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Items: 8

1.

Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell Cycle Kinetics.

Thompson CA, Gu A, Yang S, Mathew V, Fleisig HB, Wong JM.

Mol Cancer Res. 2018 May 14. pii: molcanres.0772.2017. doi: 10.1158/1541-7786.MCR-17-0772. [Epub ahead of print]

PMID:
29759988
2.

Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability.

Fleisig HB, Hukezalie KR, Thompson CA, Au-Yeung TT, Ludlow AT, Zhao CR, Wong JM.

Oncogene. 2016 Jan 14;35(2):218-27. doi: 10.1038/onc.2015.75. Epub 2015 Apr 20.

PMID:
25893297
3.

The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita.

Zeng XL, Thumati NR, Fleisig HB, Hukezalie KR, Savage SA, Giri N, Alter BP, Wong JM.

Hum Mol Genet. 2012 Feb 15;21(4):721-9. doi: 10.1093/hmg/ddr504. Epub 2011 Nov 4.

4.

Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells.

Fleisig HB, Wong JM.

Oncogene. 2012 Feb 23;31(8):954-65. doi: 10.1038/onc.2011.292. Epub 2011 Jul 11.

PMID:
21743490
5.

Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.

Tamakawa RA, Fleisig HB, Wong JM.

Cancer Res. 2010 Nov 1;70(21):8684-94. doi: 10.1158/0008-5472.CAN-10-2227. Epub 2010 Sep 13.

6.

Adenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stress.

Fleisig HB, Liang H, Nagarajan L.

J Mol Signal. 2010 Jun 11;5:6. doi: 10.1186/1750-2187-5-6.

7.

Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.

Fleisig HB, Orazio NI, Liang H, Tyler AF, Adams HP, Weitzman MD, Nagarajan L.

Oncogene. 2007 Jul 19;26(33):4797-805. Epub 2007 Feb 19.

PMID:
17311003
8.

Telomerase as a clinical target: current strategies and potential applications.

Fleisig HB, Wong JM.

Exp Gerontol. 2007 Jan-Feb;42(1-2):102-12. Epub 2006 Jun 30. Review.

PMID:
16814507

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