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Point-of-care urine culture for managing urinary tract infection in primary care: a randomised controlled trial of clinical and cost-effectiveness.

Butler CC, Francis NA, Thomas-Jones E, Longo M, Wootton M, Llor C, Little P, Moore M, Bates J, Pickles T, Kirby N, Gillespie D, Rumsby K, Brugman C, Gal M, Hood K, Verheij T.

Br J Gen Pract. 2018 Feb 26. pii: bjgp18X695285. doi: 10.3399/bjgp18X695285. [Epub ahead of print]


Effectiveness of general practitioner online training and an information booklet for parents on antibiotic prescribing for children with respiratory tract infection in primary care: a cluster randomized controlled trial.

Dekker ARJ, Verheij TJM, Broekhuizen BDL, Butler CC, Cals JWL, Francis NA, Little P, Sanders EAM, Yardley L, Zuithoff NPA, van der Velden AW.

J Antimicrob Chemother. 2018 Feb 9. doi: 10.1093/jac/dkx542. [Epub ahead of print]


Small Networks Encode Decision-Making in Primary Auditory Cortex.

Francis NA, Winkowski DE, Sheikhattar A, Armengol K, Babadi B, Kanold PO.

Neuron. 2018 Feb 21;97(4):885-897.e6. doi: 10.1016/j.neuron.2018.01.019. Epub 2018 Feb 1.


Stemming the tide of antimicrobial resistance: implications for management of acne vulgaris.

Santer M, Francis NA, Platt D, Eady EA, Layton AM.

Br J Gen Pract. 2018 Feb;68(667):64-65. doi: 10.3399/bjgp18X694457. No abstract available.


Incidence and antibiotic prescribing for clinically diagnosed urinary tract infection in older adults in UK primary care, 2004-2014.

Ahmed H, Farewell D, Jones HM, Francis NA, Paranjothy S, Butler CC.

PLoS One. 2018 Jan 5;13(1):e0190521. doi: 10.1371/journal.pone.0190521. eCollection 2018.


An evaluation of the TARGET (Treat Antibiotics Responsibly; Guidance, Education, Tools) Antibiotics Toolkit to improve antimicrobial stewardship in primary care-is it fit for purpose?

Jones LF, Hawking MKD, Owens R, Lecky D, Francis NA, Butler C, Gal M, McNulty CAM.

Fam Pract. 2017 Dec 28. doi: 10.1093/fampra/cmx131. [Epub ahead of print]


Impact of a deferred recruitment model in a randomised controlled trial in primary care (CREAM study).

Shepherd V, Thomas-Jones E, Ridd MJ, Hood K, Addison K, Francis NA.

Trials. 2017 Nov 10;18(1):533. doi: 10.1186/s13063-017-2284-x.


General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial.

Bates J, Francis NA, White P, Gillespie D, Thomas-Jones E, Breen R, Kirby N, Hood K, Gal M, Phillips R, Naik G, Cals J, Llor C, Melbye H, Wootton M, Riga E, Cochrane A, Howe R, Fitzsimmons D, Sewell B, Alam MF, Butler CC.

Trials. 2017 Sep 29;18(1):442. doi: 10.1186/s13063-017-2144-8.


Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries.

Gobat NH, Gal M, Butler CC, Webb SAR, Francis NA, Stanton H, Anthierens S, Bastiaens H, Godycki-Ćwirko M, Kowalczyk A, Pons-Vigués M, Pujol-Ribera E, Berenguera A, Watkins A, Sukumar P, Moore RG, Hood K, Nichol A.

Health Expect. 2018 Feb;21(1):387-395. doi: 10.1111/hex.12634. Epub 2017 Sep 27.


Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study).

Ingram JR, Cawley S, Coulman E, Gregory C, Thomas-Jones E, Pickles T, Cannings-John R, Francis NA, Harding K, Hood K, Piguet V.

Diabet Med. 2018 Feb;35(2):255-261. doi: 10.1111/dme.13431. Epub 2017 Aug 15.


Feasibility cluster randomised controlled trial of a within-consultation intervention to reduce antibiotic prescribing for children presenting to primary care with acute respiratory tract infection and cough.

Blair PS, Turnbull S, Ingram J, Redmond N, Lucas PJ, Cabral C, Hollinghurst S, Dixon P, Peters T, Horwood J, Little P, Francis NA, Gilbertson A, Jameson C, Hay AD.

BMJ Open. 2017 May 9;7(5):e014506. doi: 10.1136/bmjopen-2016-014506.


Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership.

Thomas KS, Brindle R, Chalmers JR, Gamble B, Francis NA, Hardy D, Hooper J, Keeley V, Levell NJ, McPhee M, Metcalf L, Santer M, Tarpey M, Smart P, Wallace A, Wilkes S.

Br J Dermatol. 2017 Aug;177(2):541-543. doi: 10.1111/bjd.15634. Epub 2017 Jun 14. No abstract available.


Determinants of initiation, implementation, and discontinuation of amoxicillin by adults with acute cough in primary care.

Gillespie D, Farewell D, Brookes-Howell L, Butler CC, Coenen S, Francis NA, Little P, Stuart B, Verheij T, Hood K.

Patient Prefer Adherence. 2017 Mar 15;11:561-569. doi: 10.2147/PPA.S119256. eCollection 2017.


Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care.

Hullegie S, Wootton M, Verheij TJM, Thomas-Jones E, Bates J, Hood K, Gal M, Francis NA, Little P, Moore M, Llor C, Pickles T, Gillespie D, Kirby N, Brugman C, Butler CC.

Fam Pract. 2017 Aug 1;34(4):392-399. doi: 10.1093/fampra/cmx009.


Automated Operant Conditioning in the Mouse Home Cage.

Francis NA, Kanold PO.

Front Neural Circuits. 2017 Mar 1;11:10. doi: 10.3389/fncir.2017.00010. eCollection 2017.


Dermatology Life Quality Index (DLQI) as a psoriasis referral triage tool.

Atwan A, Piguet V, Finlay AY, Francis NA, Ingram JR.

Br J Dermatol. 2017 Oct;177(4):e136-e137. doi: 10.1111/bjd.15446. Epub 2017 Sep 19. No abstract available.


Oral and Topical Antibiotics for Clinically Infected Eczema in Children: A Pragmatic Randomized Controlled Trial in Ambulatory Care.

Francis NA, Ridd MJ, Thomas-Jones E, Butler CC, Hood K, Shepherd V, Marwick CA, Huang C, Longo M, Wootton M, Sullivan F; CREAM Trial Management Group.

Ann Fam Med. 2017 Mar;15(2):124-130. doi: 10.1370/afm.2038.


Views of oral antibiotics and advice seeking about acne: a qualitative study of online discussion forums.

Santer M, Chandler D, Lown M, Francis NA, Muller I.

Br J Dermatol. 2017 Sep;177(3):751-757. doi: 10.1111/bjd.15398. Epub 2017 Jun 8.


How do general practitioners implement decision-making regarding COPD patients with exacerbations? An international focus group study.

Laue J, Melbye H, Halvorsen PA, Andreeva EA, Godycki-Cwirko M, Wollny A, Francis NA, Spigt M, Kung K, Risør MB.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 8;11:3109-3119. eCollection 2016.


The management of acne vulgaris in primary care: a cohort study of consulting and prescribing patterns using the Clinical Practice Research Datalink.

Francis NA, Entwistle K, Santer M, Layton AM, Eady EA, Butler CC.

Br J Dermatol. 2017 Jan;176(1):107-115. doi: 10.1111/bjd.15081. Epub 2016 Dec 27.


Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation.

Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij TJ, Goossens H, Little P; GRACE INTRO/CHAMP consortium.

Implement Sci. 2016 May 12;11:66. doi: 10.1186/s13012-016-0436-0.


Understanding flucloxacillin prescribing trends and treatment non-response in UK primary care: a Clinical Practice Research Datalink (CPRD) study.

Francis NA, Hood K, Lyons R, Butler CC.

J Antimicrob Chemother. 2016 Jul;71(7):2037-46. doi: 10.1093/jac/dkw084. Epub 2016 Apr 18.


Dental consultations in UK general practice and antibiotic prescribing rates: a retrospective cohort study.

Cope AL, Chestnutt IG, Wood F, Francis NA.

Br J Gen Pract. 2016 May;66(646):e329-36. doi: 10.3399/bjgp16X684757. Epub 2016 Mar 29.


A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study.

Francis NA, Ridd MJ, Thomas-Jones E, Shepherd V, Butler CC, Hood K, Huang C, Addison K, Longo M, Marwick C, Wootton M, Howe R, Roberts A, Haq MI, Madhok V, Sullivan F; CREAM team.

Health Technol Assess. 2016 Mar;20(19):i-xxiv, 1-84. doi: 10.3310/hta20190.


Identification, pathogenicity and abundance of Paracremonium pembeum sp. nov. and Graphium euwallaceae sp. nov.--two newly discovered mycangial associates of the polyphagous shot hole borer (Euwallacea sp.) in California.

Lynch SC, Twizeyimana M, Mayorquin JS, Wang DH, Na F, Kayim M, Kasson MT, Thu PQ, Bateman C, Rugman-Jones P, Hulcr J, Stouthamer R, Eskalen A.

Mycologia. 2016 Mar-Apr;108(2):313-29. doi: 10.3852/15-063. Epub 2016 Jan 6.


Key stakeholder perceptions about consent to participate in acute illness research: a rapid, systematic review to inform epi/pandemic research preparedness.

Gobat NH, Gal M, Francis NA, Hood K, Watkins A, Turner J, Moore R, Webb SA, Butler CC, Nichol A.

Trials. 2015 Dec 29;16:591. doi: 10.1186/s13063-015-1110-6. Review.


Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis.

Olsen JR, Gallacher J, Finlay AY, Piguet V, Francis NA.

Br J Dermatol. 2016 Apr;174(4):853-61. doi: 10.1111/bjd.14361. Epub 2016 Mar 6. Review.


Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care.

Olsen JR, Piguet V, Gallacher J, Francis NA.

Br J Gen Pract. 2016 Jan;66(642):e53-8. doi: 10.3399/bjgp15X688093. Epub 2015 Dec 6.


Bath additives for the treatment of childhood eczema (BATHE): protocol for multicentre parallel group randomised trial.

Santer M, Rumsby K, Ridd MJ, Francis NA, Stuart B, Chorozoglou M, Wood W, Roberts A, Thomas KS, Williams HC, Little P.

BMJ Open. 2015 Nov 1;5(10):e009575. doi: 10.1136/bmjopen-2015-009575.


Antibiotic prescribing in UK general dental practice: a cross-sectional study.

Cope AL, Francis NA, Wood F, Chestnutt IG.

Community Dent Oral Epidemiol. 2016 Apr;44(2):145-53. doi: 10.1111/cdoe.12199. Epub 2015 Oct 27.


General practitioners' attitudes towards the management of dental conditions and use of antibiotics in these consultations: a qualitative study.

Cope AL, Wood F, Francis NA, Chestnutt IG.

BMJ Open. 2015 Oct 1;5(10):e008551. doi: 10.1136/bmjopen-2015-008551.


Parental views on childhood vaccination against viral gastroenteritis-a qualitative interview study.

Lugg FV, Butler CC, Evans MR, Wood F, Francis NA.

Fam Pract. 2015 Aug;32(4):456-61. doi: 10.1093/fampra/cmv035. Epub 2015 May 22.


Childhood fever: a qualitative study on GPs' experiences during out-of-hours care.

de Bont EG, Peetoom KK, Moser A, Francis NA, Dinant GJ, Cals JW.

Fam Pract. 2015 Aug;32(4):449-55. doi: 10.1093/fampra/cmv029. Epub 2015 Apr 25.


Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study.

Olsen JR, Gallacher J, Finlay AY, Piguet V, Francis NA.

Lancet Infect Dis. 2015 Feb;15(2):190-5. doi: 10.1016/S1473-3099(14)71053-9. Epub 2014 Dec 23.


Discordant phylogenies suggest repeated host shifts in the Fusarium-Euwallacea ambrosia beetle mutualism.

O'Donnell K, Sink S, Libeskind-Hadas R, Hulcr J, Kasson MT, Ploetz RC, Konkol JL, Ploetz JN, Carrillo D, Campbell A, Duncan RE, Liyanage PN, Eskalen A, Na F, Geiser DM, Bateman C, Freeman S, Mendel Z, Sharon M, Aoki T, Cossé AA, Rooney AP.

Fungal Genet Biol. 2015 Sep;82:277-90. doi: 10.1016/j.fgb.2014.10.014. Epub 2014 Nov 1.


Clinicians' views and experiences of interventions to enhance the quality of antibiotic prescribing for acute respiratory tract infections.

Anthierens S, Tonkin-Crine S, Cals JW, Coenen S, Yardley L, Brookes-Howell L, Fernandez-Vandellos P, Krawczyk J, Godycki-Cwirko M, Llor C, Butler CC, Verheij T, Goossens H, Little P, Francis NA; GRACE/CHAMP INTRO team.

J Gen Intern Med. 2015 Apr;30(4):408-16. doi: 10.1007/s11606-014-3076-6. Epub 2014 Nov 6.


General dental practitioners' perceptions of antimicrobial use and resistance: a qualitative interview study.

Cope AL, Wood F, Francis NA, Chestnutt IG.

Br Dent J. 2014 Sep;217(5):E9. doi: 10.1038/sj.bdj.2014.761.


Development and validation of the Molluscum Contagiosum Diagnostic Tool for Parents: diagnostic accuracy study in primary care.

Olsen JR, Gallacher J, Piguet V, Francis NA.

Br J Gen Pract. 2014 Aug;64(625):e471-6. doi: 10.3399/bjgp14X680941.


Exploring patients' views of primary care consultations with contrasting interventions for acute cough: a six-country European qualitative study.

Tonkin-Crine S, Anthierens S, Francis NA, Brugman C, Fernandez-Vandellos P, Krawczyk J, Llor C, Yardley L, Coenen S, Godycki-Cwirko M, Butler CC, Verheij TJ, Goossens H, Little P, Cals JW; GRACE INTRO team.

NPJ Prim Care Respir Med. 2014 Jul 17;24:14026. doi: 10.1038/npjpcrm.2014.26.


Medication use in European primary care patients with lower respiratory tract infection: an observational study.

Hamoen M, Broekhuizen BD, Little P, Melbye H, Coenen S, Goossens H, Butler CC, Francis NA, Verheij TJ; GRACE clinical study group.

Br J Gen Pract. 2014 Feb;64(619):e81-91. doi: 10.3399/bjgp14X677130. Review.


Parents' knowledge, attitudes, and practice in childhood fever: an internet-based survey.

de Bont EG, Francis NA, Dinant GJ, Cals JW.

Br J Gen Pract. 2014 Jan;64(618):e10-6. doi: 10.3399/bjgp14X676401.


Epidemiology of molluscum contagiosum in children: a systematic review.

Olsen JR, Gallacher J, Piguet V, Francis NA.

Fam Pract. 2014 Apr;31(2):130-6. doi: 10.1093/fampra/cmt075. Epub 2013 Dec 2. Review.


Parents' and clinicians' views of an interactive booklet about respiratory tract infections in children: a qualitative process evaluation of the EQUIP randomised controlled trial.

Francis NA, Phillips R, Wood F, Hood K, Simpson S, Butler CC.

BMC Fam Pract. 2013 Dec 1;14:182. doi: 10.1186/1471-2296-14-182.


Evaluation of a web-based intervention to reduce antibiotic prescribing for LRTI in six European countries: quantitative process analysis of the GRACE/INTRO randomised controlled trial.

Yardley L, Douglas E, Anthierens S, Tonkin-Crine S, O'Reilly G, Stuart B, Geraghty AW, Arden-Close E, van der Velden AW, Goosens H, Verheij TJ, Butler CC, Francis NA, Little P; GRACE consortium.

Implement Sci. 2013 Nov 15;8:134. doi: 10.1186/1748-5908-8-134.


Asthma prevalence and humoral immune response in Somali immigrants in the US: implications for the hygiene hypothesis.

Butler CC, Francis NA.

Prim Care Respir J. 2013 Sep;22(3):262-4. doi: 10.4104/pcrj.2013.00081. No abstract available.


Variation in family physicians' recording of auscultation abnormalities in patients with acute cough is not explained by case mix. A study from 12 European networks.

Francis NA, Melbye H, Kelly MJ, Cals JW, Hopstaken RM, Coenen S, Butler CC.

Eur J Gen Pract. 2013 Jun;19(2):77-84. doi: 10.3109/13814788.2012.733690. Epub 2013 Apr 2.


Enhanced communication skills and C-reactive protein point-of-care testing for respiratory tract infection: 3.5-year follow-up of a cluster randomized trial.

Cals JW, de Bock L, Beckers PJ, Francis NA, Hopstaken RM, Hood K, de Bont EG, Butler CC, Dinant GJ.

Ann Fam Med. 2013 Mar-Apr;11(2):157-64. doi: 10.1370/afm.1477.


General practitioners' views on the acceptability and applicability of a web-based intervention to reduce antibiotic prescribing for acute cough in multiple European countries: a qualitative study prior to a randomised trial.

Anthierens S, Tonkin-Crine S, Douglas E, Fernandez-Vandellos P, Krawczyk J, Llor C, Cals JW, Francis NA, Yardley L, Coenen S, Verheij T, Goossens H, Little P; GRACE INTRO study team.

BMC Fam Pract. 2012 Oct 11;13:101. doi: 10.1186/1471-2296-13-101.


Delayed antibiotic prescribing and associated antibiotic consumption in adults with acute cough.

Francis NA, Gillespie D, Nuttall J, Hood K, Little P, Verheij T, Goossens H, Coenen S, Butler CC.

Br J Gen Pract. 2012 Sep;62(602):e639-46. doi: 10.3399/bjgp12X653561. Erratum in: Br J Gen Pract. 2013 Jan;63(606):12.

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