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Pharmacoproteomic characterisation of human colon and rectal cancer.

Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B.

Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701.


The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.

Bongartz H, Hessenkemper W, Müller C, Fensky M, Fritsch J, Mandel K, Behrmann I, Haan C, Fischer T, Feller SM, Schaper F.

Cell Signal. 2017 Jul;35:37-47. doi: 10.1016/j.cellsig.2017.03.021. Epub 2017 Mar 30.


Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET.

Huang F, Ma Z, Pollan S, Yuan X, Swartwood S, Gertych A, Rodriguez M, Mallick J, Bhele S, Guindi M, Dhall D, Walts AE, Bose S, de Peralta Venturina M, Marchevsky AM, Luthringer DJ, Feller SM, Berman B, Freeman MR, Alvord WG, Vande Woude G, Amin MB, Knudsen BS.

J Pathol Clin Res. 2016 Jul 1;2(4):210-222. eCollection 2016 Oct.


Hunting for the ultimate liquid cancer biopsy - let the TEP dance begin.

Feller SM, Lewitzky M.

Cell Commun Signal. 2016 Sep 27;14(1):24.


LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.

Kramer HB, Lai CF, Patel H, Periyasamy M, Lin ML, Feller SM, Fuller-Pace FV, Meek DW, Ali S, Buluwela L.

Nucleic Acids Res. 2016 Jan 29;44(2):582-94. doi: 10.1093/nar/gkv948. Epub 2015 Sep 22.


Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM.

J Biol Chem. 2015 Oct 16;290(42):25275-92. doi: 10.1074/jbc.M115.637207. Epub 2015 Aug 20.


Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer.

Stoepker C, Ameziane N, van der Lelij P, Kooi IE, Oostra AB, Rooimans MA, van Mil SE, Brink A, Dietrich R, Balk JA, Ylstra B, Joenje H, Feller SM, Brakenhoff RH.

Cancer Res. 2015 Sep 1;75(17):3543-53. doi: 10.1158/0008-5472.CAN-15-0528. Epub 2015 Jun 29.


A THEMIS:SHP1 complex promotes T-cell survival.

Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O.

EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22.


MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.

Wolf A, Eulenfeld R, Bongartz H, Hessenkemper W, Simister PC, Lievens S, Tavernier J, Feller SM, Schaper F.

Cell Signal. 2015 Feb;27(2):340-52. doi: 10.1016/j.cellsig.2014.11.017. Epub 2014 Nov 25.


Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site.

Perna AM, Reisen F, Schmidt TP, Geppert T, Pillong M, Weisel M, Hoy B, Simister PC, Feller SM, Wessler S, Schneider G.

Chem Sci. 2014 Jun 30;5:3583-3590.


Conformational recognition of an intrinsically disordered protein.

Krieger JM, Fusco G, Lewitzky M, Simister PC, Marchant J, Camilloni C, Feller SM, De Simone A.

Biophys J. 2014 Apr 15;106(8):1771-9. doi: 10.1016/j.bpj.2014.03.004.


Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.

Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE.

PLoS One. 2013 Oct 22;8(10):e77288. doi: 10.1371/journal.pone.0077288. eCollection 2013.


ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.

Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17969-74. doi: 10.1073/pnas.1309362110. Epub 2013 Oct 14.


Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.

Benz PM, Merkel CJ, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti JA, Adham IM, Linke WA, Feller SM, Fleming I, Renné T, Frantz S, Unger A, Schuh K.

Cell Commun Signal. 2013 Aug 12;11:56. doi: 10.1186/1478-811X-11-56.


Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.

Lourenço FC, Munro J, Brown J, Cordero J, Stefanatos R, Strathdee K, Orange C, Feller SM, Sansom OJ, Vidal M, Murray GI, Olson MF.

Gut. 2014 Mar;63(3):480-93. doi: 10.1136/gutjnl-2012-303883. Epub 2013 Apr 12.


Excellence in cell signaling research recognized with major new award.

Feller SM.

Cell Commun Signal. 2013 Mar 4;11(1):17. doi: 10.1186/1478-811X-11-17.


GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riaño A, Hoerter JA, Feller SM, Wülfing C, Gascoigne NR, Acuto O.

J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4.


Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.

Rose HM, Stuiver M, Thongwichian R, Theillet FX, Feller SM, Selenko P.

Biochim Biophys Acta. 2013 Jul;1834(7):1396-401. doi: 10.1016/j.bbapap.2013.01.023. Epub 2013 Jan 27.


Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.

Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD.

Bioorg Med Chem. 2013 Jul 15;21(14):4027-33. doi: 10.1016/j.bmc.2012.10.023. Epub 2012 Oct 27.


Phosphotyrosine recognition domains: the typical, the atypical and the versatile.

Kaneko T, Joshi R, Feller SM, Li SS.

Cell Commun Signal. 2012 Nov 7;10(1):32. doi: 10.1186/1478-811X-10-32.


What's in a loop?

Feller SM, Lewitzky M.

Cell Commun Signal. 2012 Oct 30;10(1):31. doi: 10.1186/1478-811X-10-31.


Science, democracy and emerging threats to scientific progress.

Feller SM.

Cell Commun Signal. 2012 Aug 23;10(1):24. doi: 10.1186/1478-811X-10-24.


Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns.

Schuh A, Becq J, Humphray S, Alexa A, Burns A, Clifford R, Feller SM, Grocock R, Henderson S, Khrebtukova I, Kingsbury Z, Luo S, McBride D, Murray L, Menju T, Timbs A, Ross M, Taylor J, Bentley D.

Blood. 2012 Nov 15;120(20):4191-6. doi: 10.1182/blood-2012-05-433540. Epub 2012 Aug 22.


Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.

Lewitzky M, Simister PC, Feller SM.

FEBS Lett. 2012 Aug 14;586(17):2740-50. doi: 10.1016/j.febslet.2012.04.029. Epub 2012 Apr 25. Review.


Very 'sticky' proteins - not too sticky after all?

Feller SM, Lewitzky M.

Cell Commun Signal. 2012 Jun 14;10(1):15. doi: 10.1186/1478-811X-10-15.


Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.

Wu Z, Doondeea JB, Gholami AM, Janning MC, Lemeer S, Kramer K, Eccles SA, Gollin SM, Grenman R, Walch A, Feller SM, Kuster B.

Mol Cell Proteomics. 2011 Dec;10(12):M111.011635. doi: 10.1074/mcp.M111.011635. Epub 2011 Sep 28.


Science under the lamppost.

Feller SM.

Cell Commun Signal. 2011 Sep 22;9:21. doi: 10.1186/1478-811X-9-21. No abstract available.


Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies.

Simister PC, Feller SM.

Mol Biosyst. 2012 Jan;8(1):33-46. doi: 10.1039/c1mb05272a. Epub 2011 Sep 20. Review.


Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.

Liu F, Giubellino A, Simister PC, Qian W, Giano MC, Feller SM, Bottaro DP, Burke TR Jr.

Biopolymers. 2011;96(6):780-8. doi: 10.1002/bip.21692.


Self-organization and regulation of intrinsically disordered proteins with folded N-termini.

Simister PC, Schaper F, O'Reilly N, McGowan S, Feller SM.

PLoS Biol. 2011 Feb 15;9(2):e1000591. doi: 10.1371/journal.pbio.1000591.


Early beginnings - the emergence of complex signaling systems and cell-to-cell communication.

Feller SM.

Cell Commun Signal. 2010 Jul 12;8:16. doi: 10.1186/1478-811X-8-16. No abstract available.


Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.

Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.

J Virol. 2010 Aug;84(16):8231-40. doi: 10.1128/JVI.01696-09. Epub 2010 Jun 9.


Life v2.0 - Quo vadis Homo sapiens?

Feller SM.

Cell Commun Signal. 2010 Jun 4;8:9. doi: 10.1186/1478-811X-8-9.


The dawn of a new era in cell signalling research.

Feller SM.

Cell Commun Signal. 2010 May 24;8(1):7. doi: 10.1186/1478-811X-8-7. No abstract available.


Beyond journal impact factors?

Feller SM.

Cell Commun Signal. 2010 Mar 10;8(1):4. doi: 10.1186/1478-811X-8-4. No abstract available.


Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D.

J Immunol. 2010 Apr 1;184(7):3665-76. doi: 10.4049/jimmunol.0903642. Epub 2010 Mar 1.


High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.

Kress TR, Raabe T, Feller SM.

Cell Commun Signal. 2010 Feb 2;8(1):1. doi: 10.1186/1478-811X-8-1.


Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.

Brady SC, Coleman ML, Munro J, Feller SM, Morrice NA, Olson MF.

Cancer Res. 2009 Sep 1;69(17):6773-81. doi: 10.1158/0008-5472.CAN-08-4447. Epub 2009 Aug 18.


Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM.

Structure. 2009 Jun 10;17(6):809-22. doi: 10.1016/j.str.2009.03.017.


Obituary: hidesaburo hanafusa 1929-2009.

Feller SM.

Cell Commun Signal. 2009 Apr 20;7:7. doi: 10.1186/1478-811X-7-7. No abstract available.


Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.

Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S.

Cell Res. 2009 May;19(5):638-50. doi: 10.1038/cr.2009.40.


Signal transduction--receptors, mediators, and genes.

Entschladen F, Lindquist JA, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K.

Sci Signal. 2009 Mar 24;2(63):mr3. doi: 10.1126/scisignal.263mr3. Review.


Signal transduction in the footsteps of goethe and schiller.

Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R.

Cell Commun Signal. 2009 Feb 4;7:2. doi: 10.1186/1478-811X-7-2.


Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells.

Emaduddin M, Edelmann MJ, Kessler BM, Feller SM.

Cell Commun Signal. 2008 Oct 9;6:7. doi: 10.1186/1478-811X-6-7.


Cell Communication and Signaling is becoming the official journal of the Signal Transduction Society.

Feller SM, Hass R, Janssen O, Friedrich K.

Cell Commun Signal. 2008 Aug 6;6:1. doi: 10.1186/1478-811X-6-1. No abstract available.


Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.

Emaduddin M, Bicknell DC, Bodmer WF, Feller SM.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2358-62. doi: 10.1073/pnas.0712176105. Epub 2008 Feb 7.


Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes.

Benz PM, Blume C, Moebius J, Oschatz C, Schuh K, Sickmann A, Walter U, Feller SM, Renné T.

J Cell Biol. 2008 Jan 14;180(1):205-19. doi: 10.1083/jcb.200709181.

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