelfinger ED.

J Cell Biol. 2009 Apr 20;185(2):341-55. doi: 10.1083/jcb.200807155.


Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate.

Waites CL, Specht CG, Härtel K, Leal-Ortiz S, Genoux D, Li D, Drisdel RC, Jeyifous O, Cheyne JE, Green WN, Montgomery JM, Garner CC.

J Neurosci. 2009 Apr 8;29(14):4332-45. doi: 10.1523/JNEUROSCI.4431-08.2009.


Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon.

Tsuriel S, Fisher A, Wittenmayer N, Dresbach T, Garner CC, Ziv NE.

J Neurosci. 2009 Jan 14;29(2):351-8. doi: 10.1523/JNEUROSCI.4777-08.2009.


Molecular mechanisms of presynaptic differentiation.

Jin Y, Garner CC.

Annu Rev Cell Dev Biol. 2008;24:237-62. doi: 10.1146/annurev.cellbio.23.090506.123417. Review.


Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis.

Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED, Garner CC.

J Cell Biol. 2008 Jun 2;181(5):831-46. doi: 10.1083/jcb.200711167.


Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus.

Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, König I, Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, Reissner C, Boeckers TM, Zuschratter W, Spilker C, Seidenbecher CI, Garner CC, Gundelfinger ED, Kreutz MR.

PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034. Erratum in: PLoS Biol. 2009 Jan;7(1):e1000022.


Episodic-like memory in Ts65Dn, a mouse model of Down syndrome.

Fernandez F, Garner CC.

Behav Brain Res. 2008 Mar 17;188(1):233-7. Epub 2007 Sep 19.


A year of unprecedented progress in Down syndrome basic research.

Reeves RH, Garner CC.

Ment Retard Dev Disabil Res Rev. 2007;13(3):215-20. Review.


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