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Items: 29

1.

BRD4 facilitates replication stress-induced DNA damage response.

Zhang J, Dulak AM, Hattersley MM, Willis BS, Nikkilä J, Wang A, Lau A, Reimer C, Zinda M, Fawell SE, Mills GB, Chen H.

Oncogene. 2018 Apr 11. doi: 10.1038/s41388-018-0194-3. [Epub ahead of print]

PMID:
29636547
2.

AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.

Rhyasen GW, Hattersley MM, Yao Y, Dulak A, Wang W, Petteruti P, Dale IL, Boiko S, Cheung T, Zhang J, Wen S, Castriotta L, Lawson D, Collins M, Bao L, Ahdesmaki MJ, Walker G, O'Connor G, Yeh TC, Rabow AA, Dry JR, Reimer C, Lyne P, Mills GB, Fawell SE, Waring MJ, Zinda M, Clark E, Chen H.

Mol Cancer Ther. 2016 Nov;15(11):2563-2574. Epub 2016 Aug 29.

3.

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.

Schuller AG, Barry ER, Jones RD, Henry RE, Frigault MM, Beran G, Linsenmayer D, Hattersley M, Smith A, Wilson J, Cairo S, Déas O, Nicolle D, Adam A, Zinda M, Reimer C, Fawell SE, Clark EA, D'Cruz CM.

Clin Cancer Res. 2015 Jun 15;21(12):2811-9. doi: 10.1158/1078-0432.CCR-14-2685. Epub 2015 Mar 16.

4.

MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.

Booher RN, Hatch H, Dolinski BM, Nguyen T, Harmonay L, Al-Assaad AS, Ayers M, Nebozhyn M, Loboda A, Hirsch HA, Zhang T, Shi B, Merkel CE, Angagaw MH, Wang Y, Long BJ, Lennon XQ, Miselis N, Pucci V, Monahan JW, Lee J, Kondic AG, Im EK, Mauro D, Blanchard R, Gilliland G, Fawell SE, Zawel L, Schuller AG, Strack P.

PLoS One. 2014 Oct 7;9(10):e108371. doi: 10.1371/journal.pone.0108371. eCollection 2014.

5.

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.

Guertin AD, Li J, Liu Y, Hurd MS, Schuller AG, Long B, Hirsch HA, Feldman I, Benita Y, Toniatti C, Zawel L, Fawell SE, Gilliland DG, Shumway SD.

Mol Cancer Ther. 2013 Aug;12(8):1442-52. doi: 10.1158/1535-7163.MCT-13-0025. Epub 2013 May 22.

6.

Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.

Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM.

Cancer Res. 2008 Jan 15;68(2):561-70. doi: 10.1158/0008-5472.CAN-07-2307.

7.

Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.

Joesting MS, Perrin S, Elenbaas B, Fawell SE, Rubin JS, Franco OE, Hayward SW, Cunha GR, Marker PC.

Cancer Res. 2005 Nov 15;65(22):10423-30.

8.

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver.

Tao N, Gao GP, Parr M, Johnston J, Baradet T, Wilson JM, Barsoum J, Fawell SE.

Mol Ther. 2001 Jan;3(1):28-35.

9.

Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins.

Chi-Rosso G, Gotwals PJ, Yang J, Ling L, Jiang K, Chao B, Baker DP, Burkly LC, Fawell SE, Koteliansky VE.

J Biol Chem. 1997 Dec 12;272(50):31447-52.

10.

The alpha1beta1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganization.

Gotwals PJ, Chi-Rosso G, Lindner V, Yang J, Ling L, Fawell SE, Koteliansky VE.

J Clin Invest. 1996 Jun 1;97(11):2469-77.

11.

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen.

Danielian PS, White R, Hoare SA, Fawell SE, Parker MG.

Mol Endocrinol. 1993 Feb;7(2):232-40.

PMID:
8469236
12.

Effect of ligand binding and DNA binding on the structure of the mouse oestrogen receptor.

Emmas CE, Fawell SE, Hoare SA, Parker MG.

J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):291-9.

PMID:
1562507
13.

Role of ligand in oestrogen-receptor function.

Parker MG, Fawell SE, Danielian P, Arbuckle N.

Biochem Soc Trans. 1991 Nov;19(4):897-9. No abstract available.

PMID:
1794579
14.

Analysis of oestrogen receptor dimerisation using chimeric proteins.

White R, Fawell SE, Parker MG.

J Steroid Biochem Mol Biol. 1991;40(1-3):333-41.

PMID:
1720327
15.

Mechanism of estrogen receptor-dependent transcription in a cell-free system.

Elliston JF, Fawell SE, Klein-Hitpass L, Tsai SY, Tsai MJ, Parker MG, O'Malley BW.

Mol Cell Biol. 1990 Dec;10(12):6607-12.

16.
17.

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

Fawell SE, White R, Hoare S, Sydenham M, Page M, Parker MG.

Proc Natl Acad Sci U S A. 1990 Sep;87(17):6883-7.

18.
19.

Identification of two transactivation domains in the mouse oestrogen receptor.

Lees JA, Fawell SE, Parker MG.

Nucleic Acids Res. 1989 Jul 25;17(14):5477-88.

20.

A proposed consensus steroid-binding sequence--a reply.

Fawell SE, Lees JA, Parker MG.

Mol Endocrinol. 1989 Jun;3(6):1002-5.

PMID:
2739652
21.
22.

A specific insulin receptor and tyrosine kinase activity in the membranes of Neurospora crassa.

Fawell SE, Lenard J.

Biochem Biophys Res Commun. 1988 Aug 30;155(1):59-65.

PMID:
2970849
23.

Stimulation by mammalian insulin of glycogen metabolism in a wall-less strain of Neurospora crassa.

Fawell SE, McKenzie MA, Greenfield NJ, Adebodun F, Jordan F, Lenard J.

Endocrinology. 1988 Feb;122(2):518-23.

PMID:
2962852
24.

Effects of mammalian insulin on metabolism, growth, and morphology of a wall-less strain of Neurospora crassa.

McKenzie MA, Fawell SE, Cha M, Lenard J.

Endocrinology. 1988 Feb;122(2):511-7.

PMID:
2962851
25.
26.

Comparison of seminal vesicle secretory proteins of rodents using antibody and nucleotide probes.

Fawell SE, McDonald CJ, Higgins SJ.

Mol Cell Endocrinol. 1987 Mar;50(1-2):107-14.

PMID:
2438167
28.

Androgen-regulated proteins of rat seminal vesicle secretion constitute a structurally related family present in the copulatory plug.

Fawell SE, Pappin DJ, McDonald CJ, Higgins SJ.

Mol Cell Endocrinol. 1986 May;45(2-3):205-13.

PMID:
2423395
29.

Androgen regulation of specific mRNAs, endoplasmic reticulum and Golgi-system.

Fawell SE, Higgins SJ.

Mol Cell Endocrinol. 1984 Aug;37(1):15-27.

PMID:
6468750

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