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Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells.

Wu Y, Chitranshi P, Loukotková L, Gamboa da Costa G, Beland FA, Zhang J, Fang JL.

Arch Toxicol. 2017 Jun;91(6):2405-2423. doi: 10.1007/s00204-016-1893-6. Epub 2016 Nov 28.


Intrinsic Resistance of Burkholderia cepacia Complex to Benzalkonium Chloride.

Ahn Y, Kim JM, Kweon O, Kim SJ, Jones RC, Woodling K, Gamboa da Costa G, LiPuma JJ, Hussong D, Marasa BS, Cerniglia CE.

MBio. 2016 Nov 22;7(6). pii: e01716-16. doi: 10.1128/mBio.01716-16.


Effects of a 28-day dietary co-exposure to melamine and cyanuric acid on the levels of serum microRNAs in male and female Fisher 344 rats.

Silva CS, Chang CW, Williams D, Porter-Gill P, Gamboa da Costa G, Camacho L.

Food Chem Toxicol. 2016 Dec;98(Pt A):11-16. doi: 10.1016/j.fct.2016.09.013. Epub 2016 Sep 9.


Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90.

Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT.

Toxicol Sci. 2016 Sep;153(1):212. doi: 10.1093/toxsci/kfw123. Epub 2016 Aug 9. No abstract available.


Simple and rapid quantification of brominated vegetable oil in commercial soft drinks by LC-MS.

Chitranshi P, Gamboa da Costa G.

Food Chem. 2016 Dec 15;213:567-570. doi: 10.1016/j.foodchem.2016.06.110. Epub 2016 Jul 2.


Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents.

Camacho L, Lewis SM, Vanlandingham MM, Juliar BE, Olson GR, Patton RE, Gamboa da Costa G, Woodling K, Sepehr E, Bryant MS, Doerge DR, Basavarajappa MS, Felton RP, Delclos KB.

Food Chem Toxicol. 2016 Aug;94:39-56. doi: 10.1016/j.fct.2016.05.014. Epub 2016 May 24.


Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan.

Fang JL, Wu Y, Gamboa da Costa G, Chen S, Chitranshi P, Beland FA.

Toxicol Sci. 2016 Mar;150(1):27-39. doi: 10.1093/toxsci/kfv311. Epub 2015 Dec 10.


Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats.

Churchwell MI, Scheri RC, Von Tungeln LS, Gamboa da Costa G, Beland FA, Doerge DR.

Food Chem Toxicol. 2015 Dec;86:1-8. doi: 10.1016/j.fct.2015.08.029. Epub 2015 Sep 11.


Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.

Krais AM, Speksnijder EN, Melis JP, Singh R, Caldwell A, Gamboa da Costa G, Luijten M, Phillips DH, Arlt VM.

Int J Cancer. 2016 Feb 15;138(4):976-82. doi: 10.1002/ijc.29836. Epub 2015 Sep 22.


NIEHS/FDA CLARITY-BPA research program update.

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.

Reprod Toxicol. 2015 Dec;58:33-44. doi: 10.1016/j.reprotox.2015.07.075. Epub 2015 Jul 29. Review.


Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.

Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB.

Food Chem Toxicol. 2015 Jul;81:92-103. doi: 10.1016/j.fct.2015.04.009. Epub 2015 Apr 8.


Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin.

Zhao Y, Wang S, Xia Q, Gamboa da Costa G, Doerge DR, Cai L, Fu PP.

Chem Res Toxicol. 2014 Oct 20;27(10):1720-31. doi: 10.1021/tx5002139. Epub 2014 Sep 11.


Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy.

Schmeiser HH, Nortier JL, Singh R, Gamboa da Costa G, Sennesael J, Cassuto-Viguier E, Ambrosetti D, Rorive S, Pozdzik A, Phillips DH, Stiborova M, Arlt VM.

Int J Cancer. 2014 Jul 15;135(2):502-7.


Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90.

Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT.

Toxicol Sci. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. Epub 2014 Feb 4. Erratum in: Toxicol Sci. 2016 Sep;153(1):212.


Soil humic-like organic compounds in prescribed fire emissions using nuclear magnetic resonance spectroscopy.

Chalbot MC, Nikolich G, Etyemezian V, Dubois DW, King J, Shafer D, Gamboa da Costa G, Hinton JF, Kavouras IG.

Environ Pollut. 2013 Oct;181:167-71. doi: 10.1016/j.envpol.2013.06.008. Epub 2013 Jul 15.


Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents.

Pogribny IP, Tryndyak VP, Pogribna M, Shpyleva S, Surratt G, Gamboa da Costa G, Beland FA.

Int J Oncol. 2013 May;42(5):1822-32. doi: 10.3892/ijo.2013.1855. Epub 2013 Mar 12.


Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.

Bandele O, Camacho L, Ferguson M, Reimschuessel R, Stine C, Black T, Olejnik N, Keltner Z, Scott M, Gamboa da Costa G, Sprando R.

Food Chem Toxicol. 2013 Jan;51:106-13. doi: 10.1016/j.fct.2012.09.022. Epub 2012 Sep 26.


Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: gavage vs. feeding.

Sprando RL, Reimschuessel R, Stine CB, Black T, Olejnik N, Scott M, Keltner Z, Bandele O, Ferguson M, Nemser SM, Tkachenko A, Evans E, Crosby T, Woodling K, Loukotková L, Gamboa da Costa G.

Food Chem Toxicol. 2012 Dec;50(12):4389-97. doi: 10.1016/j.fct.2012.07.051. Epub 2012 Sep 3.


Metabolomics evaluation of hydroxyproline as a potential marker of melamine and cyanuric acid nephrotoxicity in male and female Fischer F344 rats.

Schnackenberg LK, Sun J, Pence LM, Bhattacharyya S, Gamboa da Costa G, Beger RD.

Food Chem Toxicol. 2012 Nov;50(11):3978-83. doi: 10.1016/j.fct.2012.08.010. Epub 2012 Aug 10.


Full structure assignments of pyrrolizidine alkaloid DNA adducts and mechanism of tumor initiation.

Zhao Y, Xia Q, Gamboa da Costa G, Yu H, Cai L, Fu PP.

Chem Res Toxicol. 2012 Sep 17;25(9):1985-96. doi: 10.1021/tx300292h. Epub 2012 Aug 16.


Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.

Zhang Q, Gamboa da Costa G, Von Tungeln LS, Jacob CC, Brown RP, Goering PL.

Toxicol Sci. 2012 Sep;129(1):1-8. doi: 10.1093/toxsci/kfs182. Epub 2012 May 19.


Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.

Gamboa da Costa G, Jacob CC, Von Tungeln LS, Hasbrouck NR, Olson GR, Hattan DG, Reimschuessel R, Beland FA.

Toxicol Appl Pharmacol. 2012 Jul 15;262(2):99-106. doi: 10.1016/j.taap.2012.04.031. Epub 2012 May 2.


Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.

Von Tungeln LS, Doerge DR, Gamboa da Costa G, Matilde Marques M, Witt WM, Koturbash I, Pogribny IP, Beland FA.

Int J Cancer. 2012 Nov 1;131(9):2008-15. doi: 10.1002/ijc.27493. Epub 2012 Mar 28.


Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats.

Jacob CC, Von Tungeln LS, Vanlandingham M, Beland FA, Gamboa da Costa G.

Toxicol Sci. 2012 Apr;126(2):317-24. doi: 10.1093/toxsci/kfr348. Epub 2012 Jan 6.


Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

Arlt VM, Singh R, Stiborová M, Gamboa da Costa G, Frei E, Evans JD, Farmer PB, Wolf CR, Henderson CJ, Phillips DH.

Drug Metab Dispos. 2011 Dec;39(12):2169-73. doi: 10.1124/dmd.111.041343. Epub 2011 Sep 22.


Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days.

Camacho L, Kelly KP, Beland FA, Gamboa da Costa G.

Toxicol Lett. 2011 Oct 10;206(2):166-71. doi: 10.1016/j.toxlet.2011.07.009. Epub 2011 Jul 18.


A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid.

Stine CB, Reimschuessel R, Gieseker CM, Evans ER, Mayer TD, Hasbrouck NR, Tall E, Boehmer J, Gamboa da Costa G, Ward JL.

Regul Toxicol Pharmacol. 2011 Aug;60(3):363-72. doi: 10.1016/j.yrtph.2011.05.004. Epub 2011 May 18.


Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry.

Jacob CC, Gamboa da Costa G.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Mar 15;879(9-10):652-6. doi: 10.1016/j.jchromb.2011.01.035. Epub 2011 Feb 21.


Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.

Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, Gamboa da Costa G.

Toxicol Sci. 2011 Feb;119(2):391-7. doi: 10.1093/toxsci/kfq333. Epub 2010 Oct 28.


Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.

Singh R, Arlt VM, Henderson CJ, Phillips DH, Farmer PB, Gamboa da Costa G.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1;878(23):2155-62. doi: 10.1016/j.jchromb.2010.06.008. Epub 2010 Jun 11.


High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.

Fu PP, Chou MW, Churchwell M, Wang Y, Zhao Y, Xia Q, Gamboa da Costa G, Marques MM, Beland FA, Doerge DR.

Chem Res Toxicol. 2010 Mar 15;23(3):637-52. doi: 10.1021/tx900402x.


Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptosis.

Mercer KE, Apostolov EO, Gamboa da Costa G, Yu X, Lang P, Roberts DW, Davis W, Basnakian AG, Kadlubar FF, Kadlubar SA.

Int J Mol Epidemiol Genet. 2010 Jan 30;1(2):92-103.


Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry.

Gamboa da Costa G, Singh R, Arlt VM, Mirza A, Richards M, Takamura-Enya T, Schmeiser HH, Farmer PB, Phillips DH.

Chem Res Toxicol. 2009 Nov;22(11):1860-8. doi: 10.1021/tx900264v.


Comparison of the metabolic activities of four wild-type Clostridium perfringens strains with their gatifloxacin-selected resistant mutants.

Rafii F, Park M, Gamboa da Costa G, Camacho L.

Arch Microbiol. 2009 Dec;191(12):895-902. doi: 10.1007/s00203-009-0518-3. Epub 2009 Oct 24.


Acrylamide formed at physiological temperature as a result of asparagine oxidation.

Tareke E, Heinze TM, Gamboa da Costa G, Ali S.

J Agric Food Chem. 2009 Oct 28;57(20):9730-3. doi: 10.1021/jf901812u.


DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

Von Tungeln LS, Churchwell MI, Doerge DR, Shaddock JG, McGarrity LJ, Heflich RH, Gamboa da Costa G, Marques MM, Beland FA.

Int J Cancer. 2009 May 1;124(9):2006-15. doi: 10.1002/ijc.24165.


Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53.

Simões ML, Hockley SL, Schwerdtle T, Gamboa da Costa G, Schmeiser HH, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2008 Oct 1;232(1):86-98. doi: 10.1016/j.taap.2008.06.006. Epub 2008 Jun 25. Erratum in: Toxicol Appl Pharmacol. 2018 Feb 19;:.


Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment.

Reynisson J, Stiborová M, Martínek V, Gamboa da Costa G, Phillips DH, Arlt VM.

Environ Mol Mutagen. 2008 Oct;49(8):659-67. doi: 10.1002/em.20411.


Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine.

Antunes AM, Duarte MP, Santos PP, Gamboa da Costa G, Heinze TM, Beland FA, Marques MM.

Chem Res Toxicol. 2008 Jul;21(7):1443-56. doi: 10.1021/tx8000972. Epub 2008 Jul 3.


Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Arlt VM, Stiborová M, Henderson CJ, Thiemann M, Frei E, Aimová D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH.

Carcinogenesis. 2008 Mar;29(3):656-65. doi: 10.1093/carcin/bgn002. Epub 2008 Jan 19.


Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.

Gamboa da Costa G, Marques MM, Fu X, Churchwell MI, Wang YP, Doerge DR, Beland FA.

Cancer Lett. 2007 Nov 18;257(2):191-8. Epub 2007 Aug 31.


Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone.

Arlt VM, Glatt H, Gamboa da Costa G, Reynisson J, Takamura-Enya T, Phillips DH.

Toxicol Sci. 2007 Aug;98(2):445-57. Epub 2007 May 4.


DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.

Gamboa da Costa G, Pereira PC, Churchwell MI, Beland FA, Marques MM.

Chem Res Toxicol. 2007 Feb;20(2):300-10. Epub 2007 Jan 30.


Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts.

Martins C, Oliveira NG, Pingarilho M, Gamboa da Costa G, Martins V, Marques MM, Beland FA, Churchwell MI, Doerge DR, Rueff J, Gaspar JF.

Toxicol Sci. 2007 Feb;95(2):383-90. Epub 2006 Nov 6.


Tamoxifen-DNA adduct formation in human endometrium.

Beland FA, Marques MM, Gamboa da Costa G, Phillips DH.

Chem Res Toxicol. 2005 Oct;18(10):1507-9; author reply 1509-11. No abstract available.


DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.

Doerge DR, Gamboa da Costa G, McDaniel LP, Churchwell MI, Twaddle NC, Beland FA.

Mutat Res. 2005 Feb 7;580(1-2):131-41.


Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover).

Roberts DW, Doerge DR, Churchwell MI, Gamboa da Costa G, Marques MM, Tolleson WH.

J Agric Food Chem. 2004 Oct 20;52(21):6623-32.


Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.

Beland FA, Churchwell MI, Doerge DR, Parkin DR, Malejka-Giganti D, Hewer A, Phillips DH, Carmichael PL, Gamboa da Costa G, Marques MM.

J Natl Cancer Inst. 2004 Jul 21;96(14):1099-104.


Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling.

Beland FA, Churchwell MI, Hewer A, Phillips DH, Gamboa da Costa G, Marques MM.

Biochem Biophys Res Commun. 2004 Jul 23;320(2):297-302.


Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC-ES/MS/MS.

Twaddle NC, McDaniel LP, Gamboa da Costa G, Churchwell MI, Beland FA, Doerge DR.

Cancer Lett. 2004 Apr 15;207(1):9-17.


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