Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 64

1.

Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy.

Cordero JG, García-Escudero R, Avila J, Gargini R, García-Escudero V.

Oxid Med Cell Longev. 2018 Feb 20;2018:5010741. doi: 10.1155/2018/5010741. eCollection 2018. Review.

2.

Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.

García-Escudero R, Segrelles C, Dueñas M, Pombo M, Ballestín C, Alonso-Riaño M, Nenclares P, Álvarez-Rodríguez R, Sánchez-Aniceto G, Ruíz-Alonso A, López-Cedrún JL, Paramio JM, Lorz C.

Oral Oncol. 2018 Apr;79:55-63. doi: 10.1016/j.oraloncology.2018.02.014. Epub 2018 Mar 3.

PMID:
29598951
3.

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.

Chen J, Guccini I, Mitri DD, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, Bono J, Carracedo A, Alimonti A.

Nat Genet. 2018 Feb;50(2):219-228. doi: 10.1038/s41588-017-0026-3. Epub 2018 Jan 15.

PMID:
29335542
4.

Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease.

García-Escudero V, Gargini R, Martín-Maestro P, García E, García-Escudero R, Avila J.

Neurosci Lett. 2017 Aug 10;655:101-108. doi: 10.1016/j.neulet.2017.07.007. Epub 2017 Jul 8.

PMID:
28689927
5.

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.

Pisignano G, Napoli S, Magistri M, Mapelli SN, Pastori C, Di Marco S, Civenni G, Albino D, Enriquez C, Allegrini S, Mitra A, D'Ambrosio G, Mello-Grand M, Chiorino G, Garcia-Escudero R, Varani G, Carbone GM, Catapano CV.

Nat Commun. 2017 May 30;8:15622. doi: 10.1038/ncomms15622.

6.

Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2017 May 1;214(5):1559. doi: 10.1084/jem.2015028204172017c. Epub 2017 Apr 18. No abstract available.

7.

Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates.

de Lena PG, Paz-Gallardo A, Paramio JM, García-Escudero R.

Clin Epigenetics. 2017 Apr 8;9:36. doi: 10.1186/s13148-017-0334-6. eCollection 2017.

8.

WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth.

Gargini R, Escoll M, García E, García-Escudero R, Wandosell F, Antón IM.

Cell Rep. 2016 Nov 15;17(8):1962-1977. doi: 10.1016/j.celrep.2016.10.064.

9.

MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.

Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello-Grand M, Rossi S, Losa M, D'Ambrosio G, Sessa F, Thalmann GN, Garcia-Escudero R, Zitella A, Chiorino G, Catapano CV, Carbone GM.

J Clin Invest. 2016 Dec 1;126(12):4585-4602. doi: 10.1172/JCI86505. Epub 2016 Nov 7.

10.

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.

Tordella L, Khan S, Hohmeyer A, Banito A, Klotz S, Raguz S, Martin N, Dhamarlingam G, Carroll T, González Meljem JM, Deswal S, Martínez-Barbera JP, García-Escudero R, Zuber J, Zender L, Gil J.

Genes Dev. 2016 Oct 1;30(19):2187-2198. Epub 2016 Oct 13.

11.

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A.

J Exp Med. 2016 Sep 19;213(10):2167-85. doi: 10.1084/jem.20150282. Epub 2016 Sep 12. Erratum in: J Exp Med. 2017 May 1;214(5):1559.

12.

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer.

Martínez-Fernández M, Dueñas M, Feber A, Segovia C, García-Escudero R, Rubio C, López-Calderón FF, Díaz-García C, Villacampa F, Duarte J, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.

Oncotarget. 2015 Dec 8;6(39):42258-75. doi: 10.18632/oncotarget.5546.

13.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.

Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A.

Nat Commun. 2015 Jun 18;6:7227. doi: 10.1038/ncomms8227.

PMID:
26085373
14.

Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer.

Alajati A, Guccini I, Pinton S, Garcia-Escudero R, Bernasocchi T, Sarti M, Montani E, Rinaldi A, Montemurro F, Catapano C, Bertoni F, Alimonti A.

Cell Rep. 2015 Apr 28;11(4):564-76. doi: 10.1016/j.celrep.2015.03.044. Epub 2015 Apr 16.

15.

Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.

Toso A, Revandkar A, Di Mitri D, Guccini I, Proietti M, Sarti M, Pinton S, Zhang J, Kalathur M, Civenni G, Jarrossay D, Montani E, Marini C, Garcia-Escudero R, Scanziani E, Grassi F, Pandolfi PP, Catapano CV, Alimonti A.

Cell Rep. 2014 Oct 9;9(1):75-89. doi: 10.1016/j.celrep.2014.08.044. Epub 2014 Sep 25.

16.

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.

Santos M, Martínez-Fernández M, Dueñas M, García-Escudero R, Alfaya B, Villacampa F, Saiz-Ladera C, Costa C, Oteo M, Duarte J, Martínez V, Gómez-Rodriguez MJ, Martín ML, Fernández M, Viatour P, Morcillo MA, Sage J, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Paramio JM.

Cancer Res. 2014 Nov 15;74(22):6565-6577. doi: 10.1158/0008-5472.CAN-14-1218. Epub 2014 Sep 24.

17.

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.

Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, D'Antuono R, Montani E, Garcia-Escudero R, Guccini I, Da Silva-Alvarez S, Collado M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Alimonti A.

Nature. 2014 Nov 6;515(7525):134-7. doi: 10.1038/nature13638. Epub 2014 Aug 24.

PMID:
25156255
18.

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.

Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669.

19.

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.

Dueñas M, Martínez-Fernández M, García-Escudero R, Villacampa F, Marqués M, Saiz-Ladera C, Duarte J, Martínez V, Gómez MJ, Martín ML, Fernández M, Castellano D, Real FX, Rodriguez-Peralto JL, De La Rosa F, Paramio JM.

Mol Carcinog. 2015 Jul;54(7):566-76. doi: 10.1002/mc.22125. Epub 2013 Dec 18.

PMID:
24347284
20.

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.

Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW 2nd, Hardisson D, Mayor F Jr, Penela P.

J Clin Invest. 2013 Nov;123(11):4714-30. doi: 10.1172/JCI67333. Epub 2013 Oct 25.

21.

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14.

22.

RNAi-mediated silencing of Myc transcription inhibits stem-like cell maintenance and tumorigenicity in prostate cancer.

Civenni G, Malek A, Albino D, Garcia-Escudero R, Napoli S, Di Marco S, Pinton S, Sarti M, Carbone GM, Catapano CV.

Cancer Res. 2013 Nov 15;73(22):6816-27. doi: 10.1158/0008-5472.CAN-13-0615. Epub 2013 Sep 24.

23.

Keratinocyte cell lines derived from severe generalized recessive epidermolysis bullosa patients carrying a highly recurrent COL7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo.

Chamorro C, Almarza D, Duarte B, Llames SG, Murillas R, García M, Cigudosa JC, Espinosa-Hevia L, Escámez MJ, Mencía A, Meana A, García-Escudero R, Moro R, Conti CJ, Del Río M, Larcher F.

Exp Dermatol. 2013 Sep;22(9):601-3. doi: 10.1111/exd.12203.

PMID:
23947675
24.

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

Menacho-Márquez M, García-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcón B, Paramio JM, Bustelo XR.

PLoS Biol. 2013 Jul;11(7):e1001615. doi: 10.1371/journal.pbio.1001615. Epub 2013 Jul 23.

25.

ETS transcription factor ESE1/ELF3 orchestrates a positive feedback loop that constitutively activates NF-κB and drives prostate cancer progression.

Longoni N, Sarti M, Albino D, Civenni G, Malek A, Ortelli E, Pinton S, Mello-Grand M, Ostano P, D'Ambrosio G, Sessa F, Garcia-Escudero R, Thalmann GN, Chiorino G, Catapano CV, Carbone GM.

Cancer Res. 2013 Jul 15;73(14):4533-47. doi: 10.1158/0008-5472.CAN-12-4537. Epub 2013 May 16.

26.

A novel tumor suppressor network in squamous malignancies.

Costa C, Santos M, Segrelles C, Dueñas M, Lara MF, Agirre X, Prosper F, García-Escudero R, Paramio JM.

Sci Rep. 2012;2:828. doi: 10.1038/srep00828. Epub 2012 Nov 9.

27.

Transcriptional and Non-Transcriptional Functions of PPARβ/δ in Non-Small Cell Lung Cancer.

Genini D, Garcia-Escudero R, Carbone GM, Catapano CV.

PLoS One. 2012;7(9):e46009. doi: 10.1371/journal.pone.0046009. Epub 2012 Sep 25.

28.

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

Citterio C, Menacho-Márquez M, García-Escudero R, Larive RM, Barreiro O, Sánchez-Madrid F, Paramio JM, Bustelo XR.

Sci Signal. 2012 Oct 2;5(244):ra71. doi: 10.1126/scisignal.2002962.

29.

A humanized mouse model of HPV-associated pathology driven by E7 expression.

Buitrago-Pérez Á, Hachimi M, Dueñas M, Lloveras B, Santos A, Holguín A, Duarte B, Santiago JL, Akgül B, Rodríguez-Peralto JL, Storey A, Ribas C, Larcher F, del Rio M, Paramio JM, García-Escudero R.

PLoS One. 2012;7(7):e41743. doi: 10.1371/journal.pone.0041743. Epub 2012 Jul 23.

30.

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis.

Costa C, Santos M, Martínez-Fernández M, Dueñas M, Lorz C, García-Escudero R, Paramio JM.

Oncogene. 2013 Jun 13;32(24):2937-51. doi: 10.1038/onc.2012.316. Epub 2012 Aug 13.

PMID:
22890321
31.

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.

Dueñas M, Santos M, Aranda JF, Bielza C, Martínez-Cruz AB, Lorz C, Taron M, Ciruelos EM, Rodríguez-Peralto JL, Martín M, Larrañaga P, Dahabreh J, Stathopoulos GP, Rosell R, Paramio JM, García-Escudero R.

PLoS One. 2012;7(8):e42494. doi: 10.1371/journal.pone.0042494. Epub 2012 Aug 7.

32.

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.

Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M, Paramio JM.

Sci Rep. 2012;2:434. doi: 10.1038/srep00434. Epub 2012 May 31.

33.

Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo.

Quintana-Bustamante O, Grueso E, Garcia-Escudero R, Arza E, Alvarez-Barrientos A, Fabregat I, Garcia-Bravo M, Meza NW, Segovia JC.

PLoS One. 2012;7(3):e33945. doi: 10.1371/journal.pone.0033945. Epub 2012 Mar 23.

34.

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.

García-Hoz C, Sánchez-Fernández G, García-Escudero R, Fernández-Velasco M, Palacios-García J, Ruiz-Meana M, Díaz-Meco MT, Leitges M, Moscat J, García-Dorado D, Boscá L, Mayor F Jr, Ribas C.

J Biol Chem. 2012 Mar 2;287(10):7792-802. doi: 10.1074/jbc.M111.282210. Epub 2012 Jan 9.

35.

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes.

Pippa R, Espinosa L, Gundem G, García-Escudero R, Dominguez A, Orlando S, Gallastegui E, Saiz C, Besson A, Pujol MJ, López-Bigas N, Paramio JM, Bigas A, Bachs O.

Oncogene. 2012 Sep 20;31(38):4207-20. doi: 10.1038/onc.2011.582. Epub 2011 Dec 19.

PMID:
22179826
36.

The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures.

Akgül B, García-Escudero R, Ekechi C, Steger G, Navsaria H, Pfister H, Storey A.

Med Microbiol Immunol. 2011 May;200(2):127-35. doi: 10.1007/s00430-011-0183-4. Epub 2011 Jan 28.

PMID:
21274725
37.

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.

García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C, Costa C, Buitrago-Pérez A, Dueñas M, Paramio JM.

Mol Cancer. 2010 Jul 14;9:193. doi: 10.1186/1476-4598-9-193.

38.

A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.

Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S, Lara MF, Martínez-Cruz AB, Costa C, Buitrago-Pérez A, Saiz-Ladera C, Dueñas M, Paramio JM.

Stem Cell Rev. 2010 Jun;6(2):162-77. doi: 10.1007/s12015-010-9139-0.

39.

Gene expression profiling of mouse epidermal keratinocytes.

García-Escudero R, Paramio JM.

Methods Mol Biol. 2010;585:171-81. doi: 10.1007/978-1-60761-380-0_13.

PMID:
19908004
40.

Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.

Moral M, Segrelles C, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Buitrago A, Costa C, Saiz C, Ariza JM, Dueñas M, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Digiovanni J, Paramio JM.

In Vivo. 2009 Sep-Oct;23(5):653-60.

41.

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling.

Buitrago-Pérez A, Garaulet G, Vázquez-Carballo A, Paramio JM, García-Escudero R.

Curr Genomics. 2009 Mar;10(1):26-34. doi: 10.2174/138920209787581235.

42.

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation.

Martínez-Cruz AB, Santos M, García-Escudero R, Moral M, Segrelles C, Lorz C, Saiz C, Buitrago-Pérez A, Costa C, Paramio JM.

Anticancer Res. 2009 Aug;29(8):3035-42.

43.

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.

Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garín M, Grande T, Bravo A, DiGiovanni J, Paramio JM.

Cancer Res. 2009 Feb 1;69(3):1099-108. doi: 10.1158/0008-5472.CAN-08-3240. Epub 2009 Jan 27.

44.

Gene expression profiling as a tool for basic analysis and clinical application of human cancer.

García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Aug;47(8):573-9. doi: 10.1002/mc.20430.

PMID:
18324660
45.

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

Santos M, Ruiz S, Lara MF, Segrelles C, Moral M, Martínez-Cruz AB, Ballestín C, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Nov;47(11):815-21. doi: 10.1002/mc.20426.

PMID:
18300254
46.

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.

Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, Lorz C, García-Escudero R, Paramio JM.

Cancer Res. 2008 Feb 1;68(3):683-92. doi: 10.1158/0008-5472.CAN-07-3049.

47.

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.

Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J.

Cancer Res. 2007 Nov 15;67(22):10879-88.

48.

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.

Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF, Carbajal S, Martínez-Cruz AB, García-Escudero R, Beltran L, Segovia JC, Bravo A, DiGiovanni J, Paramio JM.

Mol Biol Cell. 2008 Jan;19(1):137-49. Epub 2007 Oct 24.

49.

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.

Lara MF, García-Escudero R, Ruiz S, Santos M, Moral M, Martínez-Cruz AB, Segrelles C, Lorz C, Paramio JM.

Mol Carcinog. 2008 Mar;47(3):209-21.

PMID:
17932948
50.

p107 acts as a tumor suppressor in pRb-deficient epidermis.

Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P, Martínez-Palacio J, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Feb;47(2):105-13.

PMID:
17932945

Supplemental Content

Loading ...
Support Center