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Items: 9

1.

Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.

Maximov PY, Abderrahman B, Fanning SW, Sengupta S, Fan P, Curpan RF, Quintana Rincon DM, Greenland JA, Rajan SS, Greene GL, Jordan VC.

Mol Pharmacol. 2018 May 8. pii: mol.117.111385. doi: 10.1124/mol.117.111385. [Epub ahead of print]

2.

A "cross-stitched" peptide with improved helicity and proteolytic stability.

Speltz TE, Mayne CG, Fanning SW, Siddiqui Z, Tajkhorshid E, Greene GL, Moore TW.

Org Biomol Chem. 2018 May 23;16(20):3702-3706. doi: 10.1039/c8ob00790j.

PMID:
29725689
3.

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Speltz TE, Fanning SW, Mayne CG, Fowler C, Tajkhorshid E, Greene GL, Moore TW.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4252-5. doi: 10.1002/anie.201510557. Epub 2016 Mar 1.

4.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL.

Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792.

5.

Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.

Fanning SW, Walter R, Horn JR.

Protein Eng Des Sel. 2014 Oct;27(10):391-7. doi: 10.1093/protein/gzu033. Epub 2014 Aug 20.

PMID:
25143596
6.

Mutations in the coat protein-binding cis-acting RNA motifs debilitate RNA recombination of Brome mosaic virus.

Sztuba-Solińska J, Fanning SW, Horn JR, Bujarski JJ.

Virus Res. 2012 Dec;170(1-2):138-49. doi: 10.1016/j.virusres.2012.10.001. Epub 2012 Oct 16.

PMID:
23079110
7.

A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches.

Murtaugh ML, Fanning SW, Sharma TM, Terry AM, Horn JR.

Protein Sci. 2011 Sep;20(9):1619-31. doi: 10.1002/pro.696. Epub 2011 Aug 3.

8.

A combinatorial approach to engineering a dual-specific metal switch antibody.

Fanning SW, Murtaugh ML, Horn JR.

Biochemistry. 2011 Jun 14;50(23):5093-5. doi: 10.1021/bi2003845. Epub 2011 May 18.

PMID:
21568282
9.

An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop.

Fanning SW, Horn JR.

Protein Sci. 2011 Jul;20(7):1196-207. doi: 10.1002/pro.648. Epub 2011 May 23.

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