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Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System.

Fletcher EAK, van Maren W, Cordfunke R, Dinkelaar J, Codee JDC, van der Marel G, Melief CJM, Ossendorp F, Drijfhout JW, Mangsbo SM.

J Immunol. 2018 May 11. pii: ji1700911. doi: 10.4049/jimmunol.1700911. [Epub ahead of print]


[Intra-cardiac manifestation during adult-onset Still's disease's, a tricuspid vegetation as a rare expression of systemic disease].

Quelven Q, Cador B, Poinot M, Fletcher E, Le Mouel E, Jego P.

Rev Med Interne. 2018 May 3. pii: S0248-8663(18)30522-8. doi: 10.1016/j.revmed.2018.04.016. [Epub ahead of print] French.


The GP workforce pipeline: increasing the flow and plugging the leaks.

Spooner S, Fletcher E, Anderson C, Campbell JL.

Br J Gen Pract. 2018 May;68(670):245-246. doi: 10.3399/bjgp18X696125. No abstract available.


Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner.

Boshoff EL, Fletcher EJR, Duty S.

Neuropharmacology. 2018 Apr 23;137:156-163. doi: 10.1016/j.neuropharm.2018.04.017. [Epub ahead of print]


The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors.

Jobling AI, Waugh M, Vessey KA, Phipps JA, Trogrlic L, Greferath U, Mills SA, Tan ZL, Ward MM, Fletcher EL.

J Neurosci. 2018 May 16;38(20):4708-4723. doi: 10.1523/JNEUROSCI.2368-17.2018. Epub 2018 Apr 18.


Ethnoracial differences in brain structure change and cognitive change.

Gavett BE, Fletcher E, Harvey D, Farias ST, Olichney J, Beckett L, DeCarli C, Mungas D.

Neuropsychology. 2018 Apr 12. doi: 10.1037/neu0000452. [Epub ahead of print]


Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.

Rana R, Huang T, Koukos G, Fletcher EK, Turner SE, Shearer A, Gurbel PA, Rade JJ, Kimmelstiel CD, Bliden KP, Covic L, Kuliopulos A.

Arterioscler Thromb Vasc Biol. 2018 Apr 5. pii: ATVBAHA.118.310967. doi: 10.1161/ATVBAHA.118.310967. [Epub ahead of print]


Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review.

Doyle TJ, Dhillon N, Madan R, Cabral F, Fletcher EA, Koontz DC, Aggarwal R, Osorio JC, Rosas IO, Oddis CV, Dellaripa PF.

J Rheumatol. 2018 Apr 1. pii: jrheum.170541. doi: 10.3899/jrheum.170541. [Epub ahead of print]


Ganglion Cell Assessment in Rodents with Retinal Degeneration.

Fletcher EL, Greferath U, Saha S, Anderson EE, Vessey KA.

Methods Mol Biol. 2018;1753:261-273. doi: 10.1007/978-1-4939-7720-8_18.


Prophylactic laser in age-related macular degeneration: the past, the present and the future.

Findlay Q, Jobling AI, Vessey KA, Greferath U, Phipps JA, Guymer RH, Fletcher EL.

Eye (Lond). 2018 May;32(5):972-980. doi: 10.1038/s41433-018-0035-1. Epub 2018 Mar 9. Review.


Imidacloprid soil movement under micro-sprinkler irrigation and soil-drench applications to control Asian citrus psyllid (ACP) and citrus leafminer (CLM).

Fletcher E, Morgan KT, Qureshi JA, Leiva JA, Nkedi-Kizza P.

PLoS One. 2018 Mar 8;13(3):e0192668. doi: 10.1371/journal.pone.0192668. eCollection 2018.


Brain volume change and cognitive trajectories in aging.

Fletcher E, Gavett B, Harvey D, Farias ST, Olichney J, Beckett L, DeCarli C, Mungas D.

Neuropsychology. 2018 Mar 1. doi: 10.1037/neu0000447. [Epub ahead of print]


Feasibility, acceptability and effectiveness of an online alternative to face-to-face consultation in general practice: a mixed-methods study of webGP in six Devon practices.

Carter M, Fletcher E, Sansom A, Warren FC, Campbell JL.

BMJ Open. 2018 Feb 15;8(2):e018688. doi: 10.1136/bmjopen-2017-018688.


Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study).

Figueira J, Fletcher E, Massin P, Silva R, Bandello F, Midena E, Varano M, Sivaprasad S, Eleftheriadis H, Menon G, Amaro M, Ayello Scheer S, Creuzot-Garcher C, Nascimento J, Alves D, Nunes S, Lobo C, Cunha-Vaz J; Study Group.

Ophthalmology. 2018 May;125(5):691-700. doi: 10.1016/j.ophtha.2017.12.008. Epub 2018 Feb 1.


Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina.

Vessey KA, Ho T, Jobling AI, Mills SA, Tran MX, Brandli A, Lam J, Guymer RH, Fletcher EL.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):731-745. doi: 10.1167/iovs.17-23098.


The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation.

Phipps JA, Vessey KA, Brandli A, Nag N, Tran MX, Jobling AI, Fletcher EL.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):487-498. doi: 10.1167/iovs.17-22416.


Why do GPs leave direct patient care and what might help to retain them? A qualitative study of GPs in South West England.

Sansom A, Terry R, Fletcher E, Salisbury C, Long L, Richards SH, Aylward A, Welsman J, Sims L, Campbell JL, Dean SG.

BMJ Open. 2018 Jan 10;8(1):e019849. doi: 10.1136/bmjopen-2017-019849.


Associations between sedentary behaviours and dietary intakes among adolescents.

Fletcher EA, McNaughton SA, Crawford D, Cleland V, Della Gatta J, Hatt J, Dollman J, Timperio A.

Public Health Nutr. 2018 Apr;21(6):1115-1122. doi: 10.1017/S136898001700372X. Epub 2018 Jan 10.


Genetic analysis of adults heterozygous for ALPL mutations.

Taillandier A, Domingues C, Dufour A, Debiais F, Guggenbuhl P, Roux C, Cormier C, Cortet B, Porquet-Bordes V, Coury F, Geneviève D, Chiesa J, Colin T, Fletcher E, Guichet A, Javier RM, Laroche M, Laurent M, Lausch E, LeHeup B, Lukas C, Schwabe G, van der Burgt I, Muti C, Simon-Bouy B, Mornet E.

J Bone Miner Metab. 2017 Dec 13. doi: 10.1007/s00774-017-0888-6. [Epub ahead of print]


Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses.

Mangsbo SM, Fletcher EAK, van Maren WWC, Redeker A, Cordfunke RA, Dillmann I, Dinkelaar J, Ouchaou K, Codee JDC, van der Marel GA, Hoogerhout P, Melief CJM, Ossendorp F, Drijfhout JW.

Mol Immunol. 2018 Jan;93:115-124. doi: 10.1016/j.molimm.2017.11.004. Epub 2017 Nov 22.


Selective binding, magnetic separation and purification of histidine-tagged protein using biopolymer magnetic core-shell nanoparticles.

Zhou Y, Yan D, Yuan S, Chen Y, Fletcher EE, Shi H, Han B.

Protein Expr Purif. 2018 Apr;144:5-11. doi: 10.1016/j.pep.2017.11.004. Epub 2017 Nov 15.


Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics.

Fletcher EAK, Eltahir M, Lindqvist F, Rieth J, Törnqvist G, Leja-Jarblad J, Mangsbo SM.

Int Immunopharmacol. 2018 Jan;54:1-11. doi: 10.1016/j.intimp.2017.10.021. Epub 2017 Oct 27.


Risk factors for resistance and MDR in community urine isolates: population-level analysis using the NHS Scotland Infection Intelligence Platform.

Malcolm W, Fletcher E, Kavanagh K, Deshpande A, Wiuff C, Marwick C, Bennie M.

J Antimicrob Chemother. 2018 Jan 1;73(1):223-230. doi: 10.1093/jac/dkx363.


Retrospective cohort study of breast cancer incidence, health service use and outcomes in Europe: a study of feasibility.

Williams LJ, Fletcher E, Douglas A, Anderson EDC, McCallum A, Simpson CR, Smith J, Moger TA, Peltola M, Mihalicza P, Sveréus S, Zengarini N, Campbell H, Wild SH.

Eur J Public Health. 2018 Apr 1;28(2):327-332. doi: 10.1093/eurpub/ckx127.


Restorative retinal laser therapy: Present state and future directions.

Chhablani J, Roh YJ, Jobling AI, Fletcher EL, Lek JJ, Bansal P, Guymer R, Luttrull JK.

Surv Ophthalmol. 2018 May - Jun;63(3):307-328. doi: 10.1016/j.survophthal.2017.09.008. Epub 2017 Oct 5. Review.


Cross-sectional and prospective mediating effects of dietary intake on the relationship between sedentary behaviour and body mass index in adolescents.

Fletcher EA, Lamb KE, McNaughton SA, Garnett SP, Dunstan DW, Baur LA, Salmon J.

BMC Public Health. 2017 Sep 29;17(1):751. doi: 10.1186/s12889-017-4771-0.


Design, development and characterization of synthetic Bruch's membranes.

Surrao DC, Greferath U, Chau YQ, Skabo SJ, Huynh M, Shelat KJ, Limnios IJ, Fletcher EL, Liu Q.

Acta Biomater. 2017 Dec;64:357-376. doi: 10.1016/j.actbio.2017.09.032. Epub 2017 Sep 23.


Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice.

Fletcher EK, Morgan J, Kennaway DR, Bienvenu LA, Rickard AJ, Delbridge LMD, Fuller PJ, Clyne CD, Young MJ.

Endocrinology. 2017 Sep 1;158(9):2906-2917. doi: 10.1210/en.2016-1911.


2016 Glenn A. Fry Award Lecture: Mechanisms and Potential Treatments of Early Age-Related Macular Degeneration.

Fletcher EL.

Optom Vis Sci. 2017 Oct;94(10):939-945. doi: 10.1097/OPX.0000000000001124.


Cost and Outcome of BehaviouRal Activation (COBRA): a randomised controlled trial of behavioural activation versus cognitive-behavioural therapy for depression.

Richards DA, Rhodes S, Ekers D, McMillan D, Taylor RS, Byford S, Barrett B, Finning K, Ganguli P, Warren F, Farrand P, Gilbody S, Kuyken W, O'Mahen H, Watkins E, Wright K, Reed N, Fletcher E, Hollon SD, Moore L, Backhouse A, Farrow C, Garry J, Kemp D, Plummer F, Warner F, Woodhouse R.

Health Technol Assess. 2017 Aug;21(46):1-366. doi: 10.3310/hta21460.


Autonomy support and autonomous motivation in the outpatient treatment of adults with an eating disorder.

Steiger H, Sansfaçon J, Thaler L, Leonard N, Cottier D, Kahan E, Fletcher E, Rossi E, Israel M, Gauvin L.

Int J Eat Disord. 2017 Sep;50(9):1058-1066. doi: 10.1002/eat.22734. Epub 2017 Jun 14.


Environmental health policies for women's, children's and adolescents' health.

Neira M, Fletcher E, Brune-Drisse MN, Pfeiffer M, Adair-Rohani H, Dora C.

Bull World Health Organ. 2017 Aug 1;95(8):604-606. doi: 10.2471/BLT.16.171736. Epub 2017 Jul 24. No abstract available.


Fetal Dysmorphology-Still an Essential Art. Analysis of the Limitations of Microarray in a Fetal Population and a Look Toward the Genome Sequencing Era.

Fletcher E, Porteous M, McKenzie KJ, Maher EJ, Evans MJ.

Pediatr Dev Pathol. 2017 Jul-Aug;20(4):288-297. doi: 10.1177/1093526617693104. Epub 2017 Jan 1.


Navigating the Paradoxes of Neoliberalism: Quiet Subversion in Mentored Service-Learning for the Pre-Health Humanities.

Fletcher EH, Piemonte NM.

J Med Humanit. 2017 Dec;38(4):397-407. doi: 10.1007/s10912-017-9465-1.


7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds.

Schönbach EM, Chaikitmongkol V, Annam R, McDonnell EC, Wolfson Y, Fletcher E, Scholl HPN.

Ophthalmic Res. 2017;58(2):117-124. doi: 10.1159/000475996. Epub 2017 Jun 23.


Loss of Function of P2X7 Receptor Scavenger Activity in Aging Mice: A Novel Model for Investigating the Early Pathogenesis of Age-Related Macular Degeneration.

Vessey KA, Gu BJ, Jobling AI, Phipps JA, Greferath U, Tran MX, Dixon MA, Baird PN, Guymer RH, Wiley JS, Fletcher EL.

Am J Pathol. 2017 Aug;187(8):1670-1685. doi: 10.1016/j.ajpath.2017.04.016. Epub 2017 Jun 17.


Effects of breaking up sitting on adolescents' postprandial glucose after consuming meals varying in energy: a cross-over randomised trial.

Fletcher EA, Salmon J, McNaughton SA, Orellana L, Wadley GD, Bruce C, Dempsey PC, Lacy KE, Dunstan DW.

J Sci Med Sport. 2018 Mar;21(3):280-285. doi: 10.1016/j.jsams.2017.06.002. Epub 2017 Jun 9.


Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.

Fletcher EV, Simon CM, Pagiazitis JG, Chalif JI, Vukojicic A, Drobac E, Wang X, Mentis GZ.

Nat Neurosci. 2017 Jul;20(7):905-916. doi: 10.1038/nn.4561. Epub 2017 May 15.


Autosomal dominant frontometaphyseal dysplasia: Delineation of the clinical phenotype.

Wade EM, Jenkins ZA, Daniel PB, Morgan T, Addor MC, Adés LC, Bertola D, Bohring A, Carter E, Cho TJ, de Geus CM, Duba HC, Fletcher E, Hadzsiev K, Hennekam RCM, Kim CA, Krakow D, Morava E, Neuhann T, Sillence D, Superti-Furga A, Veenstra-Knol HE, Wieczorek D, Wilson LC, Markie DM, Robertson SP.

Am J Med Genet A. 2017 May 12. doi: 10.1002/ajmg.a.38267. [Epub ahead of print]


Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.

Maillard P, Mitchell GF, Himali JJ, Beiser A, Fletcher E, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C.

Stroke. 2017 Jun;48(6):1567-1573. doi: 10.1161/STROKEAHA.116.016321. Epub 2017 May 4.


Does level of motivation for change impact post-treatment outcomes in the eating disorders? Protocol for a systematic review with quantitative analysis.

Sansfaçon J, Steiger H, Gauvin L, Fletcher É, Israël M.

J Eat Disord. 2017 Apr 27;5:17. doi: 10.1186/s40337-017-0147-1. eCollection 2017.


Correction: Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study.

Numerato D, Fattore G, Tediosi F, Zanini R, Peltola M, Banks H, Mihalicza P, Lehtonen L, Sveréus S, Heijink R, Klitkou ST, Fletcher E, van der Heijden AA, Lundberg F, Over E, Häkkinen U, Seppälä TT.

PLoS One. 2017 May 1;12(5):e0177040. doi: 10.1371/journal.pone.0177040. eCollection 2017.


A Longitudinal Randomized Trial of the Effect of Consistent Pain Management for Infant Vaccinations on Future Vaccination Distress.

Taddio A, Riddell RP, Ipp M, Moss S, Baker S, Tolkin J, Dave M, Feerasta S, Govan P, Fletcher E, Wong H, McNair C, Mithal P, Stephens D.

J Pain. 2017 Sep;18(9):1060-1066. doi: 10.1016/j.jpain.2017.04.002. Epub 2017 Apr 26.


Quitting patient care and career break intentions among general practitioners in South West England: findings of a census survey of general practitioners.

Fletcher E, Abel GA, Anderson R, Richards SH, Salisbury C, Dean SG, Sansom A, Warren FC, Campbell JL.

BMJ Open. 2017 Apr 11;7(4):e015853. doi: 10.1136/bmjopen-2017-015853.


Randomized Controlled Trial of High-Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters.

Fletcher EA, Lacey CS, Aaron M, Kolasa M, Occiano A, Shah SA.

J Am Heart Assoc. 2017 Apr 26;6(5). pii: e004448. doi: 10.1161/JAHA.116.004448.


Cost and outcome of behavioural activation versus cognitive behavioural therapy for depression (COBRA): a qualitative process evaluation.

Finning K, Richards DA, Moore L, Ekers D, McMillan D, Farrand PA, O'Mahen HA, Watkins ER, Wright KA, Fletcher E, Rhodes S, Woodhouse R, Wray F.

BMJ Open. 2017 Apr 13;7(4):e014161. doi: 10.1136/bmjopen-2016-014161.


Characterization of the Circumlimbal Suture Model of Chronic IOP Elevation in Mice and Assessment of Changes in Gene Expression of Stretch Sensitive Channels.

Zhao D, Nguyen CT, Wong VH, Lim JK, He Z, Jobling AI, Fletcher EL, Chinnery HR, Vingrys AJ, Bui BV.

Front Neurosci. 2017 Feb 10;11:41. doi: 10.3389/fnins.2017.00041. eCollection 2017.


Strategies to Build Readiness in Community Mobilization Efforts for Implementation in a Multi-Year Teen Pregnancy Prevention Initiative.

Bhuiya N, House LD, Desmarais J, Fletcher E, Conlin M, Perez-McAdoo S, Waggett J, Tendulkar SA.

J Adolesc Health. 2017 Mar;60(3S):S51-S56. doi: 10.1016/j.jadohealth.2016.11.001.


Improving the help and support provided to people who take new psychoactive substances ('legal highs').

Fletcher EH, Tasker SM, Easton P, Denvir L.

J Public Health (Oxf). 2016 Dec 2;38(4):e489-e495. doi: 10.1093/pubmed/fdv191. No abstract available.


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