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Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.

Mishra AK, Bernardo-Garcia FJ, Fritsch C, Humberg TH, Egger B, Sprecher SG.

PLoS Genet. 2018 Apr 20;14(4):e1007353. doi: 10.1371/journal.pgen.1007353. [Epub ahead of print]


The relationship between strength asymmetries and jumping performance in professional volleyball players.

Schons P, Da Rosa RG, Fischer G, Berriel GP, Fritsch CG, Nakamura FY, Baroni BM, Peyré-Tartaruga LA.

Sports Biomech. 2018 Mar 26:1-12. doi: 10.1080/14763141.2018.1435712. [Epub ahead of print]


Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.

Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M.

Cell Rep. 2018 Mar 20;22(12):3115-3125. doi: 10.1016/j.celrep.2018.02.099.


The One Health Concept: 10 Years Old and a Long Road Ahead.

Destoumieux-Garzón D, Mavingui P, Boetsch G, Boissier J, Darriet F, Duboz P, Fritsch C, Giraudoux P, Le Roux F, Morand S, Paillard C, Pontier D, Sueur C, Voituron Y.

Front Vet Sci. 2018 Feb 12;5:14. doi: 10.3389/fvets.2018.00014. eCollection 2018. Review.


The landscape of transcription errors in eukaryotic cells.

Gout JF, Li W, Fritsch C, Li A, Haroon S, Singh L, Hua D, Fazelinia H, Smith Z, Seeholzer S, Thomas K, Lynch M, Vermulst M.

Sci Adv. 2017 Oct 20;3(10):e1701484. doi: 10.1126/sciadv.1701484. eCollection 2017 Oct.


The in-use stability of the rituximab biosimilar Rixathon®/Riximyo® upon preparation for intravenous infusion.

Lamanna WC, Heller K, Schneider D, Guerrasio R, Hampl V, Fritsch C, Schiestl M.

J Oncol Pharm Pract. 2017 Jan 1:1078155217731506. doi: 10.1177/1078155217731506. [Epub ahead of print]


Hydrotherapy improves pain and function in older women with knee osteoarthritis: a randomized controlled trial.

Dias JM, Cisneros L, Dias R, Fritsch C, Gomes W, Pereira L, Santos ML, Ferreira PH.

Braz J Phys Ther. 2017 Nov - Dec;21(6):449-456. doi: 10.1016/j.bjpt.2017.06.012. Epub 2017 Jul 5.


The structure-function relationship of disulfide bonds in etanercept.

Lamanna WC, Mayer RE, Rupprechter A, Fuchs M, Higel F, Fritsch C, Vogelsang C, Seidl A, Toll H, Schiestl M, Holzmann J.

Sci Rep. 2017 Jun 21;7(1):3951. doi: 10.1038/s41598-017-04320-5.


A numerical approach to determine mutant invasion fitness and evolutionary singular strategies.

Fritsch C, Campillo F, Ovaskainen O.

Theor Popul Biol. 2017 Jun;115:89-99. doi: 10.1016/j.tpb.2017.05.001. Epub 2017 May 10.


Gaussian approximations for chemostat models in finite and infinite dimensions.

Cloez B, Fritsch C.

J Math Biol. 2017 Oct;75(4):805-843. doi: 10.1007/s00285-017-1097-6. Epub 2017 Jan 27.


Characterization of Cinnamoyl Esterases from Different Lactobacilli and Bifidobacteria.

Fritsch C, Jänsch A, Ehrmann MA, Toelstede S, Vogel RF.

Curr Microbiol. 2017 Feb;74(2):247-256. doi: 10.1007/s00284-016-1182-x. Epub 2016 Dec 21.


Erratum to: Effects of low-level laser therapy applied before or after plyometric exercise on muscle damage markers: randomized, double-blind, placebo-controlled trial.

Fritsch CG, Dornelles MP, Severo-Silveira L, Marques VB, Rosso IA, Baroni BM.

Lasers Med Sci. 2017 Jan;32(1):251. doi: 10.1007/s10103-016-2113-6. No abstract available.


The adaptation of generalist predators' diet in a multi-prey context: insights from new functional responses.

Baudrot V, Perasso A, Fritsch C, Giraudoux P, Raoul F.

Ecology. 2016 Jul;97(7):1832-1841. doi: 10.1890/15-0427.1.


Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila.

Bernardo-Garcia FJ, Humberg TH, Fritsch C, Sprecher SG.

Fly (Austin). 2017 Apr 3;11(2):112-120. doi: 10.1080/19336934.2016.1244591. Epub 2016 Oct 10.


Patients with sciatica still experience pain and disability 5 years after surgery: A systematic review with meta-analysis of cohort studies.

Machado GC, Witzleb AJ, Fritsch C, Maher CG, Ferreira PH, Ferreira ML.

Eur J Pain. 2016 Nov;20(10):1700-1709. doi: 10.1002/ejp.893. Epub 2016 May 12. Review.


Effects of low-level laser therapy applied before or after plyometric exercise on muscle damage markers: randomized, double-blind, placebo-controlled trial.

Fritsch CG, Dornelles MP, Severo-Silveira L, Marques VB, Rosso IA, Baroni BM.

Lasers Med Sci. 2016 Dec;31(9):1935-1942. Epub 2016 Sep 21. Erratum in: Lasers Med Sci. 2017 Jan;32(1):251.


Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Caravatti G, Guagnano V, Aichholz R, Blanz J, Blasco F, Wipfli P, Fritsch C, Maira SM, Schnell C, Seiler FH.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4729-4734. doi: 10.1016/j.bmcl.2016.08.041. Epub 2016 Aug 17.


Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®)).

Hofmann HP, Kronthaler U, Fritsch C, Grau R, Müller SO, Mayer R, Seidl A, Da Silva A.

Expert Opin Biol Ther. 2016 Oct;16(10):1185-95. doi: 10.1080/14712598.2016.1217329. Epub 2016 Aug 16. Review.


The clinical course of pain and disability following surgery for spinal stenosis: a systematic review and meta-analysis of cohort studies.

Fritsch CG, Ferreira ML, Maher CG, Herbert RD, Pinto RZ, Koes B, Ferreira PH.

Eur Spine J. 2017 Feb;26(2):324-335. doi: 10.1007/s00586-016-4668-0. Epub 2016 Jul 21. Review.


Links between deterministic and stochastic approaches for invasion in growth-fragmentation-death models.

Campillo F, Champagnat N, Fritsch C.

J Math Biol. 2016 Dec;73(6-7):1781-1821. Epub 2016 Apr 23.


Phenolic acid degradation potential and growth behavior of lactic acid bacteria in sunflower substrates.

Fritsch C, Heinrich V, Vogel RF, Toelstede S.

Food Microbiol. 2016 Aug;57:178-86. doi: 10.1016/ Epub 2016 Mar 4.


Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.

Leroy C, Ramos P, Cornille K, Bonenfant D, Fritsch C, Voshol H, Bentires-Alj M.

Breast Cancer Res. 2016 Apr 5;18(1):41. doi: 10.1186/s13058-016-0697-1.


Competence of hosts and complex foraging behavior are two cornerstones in the dynamics of trophically transmitted parasites.

Baudrot V, Perasso A, Fritsch C, Raoul F.

J Theor Biol. 2016 May 21;397:158-68. doi: 10.1016/j.jtbi.2016.03.010. Epub 2016 Mar 15.


The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila.

Bernardo-Garcia FJ, Fritsch C, Sprecher SG.

Development. 2016 Apr 15;143(8):1413-23. doi: 10.1242/dev.128801. Epub 2016 Mar 7.


Tracking pan-continental trends in environmental contamination using sentinel raptors-what types of samples should we use?

Espín S, García-Fernández AJ, Herzke D, Shore RF, van Hattum B, Martínez-López E, Coeurdassier M, Eulaers I, Fritsch C, Gómez-Ramírez P, Jaspers VL, Krone O, Duke G, Helander B, Mateo R, Movalli P, Sonne C, van den Brink NW.

Ecotoxicology. 2016 May;25(4):777-801. doi: 10.1007/s10646-016-1636-8. Epub 2016 Mar 5.


Passive focusing techniques for piezoelectric air-coupled ultrasonic transducers.

Gómez Álvarez-Arenas TE, Camacho J, Fritsch C.

Ultrasonics. 2016 Apr;67:85-93. doi: 10.1016/j.ultras.2016.01.001. Epub 2016 Jan 13.


Functional genomics identifies regulators of the phototransduction machinery in the Drosophila larval eye and adult ocelli.

Mishra AK, Bargmann BOR, Tsachaki M, Fritsch C, Sprecher SG.

Dev Biol. 2016 Feb 15;410(2):164-177. doi: 10.1016/j.ydbio.2015.12.026. Epub 2016 Jan 6.


Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Burger MT, Nishiguchi G, Han W, Lan J, Simmons R, Atallah G, Ding Y, Tamez V, Zhang Y, Mathur M, Muller K, Bellamacina C, Lindvall MK, Zang R, Huh K, Feucht P, Zavorotinskaya T, Dai Y, Basham S, Chan J, Ginn E, Aycinena A, Holash J, Castillo J, Langowski JL, Wang Y, Chen MY, Lambert A, Fritsch C, Kauffmann A, Pfister E, Vanasse KG, Garcia PD.

J Med Chem. 2015 Nov 12;58(21):8373-86. doi: 10.1021/acs.jmedchem.5b01275. Epub 2015 Oct 27.


Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Imbach-Weese P, Gerspacher M, Caravatti G, Furet P, Zoller T, Fritsch C, Haasen D, Trappe J, Guthy DA, Arz D, Wirth J.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3569-74. doi: 10.1016/j.bmcl.2015.06.078. Epub 2015 Jun 27.


Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Gerspacher M, Imbach-Weese P, Mah R, Caravatti G, Furet P, Fritsch C, Schnell C, Blanz J, Blasco F, Desrayaud S, Guthy DA, Knapp M, Arz D, Wirth J, Roehn-Carnemolla E, Luu VH.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3575-81. doi: 10.1016/j.bmcl.2015.06.067. Epub 2015 Jun 26.


Fermentation performance of lactic acid bacteria in different lupin substrates-influence and degradation ability of antinutritives and secondary plant metabolites.

Fritsch C, Vogel RF, Toelstede S.

J Appl Microbiol. 2015 Oct;119(4):1075-88. doi: 10.1111/jam.12908. Epub 2015 Sep 4.


Effects of Electrical Stimulation in Spastic Muscles After Stroke: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Stein C, Fritsch CG, Robinson C, Sbruzzi G, Plentz RD.

Stroke. 2015 Aug;46(8):2197-205. doi: 10.1161/STROKEAHA.115.009633. Epub 2015 Jul 14. Review.


Discovery of a novel tricyclic 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity.

Gerspacher M, Fairhurst RA, Mah R, Roehn-Carnemolla E, Furet P, Fritsch C, Guthy DA.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3582-4. doi: 10.1016/j.bmcl.2015.06.077. Epub 2015 Jun 30.


Tight coordination of growth and differentiation between germline and soma provides robustness for drosophila egg development.

Vachias C, Fritsch C, Pouchin P, Bardot O, Mirouse V.

Cell Rep. 2014 Oct 23;9(2):531-41. doi: 10.1016/j.celrep.2014.09.035. Epub 2014 Oct 16.


Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons.

Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M.

Nucleic Acids Res. 2014 Aug;42(14):8895-904. doi: 10.1093/nar/gku532. Epub 2014 Jul 16.


A generalization of the bond fluctuation model to viscoelastic environments.

Fritsch CC.

J Phys Condens Matter. 2014 Aug 20;26(33):335101. doi: 10.1088/0953-8984/26/33/335101. Epub 2014 Jun 27.


An overview of existing raptor contaminant monitoring activities in Europe.

Gómez-Ramírez P, Shore RF, van den Brink NW, van Hattum B, Bustnes JO, Duke G, Fritsch C, García-Fernández AJ, Helander BO, Jaspers V, Krone O, Martínez-López E, Mateo R, Movalli P, Sonne C.

Environ Int. 2014 Jun;67:12-21. doi: 10.1016/j.envint.2014.02.004. Epub 2014 Mar 13.


Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Fritsch C, Huang A, Chatenay-Rivauday C, Schnell C, Reddy A, Liu M, Kauffmann A, Guthy D, Erdmann D, De Pover A, Furet P, Gao H, Ferretti S, Wang Y, Trappe J, Brachmann SM, Maira SM, Wilson C, Boehm M, Garcia-Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hofmann F, Sellers WR.

Mol Cancer Ther. 2014 May;13(5):1117-29. doi: 10.1158/1535-7163.MCT-13-0865. Epub 2014 Mar 7.


Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.

Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ.

J Clin Invest. 2014 Apr;124(4):1794-809. doi: 10.1172/JCI69927. Epub 2014 Feb 24.


Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.

Garcia PD, Langowski JL, Wang Y, Chen M, Castillo J, Fanton C, Ison M, Zavorotinskaya T, Dai Y, Lu J, Niu XH, Basham S, Chan J, Yu J, Doyle M, Feucht P, Warne R, Narberes J, Tsang T, Fritsch C, Kauffmann A, Pfister E, Drueckes P, Trappe J, Wilson C, Han W, Lan J, Nishiguchi G, Lindvall M, Bellamacina C, Aycinena JA, Zang R, Holash J, Burger MT.

Clin Cancer Res. 2014 Apr 1;20(7):1834-45. doi: 10.1158/1078-0432.CCR-13-2062. Epub 2014 Jan 28.


Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.

Rahal R, Frick M, Romero R, Korn JM, Kridel R, Chan FC, Meissner B, Bhang HE, Ruddy D, Kauffmann A, Farsidjani A, Derti A, Rakiec D, Naylor T, Pfister E, Kovats S, Kim S, Dietze K, Dörken B, Steidl C, Tzankov A, Hummel M, Monahan J, Morrissey MP, Fritsch C, Sellers WR, Cooke VG, Gascoyne RD, Lenz G, Stegmeier F.

Nat Med. 2014 Jan;20(1):87-92. doi: 10.1038/nm.3435. Epub 2013 Dec 22.


Retraction Notice to: Dystroglycan and Perlecan Provide a Basal Cue Required for Epithelial Polarity during Energetic Stress.

Mirouse V, Christoforou CP, Fritsch C, St Johnston D, Ray RP.

Dev Cell. 2013 Oct 28;27(2):241. doi: 10.1016/j.devcel.2013.09.019. Epub 2013 Oct 28. No abstract available.


Magnetic nanoparticles as mediators of ligand-free activation of EGFR signaling.

Bharde AA, Palankar R, Fritsch C, Klaver A, Kanger JS, Jovin TM, Arndt-Jovin DJ.

PLoS One. 2013 Jul 23;8(7):e68879. doi: 10.1371/journal.pone.0068879. Print 2013.


Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy.

Ziomkiewicz I, Loman A, Klement R, Fritsch C, Klymchenko AS, Bunt G, Jovin TM, Arndt-Jovin DJ.

Cytometry A. 2013 Sep;83(9):794-805. doi: 10.1002/cyto.a.22311. Epub 2013 Jul 9.


Can Body Condition and Somatic Indices be Used to Evaluate Metal-Induced Stress in Wild Small Mammals?

Tête N, Fritsch C, Afonso E, Coeurdassier M, Lambert JC, Giraudoux P, Scheifler R.

PLoS One. 2013 Jun 18;8(6):e66399. doi: 10.1371/journal.pone.0066399. Print 2013.


Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.

Furet P, Guagnano V, Fairhurst RA, Imbach-Weese P, Bruce I, Knapp M, Fritsch C, Blasco F, Blanz J, Aichholz R, Hamon J, Fabbro D, Caravatti G.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8. doi: 10.1016/j.bmcl.2013.05.007. Epub 2013 May 14. Erratum in: Bioorg Med Chem Lett. 2013 Aug 15;23(16):4723.


Physicochemical and functional comparability between the proposed biosimilar rituximab GP2013 and originator rituximab.

Visser J, Feuerstein I, Stangler T, Schmiederer T, Fritsch C, Schiestl M.

BioDrugs. 2013 Oct;27(5):495-507. doi: 10.1007/s40259-013-0036-3.


New method for real-time dynamic focusing through interfaces.

Cruza JF, Camacho J, Serrano-Iribarnegaray L, Fritsch C.

IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Apr;60(4):739-51. doi: 10.1109/TUFFC.2013.2622.


Kinetic lattice Monte Carlo simulation of viscoelastic subdiffusion.

Fritsch CC, Langowski J.

J Chem Phys. 2012 Aug 14;137(6):064114.


Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting.

Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M.

Genome Res. 2012 Nov;22(11):2208-18. doi: 10.1101/gr.139568.112. Epub 2012 Aug 9.

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