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Items: 1 to 50 of 747

1.

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.

PMID:
29743351
2.

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH.

Cell Stem Cell. 2018 May 3;22(5):684-697.e9. doi: 10.1016/j.stem.2018.04.009.

PMID:
29727680
3.

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2018 Apr 27. doi: 10.1038/s41593-018-0131-3. [Epub ahead of print]

PMID:
29703932
4.

Human Adult Neurogenesis: Evidence and Remaining Questions.

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.

Cell Stem Cell. 2018 Apr 18. pii: S1934-5909(18)30166-8. doi: 10.1016/j.stem.2018.04.004. [Epub ahead of print] Review.

PMID:
29681514
5.

The role of adult hippocampal neurogenesis in brain health and disease.

Toda T, Parylak SL, Linker SB, Gage FH.

Mol Psychiatry. 2018 Apr 20. doi: 10.1038/s41380-018-0036-2. [Epub ahead of print] Review.

PMID:
29679070
6.

An in vivo model of functional and vascularized human brain organoids.

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH.

Nat Biotechnol. 2018 Jun;36(5):432-441. doi: 10.1038/nbt.4127. Epub 2018 Apr 16.

PMID:
29658944
7.

Early life experience drives structural variation of neural genomes in mice.

Bedrosian TA, Quayle C, Novaresi N, Gage FH.

Science. 2018 Mar 23;359(6382):1395-1399. doi: 10.1126/science.aah3378.

PMID:
29567711
8.

Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Mar 15. doi: 10.1038/s41593-018-0125-1. [Epub ahead of print]

PMID:
29545585
9.

CRISPR interference-based specific and efficient gene inactivation in the brain.

Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J.

Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. Erratum in: Nat Neurosci. 2018 Mar 15;:.

PMID:
29403034
10.

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.

Vadodaria KC, Amatya DN, Marchetto MC, Gage FH.

Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.

11.

Insights into the role of somatic mosaicism in the brain.

Paquola ACM, Erwin JA, Gage FH.

Curr Opin Syst Biol. 2017 Feb;1:90-94. doi: 10.1016/j.coisb.2016.12.004. Epub 2016 Dec 9.

12.

Review: adult neurogenesis contributes to hippocampal plasticity.

Toda T, Gage FH.

Cell Tissue Res. 2017 Nov 29. doi: 10.1007/s00441-017-2735-4. [Epub ahead of print] Review.

PMID:
29185071
13.

Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation.

Jaeger BN, Parylak SL, Gage FH.

Mol Aspects Med. 2017 Nov 9. pii: S0098-2997(17)30111-5. doi: 10.1016/j.mam.2017.11.003. [Epub ahead of print] Review.

PMID:
29117513
14.

MicroRNAs in Post-traumatic Stress Disorder.

Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF.

Curr Top Behav Neurosci. 2017 Oct 21. doi: 10.1007/7854_2017_32. [Epub ahead of print]

PMID:
29063484
15.

Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2017 Sep 28;20(10):1427. doi: 10.1038/nn1017-1427a. No abstract available.

PMID:
28949329
16.

An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.

Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A.

Mol Psychiatry. 2017 Sep 19. doi: 10.1038/mp.2017.175. [Epub ahead of print]

PMID:
28924182
17.

Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH.

Cell Stem Cell. 2017 Nov 2;21(5):618-634.e7. doi: 10.1016/j.stem.2017.08.012. Epub 2017 Sep 14.

PMID:
28919367
18.

Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells.

Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ.

Cell Rep. 2017 Sep 5;20(10):2525. doi: 10.1016/j.celrep.2017.08.073. No abstract available.

19.

Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons.

Vadodaria KC, Stern S, Marchetto MC, Gage FH.

Cell Tissue Res. 2018 Jan;371(1):161-170. doi: 10.1007/s00441-017-2670-4. Epub 2017 Aug 15. Review.

PMID:
28812143
20.

Examining non-LTR retrotransposons in the context of the evolving primate brain.

Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage FH.

BMC Biol. 2017 Aug 11;15(1):68. doi: 10.1186/s12915-017-0409-z. Review.

21.

Intact piRNA pathway prevents L1 mobilization in male meiosis.

Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5635-E5644. doi: 10.1073/pnas.1701069114. Epub 2017 Jun 19.

22.

Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells.

Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage FH.

Stem Cell Reports. 2017 Jun 6;8(6):1757-1769. doi: 10.1016/j.stemcr.2017.05.011.

23.

An environment-dependent transcriptional network specifies human microglia identity.

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK.

Science. 2017 Jun 23;356(6344). pii: eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25.

24.

Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW.

Genes Dev. 2017 Apr 15;31(8):845. doi: 10.1101/gad.300699.117. No abstract available.

25.

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.

Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K.

Nat Commun. 2017 May 2;8:15157. doi: 10.1038/ncomms15157.

26.

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network.

Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review.

27.

A role for miR-19 in the migration of adult-born neurons and schizophrenia.

Han J, Gage FH.

Neurogenesis (Austin). 2016 Dec 5;3(1):e1251873. doi: 10.1080/23262133.2016.1251873. eCollection 2016.

28.

Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2017 Mar 17;8:15047. doi: 10.1038/ncomms15047. No abstract available.

29.

Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges.

Kim Y, Santos R, Gage FH, Marchetto MC.

Front Cell Neurosci. 2017 Feb 14;11:30. doi: 10.3389/fncel.2017.00030. eCollection 2017. Review.

30.

Conserved expression of transposon-derived non-coding transcripts in primate stem cells.

Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G.

BMC Genomics. 2017 Feb 28;18(1):214. doi: 10.1186/s12864-017-3568-y.

31.

Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

Stern S, Santos R, Marchetto MC, Mendes AP, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH.

Mol Psychiatry. 2017 Feb 28. doi: 10.1038/mp.2016.260. [Epub ahead of print]

PMID:
28242870
32.

Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.

Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH.

J Neurosci. 2017 Feb 15;37(7):1675-1684. doi: 10.1523/JNEUROSCI.3047-16.2016. Epub 2016 Dec 30.

33.

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.

Gonçalves JT, Schafer ST, Gage FH.

Cell. 2016 Nov 3;167(4):897-914. doi: 10.1016/j.cell.2016.10.021. Review.

34.

L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2016 Dec;19(12):1583-1591. doi: 10.1038/nn.4388. Epub 2016 Sep 12. Erratum in: Nat Neurosci. 2017 Sep 28;20(10 ):1427. Nat Neurosci. 2018 Apr 27;:.

35.

Generating human serotonergic neurons in vitro: Methodological advances.

Vadodaria KC, Marchetto MC, Mertens J, Gage FH.

Bioessays. 2016 Nov;38(11):1123-1129. doi: 10.1002/bies.201600127. Epub 2016 Sep 22. Review.

PMID:
27716980
36.

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology.

Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH.

Mol Psychiatry. 2016 Nov;21(11):1573-1588. doi: 10.1038/mp.2016.158. Epub 2016 Oct 4.

37.

Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding.

Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage FH, Mu Y.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5501-10. doi: 10.1073/pnas.1606951113. Epub 2016 Aug 29.

38.

A human neurodevelopmental model for Williams syndrome.

Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR.

Nature. 2016 Aug 18;536(7616):338-43. Epub 2016 Aug 10.

39.

Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility.

Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE.

Nature. 2016 Aug 11;536(7615):205-9. Epub 2016 Aug 3.

40.

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency.

van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage FH, Steinbusch HW, Rutten BP.

Epigenomics. 2016 Aug;8(8):1131-49. doi: 10.2217/epi-2016-0032. Epub 2016 Jul 15. Review.

41.

Diverse Representations of Olfactory Information in Centrifugal Feedback Projections.

Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ.

J Neurosci. 2016 Jul 13;36(28):7535-45. doi: 10.1523/JNEUROSCI.3358-15.2016.

42.

Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers.

Gage FH, Guarente LP, Wagers AJ.

Trends Mol Med. 2016 Aug;22(8):633-634. doi: 10.1016/j.molmed.2016.06.011. Epub 2016 Jul 5. No abstract available.

PMID:
27396512
43.

Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain.

Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage FH.

Neuron. 2016 Jul 6;91(1):79-89. doi: 10.1016/j.neuron.2016.05.034.

44.

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.

Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR.

Mol Psychiatry. 2017 Jun;22(6):820-835. doi: 10.1038/mp.2016.95. Epub 2016 Jul 5.

45.

Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation.

Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH.

Nat Commun. 2016 Jun 14;7:12020. doi: 10.1038/ncomms12020. No abstract available.

46.

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation.

Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T.

Elife. 2016 Jun 10;5. pii: e13374. doi: 10.7554/eLife.13374.

47.

Environment-driven somatic mosaicism in brain disorders.

Bedrosian TA, Linker S, Gage FH.

Genome Med. 2016 May 23;8(1):58. doi: 10.1186/s13073-016-0317-9.

48.

Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW.

Genes Dev. 2016 May 15;30(10):1155-71. doi: 10.1101/gad.280941.116. Epub 2016 May 19. Erratum in: Genes Dev. 2017 Apr 15;31(8):845.

49.

What is memory? The present state of the engram.

Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C.

BMC Biol. 2016 May 19;14:40. doi: 10.1186/s12915-016-0261-6.

50.

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.

Mertens J, Marchetto MC, Bardy C, Gage FH.

Nat Rev Neurosci. 2016 Jul;17(7):424-37. doi: 10.1038/nrn.2016.46. Epub 2016 May 19. Review.

PMID:
27194476

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