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Items: 7

1.

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG.

EMBO J. 2018 Jun 15;37(12). pii: e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22.

2.

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells.

Lerner TR, Queval CJ, Fearns A, Repnik U, Griffiths G, Gutierrez MG.

BMC Biol. 2018 Jan 4;16(1):1. doi: 10.1186/s12915-017-0471-6.

3.

An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer.

Ashenden M, van Weverwijk A, Murugaesu N, Fearns A, Campbell J, Gao Q, Iravani M, Isacke CM.

Mol Cancer Ther. 2017 Sep;16(9):1967-1978. doi: 10.1158/1535-7163.MCT-16-0731. Epub 2017 Jun 13.

PMID:
28611109
4.

Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts.

Andreucci E, Francica P, Fearns A, Martin LA, Chiarugi P, Isacke CM, Morandi A.

Oncotarget. 2016 Dec 6;7(49):80543-80553. doi: 10.18632/oncotarget.11826.

5.

miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.

Bacci M, Giannoni E, Fearns A, Ribas R, Gao Q, Taddei ML, Pintus G, Dowsett M, Isacke CM, Martin LA, Chiarugi P, Morandi A.

Cancer Res. 2016 Mar 15;76(6):1615-26. doi: 10.1158/0008-5472.CAN-15-2038. Epub 2016 Jan 21.

6.

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.

Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, Hanby AM, Speirs V, Sahai E, Calvo F, Isacke CM.

Nat Commun. 2016 Jan 18;7:10305. doi: 10.1038/ncomms10305.

7.

An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.

Murugaesu N, Iravani M, van Weverwijk A, Ivetic A, Johnson DA, Antonopoulos A, Fearns A, Jamal-Hanjani M, Sims D, Fenwick K, Mitsopoulos C, Gao Q, Orr N, Zvelebil M, Haslam SM, Dell A, Yarwood H, Lord CJ, Ashworth A, Isacke CM.

Cancer Discov. 2014 Mar;4(3):304-17. doi: 10.1158/2159-8290.CD-13-0287. Epub 2014 Feb 11.

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