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Items: 1 to 50 of 141

1.

Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells.

Foretz M, Viollet B.

Methods Mol Biol. 2018;1732:363-371. doi: 10.1007/978-1-4939-7598-3_23.

PMID:
29480487
2.

LKB1 as a Gatekeeper of Hepatocyte Proliferation and Genomic Integrity during Liver Regeneration.

Maillet V, Boussetta N, Leclerc J, Fauveau V, Foretz M, Viollet B, Couty JP, Celton-Morizur S, Perret C, Desdouets C.

Cell Rep. 2018 Feb 20;22(8):1994-2005. doi: 10.1016/j.celrep.2018.01.086.

3.

Promise and challenges for direct small molecule AMPK activators.

Olivier S, Foretz M, Viollet B.

Biochem Pharmacol. 2018 Feb 3. pii: S0006-2952(18)30055-8. doi: 10.1016/j.bcp.2018.01.049. [Epub ahead of print] Review.

PMID:
29408352
4.

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

Boudaba N, Marion A, Huet C, Pierre R, Viollet B, Foretz M.

EBioMedicine. 2018 Feb;28:194-209. doi: 10.1016/j.ebiom.2018.01.008. Epub 2018 Jan 9.

5.

AMPK in skeletal muscle function and metabolism.

Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L.

FASEB J. 2018 Apr;32(4):1741-1777. doi: 10.1096/fj.201700442R. Epub 2018 Jan 5.

PMID:
29242278
6.

Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.

Martin KR, Pederzoli-Ribeil M, Pacreau E, Burgener SS, Dahdah A, Candalh C, Lauret E, Foretz M, Mouthon L, Lucas B, Thieblemont N, Benarafa C, Launay P, Witko-Sarsat V.

J Immunol. 2017 Dec 1;199(11):3914-3924. doi: 10.4049/jimmunol.1601522. Epub 2017 Oct 27.

PMID:
29079698
7.

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2017 Dec 8;292(49):20125-20140. doi: 10.1074/jbc.M117.811547. Epub 2017 Oct 16.

PMID:
29038293
8.

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes.

Deschemin JC, Foretz M, Viollet B, Vaulont S.

Sci Rep. 2017 Oct 4;7(1):12679. doi: 10.1038/s41598-017-12976-2.

9.

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Wall ML, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Aug 16;12(8):e0183601. doi: 10.1371/journal.pone.0183601. eCollection 2017.

10.

Modifying the Dietary Carbohydrate-to-Protein Ratio Alters the Postprandial Macronutrient Oxidation Pattern in Liver of AMPK-Deficient Mice.

Chalvon-Demersay T, Even PC, Chaumontet C, Piedcoq J, Viollet B, Gaudichon C, Tomé D, Foretz M, Azzout-Marniche D.

J Nutr. 2017 Sep;147(9):1669-1676. doi: 10.3945/jn.117.250803. Epub 2017 Jul 26.

PMID:
28747486
11.

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.

Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R.

EMBO J. 2017 Jul 3;36(13):1946-1962. doi: 10.15252/embj.201695273. Epub 2017 May 17.

PMID:
28515121
12.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA.

Cell Metab. 2017 May 2;25(5):1147-1159.e10. doi: 10.1016/j.cmet.2017.04.010.

PMID:
28467931
13.

Corrigendum: SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2017 Feb 22;8:14745. doi: 10.1038/ncomms14745. No abstract available.

14.

Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Dam J.

Mol Metab. 2016 Nov 3;6(1):159-172. doi: 10.1016/j.molmet.2016.10.009. eCollection 2017 Jan.

15.

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Jan 20;12(1):e0170382. doi: 10.1371/journal.pone.0170382. eCollection 2017. Erratum in: PLoS One. 2017 Aug 16;12 (8):e0183601.

16.

Animal Models to Study AMPK.

Viollet B, Foretz M.

EXS. 2016;107:441-469. Review.

17.

Gain-of-function Prolactin Receptor Variants Are Not Associated With Breast Cancer and Multiple Fibroadenoma Risk.

Chakhtoura Z, Laki F, Bernadet M, Cherifi I, Chiche A, Pigat N, Bernichtein S, Courtillot C, Boutillon F, Bièche I, Vacher S, Tanguy ML, Bissery A, Grouthier V, Camparo P, Foretz M, Do Cruzeiro M, Pierre R, Rakotozafy F, Tichet J, Tejedor I, Guidotti JE, Sigal-Zafrani B, Goffin V, Touraine P.

J Clin Endocrinol Metab. 2016 Nov;101(11):4449-4460. Epub 2016 Aug 30.

PMID:
27575941
18.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R, Munk-Hansen N, Birk JB, Foretz M, Viollet B, Björnholm M, Zierath JR, Treebak JT, Wojtaszewski JF.

Diabetes. 2017 Mar;66(3):598-612. doi: 10.2337/db16-0530. Epub 2016 Oct 26.

19.

SIKs control osteocyte responses to parathyroid hormone.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM.

Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176.

20.

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis.

Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M.

Cell Metab. 2016 Oct 11;24(4):542-554. doi: 10.1016/j.cmet.2016.08.010. Epub 2016 Sep 15.

21.

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.

Bultot L, Jensen TE, Lai YC, Madsen AL, Collodet C, Kviklyte S, Deak M, Yavari A, Foretz M, Ghaffari S, Bellahcene M, Ashrafian H, Rider MH, Richter EA, Sakamoto K.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719. doi: 10.1152/ajpendo.00237.2016. Epub 2016 Aug 30.

22.

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJ, Savinko T, Wong AK, Viollet B, Sakamoto K, Fagerholm SC, Foretz M, Lang CC, Rena G.

Circ Res. 2016 Aug 19;119(5):652-65. doi: 10.1161/CIRCRESAHA.116.308445. Epub 2016 Jul 14.

23.

Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.

Nieves W, Hung LY, Oniskey TK, Boon L, Foretz M, Viollet B, Herbert DR.

J Immunol. 2016 Jun 1;196(11):4632-40. doi: 10.4049/jimmunol.1502218. Epub 2016 Apr 20.

24.

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.

Cameron AR, Logie L, Patel K, Bacon S, Forteath C, Harthill J, Roberts A, Sutherland C, Stewart D, Viollet B, Sakamoto K, McDougall G, Foretz M, Rena G.

Biochim Biophys Acta. 2016 Aug;1862(8):1412-22. doi: 10.1016/j.bbadis.2016.04.015. Epub 2016 Apr 27.

25.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA.

PLoS One. 2016 Mar 24;11(3):e0149549. doi: 10.1371/journal.pone.0149549. eCollection 2016.

26.

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B.

Johanns M, Lai YC, Hsu MF, Jacobs R, Vertommen D, Van Sande J, Dumont JE, Woods A, Carling D, Hue L, Viollet B, Foretz M, Rider MH.

Nat Commun. 2016 Mar 8;7:10856. doi: 10.1038/ncomms10856.

27.

Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.

Bertoldo MJ, Guibert E, Faure M, Guillou F, Ramé C, Nadal-Desbarats L, Foretz M, Viollet B, Dupont J, Froment P.

Mol Cell Endocrinol. 2016 Mar 5;423:96-112. doi: 10.1016/j.mce.2016.01.001. Epub 2016 Jan 7.

PMID:
26772142
28.

AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea.

Mahmoud AD, Lewis S, Juričić L, Udoh UA, Hartmann S, Jansen MA, Ogunbayo OA, Puggioni P, Holmes AP, Kumar P, Navarro-Dorado J, Foretz M, Viollet B, Dutia MB, Marshall I, Evans AM.

Am J Respir Crit Care Med. 2016 May 1;193(9):1032-43. doi: 10.1164/rccm.201508-1667OC.

29.

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

Fentz J, Kjøbsted R, Kristensen CM, Hingst JR, Birk JB, Gudiksen A, Foretz M, Schjerling P, Viollet B, Pilegaard H, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2015 Dec 1;309(11):E900-14. doi: 10.1152/ajpendo.00157.2015. Epub 2015 Sep 29.

30.

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.

Fu X, Zhu M, Zhang S, Foretz M, Viollet B, Du M.

Diabetes. 2016 Jan;65(1):188-200. doi: 10.2337/db15-0647. Epub 2015 Sep 17.

31.

AMPK Signaling Involvement for the Repression of the IL-1β-Induced Group IIA Secretory Phospholipase A2 Expression in VSMCs.

El Hadri K, Denoyelle C, Ravaux L, Viollet B, Foretz M, Friguet B, Rouis M, Raymondjean M.

PLoS One. 2015 Jul 10;10(7):e0132498. doi: 10.1371/journal.pone.0132498. eCollection 2015.

32.

Therapy: Metformin takes a new route to clinical efficacy.

Foretz M, Viollet B.

Nat Rev Endocrinol. 2015 Jul;11(7):390-2. doi: 10.1038/nrendo.2015.85. Epub 2015 Jun 2. No abstract available.

33.

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.

Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda MA, Gonçalvès D, Cerezo M, Marchetti S, Rocchi S, Droin N, Cluzeau T, Robert G, Luciano F, Robaye B, Foretz M, Viollet B, Legros L, Solary E, Auberger P, Jacquel A.

Autophagy. 2015;11(7):1114-29. doi: 10.1080/15548627.2015.1034406.

34.

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.

Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, Nepstad I, Green AS, Mondesir J, Hospital MA, Jacque N, Christodoulou A, Desouza TA, Hermine O, Foretz M, Viollet B, Lacombe C, Mayeux P, Weinstock DM, Moura IC, Bouscary D, Tamburini J.

Cell Rep. 2015 Jun 9;11(9):1446-57. doi: 10.1016/j.celrep.2015.04.063. Epub 2015 May 21.

35.

AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?

Moreira D, Silvestre R, Cordeiro-da-Silva A, Estaquier J, Foretz M, Viollet B.

Curr Drug Targets. 2016;17(8):942-53. Review.

36.

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, Rutter GA.

Mol Metab. 2015 Jan 31;4(4):277-86. doi: 10.1016/j.molmet.2015.01.006. eCollection 2015 Apr.

37.

Expanding roles for AMPK in skeletal muscle plasticity.

Mounier R, Théret M, Lantier L, Foretz M, Viollet B.

Trends Endocrinol Metab. 2015 Jun;26(6):275-86. doi: 10.1016/j.tem.2015.02.009. Epub 2015 Mar 26. Review.

38.

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.

Wu Y, Song P, Zhang W, Liu J, Dai X, Liu Z, Lu Q, Ouyang C, Xie Z, Zhao Z, Zhuo X, Viollet B, Foretz M, Wu J, Yuan Z, Zou MH.

Nat Med. 2015 Apr;21(4):373-82. doi: 10.1038/nm.3826. Epub 2015 Mar 23.

39.

Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology.

Bertoldo MJ, Guibert E, Faure M, Ramé C, Foretz M, Viollet B, Dupont J, Froment P.

PLoS One. 2015 Mar 13;10(3):e0119680. doi: 10.1371/journal.pone.0119680. eCollection 2015.

40.

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis.

Moreira D, Rodrigues V, Abengozar M, Rivas L, Rial E, Laforge M, Li X, Foretz M, Viollet B, Estaquier J, Cordeiro da Silva A, Silvestre R.

PLoS Pathog. 2015 Mar 4;11(3):e1004684. doi: 10.1371/journal.ppat.1004684. eCollection 2015 Mar.

41.

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.

Ducommun S, Deak M, Sumpton D, Ford RJ, Núñez Galindo A, Kussmann M, Viollet B, Steinberg GR, Foretz M, Dayon L, Morrice NA, Sakamoto K.

Cell Signal. 2015 May;27(5):978-88. doi: 10.1016/j.cellsig.2015.02.008. Epub 2015 Feb 13.

42.

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.

Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.

J Cell Sci. 2015 Feb 1;128(3):472-86.

43.

Metformin: from mechanisms of action to therapies.

Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B.

Cell Metab. 2014 Dec 2;20(6):953-66. doi: 10.1016/j.cmet.2014.09.018. Epub 2014 Oct 30. Review.

44.

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth.

Ríos M, Foretz M, Viollet B, Prieto A, Fraga M, García-Caballero T, Costoya JA, Señarís R.

Eur J Cancer. 2014 Dec;50(18):3187-97. doi: 10.1016/j.ejca.2014.09.014. Epub 2014 Oct 13.

PMID:
25450947
45.

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.

Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA.

PLoS One. 2014 Sep 2;9(9):e106710. doi: 10.1371/journal.pone.0106710. eCollection 2014.

46.

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K.

Nat Commun. 2014 Aug 4;5:4535. doi: 10.1038/ncomms5535.

47.

LKB1 and AMPK regulate synaptic remodeling in old age.

Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JR.

Nat Neurosci. 2014 Sep;17(9):1190-7. doi: 10.1038/nn.3772. Epub 2014 Aug 3.

48.

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.

Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K.

Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014.

49.

PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation.

Zhu H, Foretz M, Xie Z, Zhang M, Zhu Z, Xing J, Leclerc J, Gaudry M, Viollet B, Zou MH.

Autophagy. 2014 Sep;10(9):1522-34. doi: 10.4161/auto.29197. Epub 2014 Jun 19.

50.

Bypassing AMPK phosphorylation.

Viollet B, Foretz M, Schlattner U.

Chem Biol. 2014 May 22;21(5):567-9. doi: 10.1016/j.chembiol.2014.05.003.

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