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Items: 8

1.

Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A.

Nature. 2017 Sep 7;549(7670):111-115. doi: 10.1038/nature23875. Epub 2017 Aug 30.

2.

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Farh KK, Franke A, Gori AS, Goyette P, Halfvarson J, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Théâtre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ; International Inflammatory Bowel Disease Genetics Consortium, Weersma RK, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M, Daly MJ, Barrett JC.

Nature. 2017 Jul 13;547(7662):173-178. doi: 10.1038/nature22969. Epub 2017 Jun 28.

3.

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE.

Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29.

4.

Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.

Malik AN, Vierbuchen T, Hemberg M, Rubin AA, Ling E, Couch CH, Stroud H, Spiegel I, Farh KK, Harmin DA, Greenberg ME.

Nat Neurosci. 2014 Oct;17(10):1330-9. doi: 10.1038/nn.3808. Epub 2014 Sep 7.

5.

Expanding the microRNA targeting code: functional sites with centered pairing.

Shin C, Nam JW, Farh KK, Chiang HR, Shkumatava A, Bartel DP.

Mol Cell. 2010 Jun 25;38(6):789-802. doi: 10.1016/j.molcel.2010.06.005.

6.

Most mammalian mRNAs are conserved targets of microRNAs.

Friedman RC, Farh KK, Burge CB, Bartel DP.

Genome Res. 2009 Jan;19(1):92-105. doi: 10.1101/gr.082701.108. Epub 2008 Oct 27.

7.

MicroRNA targeting specificity in mammals: determinants beyond seed pairing.

Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP.

Mol Cell. 2007 Jul 6;27(1):91-105.

8.

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.

Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP.

Science. 2005 Dec 16;310(5755):1817-21. Epub 2005 Nov 24.

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