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Items: 1 to 50 of 72

1.

Reactivation of mutant-EGFR degradation through clathrin inhibition overcomes resistance to EGFR tyrosine kinase inhibitors.

Ménard L, Floc'h N, Martin MJ, Cross DA.

Cancer Res. 2018 Mar 19. pii: canres.2195.2017. doi: 10.1158/0008-5472.CAN-17-2195. [Epub ahead of print]

PMID:
29555874
2.

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.

Floc'h N, Martin MJ, Riess JW, Orme JP, Staniszewska AD, Ménard L, Cuomo ME, O'Neill DJ, Ward RA, Finlay MRV, McKerrecher D, Cheng M, Vang DP, Burich RA, Keck JG, Gandara DR, Mack PC, Cross DAE.

Mol Cancer Ther. 2018 May;17(5):885-896. doi: 10.1158/1535-7163.MCT-17-0758. Epub 2018 Feb 26.

PMID:
29483211
3.

Impact of hygiene of housing conditions on performance and health of two pig genetic lines divergent for residual feed intake.

Chatelet A, Gondret F, Merlot E, Gilbert H, Friggens NC, Le Floc'h N.

Animal. 2018 Feb;12(2):350-358. doi: 10.1017/S1751731117001379. Epub 2017 Jun 27.

PMID:
28651668
4.

Comparison of plasma tryptophan-related metabolites in crossbred Piétrain and Duroc pigs.

Le Floc'h N, Simongiovanni A, Corrent E, Matte JJ.

J Anim Sci. 2017 Apr;95(4):1606-1613. doi: 10.2527/jas.2016.1179.

PMID:
28464103
5.

Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.

Floc'h N, Ashton S, Taylor P, Trueman D, Harris E, Odedra R, Maratea K, Derbyshire N, Caddy J, Jacobs VN, Hattersley M, Wen S, Curtis NJ, Pilling JE, Pease EJ, Barry ST.

Mol Cancer Ther. 2017 Jun;16(6):1031-1040. doi: 10.1158/1535-7163.MCT-16-0580. Epub 2017 Mar 14.

PMID:
28292940
6.

Influence of the inflammatory status of entire male pigs on their pubertal development and fat androstenone.

Parois SP, Faoüen A, Le Floc'h N, Prunier A.

Animal. 2017 Jun;11(6):1071-1077. doi: 10.1017/S1751731116002329. Epub 2016 Nov 11.

PMID:
27832828
7.

Impact of feed restriction and housing hygiene conditions on specific and inflammatory immune response, the cecal bacterial community and the survival of young rabbits.

Combes S, Massip K, Martin O, Furbeyre H, Cauquil L, Pascal G, Bouchez O, Le Floc'h N, Zemb O, Oswald IP, Gidenne T.

Animal. 2017 May;11(5):854-863. doi: 10.1017/S1751731116002007. Epub 2016 Oct 17.

PMID:
27745563
8.

Risk of obesity in male shift workers: A chronophysiological approach.

Haus E, Reinberg A, Mauvieux B, Le Floc'h N, Sackett-Lundeen L, Touitou Y.

Chronobiol Int. 2016;33(8):1018-36. doi: 10.3109/07420528.2016.1167079. Epub 2016 Jul 1.

PMID:
27366928
9.

Tryptophan metabolism, growth responses, and postprandial insulin metabolism in weaned piglets according to the dietary provision of niacin (vitamin B) and tryptophan.

Matte JJ, Corrent E, Simongiovanni A, Le Floc'h N.

J Anim Sci. 2016 May;94(5):1961-71. doi: 10.2527/jas.2015-0221.

PMID:
27285694
10.

Metabolic response to an inflammatory challenge in pigs divergently selected for residual feed intake.

Merlot E, Gilbert H, Le Floc'h N.

J Anim Sci. 2016 Feb;94(2):563-73. doi: 10.2527/jas.2015-9445.

PMID:
27065126
11.

[Pubertal maturation, physical self-esteem and sexuality in a sample of French adolescents].

Potard C, Courtois R, Clarisse R, Le Floc'h N, Thomine M, Réveillère C.

Encephale. 2016 Apr;42(2):138-43. doi: 10.1016/j.encep.2015.12.015. Epub 2016 Jan 19. French.

PMID:
26806140
12.

Effect of inflammation stimulation on energy and nutrient utilization in piglets selected for low and high residual feed intake.

Labussière E, Dubois S, Gilbert H, Thibault JN, Le Floc'h N, Noblet J, van Milgen J.

Animal. 2015 Oct;9(10):1653-61. doi: 10.1017/S1751731115000932.

PMID:
26381577
13.

Splanchnic tissues respond differently when piglets are offered a diet 30 % deficient in total sulfur amino acid for 10 days.

Conde-Aguilera JA, Le Floc'h N, Le Huërou-Luron I, Mercier Y, Tesseraud S, Lefaucheur L, van Milgen J.

Eur J Nutr. 2016 Oct;55(7):2209-19. doi: 10.1007/s00394-015-1031-x. Epub 2015 Sep 3.

PMID:
26335055
14.

Chronobiologic perspectives of black time--Accident risk is greatest at night: An opinion paper.

Reinberg A, Smolensky MH, Riedel M, Touitou Y, Le Floc'h N, Clarisse R, Marlot M, Berrez S, Pelisse D, Mauvieux B.

Chronobiol Int. 2015;32(7):1005-18. doi: 10.3109/07420528.2015.1053911. Review.

PMID:
26181466
15.

Skeletal muscles respond differently when piglets are offered a diet 30% deficient in total sulfur amino acid for 10 days.

Conde-Aguilera JA, Lefaucheur L, Tesseraud S, Mercier Y, Le Floc'h N, van Milgen J.

Eur J Nutr. 2016 Feb;55(1):117-26. doi: 10.1007/s00394-014-0830-9. Epub 2015 Jan 9.

PMID:
25573689
16.

Effect of feed restriction on performance and postprandial nutrient metabolism in pigs co-infected with Mycoplasma hyopneumoniae and swine influenza virus.

Le Floc'h N, Deblanc C, Cariolet R, Gautier-Bouchardon AV, Merlot E, Simon G.

PLoS One. 2014 Aug 7;9(8):e104605. doi: 10.1371/journal.pone.0104605. eCollection 2014.

17.

Impact of feed restriction on health, digestion and faecal microbiota of growing pigs housed in good or poor hygiene conditions.

Le Floc'h N, Knudsen C, Gidenne T, Montagne L, Merlot E, Zemb O.

Animal. 2014 Oct;8(10):1632-42. doi: 10.1017/S1751731114001608. Epub 2014 Jun 25.

PMID:
24963640
18.

Performance of piglets in response to the standardized ileal digestible phenylalanine and tyrosine supply in low-protein diets.

Gloaguen M, Le Floc'h N, Primot Y, Corrent E, van Milgen J.

Animal. 2014 Sep;8(9):1412-9. doi: 10.1017/S1751731114001360. Epub 2014 Jun 10.

PMID:
24912487
19.

Effect of repeated administration of lipopolysaccharide on inflammatory and stress markers in saliva of growing pigs.

Escribano D, Campos PH, Gutiérrez AM, Le Floc'h N, Cerón JJ, Merlot E.

Vet J. 2014 Jun;200(3):393-7. doi: 10.1016/j.tvjl.2014.04.007. Epub 2014 Apr 16.

PMID:
24814313
20.

High ambient temperature alleviates the inflammatory response and growth depression in pigs challenged with Escherichia coli lipopolysaccharide.

Campos PH, Merlot E, Damon M, Noblet J, Le Floc'h N.

Vet J. 2014 Jun;200(3):404-9. doi: 10.1016/j.tvjl.2014.04.001. Epub 2014 Apr 13.

PMID:
24792207
21.

Meal frequency changes the basal and time-course profiles of plasma nutrient concentrations and affects feed efficiency in young growing pigs.

Le Naou T, Le Floc'h N, Louveau I, van Milgen J, Gondret F.

J Anim Sci. 2014 May;92(5):2008-16. doi: 10.2527/jas.2013-7505. Epub 2014 Mar 18.

PMID:
24663180
22.

The use of free amino acids allows formulating very low crude protein diets for piglets.

Gloaguen M, Le Floc'h N, Corrent E, Primot Y, van Milgen J.

J Anim Sci. 2014 Feb;92(2):637-44. doi: 10.2527/jas.2013-6514. Epub 2014 Jan 7.

PMID:
24398840
23.

Modulation of oxidative stress by twist oncoproteins.

Floc'h N, Kolodziejski J, Akkari L, Simonin Y, Ansieau S, Puisieux A, Hibner U, Lassus P.

PLoS One. 2013 Aug 13;8(8):e72490. doi: 10.1371/journal.pone.0072490. eCollection 2013.

24.

Circadian time organization of professional firemen: desynchronization-tau differing from 24.0 hours-documented by longitudinal self-assessment of 16 variables.

Reinberg A, Riedel M, Brousse E, Floc'h NL, Clarisse R, Mauvieux B, Touitou Y, Smolensky MH, Marlot M, Berrez S, Mechkouri M.

Chronobiol Int. 2013 Oct;30(8):1050-65. doi: 10.3109/07420528.2013.800087. Epub 2013 Aug 14.

PMID:
23944871
25.

Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.

Simonin Y, Vegna S, Akkari L, Grégoire D, Antoine E, Piette J, Floc'h N, Lassus P, Yu GY, Rosenberg AR, Karin M, Durantel D, Hibner U.

PLoS Pathog. 2013 Mar;9(3):e1003234. doi: 10.1371/journal.ppat.1003234. Epub 2013 Mar 21.

26.

Meal patterns in relation to the supply of branched-chain amino acids in pigs.

Gloaguen M, Le Floc'h N, Corrent E, Primot Y, Val-Laillet D, Meunier-Salaün MC, van Milgen J.

J Anim Sci. 2013 Jan;91(1):292-7. doi: 10.2527/jas.2012-5272.

PMID:
23404989
27.

The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer.

Floc'h N, Abate-Shen C.

Oncotarget. 2012 Dec;3(12):1483-4. No abstract available.

28.

Response of piglets to the standardized ileal digestible isoleucine, histidine and leucine supply in cereal-soybean meal-based diets.

Gloaguen M, Le Floc'h N, Primot Y, Corrent E, van Milgen J.

Animal. 2013 Jun;7(6):901-8. doi: 10.1017/S1751731112002339. Epub 2012 Dec 11.

PMID:
23228192
29.

Sanitary housing conditions modify the performance and behavioural response of weaned pigs to feed- and housing-related stressors.

Pastorelli H, Le Floc'h N, Merlot E, Meunier-Salaün MC, van Milgen J, Montagne L.

Animal. 2012 Nov;6(11):1811-20. doi: 10.1017/S1751731112001231.

PMID:
23031600
30.

Meta-analysis of the response of growing pigs to the isoleucine concentration in the diet.

van Milgen J, Gloaguen M, Le Floc'h N, Brossard L, Primot Y, Corrent E.

Animal. 2012 Oct;6(10):1601-8. doi: 10.1017/S1751731112000420.

PMID:
23031559
31.

Feed restriction applied after weaning has different effects on pig performance and health depending on the sanitary conditions.

Pastorelli H, Le Floc'h N, Merlot E, Meunier-Salaün MC, van Milgen J, Montagne L.

J Anim Sci. 2012 Dec;90(13):4866-75. doi: 10.2527/jas.2012-5309. Epub 2012 Sep 5.

PMID:
22952368
32.

Metabolic changes and tissue responses to selection on residual feed intake in growing pigs.

Le Naou T, Le Floc'h N, Louveau I, Gilbert H, Gondret F.

J Anim Sci. 2012 Dec;90(13):4771-80. doi: 10.2527/jas.2012-5226. Epub 2012 Aug 7.

PMID:
22871936
33.

B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer.

Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C.

Cancer Res. 2012 Sep 15;72(18):4765-76. Epub 2012 Jul 25.

34.

Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.

Floc'h N, Kinkade CW, Kobayashi T, Aytes A, Lefebvre C, Mitrofanova A, Cardiff RD, Califano A, Shen MM, Abate-Shen C.

Cancer Res. 2012 Sep 1;72(17):4483-93. doi: 10.1158/0008-5472.CAN-12-0283. Epub 2012 Jul 19.

35.

Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors.

Akkari L, Grégoire D, Floc'h N, Moreau M, Hernandez C, Simonin Y, Rosenberg AR, Lassus P, Hibner U.

J Hepatol. 2012 Nov;57(5):1021-8. doi: 10.1016/j.jhep.2012.06.027. Epub 2012 Jun 28.

PMID:
22750466
36.

Towards amino acid recommendations for specific physiological and patho-physiological states in pigs.

Le Floc'h N, Gondret F, Matte JJ, Quesnel H.

Proc Nutr Soc. 2012 Aug;71(3):425-32. doi: 10.1017/S0029665112000560. Epub 2012 May 21. Review.

PMID:
22607969
37.

Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs.

Gloaguen M, Le Floc'h N, Corrent E, Primot Y, van Milgen J.

J Anim Sci. 2012 Sep;90(9):3135-42. doi: 10.2527/jas.2011-4956. Epub 2012 May 14.

PMID:
22585822
38.

Response of piglets to the valine content in diet in combination with the supply of other branched-chain amino acids.

Gloaguen M, Le Floc'h N, Brossard L, Barea R, Primot Y, Corrent E, van Milgen J.

Animal. 2011 Sep;5(11):1734-42. doi: 10.1017/S1751731111000760.

PMID:
22440413
39.

Estimation of the tryptophan requirement in piglets by meta-analysis.

Simongiovanni A, Corrent E, Le Floc'h N, van Milgen J.

Animal. 2012 Apr;6(4):594-602. doi: 10.1017/S1751731111001960.

PMID:
22436275
40.

Accelerated growth rate induced by neonatal high-protein milk formula is not supported by increased tissue protein synthesis in low-birth-weight piglets.

Jamin A, Sève B, Thibault JN, Floc'h N.

J Nutr Metab. 2012;2012:545341. doi: 10.1155/2012/545341. Epub 2012 Jan 24.

41.

Comparative effects of level of dietary fiber and sanitary conditions on the growth and health of weanling pigs.

Montagne L, Le Floc'h N, Arturo-Schaan M, Foret R, Urdaci MC, Le Gall M.

J Anim Sci. 2012 Aug;90(8):2556-69. doi: 10.2527/jas.2011-4160. Epub 2012 Feb 3.

PMID:
22307482
42.

Effects of surplus dietary L-tryptophan on stress, immunology, behavior, and nitrogen retention in endotoxemic pigs.

Koopmans SJ, van der Staay FJ, Le Floc'h N, Dekker R, van Diepen JT, Jansman AJ.

J Anim Sci. 2012 Jan;90(1):241-51. doi: 10.2527/jas.2010-3372. Epub 2011 Aug 19.

PMID:
21856896
43.

A moderate inflammation caused by the deterioration of housing conditions modifies Trp metabolism but not Trp requirement for growth of post-weaned piglets.

Le Floc'h N, Matte JJ, Melchior D, van Milgen J, Sève B.

Animal. 2010 Nov;4(11):1891-8. doi: 10.1017/S1751731110000236.

PMID:
22445150
44.

Tryptophan metabolism, from nutrition to potential therapeutic applications.

Le Floc'h N, Otten W, Merlot E.

Amino Acids. 2011 Nov;41(5):1195-205. doi: 10.1007/s00726-010-0752-7. Epub 2010 Sep 25. Review.

PMID:
20872026
45.

Bioavailability of dietary cyanocobalamin (vitamin B12) in growing pigs.

Matte JJ, Guay F, Le Floc'h N, Girard CL.

J Anim Sci. 2010 Dec;88(12):3936-44. doi: 10.2527/jas.2010-2979. Epub 2010 Aug 13.

PMID:
20709870
46.

A sulfur amino acid deficiency changes the amino acid composition of body protein in piglets.

Conde-Aguilera JA, Barea R, Le Floc'h N, Lefaucheur L, van Milgen J.

Animal. 2010 Aug;4(8):1349-58. doi: 10.1017/S1751731110000340.

PMID:
22444655
47.

Daily rhythmicity of attention in morning- vs. evening-type adolescents at boarding school under different psychosociological testing conditions.

Clarisse R, Le Floc'h N, Kindelberger C, Feunteun P.

Chronobiol Int. 2010 Jun;27(4):826-41. doi: 10.3109/07420521003794051.

PMID:
20560713
48.

Cell shape and TGF-beta signaling define the choice of lineage during in vitro differentiation of mouse primary hepatic precursors.

Akkari L, Haouzi D, Binamé F, Floc'h N, Lassus P, Baghdiguian S, Hibner U.

J Cell Physiol. 2010 Oct;225(1):186-95. doi: 10.1002/jcp.22219.

PMID:
20458741
49.

A moderate threonine deficiency affects gene expression profile, paracellular permeability and glucose absorption capacity in the ileum of piglets.

Hamard A, Mazurais D, Boudry G, Le Huërou-Luron I, Sève B, Le Floc'h N.

J Nutr Biochem. 2010 Oct;21(10):914-21. doi: 10.1016/j.jnutbio.2009.07.004. Epub 2009 Dec 1.

PMID:
19954951
50.

Tryptophan metabolism and related B vitamins in the multiparous sow fed ad libitum after farrowing.

Mosnier E, Matte JJ, Etienne M, Ramaekers P, Sève B, Le Floc'h N.

Arch Anim Nutr. 2009;63(6):467-78. doi: 10.1080/17450390903217465.

PMID:
26967955

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