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Items: 35

1.

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V.

Immunity. 2017 Dec 19;47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12.

PMID:
29246441
2.

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V, Floess S, Huehn J, Owens T, Korn T, Stangel M.

J Neuroinflammation. 2017 Oct 16;14(1):204. doi: 10.1186/s12974-017-0978-3.

3.

Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.

Kyburz A, Urban S, Altobelli A, Floess S, Huehn J, Cover TL, Müller A.

Clin Exp Allergy. 2017 Oct;47(10):1331-1341. doi: 10.1111/cea.12996. Epub 2017 Sep 11.

PMID:
28802077
4.

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance.

Nikolouli E, Hardtke-Wolenski M, Hapke M, Beckstette M, Geffers R, Floess S, Jaeckel E, Huehn J.

Front Immunol. 2017 Jun 28;8:748. doi: 10.3389/fimmu.2017.00748. eCollection 2017.

5.

Cytotoxic CD8+ T cell ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis.

Ciurkiewicz M, Herder V, Khan MA, Uhde AK, Teich R, Floess S, Baumgärtner W, Huehn J, Beineke A.

Brain Pathol. 2017 Apr 27. doi: 10.1111/bpa.12518. [Epub ahead of print]

PMID:
28452087
6.

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.

Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.

7.

Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells.

Szilagyi BA, Triebus J, Kressler C, de Almeida M, Tierling S, Durek P, Mardahl M, Szilagyi A, Floess S, Huehn J, Syrbe U, Walter J, Polansky JK, Hamann A.

Mucosal Immunol. 2017 Nov;10(6):1443-1454. doi: 10.1038/mi.2017.7. Epub 2017 Feb 15.

PMID:
28198363
8.

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

Uhde AK, Herder V, Akram Khan M, Ciurkiewicz M, Schaudien D, Teich R, Floess S, Baumgärtner W, Huehn J, Beineke A.

PLoS One. 2016 Sep 9;11(9):e0161883. doi: 10.1371/journal.pone.0161883. eCollection 2016.

9.

Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.

Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U.

J Immunol. 2016 Oct 15;197(8):3406-3414. Epub 2016 Sep 2.

10.

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation.

Klysz D, Tai X, Robert PA, Craveiro M, Cretenet G, Oburoglu L, Mongellaz C, Floess S, Fritz V, Matias MI, Yong C, Surh N, Marie JC, Huehn J, Zimmermann V, Kinet S, Dardalhon V, Taylor N.

Sci Signal. 2015 Sep 29;8(396):ra97. doi: 10.1126/scisignal.aab2610.

PMID:
26420908
11.

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M.

Mucosal Immunol. 2016 Mar;9(2):444-57. doi: 10.1038/mi.2015.74. Epub 2015 Aug 26.

PMID:
26307665
12.

Foxp3(+) regulatory T cells are expanded in severe atopic dermatitis patients.

Roesner LM, Floess S, Witte T, Olek S, Huehn J, Werfel T.

Allergy. 2015 Dec;70(12):1656-60. doi: 10.1111/all.12712. Epub 2015 Aug 26.

13.

Comment on "cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans".

Huehn J, Floess S, Ohkura N, Sakaguchi S.

J Immunol. 2015 Apr 15;194(8):3533. doi: 10.4049/jimmunol.1500248. No abstract available.

14.

Development of a unique epigenetic signature during in vivo Th17 differentiation.

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J.

Nucleic Acids Res. 2015 Feb 18;43(3):1537-48. doi: 10.1093/nar/gkv014. Epub 2015 Jan 15.

15.

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.

Franckaert D, Dooley J, Roos E, Floess S, Huehn J, Luche H, Fehling HJ, Liston A, Linterman MA, Schlenner SM.

Immunol Cell Biol. 2015 Apr;93(4):417-23. doi: 10.1038/icb.2014.108. Epub 2014 Dec 23.

16.

The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling.

Schreiber L, Pietzsch B, Floess S, Farah C, Jänsch L, Schmitz I, Huehn J.

PLoS One. 2014 Feb 5;9(2):e88318. doi: 10.1371/journal.pone.0088318. eCollection 2014.

17.

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia.

Prajeeth CK, Löhr K, Floess S, Zimmermann J, Ulrich R, Gudi V, Beineke A, Baumgärtner W, Müller M, Huehn J, Stangel M.

Brain Behav Immun. 2014 Mar;37:248-59. doi: 10.1016/j.bbi.2014.01.001. Epub 2014 Jan 9.

PMID:
24412213
18.

Induced and thymus-derived Foxp3⁺ regulatory T cells share a common niche.

Huang YJ, Haist V, Baumgärtner W, Föhse L, Prinz I, Suerbaum S, Floess S, Huehn J.

Eur J Immunol. 2014 Feb;44(2):460-8. doi: 10.1002/eji.201343463. Epub 2013 Oct 30.

19.

Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.

Toker A, Engelbert D, Garg G, Polansky JK, Floess S, Miyao T, Baron U, Düber S, Geffers R, Giehr P, Schallenberg S, Kretschmer K, Olek S, Walter J, Weiss S, Hori S, Hamann A, Huehn J.

J Immunol. 2013 Apr 1;190(7):3180-8. doi: 10.4049/jimmunol.1203473. Epub 2013 Feb 18.

20.

IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.

Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kühl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I.

Immunity. 2012 Dec 14;37(6):998-1008. doi: 10.1016/j.immuni.2012.08.023. Epub 2012 Nov 29.

21.

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.

Weiss JM, Bilate AM, Gobert M, Ding Y, Curotto de Lafaille MA, Parkhurst CN, Xiong H, Dolpady J, Frey AB, Ruocco MG, Yang Y, Floess S, Huehn J, Oh S, Li MO, Niec RE, Rudensky AY, Dustin ML, Littman DR, Lafaille JJ.

J Exp Med. 2012 Sep 24;209(10):1723-42, S1. Epub 2012 Sep 10.

22.

IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease.

Koenecke C, Lee CW, Thamm K, Föhse L, Schafferus M, Mittrücker HW, Floess S, Huehn J, Ganser A, Förster R, Prinz I.

J Immunol. 2012 Sep 15;189(6):2890-6. doi: 10.4049/jimmunol.1200413. Epub 2012 Aug 6.

23.

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.

Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA.

Immunity. 2012 May 25;36(5):717-30. doi: 10.1016/j.immuni.2012.03.020. Epub 2012 May 10.

24.

Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.

O'Connor RA, Floess S, Huehn J, Jones SA, Anderton SM.

Eur J Immunol. 2012 May;42(5):1174-9. doi: 10.1002/eji.201142216.

25.

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S.

Immunity. 2012 Feb 24;36(2):262-75. doi: 10.1016/j.immuni.2011.12.012. Epub 2012 Feb 9.

26.

CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.

Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T.

Eur J Immunol. 2011 Mar;41(3):716-25. doi: 10.1002/eji.201040913. Epub 2011 Feb 11.

27.

Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.

Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, Steckel B, Gruetzkau A, Olek S, Geginat J, Huehn J, Hamann A.

Blood. 2011 Mar 10;117(10):2839-46. doi: 10.1182/blood-2010-06-293027. Epub 2011 Jan 12.

28.

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.

Polansky JK, Schreiber L, Thelemann C, Ludwig L, Krüger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J.

J Mol Med (Berl). 2010 Oct;88(10):1029-40. doi: 10.1007/s00109-010-0642-1. Epub 2010 Jun 24.

29.

Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection.

Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, Roberts S, Paukovic G, Plebanski M, Loveland BE, Aitken C, Barry S, Schofield L, Gowans EJ.

PLoS Pathog. 2009 Dec;5(12):e1000707. doi: 10.1371/journal.ppat.1000707. Epub 2009 Dec 24. Erratum in: PLoS Pathog. 2012 Jun;8(6). doi:10.1371/annotation/523d94fe-9730-499b-95b1-addd94089ff8.

30.

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, Olek S, Dietmaier W, Andreesen R, Edinger M.

Eur J Immunol. 2009 Apr;39(4):1088-97. doi: 10.1002/eji.200838904.

31.

Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.

Wieczorek G, Asemissen A, Model F, Turbachova I, Floess S, Liebenberg V, Baron U, Stauch D, Kotsch K, Pratschke J, Hamann A, Loddenkemper C, Stein H, Volk HD, Hoffmüller U, Grützkau A, Mustea A, Huehn J, Scheibenbogen C, Olek S.

Cancer Res. 2009 Jan 15;69(2):599-608. doi: 10.1158/0008-5472.CAN-08-2361.

32.

DNA methylation controls Foxp3 gene expression.

Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J.

Eur J Immunol. 2008 Jun;38(6):1654-63. doi: 10.1002/eji.200838105.

33.

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

Baron U, Floess S, Wieczorek G, Baumann K, Grützkau A, Dong J, Thiel A, Boeld TJ, Hoffmann P, Edinger M, Türbachova I, Hamann A, Olek S, Huehn J.

Eur J Immunol. 2007 Sep;37(9):2378-89.

34.

Induction of organ-selective CD4+ regulatory T cell homing.

Siewert C, Menning A, Dudda J, Siegmund K, Lauer U, Floess S, Campbell DJ, Hamann A, Huehn J.

Eur J Immunol. 2007 Apr;37(4):978-89.

35.

Epigenetic control of the foxp3 locus in regulatory T cells.

Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J.

PLoS Biol. 2007 Feb;5(2):e38.

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