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Items: 1 to 50 of 65

1.

Targeting G Protein-Coupled Receptors by Capture Compound Mass Spectrometry: A Case Study with Sertindole.

Blex C, Michaelis S, Schrey AK, Furkert J, Eichhorst J, Bartho K, Gyapon Quast F, Marais A, Hakelberg M, Gruber U, Niquet S, Popp O, Kroll F, Sefkow M, Schülein R, Dreger M, Köster H.

Chembiochem. 2017 Aug 17;18(16):1639-1649. doi: 10.1002/cbic.201700152. Epub 2017 Jul 7.

PMID:
28557180
2.

Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids.

Hinz KM, Neef D, Rutz C, Furkert J, Köhrle J, Schülein R, Krause G.

Mol Cell Endocrinol. 2017 Mar 5;443:163-174. doi: 10.1016/j.mce.2017.01.024. Epub 2017 Jan 18.

PMID:
28108384
3.

Green tea reduces body fat via upregulation of neprilysin.

Muenzner M, Tappenbeck N, Gembardt F, Rülke R, Furkert J, Melzig MF, Siems WE, Brockmann GA, Walther T.

Int J Obes (Lond). 2016 Dec;40(12):1850-1855. doi: 10.1038/ijo.2016.172. Epub 2016 Oct 4.

PMID:
27698343
4.

Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge Region.

Grzesik P, Kreuchwig A, Rutz C, Furkert J, Wiesner B, Schuelein R, Kleinau G, Gromoll J, Krause G.

Front Endocrinol (Lausanne). 2015 Sep 22;6:140. doi: 10.3389/fendo.2015.00140. eCollection 2015.

5.

AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH.

Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13.

PMID:
25119038
6.

The specific monomer/dimer equilibrium of the corticotropin-releasing factor receptor type 1 is established in the endoplasmic reticulum.

Teichmann A, Gibert A, Lampe A, Grzesik P, Rutz C, Furkert J, Schmoranzer J, Krause G, Wiesner B, Schülein R.

J Biol Chem. 2014 Aug 29;289(35):24250-62. doi: 10.1074/jbc.M114.553644. Epub 2014 Jun 25.

7.

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation.

Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G.

FEBS J. 2014 Mar;281(5):1479-92. doi: 10.1111/febs.12718. Epub 2014 Feb 10.

8.

Small-molecule screening identifies modulators of aquaporin-2 trafficking.

Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2013 Apr;24(5):744-58. doi: 10.1681/ASN.2012030295. Epub 2013 Apr 4.

9.

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.

Zampatis DE, Rutz C, Furkert J, Schmidt A, Wüstenhagen D, Kubick S, Tsopanoglou NE, Schülein R.

FEBS Lett. 2012 Jul 30;586(16):2351-9. doi: 10.1016/j.febslet.2012.05.042. Epub 2012 May 31.

10.

Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors.

Ridelis I, Schmidt A, Teichmann A, Furkert J, Wiesner B, Schülein R.

FEBS Lett. 2012 Mar 23;586(6):784-91. doi: 10.1016/j.febslet.2012.01.043. Epub 2012 Jan 28.

11.

Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin.

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R.

J Biol Chem. 2011 Oct 14;286(41):35588-600. doi: 10.1074/jbc.M111.239244. Epub 2011 Jul 30.

12.

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).

Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R.

J Biol Chem. 2011 Jul 22;286(29):25859-71. doi: 10.1074/jbc.M110.196980. Epub 2011 May 17.

13.

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.

Christian F, Szaszák M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Götz F, Zühlke K, Moutty M, Göttert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gáspár R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E.

J Biol Chem. 2011 Mar 18;286(11):9079-96. doi: 10.1074/jbc.M110.160614. Epub 2010 Dec 22.

14.

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.

Schulz K, Rutz C, Westendorf C, Ridelis I, Vogelbein S, Furkert J, Schmidt A, Wiesner B, Schülein R.

J Biol Chem. 2010 Oct 22;285(43):32878-87. doi: 10.1074/jbc.M110.129627. Epub 2010 Aug 3.

15.

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.

Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G.

Cell Mol Life Sci. 2011 Jan;68(1):159-67. doi: 10.1007/s00018-010-0451-2. Epub 2010 Jul 22.

16.

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G.

FASEB J. 2010 Jul;24(7):2347-54. doi: 10.1096/fj.09-149146. Epub 2010 Feb 23.

17.

Feasibility of functional cardiac MR imaging in mice using a clinical 3 Tesla whole body scanner.

Bunck AC, Engelen MA, Schnackenburg B, Furkert J, Bremer C, Heindel W, Stypmann J, Maintz D.

Invest Radiol. 2009 Dec;44(12):749-56. doi: 10.1097/RLI.0b013e3181b2c135.

PMID:
19838122
18.

Ago-antagonists for G protein-coupled peptide hormone receptor by modifying the agonist's signalling domain.

Beyermann M, Heinrich N, Fechner K, Furkert J, Zhang W, Kraetke O, Bienert M, Berger H.

Adv Exp Med Biol. 2009;611:541-2. No abstract available.

PMID:
19400304
19.

Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.

Walther T, Albrecht D, Becker M, Schubert M, Kouznetsova E, Wiesner B, Maul B, Schliebs R, Grecksch G, Furkert J, Sterner-Kock A, Schultheiss HP, Becker A, Siems WE.

PLoS One. 2009;4(2):e4590. doi: 10.1371/journal.pone.0004590. Epub 2009 Feb 25.

20.

CAPD: developments during changing times.

Furkert J, Zeier M, Schwenger V.

Perit Dial Int. 2009 Jan-Feb;29(1):115-6. No abstract available.

PMID:
19164262
21.

The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane.

Alken M, Schmidt A, Rutz C, Furkert J, Kleinau G, Rosenthal W, Schülein R.

Mol Pharmacol. 2009 Apr;75(4):801-11. doi: 10.1124/mol.108.051581. Epub 2009 Jan 9.

22.

Gastrointestinal hemorrhage in hemodialysis patients.

Furkert JD, Zeier M, Schwenger V.

Z Gastroenterol. 2008 Nov;46(11):1266-9. doi: 10.1055/s-2008-1027522. Epub 2008 Nov 14.

PMID:
19012197
23.

Effects of peritoneal dialysis solutions low in GDPs on peritonitis and exit-site infection rates.

Furkert J, Zeier M, Schwenger V.

Perit Dial Int. 2008 Nov-Dec;28(6):637-40.

PMID:
18981395
24.

Use of Kaede fusions to visualize recycling of G protein-coupled receptors.

Schmidt A, Wiesner B, Weisshart K, Schulz K, Furkert J, Lamprecht B, Rosenthal W, Schülein R.

Traffic. 2009 Jan;10(1):2-15. doi: 10.1111/j.1600-0854.2008.00843.x. Epub 2008 Oct 14.

25.

Continuous ambulatory peritoneal dialysis--developments during changing times.

Furkert JD, Zeier M, Schwenger V.

Nephron Clin Pract. 2008;110(2):c139-43. doi: 10.1159/000163847. Epub 2008 Oct 16.

PMID:
18931518
26.

Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.

Plant TD, Zöllner C, Kepura F, Mousa SS, Eichhorst J, Schaefer M, Furkert J, Stein C, Oksche A.

Mol Pain. 2007 Nov 14;3:35.

27.

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.

Vossenkämper A, Nedvetsky PI, Wiesner B, Furkert J, Rosenthal W, Klussmann E.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C1129-38. Epub 2007 Jul 11.

28.

Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

Beyermann M, Heinrich N, Fechner K, Furkert J, Zhang W, Kraetke O, Bienert M, Berger H.

Br J Pharmacol. 2007 Jul;151(6):851-9. Epub 2007 May 29.

29.

Mass-spectrometric identification of a novel angiotensin peptide in human plasma.

Jankowski V, Vanholder R, van der Giet M, Tölle M, Karadogan S, Gobom J, Furkert J, Oksche A, Krause E, Tran TN, Tepel M, Schuchardt M, Schlüter H, Wiedon A, Beyermann M, Bader M, Todiras M, Zidek W, Jankowski J.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):297-302. Epub 2006 Nov 30.

30.

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.

Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky P, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E.

J Am Soc Nephrol. 2007 Jan;18(1):199-212. Epub 2006 Nov 29.

31.

Dimerization of corticotropin-releasing factor receptor type 1 is not coupled to ligand binding.

Kraetke O, Wiesner B, Eichhorst J, Furkert J, Bienert M, Beyermann M.

J Recept Signal Transduct Res. 2005;25(4-6):251-76.

PMID:
16393915
32.

Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction.

Giebing G, Tölle M, Jürgensen J, Eichhorst J, Furkert J, Beyermann M, Neuschäfer-Rube F, Rosenthal W, Zidek W, van der Giet M, Oksche A.

Circ Res. 2005 Sep 30;97(7):707-15. Epub 2005 Sep 1.

33.

The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor.

Alken M, Rutz C, Köchl R, Donalies U, Oueslati M, Furkert J, Wietfeld D, Hermosilla R, Scholz A, Beyermann M, Rosenthal W, Schülein R.

Biochem J. 2005 Sep 1;390(Pt 2):455-64.

34.

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.

Wüller S, Wiesner B, Löffler A, Furkert J, Krause G, Hermosilla R, Schaefer M, Schülein R, Rosenthal W, Oksche A.

J Biol Chem. 2004 Nov 5;279(45):47254-63. Epub 2004 Aug 19.

35.

Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells.

Wietfeld D, Heinrich N, Furkert J, Fechner K, Beyermann M, Bienert M, Berger H.

J Biol Chem. 2004 Sep 10;279(37):38386-94. Epub 2004 Jul 12.

36.

Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers.

Gregan B, Jürgensen J, Papsdorf G, Furkert J, Schaefer M, Beyermann M, Rosenthal W, Oksche A.

J Biol Chem. 2004 Jun 25;279(26):27679-87. Epub 2004 Apr 9.

37.

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.

Tamma G, Wiesner B, Furkert J, Hahm D, Oksche A, Schaefer M, Valenti G, Rosenthal W, Klussmann E.

J Cell Sci. 2003 Aug 15;116(Pt 16):3285-94. Epub 2003 Jun 26.

38.

The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.

Grantcharova E, Furkert J, Reusch HP, Krell HW, Papsdorf G, Beyermann M, Schulein R, Rosenthal W, Oksche A.

J Biol Chem. 2002 Nov 15;277(46):43933-41. Epub 2002 Sep 10.

39.

Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein.

Oksche A, Boese G, Horstmeyer A, Papsdorf G, Furkert J, Beyermann M, Bienert M, Rosenthal W.

J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S44-7.

PMID:
11078332
40.

Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor.

Oksche A, Boese G, Horstmeyer A, Furkert J, Beyermann M, Bienert M, Rosenthal W.

Mol Pharmacol. 2000 Jun;57(6):1104-13.

41.

Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?".

Slominski AT, Botchkarev V, Choudhry M, Fazal N, Fechner K, Furkert J, Krause E, Roloff B, Sayeed M, Wei E, Zbytek B, Zipper J, Wortsman J, Paus R.

Ann N Y Acad Sci. 1999 Oct 20;885:287-311. Review.

PMID:
10816662
42.
43.

Adaptation of corticosterone-but not beta-endorphin-secretion to repeated blood sampling in rats.

Haemisch A, Guerra G, Furkert J.

Lab Anim. 1999 Apr;33(2):185-91.

PMID:
10780823
44.

A role for a helical connector between two receptor binding sites of a long-chain peptide hormone.

Beyermann M, Rothemund S, Heinrich N, Fechner K, Furkert J, Dathe M, Winter R, Krause E, Bienert M.

J Biol Chem. 2000 Feb 25;275(8):5702-9.

45.

The role of conserved extracellular cysteine residues in vasopressin V2 receptor function and properties of two naturally occurring mutant receptors with additional extracellular cysteine residues.

Schülein R, Zühlke K, Oksche A, Hermosilla R, Furkert J, Rosenthal W.

FEBS Lett. 2000 Jan 21;466(1):101-6. Erratum in: FEBS Lett 2000 May 4;473(1):124.

46.

The degradation of corticotropin-releasing factor by enzymes of the rat brain studied by liquid chromatography-mass spectrometry.

Kertscher U, Beyermann M, Krause E, Furkert J, Berger H, Bienert M, Mehlis B.

Peptides. 1998;19(4):649-58.

PMID:
9622019
47.

Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin.

Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Bulfone-Paus S, Zipper J, Krause E, Paus R.

FASEB J. 1998 Mar;12(3):287-97.

PMID:
9506472
48.

Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1.

Heinrich N, Meyer MR, Furkert J, Sasse A, Beyermann M, Bönigk W, Berger H.

Endocrinology. 1998 Feb;139(2):651-8.

PMID:
9449637
49.

Identification and measurement of beta-endorphin levels in the skin during induced hair growth in mice.

Furkert J, Klug U, Slominski A, Eichmüller S, Mehlis B, Kertscher U, Paus R.

Biochim Biophys Acta. 1997 Aug 29;1336(2):315-22.

PMID:
9305804
50.

Corticotropin-releasing hormone (CRH) receptors in the mesenteric small arteries of rats resemble the (2)-subtype.

Rohde E, Furkert J, Fechner K, Beyermann M, Mulvany MJ, Richter RM, Denef C, Bienert M, Berger H.

Biochem Pharmacol. 1996 Sep 27;52(6):829-33.

PMID:
8781499

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