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Items: 1 to 50 of 185

1.

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer.

Garlanda C, Bottazzi B, Magrini E, Inforzato A, Mantovani A.

Physiol Rev. 2018 Apr 1;98(2):623-639. doi: 10.1152/physrev.00016.2017.

PMID:
29412047
2.

IL-1 and IL-1 regulatory pathways in cancer progression and therapy.

Mantovani A, Barajon I, Garlanda C.

Immunol Rev. 2018 Jan;281(1):57-61. doi: 10.1111/imr.12614. Review.

PMID:
29247996
3.

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8.

Molgora M, Supino D, Mantovani A, Garlanda C.

Immunol Rev. 2018 Jan;281(1):233-247. doi: 10.1111/imr.12609. Review.

PMID:
29247989
4.

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C, Mantovani A.

Nature. 2017 Nov 2;551(7678):110-114. doi: 10.1038/nature24293. Epub 2017 Oct 25.

5.

The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis.

Erreni M, Manfredi AA, Garlanda C, Mantovani A, Rovere-Querini P.

Immunol Rev. 2017 Nov;280(1):112-125. doi: 10.1111/imr.12570. Review.

PMID:
29027216
6.

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.

Cavalli G, Koenders M, Kalabokis V, Kim J, Choon Tan A, Garlanda C, Mantovani A, Dagna L, Joosten LAB, Dinarello CA.

Rheumatology (Oxford). 2017 Dec 1;56(12):2256. doi: 10.1093/rheumatology/kex348. No abstract available.

PMID:
28968825
7.

Pro-inflammatory M1/Th1 type immune network and increased expression of TSG-6 in the eutopic endometrium from women with endometriosis.

Matteo M, Cicinelli E, Neri M, Carrubba R, Carpagnano FA, Romeo F, Scutiero G, Greco P, Garlanda C, Vendemiale G, Levi Setti PE, Serviddio G.

Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:99-105. doi: 10.1016/j.ejogrb.2017.08.014. Epub 2017 Sep 7.

PMID:
28963923
8.

Sexual Dimorphism in Innate Immunity.

Jaillon S, Berthenet K, Garlanda C.

Clin Rev Allergy Immunol. 2017 Sep 30. doi: 10.1007/s12016-017-8648-x. [Epub ahead of print] Review.

PMID:
28963611
9.

Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer.

Rubino M, Kunderfranco P, Basso G, Greco CM, Pasqualini F, Serio S, Roncalli M, Laghi L, Mantovani A, Papait R, Garlanda C.

Oncoimmunology. 2017 May 30;6(7):e1333215. doi: 10.1080/2162402X.2017.1333215. eCollection 2017.

10.

High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity.

Campesato LF, Silva APM, Cordeiro L, Correa BR, Navarro FCP, Zanin RF, Marçola M, Inoue LT, Duarte ML, Molgora M, Pasqualini F, Massara M, Galante P, Barroso-Sousa R, Polentarutti N, Riva F, Costa ET, Mantovani A, Garlanda C, Camargo AA.

Oncotarget. 2017 Jul 25;8(30):49470-49483. doi: 10.18632/oncotarget.17713.

11.

Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2017 May 1;214(5):1559. doi: 10.1084/jem.2015028204172017c. Epub 2017 Apr 18. No abstract available.

12.

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

Tomasoni R, Morini R, Lopez-Atalaya JP, Corradini I, Canzi A, Rasile M, Mantovani C, Pozzi D, Garlanda C, Mantovani A, Menna E, Barco A, Matteoli M.

Elife. 2017 Mar 28;6. pii: e21735. doi: 10.7554/eLife.21735.

13.

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice.

Mauri T, Zambelli V, Cappuzzello C, Bellani G, Dander E, Sironi M, Castiglioni V, Doni A, Mantovani A, Biondi A, Garlanda C, D'amico G, Pesenti A.

Intensive Care Med Exp. 2017 Dec;5(1):13. doi: 10.1186/s40635-017-0126-5. Epub 2017 Mar 6.

14.

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.

15.

Interplay between Myeloid Cells and Humoral Innate Immunity.

Jaillon S, Bonavita E, Garlanda C, Mantovani A.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0051-2016. Review.

PMID:
28087941
16.

The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3.

Vezzoli M, Sciorati C, Campana L, Monno A, Doglio MG, Rigamonti E, Corna G, Touvier T, Castiglioni A, Capobianco A, Mantovani A, Manfredi AA, Garlanda C, Rovere-Querini P.

Mol Med. 2016 Nov 23;22. doi: 10.2119/molmed.2016.00002. [Epub ahead of print]

17.

Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation.

Dander E, De Lorenzo P, Bottazzi B, Quarello P, Vinci P, Balduzzi A, Masciocchi F, Bonanomi S, Cappuzzello C, Prunotto G, Pavan F, Pasqualini F, Sironi M, Cuccovillo I, Leone R, Salvatori G, Parma M, Terruzzi E, Pagni F, Locatelli F, Mantovani A, Fagioli F, Biondi A, Garlanda C, Valsecchi MG, Rovelli A, D'Amico G.

Oncotarget. 2016 Dec 13;7(50):82123-82138. doi: 10.18632/oncotarget.13488.

18.

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link.

Doni A, Garlanda C, Mantovani A.

Semin Immunol. 2016 Dec;28(6):570-577. doi: 10.1016/j.smim.2016.10.012. Epub 2016 Nov 20. Review.

19.

Pentraxins in the activation and regulation of innate immunity.

Daigo K, Inforzato A, Barajon I, Garlanda C, Bottazzi B, Meri S, Mantovani A.

Immunol Rev. 2016 Nov;274(1):202-217. doi: 10.1111/imr.12476. Review.

20.

Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation.

Wang L, Cano M, Datta S, Wei H, Ebrahimi KB, Gorashi Y, Garlanda C, Handa JT.

J Pathol. 2016 Dec;240(4):495-506. doi: 10.1002/path.4811.

PMID:
27659908
21.

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2016 Sep 19;213(10):2167-85. doi: 10.1084/jem.20150282. Epub 2016 Sep 12. Erratum in: J Exp Med. 2017 May 1;214(5):1559.

22.

Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.

Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA.

Rheumatology (Oxford). 2016 Dec;55(12):2220-2229. Epub 2016 Aug 26. Erratum in: Rheumatology (Oxford). 2017 Dec 1;56(12 ):2256.

23.

Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.

Bonecchi R, Garlanda C, Mantovani A, Riva F.

Cytokine. 2016 Nov;87:37-45. doi: 10.1016/j.cyto.2016.06.023. Epub 2016 Aug 4.

24.

Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage.

Doni A, D'Amico G, Morone D, Mantovani A, Garlanda C.

Semin Cell Dev Biol. 2017 Jan;61:31-40. doi: 10.1016/j.semcdb.2016.07.026. Epub 2016 Jul 29. Review.

25.

Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets.

Anselmo A, Riva F, Gentile S, Soldani C, Barbagallo M, Mazzon C, Feruglio F, Polentarutti N, Somma P, Carullo P, Angelini C, Bacci M, Mendolicchio GL, Voza A, Nebuloni M, Mantovani A, Garlanda C.

Cardiovasc Res. 2016 Sep;111(4):373-84. doi: 10.1093/cvr/cvw162. Epub 2016 Jun 13. Erratum in: Cardiovasc Res. 2017 Jan;113(1):112.

PMID:
27297888
26.

The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Magrini E, Mantovani A, Garlanda C.

Trends Mol Med. 2016 Jun;22(6):497-510. doi: 10.1016/j.molmed.2016.04.007. Epub 2016 May 11. Review.

27.

Regulatory Role of IL-1R8 in Immunity and Disease.

Molgora M, Barajon I, Mantovani A, Garlanda C.

Front Immunol. 2016 Apr 20;7:149. doi: 10.3389/fimmu.2016.00149. eCollection 2016. Review.

28.

Fluid phase recognition molecules in neutrophil-dependent immune responses.

Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, Mantovani A.

Semin Immunol. 2016 Apr;28(2):109-18. doi: 10.1016/j.smim.2016.03.005. Epub 2016 Mar 25. Review.

29.

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.

Bonacina F, Barbieri SS, Cutuli L, Amadio P, Doni A, Sironi M, Tartari S, Mantovani A, Bottazzi B, Garlanda C, Tremoli E, Catapano AL, Norata GD.

Biochim Biophys Acta. 2016 Jun;1862(6):1182-90. doi: 10.1016/j.bbadis.2016.03.007. Epub 2016 Mar 11.

30.

Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer.

Galdiero MR, Bianchi P, Grizzi F, Di Caro G, Basso G, Ponzetta A, Bonavita E, Barbagallo M, Tartari S, Polentarutti N, Malesci A, Marone G, Roncalli M, Laghi L, Garlanda C, Mantovani A, Jaillon S.

Int J Cancer. 2016 Jul 15;139(2):446-56. doi: 10.1002/ijc.30076. Epub 2016 Mar 24.

31.

Glucose availability enhances lipopolysaccharide production and immunogenicity in the opportunistic pathogen Acinetobacter baumannii.

Rossi E, Longo F, Barbagallo M, Peano C, Consolandi C, Pietrelli A, Jaillon S, Garlanda C, Landini P.

Future Microbiol. 2016;11(3):335-49. doi: 10.2217/fmb.15.153. Epub 2016 Mar 2.

PMID:
26934424
32.

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.

Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, Mantovani A.

J Hepatol. 2016 Jun;64(6):1416-27. doi: 10.1016/j.jhep.2016.02.029. Epub 2016 Feb 26. Review.

33.

Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.

Cappuzzello C, Doni A, Dander E, Pasqualini F, Nebuloni M, Bottazzi B, Mantovani A, Biondi A, Garlanda C, D'Amico G.

J Invest Dermatol. 2016 Jan;136(1):293-300. doi: 10.1038/JID.2015.346.

34.

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition.

Garlanda C, Jaillon S, Doni A, Bottazzi B, Mantovani A.

Curr Opin Immunol. 2016 Feb;38:39-44. doi: 10.1016/j.coi.2015.11.002. Epub 2015 Nov 30. Review.

35.

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.

Paeschke A, Possehl A, Klingel K, Voss M, Voss K, Kespohl M, Sauter M, Overkleeft HS, Althof N, Garlanda C, Voigt A.

Eur J Immunol. 2016 Mar;46(3):619-33. doi: 10.1002/eji.201545892. Epub 2015 Dec 28.

36.

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.

Ummenthum K, Peferoen LA, Finardi A, Baker D, Pryce G, Mantovani A, Bsibsi M, Bottazzi B, Peferoen-Baert R, van der Valk P, Garlanda C, Kipp M, Furlan R, van Noort JM, Amor S.

Eur J Immunol. 2016 Mar;46(3):701-11. doi: 10.1002/eji.201545950. Epub 2015 Dec 14.

37.

PTX3 acts as an extrinsic oncosuppressor.

Bonavita E, Mantovani A, Garlanda C.

Oncotarget. 2015 Oct 20;6(32):32309-10. doi: 10.18632/oncotarget.4845. No abstract available.

38.

MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes.

Renzi TA, Rubino M, Gornati L, Garlanda C, Locati M, Curtale G.

Mediators Inflamm. 2015;2015:145305. doi: 10.1155/2015/145305. Epub 2015 Sep 14.

39.

PTX3 orchestrates tissue repair.

Doni A, Garlanda C, Mantovani A.

Oncotarget. 2015 Oct 13;6(31):30435-6. doi: 10.18632/oncotarget.5453. No abstract available.

40.

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients.

Infante M, Allavena P, Garlanda C, Nebuloni M, Morenghi E, Rahal D, Roncalli M, Cavuto S, Pesce S, Monari M, Valaperta S, Montanelli A, Solomon D, Bottoni E, Errico V, Voulaz E, Bossi M, Chiesa G, Passera E, Mantovani A, Alloisio M.

Int J Cancer. 2016 Feb 15;138(4):983-91. doi: 10.1002/ijc.29822. Epub 2015 Sep 8.

41.

Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.

Cappuzzello C, Doni A, Dander E, Pasqualini F, Nebuloni M, Bottazzi B, Mantovani A, Biondi A, Garlanda C, D'Amico G.

J Invest Dermatol. 2015 Sep 3. doi: 10.1038/jid.2015.346. [Epub ahead of print]

PMID:
26340034
42.

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra.

Borghi M, De Luca A, Puccetti M, Jaeger M, Mencacci A, Oikonomou V, Pariano M, Garlanda C, Moretti S, Bartoli A, Sobel J, van de Veerdonk FL, Dinarello CA, Netea MG, Romani L.

Cell Host Microbe. 2015 Aug 12;18(2):198-209. doi: 10.1016/j.chom.2015.07.004.

43.

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, Castagnoli C, Cambieri I, Stravalaci M, Pasqualini F, Laface I, Valentino S, Tartari S, Ponzetta A, Maina V, Barbieri SS, Tremoli E, Catapano AL, Norata GD, Bottazzi B, Garlanda C, Mantovani A.

J Exp Med. 2015 Jun 1;212(6):905-25. doi: 10.1084/jem.20141268. Epub 2015 May 11.

44.

Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.

Bottazzi B, Santini L, Savino S, Giuliani MM, Dueñas Díez AI, Mancuso G, Beninati C, Sironi M, Valentino S, Deban L, Garlanda C, Teti G, Pizza M, Rappuoli R, Mantovani A.

PLoS One. 2015 Mar 18;10(3):e0120807. doi: 10.1371/journal.pone.0120807. eCollection 2015.

45.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.

PMID:
25729923
46.

Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.

Foo SS, Chen W, Taylor A, Sheng KC, Yu X, Teng TS, Reading PC, Blanchard H, Garlanda C, Mantovani A, Ng LF, Herrero LJ, Mahalingam S.

PLoS Pathog. 2015 Feb 19;11(2):e1004649. doi: 10.1371/journal.ppat.1004649. eCollection 2015 Feb. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004797.

47.

PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.

Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A.

Cell. 2015 Feb 12;160(4):700-714. doi: 10.1016/j.cell.2015.01.004.

48.

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.

Li S, Neff CP, Barber K, Hong J, Luo Y, Azam T, Palmer BE, Fujita M, Garlanda C, Mantovani A, Kim S, Dinarello CA.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2497-502. doi: 10.1073/pnas.1424626112. Epub 2015 Feb 5.

49.

Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia.

Rodriguez-Grande B, Varghese L, Molina-Holgado F, Rajkovic O, Garlanda C, Denes A, Pinteaux E.

J Neuroinflammation. 2015 Jan 24;12:15. doi: 10.1186/s12974-014-0227-y.

50.

The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases.

Jaillon S, Bonavita E, Gentile S, Rubino M, Laface I, Garlanda C, Mantovani A.

Int Arch Allergy Immunol. 2014;165(3):165-78. doi: 10.1159/000368778. Epub 2014 Dec 20. Review.

PMID:
25531094

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