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Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ; NASA study group, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F.

Sci Immunol. 2018 Apr 13;3(22). pii: eaan5997. doi: 10.1126/sciimmunol.aan5997.


Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo.

Ouadi A, Bekaert V, Receveur N, Thomas L, Lanza F, Marchand P, Gachet C, Mangin PH, Brasse D, Laquerriere P.

Nucl Med Biol. 2018 Mar 17;61:21-27. doi: 10.1016/j.nucmedbio.2018.03.003. [Epub ahead of print]


Retinoic acid receptor-α regulates synthetic events in human platelets: comment.

de la Salle H, Angénieux C, Lanza F, Gachet C.

J Thromb Haemost. 2018 Mar 5. doi: 10.1111/jth.13992. [Epub ahead of print] No abstract available.


Immobilized fibrinogen activates human platelets through GPVI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP.

Haematologica. 2018 Feb 22. pii: haematol.2017.182972. doi: 10.3324/haematol.2017.182972. [Epub ahead of print]


A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors.

Brouard N, Jost C, Matthias N, Albrecht C, Egard S, Gandhi P, Strassel C, Inoue T, Sugiyama D, Simmons PJ, Gachet C, Lanza F.

Blood Adv. 2017 Sep 26;1(21):1854-1866. doi: 10.1182/bloodadvances.2016003541. eCollection 2017 Sep 26.


The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

Leiva O, Leon C, Kah Ng S, Mangin P, Gachet C, Ravid K.

Am J Hematol. 2018 Mar;93(3):430-441. doi: 10.1002/ajh.25008. Epub 2018 Jan 12. Review.


Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S.

Cell. 2017 Nov 30;171(6):1368-1382.e23. doi: 10.1016/j.cell.2017.11.001.


Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance.

Hechler B, Ravanat C, Gachet C.

Haematologica. 2017 Dec;102(12):e502-e503. doi: 10.3324/haematol.2017.180539. No abstract available.


Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

Lavergne M, Janus-Bell E, Schaff M, Gachet C, Mangin PH.

Cancers (Basel). 2017 Sep 28;9(10). pii: E133. doi: 10.3390/cancers9100133. Review.


The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L.

Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15.


Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.

Cell Rep. 2017 May 9;19(6):1151-1164. doi: 10.1016/j.celrep.2017.04.047.


Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.

Alberio L, Ravanat C, Hechler B, Mangin PH, Lanza F, Gachet C.

Thromb Haemost. 2017 Jun 2;117(6):1101-1114. doi: 10.1160/TH16-09-0711. Epub 2017 Apr 6.


Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Saultier P, Vidal L, Canault M, Bernot D, Falaise C, Pouymayou C, Bordet JC, Saut N, Rostan A, Baccini V, Peiretti F, Favier M, Lucca P, Deleuze JF, Olaso R, Boland A, Morange PE, Gachet C, Malergue F, Fauré S, Eckly A, Trégouët DA, Poggi M, Alessi MC.

Haematologica. 2017 Jun;102(6):1006-1016. doi: 10.3324/haematol.2016.153577. Epub 2017 Mar 2.


Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.

Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H.

Haematologica. 2017 Apr;102(4):637-646. doi: 10.3324/haematol.2016.143958. Epub 2017 Jan 5.


Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro.

Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M.

Platelets. 2017 Sep;28(6):529-539. doi: 10.1080/09537104.2016.1252836. Epub 2016 Dec 29.


Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9.

Mammadova-Bach E, Zigrino P, Brucker C, Bourdon C, Freund M, De Arcangelis A, Abrams SI, Orend G, Gachet C, Mangin PH.

JCI Insight. 2016 Sep 8;1(14):e88245.


A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease.

Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F.

Thromb Haemost. 2016 Nov 30;116(6):1070-1078. Epub 2016 Sep 29.


Pre-existing donor-specific antibodies are detrimental to kidney allograft only when persistent after transplantation.

Caillard S, Becmeur C, Gautier-Vargas G, Olagne J, Muller C, Cognard N, Perrin P, Braun L, Heibel F, Lefebre F, Renner V, Gachet C, Moulin B, Parissiadis A.

Transpl Int. 2017 Jan;30(1):29-40. doi: 10.1111/tri.12864. Epub 2016 Oct 17.


Respective contributions of single and compound granule fusion to secretion by activated platelets.

Eckly A, Rinckel JY, Proamer F, Ulas N, Joshi S, Whiteheart SW, Gachet C.

Blood. 2016 Nov 24;128(21):2538-2549. Epub 2016 Sep 13.


Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Aguilar A, Pertuy F, Eckly A, Strassel C, Collin D, Gachet C, Lanza F, Léon C.

Blood. 2016 Oct 20;128(16):2022-2032. doi: 10.1182/blood-2016-02-699959. Epub 2016 Aug 8.


Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

Lecchi A, Femia EA, Paoletta S, Dupuis A, Ohlmann P, Gachet C, Jacobson KA, Machura K, Podda GM, Zieger B, Cattaneo M.

Hamostaseologie. 2016 Nov 7;36(4):279-283. Epub 2016 Aug 4. Review.


The contribution of mouse models to the understanding of constitutional thrombocytopenia.

Léon C, Dupuis A, Gachet C, Lanza F.

Haematologica. 2016 Aug;101(8):896-908. doi: 10.3324/haematol.2015.139394. Review.


Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

Podoplelova NA, Sveshnikova AN, Kotova YN, Eckly A, Receveur N, Nechipurenko DY, Obydennyi SI, Kireev II, Gachet C, Ataullakhanov FI, Mangin PH, Panteleev MA.

Blood. 2016 Sep 29;128(13):1745-55. doi: 10.1182/blood-2016-02-696898. Epub 2016 Jul 18.


Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C.

Transfusion. 2016 Sep;56(9):2239-47. doi: 10.1111/trf.13670. Epub 2016 Jun 1.


Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function.

Strassel C, Bull A, Moog S, Receveur N, Mallo L, Mangin P, Eckly A, Freund M, Dubart-Kupperschmitt A, Gachet C, Lanza F.

J Thromb Haemost. 2016 Jul;14(7):1470-9. doi: 10.1111/jth.13355. Epub 2016 Jul 14. Erratum in: J Thromb Haemost. 2017 Jan;15(1):208.


Platelets are dispensable for antibody-mediated transfusion-related acute lung injury in the mouse.

Hechler B, Maître B, Magnenat S, Heim V, El Mdawar MB, Gachet C, de la Salle H.

J Thromb Haemost. 2016 Jun;14(6):1255-67. doi: 10.1111/jth.13335. Epub 2016 May 21.


Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes.

Antkowiak A, Viaud J, Severin S, Zanoun M, Ceccato L, Chicanne G, Strassel C, Eckly A, Leon C, Gachet C, Payrastre B, Gaits-Iacovoni F.

J Thromb Haemost. 2016 Jun;14(6):1268-84. doi: 10.1111/jth.13318. Epub 2016 Apr 21.


Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.

Tang C, Wang Y, Lei D, Huang L, Wang G, Chi Q, Zheng Y, Gachet C, Mangin PH, Zhu L.

Thromb Res. 2016 May;141:49-57. doi: 10.1016/j.thromres.2016.02.032. Epub 2016 Mar 2.


Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets.

Strassel C, Brouard N, Mallo L, Receveur N, Mangin P, Eckly A, Bieche I, Tarte K, Gachet C, Lanza F.

Blood. 2016 May 5;127(18):2231-40. doi: 10.1182/blood-2015-09-670208. Epub 2016 Mar 10.


[Anti-platelets without a bleeding risk: novel targets and strategies].

Schaff M, Gachet C, Mangin PH.

Biol Aujourdhui. 2015;209(3):211-28. doi: 10.1051/jbio/2015023. Epub 2016 Jan 28. Review. French.


Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity.

Angénieux C, Maître B, Eckly A, Lanza F, Gachet C, de la Salle H.

PLoS One. 2016 Jan 25;11(1):e0148064. doi: 10.1371/journal.pone.0148064. eCollection 2016.


In Vitro Binding of [³H]PSB-0413 to P2Y₁₂ Receptors.

Dupuis A, Heim V, Ohlmann P, Gachet C.

Curr Protoc Pharmacol. 2015 Dec 8;71:1.35.1-19. doi: 10.1002/0471141755.ph0135s71.


Purinergic Receptors in Thrombosis and Inflammation.

Hechler B, Gachet C.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2307-15. doi: 10.1161/ATVBAHA.115.303395. Epub 2015 Sep 10. Review.


Platelets in cancer. From basic research to therapeutic implications.

Mammadova-Bach E, Mangin P, Lanza F, Gachet C.

Hamostaseologie. 2015;35(4):325-36. doi: 10.5482/hamo-14-11-0065. Epub 2015 Aug 20. Review.


Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity.

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH.

Thromb Haemost. 2015 Nov 25;114(6):1175-88. doi: 10.1160/TH14-11-0958. Epub 2015 Aug 6.


Antiplatelet drugs: which targets for which treatments?

Gachet C.

J Thromb Haemost. 2015 Jun;13 Suppl 1:S313-22. doi: 10.1111/jth.12947. Review.


Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis.

Henriques A, Blasco H, Fleury MC, Corcia P, Echaniz-Laguna A, Robelin L, Rudolf G, Lequeu T, Bergaentzle M, Gachet C, Pradat PF, Marchioni E, Andres CR, Tranchant C, Gonzalez De Aguilar JL, Loeffler JP.

PLoS One. 2015 Jul 6;10(7):e0131512. doi: 10.1371/journal.pone.0131512. eCollection 2015.


Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.

Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M.

Blood. 2015 Jul 30;126(5):683-91. doi: 10.1182/blood-2015-02-629717. Epub 2015 May 14.


Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

Ciciliano JC, Sakurai Y, Myers DR, Fay ME, Hechler B, Meeks S, Li R, Dixon JB, Lyon LA, Gachet C, Lam WA.

Blood. 2015 Aug 6;126(6):817-24. doi: 10.1182/blood-2015-02-628594. Epub 2015 Apr 30.


A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders.

Mumford AD, Frelinger AL 3rd, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D.

Thromb Haemost. 2015 Jul;114(1):14-25. doi: 10.1160/TH14-11-0999. Epub 2015 Apr 16. Review.


Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.

Donnet T, Ravanat C, Eckly A, Maurer E, Alame G, Ziessel C, Mangin PH, Freund M, Cazenave JP, Gachet C, Rendu F.

Transfusion. 2015 Sep;55(9):2207-18. doi: 10.1111/trf.13121. Epub 2015 Apr 9.


The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP.

Nat Commun. 2015 Mar 17;6:6535. doi: 10.1038/ncomms7535.


Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release.

Badirou I, Pan J, Souquere S, Legrand C, Pierron G, Wang A, Eckly A, Roy A, Gachet C, Vainchenker W, Chang Y, Léon C.

J Thromb Haemost. 2015 May;13(5):851-9. doi: 10.1111/jth.12887. Epub 2015 Apr 1.


NTPDase2 and the P2Y1 receptor are not required for mammalian eye formation.

Gampe K, Haverkamp S, Robson SC, Gachet C, Hüser L, Acker-Palmer A, Zimmermann H.

Purinergic Signal. 2015 Mar;11(1):155-60. doi: 10.1007/s11302-014-9440-5. Epub 2014 Dec 12.


The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice.

Maître B, Magnenat S, Heim V, Ravanat C, Evans RJ, de la Salle H, Gachet C, Hechler B.

J Immunol. 2015 Jan 15;194(2):739-49. doi: 10.4049/jimmunol.1401786. Epub 2014 Dec 5.


Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.

Lecchi A, Razzari C, Paoletta S, Dupuis A, Nakamura L, Ohlmann P, Gachet C, Jacobson KA, Zieger B, Cattaneo M.

Blood. 2015 Feb 5;125(6):1006-13. doi: 10.1182/blood-2013-07-517896. Epub 2014 Nov 26.


Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

Pertuy F, Aguilar A, Strassel C, Eckly A, Freund JN, Duluc I, Gachet C, Lanza F, Léon C.

J Thromb Haemost. 2015 Jan;13(1):115-25. doi: 10.1111/jth.12784. Epub 2014 Dec 17.


EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis.

Alame G, Mangin PH, Freund M, Riehl N, Magnenat S, Petitou M, Hechler B, Gachet C.

Thromb Haemost. 2015 Feb;113(2):385-95. doi: 10.1160/TH14-05-0399. Epub 2014 Nov 6.


Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis.

Strassel C, Kubovcakova L, Mangin PH, Ravanat C, Freund M, Skoda RC, Denis CV, Dupuis A, Herbrecht R, Gachet C, Lanza F.

Thromb Haemost. 2015 Feb;113(2):414-25. doi: 10.1160/TH14-08-0667. Epub 2014 Oct 9.


Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey.

Gresele P, Harrison P, Bury L, Falcinelli E, Gachet C, Hayward CP, Kenny D, Mezzano D, Mumford AD, Nugent D, Nurden AT, Orsini S, Cattaneo M.

J Thromb Haemost. 2014 Sep;12(9):1562-9. doi: 10.1111/jth.12650. Epub 2014 Jul 25.

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